基本信息


主要研究生物医学显微影像处理涉及的精准成像原理、深度学习模型和快速分析技术。

中科院自动化所模式识别国家重点实验室类脑智能中心研究员/博导,中科院大学未来技术学院岗位教授/博导,中科院自动化所微观重建团队负责人、显微分析平台负责人、中科院十三五科教基础设施“脑认知功能图谱与类脑智能交叉研究平台”总工程师、技术总师。

中科院自动化所学术委员会委员、学位评定委员会委员,中科院脑科学与智能技术卓越中心骨干,中科院关键技术人才。


电子邮件: hua.han@ia.ac.cn
通信地址: 北京市海淀区中关村东路95号自动化大厦
邮政编码: 100190

研究领域

研究领域:面向海量显微影像数据的三维重建和深度分析,探索深度学习、机器学习、模式识别等前沿理论,解决海量显微图像分类、检测、识别等挑战性问题。


高通量显微成像技术产生海量影像数据,如何重构数据、分析数据、可视数据等已成为脑科学与类脑研究领域的重大挑战。课题组致力于将人工智能最新进展和生命科学前沿问题紧密结合,建立以机器学习为驱动内核的显微大数据智能分析技术体系,为构建类脑计算仿真提供生物真实网络和仿生建模依据。


已在SCIENCE、NAT.COMM.、JMCB、CMPB、NEUROSCI BULL、IJCAI、CVPR、EMBC、ISBI、SPIE等高水平杂志和会议上发表学术论文40余篇,授权发明专利20余项。



招生信息

招生专业:模式识别与智能系统

招生方向:图像与视频处理、智能医学生物影像

招生部门:模式识别国家重点实验室/类脑智能研究中心(直博)、中国科学院大学未来技术学院(直博)

欢迎自动化、计算机、电子、数学、物理、生物等专业优秀学生报考。

出版信息





发表论文
(1) Synaptic degeneration in the prefrontal cortex of a rat AD model revealed by volume electron microscopy, Journal of Molecular Cell Biology, 2022, 通讯作者
(2) Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells, NEUROSCIENCE BULLETIN(Cover), 2022, 通讯作者
(3) Neuronal Morphological Model-Driven Image Registration for Serial Electron Microscopy Sections, Frontiers in Human Neuroscience, 2022, 通讯作者
(4) Classifying Drosophila olfactory projection neuron boutons by quantitative analysis of electron microscopic reconstruction, iScience, 2022, 第 13 作者
(5) Deep residual contextual and subpixel convolution network for automated neuronal structure segmentation in micro-connectomics, Computer Methods and Programs in Biomedicine, 2022, 通讯作者
(6) Blind2Unblind: Self-Supervised Image Denoising with Visible Blind Spots, IEEE Conference on Computer Vision and Pattern Recognition(CVPR), 2022, 通讯作者
(7) Phase prediction of Ni-base superalloys via high-throughput experiments and machine learning, MATERIALS RESEARCH LETTERS, 2021, 第 14 作者
(8) Three-dimensional ATUM-SEM reconstruction and analysis of hepatic endoplasmic reticulum-organelle interactions, Three-dimensional ATUM-SEM reconstruction and analysis of hepatic endoplasmic reticulum-organelle interactions, JOURNAL OF MOLECULAR CELL BIOLOGY(Cover), 2021, 通讯作者
(9) Sparse self-attention aggregation networks for neural sequence slice interpolation, BIODATA MINING, 2021, 通讯作者
(10) Virus identification in electron microscopy images by residual mixed attention network, COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 2021, 通讯作者
(11) An effective AI integrated system for neuron tracing on anisotropic electron microscopy volume, BIOMEDICAL SIGNAL PROCESSING AND CONTROL, 2021, 通讯作者
(12) A high-throughput approach to explore the multi-component alloy space: A case study of nickel-based superalloys, JOURNAL OF ALLOYS AND COMPOUNDS, 2021, 通讯作者
(13) An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments, Cell Research, 2021, 第 17 作者
(14) Geolocation Error Estimation and Correction on Long-Term MWRI Data, IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING, 2021, 第 5 作者
(15) Human attention-inspired volume reconstruction method on serial section electron microscopy images, CYTOMETRY PART A, 2021, 通讯作者
(16) Quality metrology of carbon nanotube thin films and its application for carbon nanotube-based electronics, Quality metrology of carbon nanotube thin films and its application for carbon nanotube-based electronics, NANO RESEARCH, 2020, 第 6 作者
(17) Automatic Reconstruction of Mitochondria and Endoplasmic Reticulum in Electron Microscopy Volumes by Deep Learning, FRONTIERS IN NEUROSCIENCE, 2020, 通讯作者
(18) An innovative method for screening and evaluating the degree of diabetic retinopathy and drug treatment based on artificial intelligence algorithms, PHARMACOLOGICAL RESEARCH, 2020, 通讯作者
(19) High throughput experiment assisted discovery of new Ni-base superalloys, SCRIPTA MATERIALIA, 2020, 第 10 作者
(20) Dual Networks for High-Precision and High-Speed Registration of Brain Electron Microscopy Images, BRAIN SCIENCES, 2020, 通讯作者
(21) Massive Data Management and Sharing Module for Connectome Reconstruction, BRAIN SCIENCES, 2020, 通讯作者
(22) 辣根过氧化物酶标记与样品后染色联用在微观脑联结组学中的应用, Application of Horseradish Peroxidase Labeling Along With Post-Staining Improves Data Quality in Micro-Brain Connectomics, 生物化学与生物物理进展(封面), 2020, 通讯作者
(23) Electron Microscopic Sequential Images Stitching Based on Belief Propagation, ELEVENTH INTERNATIONAL CONFERENCE ON GRAPHICS AND IMAGE PROCESSING (ICGIP 2019), 2020, 第 3 作者
(24) 前沿生物医学电子显微技术的发展态势与战略分析, Frontiers of electron microscopy for biomedical research, 中国科学:生命科学, 2020, 第 3 作者
(25) SiamBOMB: A Real-time AI-based System for Home-cage Animal Tracking, Segmentation and Behavioral Analysis, International Conference on Artificial Intelligence(IJCAI), 2020, 通讯作者
(26) A common hub for sleep and motor control in the substantia nigra, SCIENCE, 2020, 其他(合作组作者)
(27) ROBUST GLOBAL OPTIMIZED AFFINE REGISTRATION METHOD FOR MICROSCOPIC IMAGES OF BIOLOGICAL TISSUE, 2020 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING, 2020, 第 3 作者
(28) Using Scale Information to Improve SIFT-Based Electron Microscope Image Registration Method, ELEVENTH INTERNATIONAL CONFERENCE ON GRAPHICS AND IMAGE PROCESSING (ICGIP 2019), 2020, 第 3 作者
(29) Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution, National Science Review, 2019, 第 20 作者
(30) Automatic Classification for the Type of Multiple Synapse Based on Deep Learning, 2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2019, 通讯作者
(31) Image deformation based on contour using moving integral least squares, IET IMAGE PROCESSING, 2019, 第 6 作者
(32) L(0 )sparse approximation of coastline inflection method on fy-3c mwri data, IEEE GEOSCIENCE AND REMOTE SENSING LETTERS, 2019, 第 7 作者
(33) EA-LSTM: Evolutionary attention-based LSTM for time series prediction, KNOWLEDGE-BASED SYSTEMS, 2019, 第 4 作者
(34) An Effective Encoder-Decoder Network for Neural Cell Bodies and Cell Nucleus Segmentation of EM Images, 2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2019, 通讯作者
(35) Skeleton-based Image Registration of Serial Electron Microscopy Sections, MEDICAL IMAGING 2019: DIGITAL PATHOLOGY, 2019, 通讯作者
(36) Brain activity regulates loose coupling between mitochondrial and cytosolic Ca 2+ transients, NATURE COMMUNICATIONS, 2019, 第 9 作者
(37) MORPHOLOGY-RETAINED NON-LINEAR IMAGE REGISTRATION OF SERIAL ELECTRON MICROSCOPY SECTIONS, 2018 25TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP), 2018, 第 3 作者
(38) A Refined Spatial Transformer Network, International Conference on Neural Information Processing (ICONIP 2018), 2018, 通讯作者
(39) DEEP CONTEXTUAL RESIDUAL NETWORK FOR ELECTRON MICROSCOPY IMAGE SEGMENTATION IN CONNECTOMICS, 2018 IEEE 15TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2018), 2018, 第 3 作者
(40) Grayscale Inhomogeneity Correction Method for Multiple Mosaicked Electron Microscope Images, NINTH INTERNATIONAL CONFERENCE ON GRAPHIC AND IMAGE PROCESSING (ICGIP 2017), 2018, 第 3 作者
(41) Effective automated pipeline for 3D reconstruction of synapses based on deep learning, BMC BIOINFORMATICS, 2018, 通讯作者
(42) An Unsupervised Network for Fast Microscopic Image Registration, MEDICAL IMAGING 2018: DIGITAL PATHOLOGY, 2018, 第 3 作者
(43) A Novel 3D Connection Algorithm of Mitochondria from ATUM-SEM Stacks Based on Segmentation Information in Context, IEEE Engineering in Medicine and Biology Society(EMBC), 2018, 通讯作者
(44) Deep Contextual Residual Network for Electron Microscopy Image Segmentation in Connectomics, 2018 IEEE 15TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2018), 2018, 第 3 作者
(45) Large-area and highly uniform carbon nanotube film for high-performance thin film transistors, NANO RESEARCH, 2018, 第 8 作者
(46) Automatic Mitochondria Segmentation for EM Data Using a 3D Supervised Convolutional Network, FRONTIERS IN NEUROANATOMY, 2018, 通讯作者
(47) Large-area and highly uniform carbon nanotube film for nigh-performance thin film transistors, Large-area and highly uniform carbon nanotube film for nigh-performance thin film transistors, 纳米研究:英文版, 2018, 第 8 作者
(48) Morphology-Retained Non-Linear Image Registration of Serial Electron Microscopy Sections, 2018 25TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP), 2018, 第 3 作者
(49) NON-ITERATIVE SIMULTANEOUS RIGID REGISTRATION METHOD FOR SERIAL SECTIONS OF BIOLOGICAL TISSUE, 2018 IEEE 15TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2018), 2018, 第 4 作者
(50) Correlative light and electron microscopy for complex cellular structures on pdms substrates with coded micro-patterns, LAB ON A CHIP, 2018, 第 6 作者
(51) A fast forward 3D connection algorithm for mitochondria and synapse segmentations from serial EM images, BIODATA MINING, 2018, 通讯作者
(52) Learning With Coefficient-Based Regularized Regression on Markov Resampling, IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS, 2018, 第 6 作者
(53) An Effective Fully Deep Convolutional Neural Networks for Mitochondria Segmentation Based on ATUM-SEM, MEDICAL IMAGING 2018: IMAGE PROCESSING, 2018, 通讯作者
(54) GAN Based Sample Simulation for SEM-Image Super Resolution, COMPUTER VISION, PT II, 2017, 第 4 作者
(55) Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity, CELL RESEARCH, 2017, 第 8 作者
(56) An automated pipeline for mitochondrial segmentation on ATUM-SEM stacks, JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 2017, 通讯作者
(57) Large scale three-dimensional reconstruction of an entire Caenorhabditis elegans larva using AutoCUTS-SEM, Journal of Structural Biology, 2017, 第 6 作者
(58) Microscopic neural image registration based on the structure of mitochondria, MEDICAL IMAGING 2017: IMAGE PROCESSING, 2017, 第 1 作者
(59) Deep Learning and Shapes Similarity for Joint Segmentation and Tracing single Neurons in SEM images, MEDICAL IMAGING 2017: IMAGE PROCESSING, 2017, 第 2 作者
(60) Formation mechanism of anodic titanium oxide in mixed electrolytes, MATERIALS RESEARCH BULLETIN, 2017, 通讯作者
(61) 3D-Reconstruction of Synapses with deep learning Based on EM, MEDICAL IMAGING 2017: PHYSICS OF MEDICAL IMAGING, 2017, 通讯作者
(62) Image Deformation Using Modified Moving Least Squares with Outlines, 2017 IEEE INTERNATIONAL CONFERENCE ON MECHATRONICS AND AUTOMATION (ICMA), 2017, 第 5 作者
(63) An automated pipeline for bouton, spine, and synapse detection of in vivo two-photon images, BIODATA MINING, 2017, 通讯作者
(64) Watershed Learning Merge Tree used for Segmenting Neurons in SEM Images, 2017 IEEE INTERNATIONAL CONFERENCE ON MECHATRONICS AND AUTOMATION (ICMA), 2017, 通讯作者
(65) Large scale three-dimensional reconstruction of an entire Caenorhabditis elegans larva using AutoCUTS-SEM, Journal of Structural Biology, 2017, 第 7 作者
(66) Sequentially Supervised Long Short-Term Memory for Gesture Recognition, COGNITIVE COMPUTATION, 2016, 第 3 作者
(67) Automatically Segmenting and Reconstructing Neurons in SEM images, 2016 IEEE INTERNATIONAL CONFERENCE ON MECHATRONICS AND AUTOMATION, 2016, 通讯作者

学生培养

2010级

张旭  硕士研究生  430112-计算机技术  华北电力大学  毕业去向:大唐电信

2011级

胡敏  硕士研究生  085211-计算机技术  华中科技大学  毕业去向IBM研究院

2014级

曹会文  硕士研究生  085211-计算机技术  天津大学  毕业去向:中科院自动化所

饶强     硕士研究生  081104-模式识别与智能系统  西安交通大学  毕业去向:华为 

2015级

舒畅      直博研究生  081203-计算机应用技术 华中科技大学 毕业去向:美团

杨茂柯  硕士研究生  085211-计算机技术  中南大学 毕业去向:深动科技 

肖振鹏  硕士联培生   085211-计算机技术  武汉理工大学 毕业去向:比特大陆 

2016级

肖驰     博士研究生  081104-模式识别与智能系统  北京理工大学 毕业去向:海南大学

刘静     硕博研究生  081104-模式识别与智能系统  西北工业大学 毕业去向:中科院自动化所

赵盼     硕士联培生  085211-计算机技术    青岛科技大学 毕业去向:阿里

2017级

周芳旭 直博研究生  081104-模式识别与智能系统   北京交通大学 毕业去向:北京大学

江熠     直博研究生  081104-模式识别与智能系统  安徽大学 毕业去向:上海精准医学研究院

常胜     硕博研究生  085211-计算机技术  北京化工大学

2018级

刘家正  直博研究生  081104-模式识别与智能系统  中国地质大学(武汉)

辛桐     直博研究生  081104-模式识别与智能系统  南京邮电大学

王泽锦 硕博研究生  081104-模式识别与智能系统  武汉理工大学

2019级

洪贝     博士研究生 081104-模式识别与智能系统 湖北大学

李贞辰 直博研究生  081104-模式识别与智能系统  西安电子科技大学

孙国栋 硕士研究生 081104-模式识别与智能系统  华北电力大学 毕业去向:华为

2020级

翟昊    直博研究生  081104-模式识别与智能系统  北京科技大学

袁静斌 博士研究生 081104-模式识别与智能系统  哈尔滨理工大学

2021级

郭锦越   直博研究生  081104-模式识别与智能系统  北京理工大学

张衍超   直博研究生  081104-模式识别与智能系统  东北大学

2022级

闫海洋   直博研究生  081104-模式识别与智能系统  北京理工大学

陈浩然   硕博研究生  081104-模式识别与智能系统  同济大学




联合培养学生

许宇璇(硕士,北京大学)

汪璐(博士,北京大学)毕业去向:中科院高能所

陈波昊(硕士,中科院自动化所

吕亚楠(硕士,中科院自动化所毕业去向:中科院自动化所

王圣雄(博士,中科院生物物理所) 毕业去向:上海精准医学研究院

李伟夫(博士,湖北大学)毕业去向:华中农业大学

邓昊(博士,澳门科技大学) 毕业去向:华中农业大学

罗杰(硕士,湖北大学) 毕业去向:中科慧眼

赵兴辉(硕士,湖北大学)毕业去向:中科院自动化所