“Total synthesis and synthetic organic chemistry as a whole provide society a fantastic return on investment with innumerable fundamental and applied tangible advancements. From a fundamental perspective, total synthesis is a barometer and proving ground for new methodologies and new strategies or ways of thinking. From an applied standpoint, having sustainable and reliable access to biologically active natural isolates can demystify new areas of biology or provide promising candidates for drug discovery.”

—— Phil S. Baran (JACS Editorial)

尽管有机合成化学在合成方法和策略上取得了令人难以置信的进展，但是复杂天然产物的高效和可放大合成仍然对科学界提出了巨大的挑战。我们的研究项目旨在通过发展简化的方法和策略为上述挑战提供创新的解决方案。

受大自然精密合成机器的启发，我们寻求识别和探索关键化学转化以快速构建目标分子的核心骨架结构。这一研究的最终目标是合成一定质量的天然产物及其合成类似物（可放大合成），从而能够评估它们的生物医学潜力。

我们研究的另一个重点是开发新的合成方法来构建化学键，并在有机合成和药物发现方面具有实用和广泛的应用。

欢迎对有机合成感兴趣者加入本课题组！

上海有机所研究生，考博生，联培生，本科生（毕业设计及暑期实习）：

请将个人简历（包括研究经历或代表性成果）发送至：guijh@sioc.ac.cn，并欢迎到办公室（上海有机所1#606）面谈。

070303-有机化学

天然产物全合成
合成方法学

2007-09--2012-07   中国科学院上海有机化学研究所   博士学位
2003-10--2007-07   安徽师范大学   本科学位

研究生

博士

2016-03 ~ 现在            中国科学院上海有机化学研究所, 课题组长，研究员
2013-02 ~ 2016-03      美国Scripps研究所, 博士后
2012-07 ~ 2013-02      中国科学院上海有机化学研究所, 助理研究员

有机合成

   

（1） 中国科学院青年五四奖章, 院级, 2022
（2） 《天然产物报告》新锐科学家奖, 其他, 2022
（3） 科学探索奖, 其他, 2021
（4） 中国科学院优秀导师奖, 院级, 2021
（5） 上海科技青年35人引领计划, 省级, 2021
（6） EurJOC Lecture Award, , 其他, 2020
（7） 中国化学会青年化学奖, 国家级, 2020
（8） 中国化学会菁青化学新锐奖, 国家级, 2020
（9） Thieme Chemistry Journals Award, , 其他, 2019
（10） Eli Lilly Asia Outstanding Graduate Thesis Award, 二等奖, 其他, 2012
（11） 中国科学院朱李月华优秀博士生奖学金, , 院级, 2012

[1] 桂敬汉, 张孟晴, 汪昀. 一种酚类甾体化合物的合成方法及其应用. CN: CN115353540A, 2022-11-18.
[2] 桂敬汉, 田伟生, 吴晶晶, 邓嘉晨, 田海龙, 包嘉靖, 汪昀. 一种甾体炔酸化合物、其合成方法及用途. CN: CN107814717A, 2018-03-20.

   

[1] Zeliang Zhang, Xiao Qian, Yucheng Gu, Gui, Jinghan. Controllable skeletal reorganizations in natural product synthesis. Natural Product Reports[J]. 2024, 第 4 作者  通讯作者  41(2): 252-272, 
[2] Ning, Yuhan, Yun Wang, Gui, Jinghan. Bioinspired Two-Phase Synthesis of Gibbosterol A. JACS Au[J]. 2024, 第 3 作者  通讯作者  4(2): 635-641, 
[3] Yu Wang, Gui, Jinghan. Bioinspired Skeletal Reorganization Approach for the Synthesis of Steroid Natural Products. Accounts of chemical research[J]. 2024, 第 2 作者  通讯作者  57(4): 568-579, 
[4] Hanxin Song, Zeliang Zhang, Chunyang Cao, Zhijun Tang, Jinghan Gui, Wen Liu. Biocatalytic Steroidal 9α-Hydroxylation and Fragmentation Enable the Concise Chemoenzymatic Synthesis of 9,10-Secosteroids. ANGEWANDTE CHEMIE INTERNATIONAL EDITION[J]. 2024, 第 5 作者  通讯作者  63: e202319624, https://doi.org/10.1002/anie.202319624.
[5] Ke Cen, Jiajing Bao, Hailong Tian, Yun Wang, Xudong Wang, Jinghan Gui. Bioinspired Divergent Synthesis of Aspersteroids A and B. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2024, 第 6 作者  通讯作者  146(10): 6481-6486, 
[6] Liangcai Yao, Jiajing Bao, Yun Wang, Jinghan Gui. Titanium-Mediated Dehydroxylative Cross-Coupling of Allylic Alcohols with Electron-Deficient Olefins. Organic Letters[J]. 2024, 第 4 作者  通讯作者  26(6): 1243-1248, 
[7] Huang Ganlin, Gui Jinghan. Nature-Inspired Asymmetric Rearrangement of Cyclopropylcarbinyl Cation. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2023, 第 2 作者  通讯作者  43(6): 2267-2268, http://dx.doi.org/10.6023/cjoc202300037.
[8] Xudong Wang, Ganlin Huang, Yun Wang, Jinghan Gui. Asymmetric Total Synthesis of the Rearranged Steroid Phomarol Enabled by a Biomimetic SN2′ Cyclization. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2023, 第 4 作者  通讯作者  145: 9354-9363, https://doi.org/10.1021/jacs.3c02817.
[9] Yinlong Miao, Xinghui Li, Mengqing Zhang, Huafang Fan, Jinghan Gui. Synthesis of 9,11-Secosteroids Pinnisterol E, Glaciasterol B, and 6-Keto-aplidiasterol B. Organic Letters[J]. 2022, 第 5 作者  通讯作者  24(8): 1684-1688, https://pubs.acs.org/doi/10.1021/acs.orglett.2c00281.
[10] Zhang, Mengqing, Fan, Huafang, Wang, Yun, Gui, Jinghan. Total Synthesis of the Phenolic Steroid Myrmenaphthol A. ORGANIC LETTERS[J]. 2022, 第 4 作者  通讯作者  24(40): 7383-7387, http://dx.doi.org/10.1021/acs.orglett.2c02910.
[11] Yao Liangcai, Gui Jinghan. Application of the Radical Polyene Cyclization Reaction in Natural Product Synthesis. CHINESE JOURNAL OF ORGANIC CHEMISTRY. 2022, 第 2 作者  通讯作者  42(9): 2703-2714, 
[12] Yang, Peicheng, Li, YanYu, Tian, Hailong, Qian, GanLu, Wang, Yun, Hong, Xin, Gui, Jinghan. Syntheses of Bufospirostenin A and Ophiopogonol A by a Conformation-Controlled Transannular Prins Cyclization. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 第 7 作者  通讯作者  144: 17769-17775, 
[13] Ju, Wei, Wang, Xudong, Tian, Hailong, Gui, Jinghan. Asymmetric Total Synthesis of Clionastatins A and B. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 第 4 作者  通讯作者  143(33): 13016-13021, http://dx.doi.org/10.1021/jacs.1c07511.
[14] Ning, Yuhan, Tian, Hailong, Gui, Jinghan. Biogenesis-Guided Synthesis and Structural Revision of Sarocladione Enabled by Ruthenium-Catalyzed Endoperoxide Fragmentation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 第 3 作者  通讯作者  60(20): 11222-11226, http://dx.doi.org/10.1002/anie.202101451.
[15] Li, Xinghui, Zhang, Zeliang, Fan, Huafang, Miao, Yinlong, Tian, Hailong, Gu, Yucheng, Gui, Jinghan. Concise Synthesis of 9,11-Secosteroids Pinnigorgiols B and E. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 第 7 作者  通讯作者  143(13): 4886-4890, http://dx.doi.org/10.1021/jacs.0c13426.
[16] Yu Wang, Hailong Tian, Jinghan Gui. Gram-Scale Synthesis of Bufospirostenin A by a Biomimetic Skeletal Rearrangement Approach. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 第 3 作者  通讯作者  143(46): 19576-19586, https://pubs.acs.org/doi/10.1021/jacs.1c10067.
[17] Wang, Yu, Chen, Bo, He, Xubiao, Gui, Jinghan. Development of Biomimetic Synthesis of Propindilactone G. CHINESE JOURNAL OF CHEMISTRY[J]. 2020, 第 4 作者  通讯作者  38(11): 1339-1352, http://lib.cqvip.com/Qikan/Article/Detail?id=7103703748.
[18] Deng, Jiachen, Ning, Yuhan, Tian, Hailong, Gui, Jinghan. Divergent Synthesis of Antiviral Diterpenes Wickerols A and B. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 第 4 作者  通讯作者  142(10): 4690-4695, https://www.webofscience.com/wos/woscc/full-record/WOS:000526392200025.
[19] Bao, Jiajing, Tian, Hailong, Yang, Peicheng, Deng, Jiachen, Gui, Jinghan. Modular Synthesis of Functionalized Butenolides by Oxidative Furan Fragmentation. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 第 5 作者  通讯作者  2020(3): 339-347, https://www.webofscience.com/wos/woscc/full-record/WOS:000506932600001.
[20] Wang, Yu, Chen, Bo, He, Xubiao, Gui, Jinghan. Bioinspired Synthesis of Nortriterpenoid Propindilactone G. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 第 4 作者  通讯作者  142(11): 5007-5012, https://www.webofscience.com/wos/woscc/full-record/WOS:000526392600011.
[21] Deng, Jiachen, Gui, Jinghan. Alkyne-Forming Furan Fragmentation: A General Method to Convert Furans into Alkynoic Acids. SYNLETT[J]. 2019, 第 2 作者  通讯作者  30(6): 642-646, 
[22] Wang, Yu, Ju, Wei, Tian, Hailong, Sun, Suyun, Li, Xinghui, Tian, Weisheng, Gui, Jinghan. Facile Access to Bridged Ring Systems via Point-to-Planar Chirality Transfer: Unified Synthesis of Ten Cyclocitrinols. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 第 7 作者  通讯作者  141(12): 5021-5033, 
[23] Deng, Jiachen, Wu, Jingjing, Tian, Hailong, Bao, Jiajing, Shi, Yong, Tian, Weisheng, Gui, Jinghan. Alkynes From Furans: A General Fragmentation Method Applied to the Synthesis of the Proposed Structure of AglatominB. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 第 7 作者  通讯作者  57(14): 3617-3621, https://www.webofscience.com/wos/woscc/full-record/WOS:000428350100011.
[24] Wang, Yu, Ju, Wei, Tian, Hailong, Tian, Weisheng, Gui, Jinghan. Scalable Synthesis of Cyclocitrinol. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 第 5 作者  通讯作者  140(30): 9413-9416, https://www.webofscience.com/wos/woscc/full-record/WOS:000440877000020.
[25] Lo, Julian C, Kim, Dongyoung, Pan, ChungMao, Edwards, Jacob T, Yabe, Yuki, Gui, Jinghan, Qin, Tian, Gutierrez, Sara, Giacoboni, Jessica, Smith, Myles W, Holland, Patrick L, Baran, Phil S. Fe-Catalyzed C-C Bond Construction from Olefins via Radicals. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 第 6 作者139(6): 2484-2503, https://www.webofscience.com/wos/woscc/full-record/WOS:000394482200052.
[26] Gui, Jinghan, Pan, ChungMao, Jin, Ying, Qin, Tian, Lo, Julian C, Lee, Bryan J, Spergel, Steven H, Mertzman, Michael E, Pitts, William J, La Cruz, Thomas E, Schmidt, Michael A, Darvatkar, Nitin, Natarajan, Swaminathan R, Baran, Phil S. Practical olefin hydroamination with nitroarenes. SCIENCE[J]. 2015, 第 1 作者348(6237): 886-891, https://www.webofscience.com/wos/woscc/full-record/WOS:000354877900038.
[27] Gui, Jinghan, Wang, Yun, Tian, Hailong, Gao, Yuqi, Tian, Weisheng. Perfluoroalkylsulfonyl fluoride-mediated abnormal Beckmann rearrangement of steroid 17-oximes with acid-labile groups. TETRAHEDRON LETTERS[J]. 2014, 第 1 作者  通讯作者  55(30): 4233-4235, http://dx.doi.org/10.1016/j.tetlet.2014.06.005.
[28] Lo, Julian C, Gui, Jinghan, Yabe, Yuki, Pan, ChungMao, Baran, Phil S. Functionalized olefin cross-coupling to construct carbon-carbon bonds. NATURE[J]. 2014, 第 2 作者516(7531): 343-348, https://www.webofscience.com/wos/woscc/full-record/WOS:000346484800036.
[29] Gui, Jinghan, Zhou, Qianghui, Pan, ChungMao, Yabe, Yuki, Burns, Aaron C, Collins, Michael R, Ornelas, Martha A, Ishihara, Yoshihiro, Baran, Phil S. C-H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2014, 第 1 作者136(13): 4853-4856, https://www.webofscience.com/wos/woscc/full-record/WOS:000333947900015.
[30] Zhou, Qianghui, Gui, Jinghan, Pan, ChungMao, Albone, Earl, Cheng, Xin, Suh, Edward M, Grasso, Luigi, Ishihara, Yoshihiro, Baran, Phil S. Bioconjugation by Native Chemical Tagging of C-H Bonds. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 第 2 作者135(35): 12994-12997, https://www.webofscience.com/wos/woscc/full-record/WOS:000330163100019.
[31] Gui, Jinghan, Tian, Hailong, Tian, Weisheng. Synthesis of Glaucogenin D, a Structurally Unique Disecopregnane Steroid with Potential Antiviral Activity. ORGANIC LETTERS[J]. 2013, 第 1 作者  通讯作者  15(18): 4802-4805, http://www.irgrid.ac.cn/handle/1471x/868769.
[32] Zhang, Shunji, Dong, Huaide, Gui, Jinghan, Tian, Weisheng. Stereoselective synthesis of the insect growth regulator (S)-(+)-hydroprene through Suzuki-Miyaura cross-coupling. TETRAHEDRON LETTERS[J]. 2012, 第 3 作者53(15): 1882-1884, http://dx.doi.org/10.1016/j.tetlet.2012.02.019.
[33] Gui, Jinghan, Wang, Dahai, Tian, Weisheng. Biomimetic Synthesis of 5,6-dihydro-glaucogenin C: Construction of the Disecopregnane Skeleton by Iron(II)-Promoted Fragmentation of an alpha-Alkoxy Hydroperoxide. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2011, 第 1 作者50(31): 7093-7096, http://www.irgrid.ac.cn/handle/1471x/593955.
[34] Hu, Yimin, Qu, Yuan, Wu, Fenghua, Gui, Jinghan, Wei, Yun, Hu, Qiong, Wang, Shaowu. Tuned C-H Functionalization to Construct Aza-Podophyllotoxin/Aza-Conidendrin Derivatives by Means of Domino Cyclization. CHEMISTRY-AN ASIAN JOURNAL[J]. 2010, 第 4 作者5(2): 309-314, https://www.webofscience.com/wos/woscc/full-record/WOS:000274539100014.

   

已指导学生

包嘉靖  硕士研究生  070303-有机化学  

杨培城  硕士研究生  085216-化学工程  

王宇  博士研究生  070303-有机化学  

李星辉  博士研究生  070303-有机化学  

邓嘉晨  博士研究生  070303-有机化学  

居炜  博士研究生  070303-有机化学  

现指导学生

包嘉靖  博士研究生  070303-有机化学  

宁宇涵  博士研究生  070303-有机化学  

陈波  博士研究生  070303-有机化学  

岑可  硕士研究生  085216-化学工程  

杨培城  博士研究生  070303-有机化学  

来晓玉  硕士研究生  070303-有机化学  

吴将  硕士研究生  070303-有机化学  

王旭东  博士研究生  070303-有机化学  

张泽良  博士研究生  070303-有机化学  

钱笑  硕士研究生  070303-有机化学  

黄柑霖  硕士研究生  070303-有机化学  

谢延诚  博士研究生  070303-有机化学  

王逸诚  博士研究生  070303-有机化学