生物分离

   

081703-生物化工
081701-化学工程
081704-应用化学

生物分离，分离介质制备，过程强化技术开发，装备设计构建

2009-09--2014-01   中国科学院过程工程研究所   博士
2006-09--2008-07   北京理工大学   硕士
2001-09--2005-07   合肥工业大学   学士

   

2020-12~现在, 中国科学院过程工程研究所, 项目研究员
2016-12~2020-10,加拿大麦克马斯特大学, 博士后
2014-03~2016-08,中国科学院过程工程研究所、北京天广实生物技术股份有限公司, 博士后

2024-05-12-今,北京膜学会会员,
2022-02-01-今,Separation and Purification Technology期刊公众号人物访谈部编辑,
2022-02-01-今,Results in Engineering 期刊青年编委,

   

（1） 第 7届全国膜与膜过程学术报告会 优秀论文奖, , 其他, 2011

（ 1 ） ANNULAR-FLOW HOLLOW FIBER MEMBRANE DEVICE, 发明专利, 2019, 第 2 作者, 专利号: 62802527

（ 2 ） FLOW DISTRIBUTION AND COLLECTION FEATURES FOR ENSURING SCALABLE UNIFORM FLOW IN A CHROMATOGRAPHY OR MEMBRANE SEPARATION DEVICE, 发明专利, 2019, 第 4 作者, 专利号: 62883891

   

[1] ACS Nano. 2024, 第 2 作者
[2] AIChE Journal. 2024, 第 3 作者
[3] 张昊, 张君怡, 武浩然, 杨欣, 樊荣, 陈国强, 陈向荣, 罗建泉, 万印华. 膜技术在单克隆抗体分离纯化中的应用研究进展. 膜科学与技术[J]. 2023, 第 6 作者43(5): 150-158, http://lib.cqvip.com/Qikan/Article/Detail?id=7110800342.
[4] Xiaotian Lu, Jiachen Huang, Manuel Pinelo, Guoqiang Chen, Yinhua Wan, Jianquan Luo. Modelling and optimization of pervaporation membrane modules: A critical review. JOURNAL OF MEMBRANE SCIENCE[J]. 2022, 第 4 作者  通讯作者  664: http://dx.doi.org/10.1016/j.memsci.2022.121084.
[5] Chen, Guoqiang, Nikhila Butani, Raja Ghosh. Fast and high-resolution fractionation of positional isomers of a PEGylated protein using membrane chromatography. Journal of Chromatography B[J]. 2022, 第 1 作者
[6] Guoqiang Chen, John Pagano, Deqiang Yu, Sanchayita Ghose, Zhengjian Li, Raja Ghosh. Fast and high-resolution purification of a PEGylated protein using a z2 laterally-fed membrane chromatography device. JOURNAL OF CHROMATOGRAPHY A[J]. 2021, 第 1 作者1652: 
[7] Cao, Yang, Chen, Guoqiang, Wan, Yinhua, Luo, Jianquan. Nanofiltration membrane for bio-separation: Process-oriented materials innovation. ENGINEERING IN LIFE SCIENCES[J]. 2021, 第 2 作者21(6): 405-416, https://doaj.org/article/55faf636a9e54dd4a4b154f403cca4e1.
[8] Guoqiang Chen, Roxana Roshankhah, Raja Ghosh. A cuboid chromatography device having short bed-height gives better protein separation at a significantly lower pressure drop than a taller column having the same bed-volume. JOURNAL OF CHROMATOGRAPHY A[J]. 2021, 第 1 作者1647: http://dx.doi.org/10.1016/j.chroma.2021.462167.
[9] Ghosh, Raja, Chen, Guoqiang, Roshankhah, Roxana, Umatheva, Umatheny, Gatt, Paul. A z(2) laterally-fed membrane chromatography device for fast high-resolution purification of biopharmaceuticals. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 第 2 作者1629: http://dx.doi.org/10.1016/j.chroma.2020.461453.
[10] Chen, Guoqiang, Raja Ghosh. Simulation and experimental study of the transport of macromolecule bands through cuboid packed-bed devices during chromatographic separations. Journal of Chromatography A[J]. 2020, 第 1 作者
[11] Chen, Guoqiang, Umatheva, Umatheny, Pagano, John, Yu, Deqiang, Ghose, Sanchayita, Li, Zhengjian, Ghosh, Raja. High-resolution purification of a therapeutic PEGylated protein using a cuboid packed-bed device. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 第 1 作者1630: http://dx.doi.org/10.1016/j.chroma.2020.461524.
[12] Ghosh, Raja, Chen, Guoqiang, Umatheva, Umatheny, Gatt, Paul. A flow distribution and collection feature for ensuring scalable uniform flow in a chromatography device. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 第 2 作者1618: http://dx.doi.org/10.1016/j.chroma.2020.460892.
[13] Chen, Guoqiang, Gerrior, Alisha, Hale, Geoffrey, Ghosh, Raja. Feasibility study of the fractionation of monoclonal antibody charge variants using a cuboid packed-bed device. BIOCHEMICAL ENGINEERING JOURNAL[J]. 2019, 第 1 作者147: 48-56, http://dx.doi.org/10.1016/j.bej.2019.04.003.
[14] Chen, Guoqiang, Umatheva, Umatheny, Alforque, Lionel, Shirataki, Hironobu, Ogawa, Shuichiro, Kato, Chihiro, Ghosh, Raja. An annular-flow, hollow-fiber membrane chromatography device for fast, high-resolution protein separation at low pressure. JOURNAL OF MEMBRANE SCIENCE[J]. 2019, 第 1 作者590: http://dx.doi.org/10.1016/j.memsci.2019.117305.
[15] Umatheva, Umatheny, Chen, Guoqiang, Ghosh, Raja. Computational fluid dynamic (CFD) simulation of a cuboid packed-bed chromatography device. CHEMICAL ENGINEERING RESEARCH & DESIGN[J]. 2019, 第 2 作者152: 393-401, http://dx.doi.org/10.1016/j.cherd.2019.10.005.
[16] Chen, Guoqiang, Zhitomirsky, Igor, Ghosh, Raja. Fast, low-pressure chromatographic separation of proteins using hydroxyapatite nanoparticles. TALANTA[J]. 2019, 第 1 作者199: 472-477, http://dx.doi.org/10.1016/j.talanta.2019.02.090.
[17] Chen Guoqiang. Efficient capture of monoclonal antibodies in the cell culture supernatant using protein-A media containing cuboid packed-bed device. Journal of Chromatography B. 2019, 第 1 作者
[18] Chen, Guoqiang, Gerrior, Alisha, Ghosh, Raja. Feasibility study for high-resolution multi-component separation of protein mixture using a cation-exchange cuboid packed-bed device. JOURNAL OF CHROMATOGRAPHY A[J]. 2018, 第 1 作者1549: 25-30, http://dx.doi.org/10.1016/j.chroma.2018.03.029.
[19] Chen, Guoqiang, Ghosh, Raja. Effect of the Length-to-Width Aspect Ratio of a Cuboid Packed-Bed Device on Efficiency of Chromatographic Separation. PROCESSES[J]. 2018, 第 1 作者6(9): https://doaj.org/article/7ec8e028241f4c6faf93509ea478eab4.
[20] Guoqiang Chen, Raja Ghosh. Effects of process parameters on the efficiency of chromatographic separations using a cuboid packed-bed device. JOURNAL OF CHROMATOGRAPHY B. 2018, 第 1 作者1086: 23-28, http://dx.doi.org/10.1016/j.jchromb.2018.04.002.
[21] Ghosh, Raja, Chen, Guoqiang. Mathematical modelling and evaluation of performance of cuboid packed-bed devices for chromatographic separations. JOURNAL OF CHROMATOGRAPHY A[J]. 2017, 第 2 作者1515: 138-145, http://dx.doi.org/10.1016/j.chroma.2017.07.088.
[22] Chen, Guoqiang, Su, Zhiguo, Li, Feng, Liu, Hui Fang. Application of calcium phosphate flocculation in high-density cell culture fluid with high product titer of monoclonal antibody. BIOPROCESS AND BIOSYSTEMS ENGINEERING[J]. 2017, 第 1 作者40(5): 703-714, https://www.webofscience.com/wos/woscc/full-record/WOS:000399681900006.
[23] Chen, Guoqiang, Song, Weijie, Qi, Benkun, Ghosh, Raja, Wan, Yinhua. Separation of human serum albumin and polyethylene glycol by electro-ultrafiltration. BIOCHEMICAL ENGINEERING JOURNAL[J]. 2016, 第 1 作者109(MAY): 127-136, http://dx.doi.org/10.1016/j.bej.2016.01.004.
[24] Chen, Guoqiang, Song, Weijie, Qi, Benkun, Li, Jing, Ghosh, Raja, Wan, Yinhua. Separation of protein mixtures by an integrated electro-ultrafiltration-electrodialysis process. SEPARATION AND PURIFICATION TECHNOLOGY[J]. 2015, 第 1 作者147(JUN): 32-43, http://dx.doi.org/10.1016/j.seppur.2015.04.003.
[25] Chen, Guoqiang, Song, Weijie, Qi, Benkun, Lu, Jianren, Wan, Yinhua. Recycling cellulase from enzymatic hydrolyzate of acid treated wheat straw by electroultrafiltration. BIORESOURCE TECHNOLOGY[J]. 2013, 第 1 作者144: 186-193, http://dx.doi.org/10.1016/j.biortech.2013.06.089.
[26] Qi, Benkun, Luo, Jianquan, Chen, Guoqiang, Chen, Xiangrong, Wan, Yinhua. Application of ultrafiltration and nanofiltration for recycling cellulase and concentrating glucose from enzymatic hydrolyzate of steam exploded wheat straw. BIORESOURCE TECHNOLOGY[J]. 2012, 第 3 作者104: 466-472, http://dx.doi.org/10.1016/j.biortech.2011.10.049.
[27] 宋伟杰, 陈国强, 齐本坤, 苏仪, 万印华. 电场强化纤维素酶超滤过程研究. 化学工程[J]. 2011, 第 2 作者39(6): 98-102, http://lib.cqvip.com/Qikan/Article/Detail?id=38270123.
[28] 陈国强. 微滤技术在发酵工艺中的应用. 生物产业技术. 2010, 第 1 作者
[29] 陈国强, 宋伟杰, 苏仪, 万印华. 超滤技术在生物分离中的应用. 生物产业技术[J]. 2010, 第 1 作者69-74, http://lib.cqvip.com/Qikan/Article/Detail?id=34023694.
[30] 宋伟杰, 陈国强, 苏仪, 万印华. 微滤技术在发酵工业中的应用. 生物产业技术[J]. 2010, 第 2 作者65-71, http://lib.cqvip.com/Qikan/Article/Detail?id=34774059.
[31] 宋伟杰, 陈国强, 苏仪, 陈向荣, 沈飞, 万印华. 电场强化蛋白质溶液超滤过程研究. 第四届中国膜科学与技术报告会论文集. 2010, 第 2 作者7, http://www.irgrid.ac.cn/handle/1471x/717305.

   

（ 1 ） 色谱介质及装备的开发及应用, 负责人, 中国科学院计划, 2021-01--2025-01
（ 2 ） 基于流体均匀分布的盒式均孔膜色谱的设计和分离机理研究, 负责人, 国家任务, 2022-01--2025-12
（ 3 ） 原位果糖分离与浓缩工艺, 参与, 地方任务, 2021-03--2023-03

（1）膜色谱装置的设计及在生物大分子分离上的应用   第七届全国医药行业膜分离技术应用研讨会   2022-07-23
（2）Cuboid packed-bed device: a nice case-study to show the importance of device design during chromatographic separation of proteins   Guoqiang Chen   2021-11-19
（3）High-resolution separation of monoclonal antibody charge variants using a cuboid packed-bed device   Guoqiang Chen   2018-03-18

现指导学生

陶璐  博士研究生  081703-生物化工