1)发展糖化学合成的新方法和新策略

2)应用新方法和策略高效合成重要生理活性的复杂糖链

请详见课题组主页：https://www.x-mol.com/groups/xiao_guozhi 

   

100701-药物化学

糖化学，糖缀物，化学合成，糖疫苗

2008-09--2013-07   中国科学院上海有机化学研究所   博士
2004-09--2008-07   中山大学   学士

博士研究生

博士

   

2017-12~现在, 中国科学院昆明植物研究所, 研究员
2015-10~2017-09,美国威斯康辛大学麦迪逊分校, 博士后
2013-10~2015-07,德国马普胶体与界面研究所, 博士后

2022-12-01-今,中国化学会糖化学专业委员会委员,

糖化学合成方法和策略研究

2019年度 入选云南省“****”青年人才专项

2020年度 入选中国科学院率先行动“****”青年项目

2021年度 中国化学会首届糖化学青年学者奖

（1） Thieme Chemistry Journals Award, , 其他, 2024
（2） Chinese Journal of Chemistry 新锐科学家奖, 其他, 2024
（3） 中国化学会首届糖化学青年学者奖, 其他, 2021
（4） 云南省“****”青年人才专项, 省级, 2019

（ 1 ） 一种牛膝多糖ABW90-1和/或ABW50-1的合成方法, 发明专利, 2024, 第 1 作者, 专利号: CN117843824A

（ 2 ） 灵芝孢子GLSWA-1多糖十四糖及其子结构的制备方法与增强胰岛素蛋白活力的应用, 发明专利, 2023, 第 1 作者, 专利号: CN116874626A

（ 3 ） 一种尿嘧啶核苷衍生物及该衍生物制备去氧氟尿苷药物的方法, 发明专利, 2020, 第 1 作者, 专利号: CN111072734A

（ 4 ） 一种胞嘧啶核苷衍生物及该衍生物制备卡培他滨药物的方法, 发明专利, 2020, 第 1 作者, 专利号: CN111100172A

（ 5 ） 一种邻-（1-苯基乙烯基）苯甲酸酯类糖苷化给体及其制备方法和应用, 发明专利, 2020, 第 1 作者, 专利号: CN111018927A

[1] Guo, Fuqiang, Tan, Qiang, Guo, Jiahui, Li, Kaifeng, Wang, Xiufang, Cao, Wei, Xiao, Guozhi. Total Synthesis of the Tridecasaccharide Motif from Angelica Sinensis APS-1 II Polysaccharide with Anti-Leukemia Activity and Structure-Activity Relationship Studies. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2025, 第 7 作者  通讯作者  http://dx.doi.org/10.1002/anie.202422887.
[2] Chen, Zhiyuan, Xiao, Guozhi. Total Synthesis of Nona-decasaccharide Motif from Ganoderma sinense Polysaccharide Enabled by Modular and One-Pot Stereoselective Glycosylation Strategy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2024, 第 2 作者  通讯作者  146(25): 17446-17455, http://dx.doi.org/10.1021/jacs.4c05188.
[3] Shou, Kunxiu, Zhang, Yunqin, Ji, Yujie, Liu, Bin, Zhou, Qingli, Tan, Qiang, Li, Fuying, Wang, Xiufang, Lu, Gang, Xiao, Guozhi. Highly stereoselective α-glycosylation with GalN 3 donors enabled collective synthesis of mucin-related tumor associated carbohydrate antigens. CHEMICAL SCIENCE[J]. 2024, 第 10 作者  通讯作者  15(17): 6552-6561, http://dx.doi.org/10.1039/d4sc01348d.
[4] NietoFabregat, Ferran, Zhu, Qian, Vives, Corinne, Zhang, Yunqin, Marseglia, Angela, Chiodo, Fabrizio, Thepaut, Michel, Rai, Diksha, Kulkarni, Suvarn S, Di Lorenzo, Flaviana, Molinaro, Antonio, Marchetti, Roberta, Fieschi, Franck, Xiao, Guozhi, Yu, Biao, Silipo, Alba. Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes. JACS AU[J]. 2024, 第 14 作者4(2): 697-712, http://dx.doi.org/10.1021/jacsau.3c00748.
[5] Ma, Yuxin, Zhang, Yunqin, Huang, Yingying, Chen, Zixi, Xian, Qingyun, Su, Rui, Jiang, Qiong, Wang, Xiufang, Xiao, Guozhi. One-Pot Assembly of Mannose-Capped Lipoarabinomannan Motifs up to 101-Mer from the Mycobacterium tuberculosis Cell Wall. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2024, 第 9 作者  通讯作者  146(6): 4112-4122, http://dx.doi.org/10.1021/jacs.3c12815.
[6] Li, Kaifeng, Liu, Bin, Wang, Xiufang, Xiao, Guozhi. Highly Stereoselective Synthesis of Branched Fructooligosaccharides ABW90-1 and ABW50-1 from Achyranthes bidentata with Potent Antiosteoporosis Activities. ORGANIC LETTERS[J]. 2024, 第 4 作者  通讯作者  26(7): 1468-1471, http://dx.doi.org/10.1021/acs.orglett.4c00092.
[7] Wan, Jie, Wang, Leilei, Xiao, Guozhi. Total Synthesis of Phellinus ribis Glycans with Immunostimulating Activities by an Orthogonal One-Pot Glycosylation Strategy. SYNLETT[J]. 2023, 第 3 作者  通讯作者  34(3): 288-292, http://dx.doi.org/10.1055/a-1969-3992.
[8] Chen, Zhiyuan, Xiao, Guozhi. One-Pot Assembly of the Highly Branched Tetradecasaccharide from Ganoderma lucidum Glycan GLSWA-1 with Immune-Enhancing Activities. ORGANIC LETTERS[J]. 2023, 第 2 作者  通讯作者  25(40): 7395-7399, http://dx.doi.org/10.1021/acs.orglett.3c02898.
[9] Sun, Xingchun, Chen, Zhiyuan, Yang, Rui, Wang, Mei, Wang, Xiufang, Zhang, Qi, Xiao, Guozhi. Modular and Stereoselective One-Pot Total Synthesis of Icosasaccharide Motif from Cordyceps sinensis EPS-1A Glycan. ORGANIC LETTERS[J]. 2023, 第 7 作者  通讯作者  25(40): 7364-7368, http://dx.doi.org/10.1021/acs.orglett.3c02842.
[10] 张云琴, 王蕾蕾, 周庆丽, Zuoshan Li, Dan Li, Caixia Yin, 王秀芳, 肖国志. Modular Synthesis of a Tridecasaccharide Motif of Bacteroides vulgatus Lipopolysaccharides against Inflammatory Bowel Diseases through an Orthogonal One‐Pot Glycosylation Strategy. Angewandte Chemie International Edition[J]. 2023, 第 8 作者  通讯作者  
[11] Wang, Xiufang, Xiao, Guozhi. Recent Advances in Chemical Synthesis of Structural Domains of Lipopolysaccharides from the Commensal Gut-Associated Microbiota. CHEMBIOCHEM[J]. 2023, 第 2 作者  通讯作者  24(23): http://dx.doi.org/10.1002/cbic.202300552.
[12] 李朋华, 肖国志. Highly Stereoselective Assembly of 1,2-cis-Arap Linkages. Organic Letters[J]. 2023, 第 2 作者  通讯作者  
[13] Wang, Xiufang, Xiao, Guozhi. Recent chemical synthesis of plant polysaccharides. CURRENT OPINION IN CHEMICAL BIOLOGY. 2023, 第 2 作者  通讯作者  77: http://dx.doi.org/10.1016/j.cbpa.2023.102387.
[14] Wan, Jie, Wang, Leilei, Xiao, Guozhi. Total Synthesis of Phellinus ribis Glycans with Immunostimulating Activities by an Orthogonal One-Pot Glycosylation Strategy. SYNLETT[J]. 2023, 第 3 作者  通讯作者  34(3): 288-292, http://dx.doi.org/10.1055/a-1969-3992.
[15] Zhang, Yunqin, Wang, Leilei, Zhou, Qingli, Li, Zuoshan, Li, Dan, Yin, Caixia, Wang, Xiufang, Xiao, Guozhi. Modular Synthesis of a Tridecasaccharide Motif of Bacteroides vulgatus Lipopolysaccharides against Inflammatory Bowel Diseases through an Orthogonal One-Pot Glycosylation Strategy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2023, 第 8 作者  通讯作者  62(22): http://dx.doi.org/10.1002/anie.202301351.
[16] 杨睿, 肖国志. The total synthesis of rhynchosporosides via orthogonal one-pot glycosylation and stereoselective α-glycosylation strategies. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2022, 第 2 作者  通讯作者  
[17] Yang, Rui, Sun, Xingchun, Zhang, Yunqin, Xiao, Guozhi. The total synthesis of rhynchosporosides via orthogonal one-pot glycosylation and stereoselective alpha-glycosylation strategies. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2022, 第 4 作者  通讯作者  20(34): 6755-6758, http://dx.doi.org/10.1039/d2ob01243j.
[18] Ma, Yuxin, Jiang, Qiong, Wang, Xiufang, Xiao, Guozhi. Total Synthesis of Cordyceps militaris Glycans via Stereoselective Orthogonal One-Pot Glycosylation and alpha-Glycosylation Strategies. ORGANIC LETTERS. 2022, 第 4 作者  通讯作者  
[19] 张云琴, 陆刚, 肖国志. Total synthesis of Lentinus giganteus glycans with antitumor activities via stereoselective α-glycosylation and orthogonal one-pot glycosylation strategies. Chemical Science[J]. 2022, 第 3 作者  通讯作者  
[20] Zhang, Yunqin, Hu, Yanlei, Liu, Shanshan, He, Haiqing, Sun, Roujing, Lu, Gang, Xiao, Guozhi. Total synthesis of Lentinus giganteus glycans with antitumor activities via stereoselective alpha-glycosylation and orthogonal one-pot glycosylation strategies. CHEMICAL SCIENCE[J]. 2022, 第 7 作者  通讯作者  13(26): 7755-7764, http://dx.doi.org/10.1039/d2sc02176e.
[21] 马雨欣, 肖国志. Total Synthesis of Cordyceps militaris Glycans via Stereoselective Orthogonal One-Pot Glycosylation and α-Glycosylation Strategies. Organic Letters[J]. 2022, 第 2 作者  通讯作者  
[22] Zhang, Yunqin, Hu, Yanlei, Liu, Shanshan, He, Haiqing, Sun, Roujing, Lu, Gang, Xiao, Guozhi. Total synthesis of Lentinus giganteus glycans with antitumor activities via stereoselective α-glycosylation and orthogonal one-pot glycosylation strategies. CHEMICAL SCIENCE[J]. 2022, 第 7 作者  通讯作者  13(26): 7755-7764, http://dx.doi.org/10.1039/d2sc02176e.
[23] Xiao, Guozhi, He, Haiqing. Chemical Synthesis of the Nucleoside Antibiotic Capuramycin. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 第 1 作者  通讯作者  2021(26): 3681-3689, http://dx.doi.org/10.1002/ejoc.202100613.
[24] Zhang, Yunqin, He, Haiqing, Chen, Zixi, Huang, Yingying, Xiang, Guisheng, Li, Penghua, Yang, Xingkuan, Lu, Gang, Xiao, Guozhi. Merging Reagent Modulation and Remote Anchimeric Assistance for Glycosylation: Highly Stereoselective Synthesis of alpha-Glycans up to a 30-mer. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 第 9 作者  通讯作者  60(22): 12597-12606, http://dx.doi.org/10.1002/anie.202103826.
[25] Yang, Rui, He, Haiqing, Chen, Zixi, Huang, Yingying, Xiao, Guozhi. A One-Pot Synthesis of Glycans and Nucleosides Based on ortho-(1-Phenylvinyl)benzyl Glycosides. ORGANIC LETTERS[J]. 2021, 第 5 作者  通讯作者  23(21): 8257-8261, http://dx.doi.org/10.1021/acs.orglett.1c02998.
[26] Penghua Li, Haiqing He, Yunqin Zhang, Rui Yang, Lili Xu, Zixi Chen, Yingying Huang, Limei Bao, Guozhi Xiao. Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides. NATURE COMMUNICATIONS[J]. 2020, 第 9 作者  通讯作者  11(1): http://dx.doi.org/10.1038/s41467-020-14295-z.
[27] Zhang, Yunqin, Chen, Zixi, Huang, Yingying, He, Shaojun, Yang, Xingkuan, Wu, Zhibing, Wang, Xiufang, Xiao, Guozhi. Modular Synthesis of Nona-Decasaccharide Motif from Psidium guajava Polysaccharides: Orthogonal One-Pot Glycosylation Strategy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 第 8 作者  通讯作者  59(19): 7576-7584, https://www.webofscience.com/wos/woscc/full-record/WOS:000527854000042.
[28] Geissner, Andreas, Reinhardt, Anika, Rademacher, Christoph, Johannssen, Timo, Monteiro, Joao, Lepenies, Bernd, Thepaut, Michel, Fieschi, Franck, Mrazkova, Jana, Wimmerova, Michaela, Schuhmacher, Frank, Goetze, Sebastian, Gruenstein, Dan, Guo, Xiaoqiang, Hahm, Heung Sik, Kandasamy, Jeyakumar, Leonori, Daniele, Martin, Christopher E, Parameswarappa, Sharavathi G, Pasari, Sandip, Schlegel, Mark K, Tanaka, Hidenori, Xiao, Guozhi, Yang, You, Pereira, Claney L, Anish, Chakkumkal, Seeberger, Peter H. Microbe-focused glycan array screening platform. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 第 23 作者116(6): 1958-1967, http://ir.kib.ac.cn/handle/151853/64217.
[29] Zhang, Yunqin, Xiang, Guisheng, He, Shaojun, Hu, Yikao, Liu, Yanjun, Xu, Lili, Xiao, Guozhi. Orthogonal One-Pot Synthesis of Oligosaccharides Based on Glycosyl ortho-Alkynylbenzoates. ORGANIC LETTERS[J]. 2019, 第 7 作者  通讯作者  21(7): 2335-2339, http://ir.kib.ac.cn/handle/151853/66364.
[30] Xiao, Guozhi, Shao, Xiaofei, Zhu, Dapeng, Yu, Biao. Chemical synthesis of marine saponins. NATURAL PRODUCT REPORTS. 2019, 第 1 作者  通讯作者  36(5): 769-787, http://dx.doi.org/10.1039/c8np00087e.
[31] Xiao, Guozhi, CintronRosado, Gabriel A, Glazier, Daniel A, Xi, Baomin, Liu, Can, Liu, Peng, Tang, Weiping. Catalytic Site-Selective Acylation of Carbohydrates Directed by Cation- n Interaction. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 第 1 作者139(12): 4346-4349, http://dx.doi.org/10.1021/jacs.7b01412.
[32] Xiao, Guozhi, Yu, Biao. Total Synthesis of Starfish Saponin Goniopectenoside B. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2013, 第 1 作者19(24): 7708-7712, http://dx.doi.org/10.1002/chem.201301186.

   

（ 1 ） 复杂糖类化合物的化学合成, 负责人, 国家任务, 2024-01--2026-12
（ 2 ） 应用正交一锅糖苷化反应策略高效合成真菌多糖, 负责人, 国家任务, 2023-01--2026-12
（ 3 ） 发展一锅糖苷化反应新策略高效合成糖类和核苷类天然产物, 负责人, 地方任务, 2021-06--2024-05
（ 4 ） 发展新方法和新策略高效合成糖类天然产物, 负责人, 中国科学院计划, 2021-01--2023-12
（ 5 ） 发展新方法和新策略高效合成复杂多糖和寡糖, 负责人, 地方任务, 2021-01--2025-12
（ 6 ） 番石榴多糖GB90-1B的化学合成和生理活性研究, 负责人, 国家任务, 2020-01--2022-12
（ 7 ） 海星皂苷的化学合成和生物活性研究, 负责人, 研究所自主部署, 2018-04--2019-03
（ 8 ） 基于B族链球菌血清型Ia, II和III抗原结构的人工合成糖疫苗研究, 负责人, 研究所自主部署, 2018-01--2020-12
（ 9 ） 中国科学院率先行动“****”青年俊才（C类）人才计划, 负责人, 中国科学院计划, 2018-01--2021-01
（ 10 ） 重要生理活性的糖缀物和多糖抗原化学合成, 负责人, 研究所自主部署, 2017-12--2020-11

（1）正交一锅法合成重要生理活性寡糖   中国化学会第八届“天然产物全合成-青年学术研讨会”   2019-11-30
（2）基于糖基邻炔基苯甲酸酯正交一锅糖苷化 反应新策略合成重要生理活性寡糖   中国化学会第三届全国糖化学会议   2019-09-21
（3）基于糖基邻炔基苯甲酸酯正交一锅糖苷化 反应新策略合成重要生理活性寡糖   中国化学会第十一届全国有机化学学术会议   2019-08-31

已指导学生

徐丽丽  硕士研究生  105500-药学  

李朋华  博士研究生  100701-药物化学  

杨睿  硕士研究生  078001-药物化学  

马雨欣  硕士研究生  105500-药学  

首坤秀  博士研究生  100701-药物化学  

王蕾蕾  硕士研究生  105500-药学  

张云琴  博士研究生  100701-药物化学  

现指导学生

万杰  博士研究生  100701-药物化学  

陈志远  博士研究生  100701-药物化学  

谭强  博士研究生  100701-药物化学  

李晨欣  硕士研究生  105500-药学  

马雨欣  博士研究生  100701-药物化学  

李思琪  硕士研究生  078001-药物化学  

苏睿  硕士研究生  105500-药学  

李晓琳  博士研究生  100701-药物化学  

周文龙  硕士研究生  078001-药物化学