Inner ear development

hair cell fate determination

hair cell regeneration

regulation of gene expression

1. Li J#, Zhang T#, Ramakrishnan A#, Fritzsch B, Xu J, Wong EYM, Loh YE, Ding J, Shen L, and Xu PX*. Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium. Nucleic Acids Research 2020, 48: 2880–2896.

2. Xu J#, Li J#, Zhang T#, Jiang H, Ramakrishnan A, Fritzsch B, Shen L, and Xu PX*. Chromatin remodelers and lineage-specific factors interact to target enhancers to establish proneurosensory fate within otic ectoderm. Proceedings of the National Academy of Sciences of the United States of America 2021, 118 (12) e2025196118. (#co-first author)

3. Li J#, Cheng C#, Xu J, Zhang T, Tokat B, Dolios G, Ramakrishnan A, Shen L, Wang R, Xu PX*. The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity. Nucleic Acids Research 2022, doi.org/10.1093/nar/gkac760.

4. Li J#, Xu J#, Jiang H#, Zhang T, Ramakrishnan A, Shen L and Xu PX*. Chromatin remodelers interact with Eya1 and Six2 to target enhancers to control nephron progenitor cell maintenance. Journal of the American Society of Nephrology 2021, 32: 2815-2833.

5. Li J, Rodriguez Y, Cheng C, Zeng L, Wong EYM, Xu CY, Zhou MM and Xu PX*. EYA1's Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer. Molecular and Cellular Biology 2017, 37(1). pii: e00499-16. 

现指导学生

王亚帆  硕士研究生  086001-生物技术与工程  

颜梦珍  博士研究生  071002-动物学