1. 纳米孔传感器在分析检测中的应用
2. 纳米孔DNA测序
3. 纳米孔蛋白质测序

070302-分析化学
0703Z1-化学生物学

纳米孔单分子技术
蛋白质测序
人工离子通道

2002-04--2005-09   英国剑桥大学化学系   博士
1998-09--2001-06   北京大学化学学院   硕士
1994-09--1998-06   北京大学化学学院   学士

-- 研究生

-- 博士

2017-01~现在, 中国科学院化学研究所, 研究员
2009-02~2016-12,中国科学院高能物理研究所, 研究员
2005-11~2008-11,英国牛津大学化学系, 博士后

   

[1] Zhang, Yun, Yi, Yakun, Li, Ziyi, Zhou, Ke, Liu, Lei, Wu, HaiChen. Peptide sequencing based on host-guest interaction-assisted nanopore sensing. NATURE METHODS. 2023, http://dx.doi.org/10.1038/s41592-023-02095-4.
[2] Zhang, Mingqian, Huang, Xiaobin, Wu, HaiChen. Application of Biological Nanopore Sequencing Technology in the Detection of Microorganisms Microorganisms†. Chinese Journal of Chemistry[J]. 2023, 41: 3473-3483, [3] Peng, Weichao, Yan, Shuaihu, Zhou, Ke, Wu, HaiChen, Liu, Lei, Zhao, Yuliang. High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes. NATURE COMMUNICATIONS[J]. 2023, 14: https://doi.org/10.1038/s41467-023-38399-4.
[4] Sheng, Yingying, Zhou, Ke, Liu, Lei, Wu, HaiChen. A Nanopore Sensing Assay Resolves Cascade Reactions in a Multienzyme System. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(20): http://dx.doi.org/10.1002/anie.202200866.
[5] Hu, WeiHu, Zhou, Ke, Liu, Lei, Wu, HaiChen. Construction of a pH-Mediated Single-Molecule Switch with a Nanopore-DNA Complex. SMALL[J]. 2022, 18(28): http://dx.doi.org/10.1002/smll.202201650.
[6] Guo, Bingyuan, Song, Peng, Zhou, Ke, Liu, Lei, Wu, HaiChen. Simultaneous Sensing of Multiple Cancer Biomarkers by a Single DNA Nanoprobe in a Nanopore. ANALYTICAL CHEMISTRY[J]. 2020, 92(13): 9405-9411, http://dx.doi.org/10.1021/acs.analchem.0c01909.
[7] Zhang, Yun, Song, Peng, Guo, Bingyuan, Hao, Wenying, Liu, Lei, Wu, HaiChen. A bifunctional DNA probe for sensing pH and microRNA using a nanopore. ANALYST[J]. 2020, 145(21): 7025-7029, http://dx.doi.org/10.1039/d0an01208d.
[8] Sheng Yingying, Zhang Shouwen, Liu Lei, Wu HaiChen. Measuring Enzymatic Activities with Nanopores. CHEMBIOCHEMnull. 2020, 21(15): 2089-2097, https://www.webofscience.com/wos/woscc/full-record/WOS:000527704600001.
[9] Sheng, Yingying, Zhou, Ke, Liu, Quansheng, Liu, Lei, Wu, HaiChen. Probing Conformational Polymorphism of DNA Assemblies with Nanopores. ANALYTICAL CHEMISTRY[J]. 2020, 92(11): 7485-7492, https://www.webofscience.com/wos/woscc/full-record/WOS:000538417400019.
[10] Liu, Lei, You, Yi, Zhou, Ke, Guo, Bingyuan, Cao, Zhong, Zhao, Yuliang, Wu, HaiChen. A Dual-Response DNA Probe for Simultaneously Monitoring Enzymatic Activity and Environmental pH Using a Nanopore. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(42): 14929-14934, http://dx.doi.org/10.1002/anie.201907816.
[11] Zhang, Zehui, Li, Ting, Sheng, Yingying, Liu, Lei, Wu, HaiChen. Enhanced Sensitivity in Nanopore Sensing of Cancer Biomarkers in Human Blood via Click Chemistry. SMALL[J]. 2019, 15(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000455545800012.
[12] You, Yi, Zhou, Ke, Guo, Bingyuan, Liu, Quansheng, Cao, Zhong, Liu, Lei, Wu, HaiChen. Measuring Binding Constants of Cucurbituril-Based Host-Guest Interactions at the Single-Molecule Level with Nanopores. ACS SENSORS[J]. 2019, 4(3): 774-779, http://www.corc.org.cn/handle/1471x/2160698.
[13] Wu, Haichen. DNA Based Nanopore Sensing. BIOPHYSICAL JOURNALnull. 2019, 116(3): 149A-149A, http://dx.doi.org/10.1016/j.bpj.2018.11.826.
[14] Zhao, Yating, Liu, Lei, Tu, Yingfeng, Wu, HaiChen. Investigating the effect of mono- and multivalent counterions on the conformation of poly(styrenesulfonic acid) by nanopores. ELECTROPHORESIS[J]. 2019, 40(16-17): 2180-2185, [15] Yao, Zhiyi, Ge, Wenqi, Guo, Mingwei, Xiao, Keren, Qiao, Yadong, Cao, Zhong, Wu, HaiChen. Ultrasensitive detection of thiophenol based on a water-soluble pyrenyl probe. TALANTA[J]. 2018, 185: 146-150, http://www.corc.org.cn/handle/1471x/2177521.
[16] Sheng, Yingying, You, Yi, Cao, Zhong, Liu, Lei, Wu, HaiChen. Rapid and selective DNA-based detection of melamine using alpha-hemolysin nanopores. ANALYST[J]. 2018, 143(10): 2411-2415, http://dx.doi.org/10.1039/c8an00580j.
[17] Wu, Xiaoyuan, Guo, Bingyuan, Sheng, Yingying, Zhang, Yun, Wang, Jin, Peng, Shuchuan, Liu, Lei, Wu, HaiChen. Multiplexed discrimination of microRNA single nucleotide variants through triplex molecular beacon sensors. CHEMICAL COMMUNICATIONS[J]. 2018, 54(55): 7673-7676, https://www.webofscience.com/wos/woscc/full-record/WOS:000442118800024.
[18] Guo, Bingyuan, Sheng, Yingying, Zhou, Ke, Liu, Quansheng, Liu, Lei, Wu, HaiChen. Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(14): 3602-3606, http://www.corc.org.cn/handle/1471x/2178141.
[19] Liu, Lei, Li, Ting, Zhang, Shouwen, Song, Peng, Guo, Bingyuan, Zhao, Yuliang, Wu, HaiChen. Simultaneous Quantification of Multiple Cancer Biomarkers in Blood Samples through DNA-Assisted Nanopore Sensing. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(37): 11882-11887, https://www.webofscience.com/wos/woscc/full-record/WOS:000443675700003.
[20] 姚志轶, 曹忠, 葛文奇, 圣迎迎, 乔亚东, 吴海臣. 苯硫酚荧光探针研究进展. 化学传感器[J]. 2017, 37(1): 9-20, http://lib.cqvip.com/Qikan/Article/Detail?id=672616803.
[21] Qiao, Yadong, Yao, Zhiyi, Ge, Wenqi, Zhang, Li, Wu, HaiChen. Rapid and visual detection of heparin based on the disassembly of polyelectrolyte-induced pyrene excimers. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2017, 15(12): 2569-2574, http://www.corc.org.cn/handle/1471x/2176689.
[22] Hu, GuoFei, Cheng, HongBo, Niu, JiaLiang, Zhang, ZhanHui, Wu, HaiChen. A multi-responsive molecular switch based on a diarylethene derivative containing dinitrobenzenesulfonic amide groups. DYES AND PIGMENTS[J]. 2017, 136: 354-360, http://www.corc.org.cn/handle/1471x/2176629.
[23] Ge WenQi, Sheng YingYing, Qiao YaDong, Cao Zhong, Wu HaiChen, Yao ZhiYi. Fluorescent Detection of p-Nitroaniline Based on an Anionic Pyrenyl Probe. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2017, 45(10): 1523-1528, http://www.corc.org.cn/handle/1471x/2176885.
[24] Cheng, HongBo, Li, Ziyan, Huang, YaoDong, Liu, Lei, Wu, HaiChen. Pillararene-Based Aggregation-Induced-Emission-Active Supramolecular System for Simultaneous Detection and Removal of Mercury(II) in Water. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(13): 11889-11894, http://dx.doi.org/10.1021/acsami.7b00363.
[25] Ge WenQi, Sheng YingYing, Qiao YaDong, Cao Zhong, Wu HaiChen, Yao ZhiYi. Fluorescent Detection of p-Nitroaniline Based on an Anionic Pyrenyl Probe. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2017, 45(10): 1523-1528, http://www.corc.org.cn/handle/1471x/2176885.
[26] Wang, Xingyong, Li, Yuru, Li, Ting, Liu, Lei, Wu, HaiChen. The effect of secondary structures on the generation of characteristic events during the translocation of DNA hybrid through alpha-hemolysin. SCIENCE CHINA-CHEMISTRY[J]. 2016, 59(1): 135-141, http://ir.ihep.ac.cn/handle/311005/247943.
[27] Liu, Lei, Li, Yuru, Li, Ting, Xie, Jiani, Chen, Chaofei, Liu, Quansheng, Zhang, Shouwen, Wu, Hai Chen. Selective Detection of 8-Oxo-2'-deoxyguanosine in Single-Stranded DNA via Nanopore Sensing Approach. ANALYTICAL CHEMISTRY[J]. 2016, 88(2): 1073-1077, http://ir.ihep.ac.cn/handle/311005/247961.
[28] Liu, Lei, Wu, HaiChen. DNA-Based Nanopore Sensing. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(49): 15216-15222, http://ir.iccas.ac.cn/handle/121111/36434.
[29] Yang, Yan, Yao, Zhiyi, Li, Wei, Chen, Kui, Liu, Lei, Wu, HaiChen. Selective detection of mercury(II) and methylmercury(II) via coordination-induced emission of a small-molecule probe. SCIENCE CHINA-CHEMISTRY[J]. 2016, 59(12): 1651-1657, http://lib.cqvip.com/Qikan/Article/Detail?id=74668871504849544950484957.
[30] Liang, Haiqin, Yao, Zhiyi, Ge, Wenqi, Qiao, Yadong, Zhang, Li, Cao, Zhong, Wu, HaiChen. Selective and sensitive detection of picric acid based on a water-soluble fluorescent probe. RSC ADVANCES[J]. 2016, 6(44): 38328-38331, http://ir.ihep.ac.cn/handle/311005/248055.
[31] Yao, Zhiyi, Qiao, Yadong, Liang, Haiqin, Ge, Wenqi, Zhang, Li, Cao, Zhong, Wu, HaiChen. Approach Based on Polyelectrolyte-Induced Nanoassemblies for Enhancing Sensitivity of Pyrenyl Probes. ANALYTICAL CHEMISTRY[J]. 2016, 88(21): 10605-10610, https://www.webofscience.com/wos/woscc/full-record/WOS:000386991200039.
[32] Cheng, HongBo, Hu, GuoFei, Zhang, ZhanHui, Gao, Liang, Gao, Xingfa, Wu, HaiChen. Photocontrolled Reversible Luminescent Lanthanide Molecular Switch Based on a Diarylethene-Europium Dyad. INORGANIC CHEMISTRY[J]. 2016, 55(16): 7962-7968, https://www.webofscience.com/wos/woscc/full-record/WOS:000381594100024.
[33] Yan Yang, Zhiyi Yao, Wei Li, Kui Chen, Lei Liu, Hai-Chen Wu. Selective detection of mercury(II) and methylmercury(II) via coordinationinduced emission of a small-molecule probe. 中国科学：化学英文版[J]. 2016, 1651-1657, http://lib.cqvip.com/Qikan/Article/Detail?id=74668871504849544950484957.
[34] Guo, Bingyuan, Yao, Zhiyi, Liu, Lei, Wu, HaiChen. Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor. CHEMICAL SCIENCE[J]. 2016, 7(8): 5287-5293, http://ir.iccas.ac.cn/handle/121111/35347.
[35] Wang, Xingyong, 李玉茹, 李婷, 多, 吴海臣, Li, Yuru, Li, Ting, Liu, Lei, Wu, HaiChen. The effect of secondary structures on the generation of characteristic events during the translocation of DNA hybrid through α-hemolysin. SCIENCE CHINA-CHEMISTRY[J]. 2015, 59(1): 135-141, http://ir.ihep.ac.cn/handle/311005/228916.
[36] Zeng, Tao, Liu, Lei, Li, Ting, Li, Yuru, Gao, Juan, Zhao, Yuliang, Wu, HaiChen. Detection of 5-methylcytosine and 5-hydroxymethylcytosine in DNA via host-guest interactions inside alpha-hemolysin nanopores. CHEMICAL SCIENCE[J]. 2015, 6(10): 5628-5634, http://ir.ihep.ac.cn/handle/311005/228750.
[37] Li, Ting, Liu, Lei, Li, Yuru, Xie, Jiani, Wu, HaiChen. A Universal Strategy for Aptamer-Based Nanopore Sensing through Host-Guest Interactions inside -Hemolysin. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(26): 7568-7571, http://ir.ihep.ac.cn/handle/311005/228413.
[38] Guo, BingYuan, Zeng, Tao, Wu, HaiChen. Recent advances of DNA sequencing via nanopore-based technologies. SCIENCE BULLETIN[J]. 2015, 60(3): 287-295, http://dx.doi.org/10.1007/s11434-014-0707-6.
[39] Cheng, HongBo, Huang, YaoDong, Zhao, Lina, Li, Xu, Wu, HaiChen. A prominent bathochromic shift effect of indole-containing diarylethene derivatives. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2015, 13(11): 3470-3475, http://ir.ihep.ac.cn/handle/311005/228282.
[40] 赵宇亮. Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand. METALLOMICS[J]. 2015, 7(11): 1508-1514, http://ir.ihep.ac.cn/handle/311005/228874.
[41] Liu, Lei, Xie, Jiani, Li, Ting, Wu, HaiChen. Fabrication of nanopores with ultrashort single-walled carbon nanotubes inserted in a lipid bilayer. NATURE PROTOCOLS[J]. 2015, 10(11): 1670-1678, http://ir.ihep.ac.cn/handle/311005/228865.
[42] Tang, Baiyang, Yang, Yan, Wang, Gefu, Yao, Zhiyi, Zhang, Li, Wu, HaiChen. A simple fluorescent probe based on a pyrene derivative for rapid detection of protamine and monitoring of trypsin activity. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2015, 13(32): 8708-8712, http://ir.ihep.ac.cn/handle/311005/228693.
[43] Zhang, Shuang, Wang, Xiaofeng, Li, Tang, Liu, Lei, Wu, HaiChen, Luo, Mengbo, Li, Jingyuan. Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube. LANGMUIR[J]. 2015, 31(36): 10094-10099, http://ir.ihep.ac.cn/handle/311005/228728.
[44] Yang, Yanbo, Yao, Zhiyi, Tang, Baiyang, Yu, Junhua, Bi, Xiaolin, Zhao, Yuliang, Wu, HaiChen. Visual detection of Cu(II) ions based on a simple pyrene derivative using click chemistry. ANALYTICAL METHODS[J]. 2014, 6(14): 4977-4981, http://ir.ihep.ac.cn/handle/311005/224811.
[45] Zeng, Tao, Li, Ting, Li, Yuru, Liu, Lei, Wang, Xingyong, Liu, Quansheng, Zhao, Yuliang, Wu, HaiChen. DNA-based detection of mercury(II) ions through characteristic current signals in nanopores with high sensitivity and selectivity. NANOSCALE[J]. 2014, 6(15): 8579-8584, http://dx.doi.org/10.1039/c4nr02062f.
[46] 赵宇亮. Regioselective alkyl transfer from phosphonium ylides to functionalized polyfluoroarenes. CHEMICAL SCIENCE[J]. 2014, 5(5): 1934-1939, http://ir.ihep.ac.cn/handle/311005/224886.
[47] 赵宇亮. Effects of different metal ions on the fluorescence of CdSe/ZnS quantum dots capped with various thiolate ligands. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2013, 15(42): 18710-18715, http://ir.ihep.ac.cn/handle/311005/224361.
[48] Haque, Farzin, Li, Jinghong, Wu, HaiChen, Liang, XingJie, Guo, Peixuan. Solid-state and biological nanopore for real-time sensing of single chemical and sequencing of DNA. NANO TODAY[J]. 2013, 8(1): 56-74, http://dx.doi.org/10.1016/j.nantod.2012.12.008.
[49] Cai, Ren, Du, Yaping, Zhang, Wenyu, Tan, Huiteng, Zeng, Tao, Huang, Xin, Yang, Hongfen, Chen, Chunping, Liu, Hai, Zhu, Jixin, Peng, Shengjie, Chen, Jing, Zhao, Yuliang, Wu, Haichen, Huang, Yizhong, Xu, Rong, Lim, Tuti Mariana, Zhang, Qichun, Zhang, Hua, Yan, Qingyu. Synthesis of Porous Amorphous FePO4 Nanotubes and Their Lithium Storage Properties. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2013, 19(5): 1568-1572, http://dx.doi.org/10.1002/chem.201203935.
[50] Rahman, Abu Zayed Mohammad Saliqur, Cao, Xingzhong, Wei, Long, Wang, Baoyi, Wu, Haichen. Luminescence properties of samarium-doped SiO2-Na2SO4 composite. MATERIALS LETTERS[J]. 2013, 99: 142-145, http://dx.doi.org/10.1016/j.matlet.2013.02.078.
[51] 赵宇亮. Colorimetric and fluorescent dual detection of paraquat and diquat based on an anionic polythiophene derivative. ANALYST[J]. 2013, 138(19): 5572-5575, http://ir.ihep.ac.cn/handle/311005/224266.
[52] Yao, Zhiyi, Ma, Wenjuan, Yang, Yan, Chen, Xueliang, Zhang, Li, Lin, Chen, Wu, HaiChen. Colorimetric and fluorescent detection of protamines with an anionic polythiophene derivative. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2013, 11(38): 6466-6469, http://ir.ihep.ac.cn/handle/311005/224279.
[53] Yang, Chun, Liu, Lei, Zeng, Tao, Yang, Daowu, Yao, Zhiyi, Zhao, Yuliang, Wu, HaiChen. Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore. ANALYTICAL CHEMISTRY[J]. 2013, 85(15): 7302-7307, http://ir.ihep.ac.cn/handle/311005/224295.
[54] 赵宇亮. Visual detection of copper (II) ions based on an anionic polythiophene derivative using click chemistry. ANALYTICAL CHEMISTRY[J]. 2013, 85(12): 5650-5653, http://ir.ihep.ac.cn/handle/311005/224267.
[55] 赵宇亮. Halochromism of a polythiophene derivative induced by conformational changes and its sensing application of carbon dioxide. ACS APPLIED MATERIALS & INTERFACES[J]. 2013, 5(12): 5783-5787, http://ir.ihep.ac.cn/handle/311005/224268.
[56] Yao, Zhiyi, Huang, Binghuan, Hu, Xianping, Zhang, Li, Li, Depeng, Guo, Ming, Zhang, Xiaohui, Yuan, Hui, Wu, HaiChen. Colorimetric detection of copper ions based on a supramolecular complex of water-soluble polythiophene and ATP. ANALYST[J]. 2013, 138(6): 1649-1652, http://ir.ihep.ac.cn/handle/311005/224159.
[57] Lee, Kwahun, Choi, Sungmoon, Yang, Chun, Wu, HaiChen, Yu, Junhua. Autofluorescence generation and elimination: a lesson from glutaraldehyde. CHEMICAL COMMUNICATIONS[J]. 2013, 49(29): 3028-3030, http://ir.ihep.ac.cn/handle/311005/224220.
[58] Liu, Lei, Yang, Chun, Zhao, Kai, Li, Jingyuan, Wu, HaiChen. Ultrashort single-walled carbon nanotubes in a lipid bilayer as a new nanopore sensor. NATURE COMMUNICATIONS[J]. 2013, 4: http://ir.ihep.ac.cn/handle/311005/224468.
[59] 杨红芬, 卢伟, 刘蕾, 刘宇, 吴海臣. Synthesis; Crystal Structure and Hydrogenation Catalysis of a CF_3-BINAP(O)-Rh-COD Complex. 结构化学[J]. 2012, 31(11): 1669-1675, http://ir.ihep.ac.cn/handle/311005/222976.
[60] Yang HongFen, Lu Wei, Liu Lei, Liu Yu, Wu HaiChen. Synthesis, Crystal Structure and Hydrogenation Catalysis of a CF3-BINAP(O)-Rh-COD Complex. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY[J]. 2012, 31(11): 1669-1675, http://ir.ihep.ac.cn/handle/311005/224161.
[61] 黄碧玉, 吴海臣, 杨镜奎. 缺电子Rh-BINAP催化剂催化氢化富电性底物的机理研究. 中国科学院研究生院学报[J]. 2012, 29(4): 571-575, http://lib.cqvip.com/Qikan/Article/Detail?id=42383247.
[62] Sun, Tinghui, Zeng, Tao, Xia, Chuanqin, Li, Shoujian, Wu, Haichen. Purification and Separation of Single-Walled Carbon Nanotubes (SWCNTs). JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY[J]. 2012, 12(4): 2955-2963, http://ir.ihep.ac.cn/handle/311005/224219.
[63] 黄碧玉, 吴海臣, 杨镜奎. 缺电子Rh-BINAP催化剂催化氢化富电性底物的机理研究（英文）. 中国科学院研究生院学报[J]. 2012, 571-575, http://ir.ihep.ac.cn/handle/311005/223002.
[64] Huang Biyu, Wu Haichen, Yang Jingkui. 缺电子Rh-BINAP催化剂催化氢化富电性底物的机理研究. 中国科学院研究生院学报[J]. 2012, 29(4): 571-575, http://lib.cqvip.com/Qikan/Article/Detail?id=42383247.
[65] Wu, HaiChen, Li, YiSan, Liu, YuChen, Lyu, SyueYi, Wu, ChangJer, Li, TsungLin. Chain Elongation and Cyclization in Type III PKS DpgA. CHEMBIOCHEM[J]. 2012, 13(6): 862-871, http://dx.doi.org/10.1002/cbic.201200051.
[66] Wen, Shuang, Zeng, Tao, Liu, Lei, Zhao, Kai, Zhao, Yuliang, Liu, Xianjin, Wu, HaiChen. Highly Sensitive and Selective DNA-Based Detection of Mercury(II) with alpha-Hemolysin Nanopore. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2011, 133(45): 18312-18317, http://www.corc.org.cn/handle/1471x/2176054.
[67] 吴海臣. Improved Syntheses of Phosphine Ligands via Direct Coupling of Diarylbromophosphine with Organometallic Reagents. Chem. Eur. J.. 2011, [68] Jin, Shan, Hu, Yanxi, Gu, Zhanjun, Liu, Lei, Wu, HaiChen. Application of Quantum Dots in Biological Imaging. JOURNAL OF NANOMATERIALS[J]. 2011, 2011: http://www.corc.org.cn/handle/1471x/2176166.
[69] Liu, Lei, Wu, HaiChen, Yu, JinQuan. Improved Syntheses of Phosphine Ligands by Direct Coupling of Diarylbromophosphine with Organometallic Reagents. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2011, 17(39): 10828-10831, http://www.corc.org.cn/handle/1471x/2176111.
[70] 赵宇亮. Chemistry of carbon nanotubes in biomedical applications. JOURNAL OF MATERIALS CHEMISTRY[J]. 2010, 20(6): 1036-1052, http://ir.ihep.ac.cn/handle/311005/238932.
[71] Wu, HaiChen, Hamid, Shafida Abd, Yu, JinQuan, Spencer, Jonathan B. Possible Origin of Electronic Effects in Rh(I)-Catalyzed Enantioselective Hydrogenation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2009, 131(28): 9604-9605, https://www.webofscience.com/wos/woscc/full-record/WOS:000268399800002.
[72] Clarke, James, Wu, HaiChen, Jayasinghe, Lakmal, Patel, Alpesh, Reid, Stuart, Bayley, Hagan. Continuous base identification for single-molecule nanopore DNA sequencing. NATURE NANOTECHNOLOGY[J]. 2009, 4(4): 265-270, http://dx.doi.org/10.1038/NNANO.2009.12.
[73] Wu, HaiChen, Bayley, Hagan. Single-molecule detection of nitrogen mustards by covalent reaction within a protein nanopore. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2008, 130(21): 6813-6819, https://www.webofscience.com/wos/woscc/full-record/WOS:000256158200051.
[74] Wu, HaiChen, Astier, Yann, Maglia, Giovanni, Mikhailova, Ellina, Bayley, Hagan. Protein nanopores with covalently attached molecular adapters. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2007, 129(51): 16142-16148, https://www.webofscience.com/wos/woscc/full-record/WOS:000251974000068.
[75] 花文廷, 吴海臣, 徐东成. 芳基取代的手性恶唑啉铝氢化物的制备及其对酮羰基的不对称还原反应. 化学学报[J]. 2001, 59(8): 1340-, http://lib.cqvip.com/Qikan/Article/Detail?id=5489565.

   

（ 1 ） 纳米材料与纳米技术在水污染物检测与治理中的应用基础研究, 负责人, 国家任务, 2010-01--2014-12
（ 2 ） 功能纳米材料的化学修饰及其在水污染物检测中的应用基础研究, 负责人, 中国科学院计划, 2010-07--2013-12
（ 3 ） DNA甲基化的快速高通量检测研究, 负责人, 国家任务, 2012-01--2015-12
（ 4 ） 蛋白质纳米机器系统的功能集成研究, 参与, 国家任务, 2013-01--2017-12
（ 5 ） 纳米孔单分子分析方法, 负责人, 国家任务, 2021-01--2025-12
（ 6 ） 纳米孔技术应用于氨肽酶的高灵敏检测, 负责人, 国家任务, 2020-01--2023-12

已指导学生

杨红芬  硕士研究生  070322-生物无机化学  

杨言  博士研究生  070301-无机化学  

张云  博士研究生  070302-分析化学  

胡为乎  硕士研究生  070302-分析化学  

圣迎迎  博士研究生  070302-分析化学  

现指导学生

闫帅虎  博士研究生  070302-分析化学  

郝文英  博士研究生  070302-分析化学  

吴雪霜  博士研究生  070302-分析化学  

李梓溢  博士研究生  070302-分析化学  

伊雅琨  博士研究生  070302-分析化学  

李若菡  博士研究生  070302-分析化学  

刘甜甜  硕士研究生  070302-分析化学  

卢奥博  硕士研究生  070302-分析化学  

黄孝斌  博士研究生  070302-分析化学  

刘云博  硕士研究生  070302-分析化学  

湛婧  博士研究生  070302-分析化学  

张鸣谦  博士研究生  070302-分析化学  

   

（ 1 ） 主客体探针结合纳米孔技术联用的酶活性浓度检测方法, 发明专利, 2019, 第 1 作者, 专利号: CN110607349A

（ 2 ） 一种DNA编码技术与纳米孔技术联用的癌症标志物检测方法, 专利授权, 2018, 第 1 作者, 专利号: CN108531592A

（ 3 ） 一种三链DNA分子信标结合纳米孔技术联用的抗体检测方法, 发明专利, 2018, 第 1 作者, 专利号: CN108467883A

（ 4 ） 无电磁辐射超微型双头磁力搅拌器, 实用新型, 2010, 第 2 作者, 专利号: CN201669078U