基本信息
陈国强  男  博导  中国科学院过程工程研究所
电子邮件: gqchen@ipe.ac.cn
通信地址: 北京市海淀区中关村北二街1号中国科学院过程工程研究所生化科研楼405
邮政编码: 100190

研究领域

生物分离

招生信息

   
招生专业
081703-生物化工
085600-材料与化工
086000-生物与医药
招生方向
生物分离,分离介质制备,过程强化技术开发,装备设计构建

教育背景

2009-09--2014-01   中国科学院过程工程研究所   博士
2006-09--2008-07   北京理工大学   硕士
2001-09--2005-07   合肥工业大学   学士

工作经历

   
工作简历
2020-12~现在, 中国科学院过程工程研究所, 项目研究员
2016-12~2020-10,加拿大麦克马斯特大学, 博士后
2014-03~2016-08,中国科学院过程工程研究所、北京天广实生物技术股份有限公司, 博士后

专利与奖励

   
奖励信息
(1) 第 7届全国膜与膜过程学术报告会 优秀论文奖, , 其他, 2011
专利成果
( 1 ) ANNULAR-FLOW HOLLOW FIBER MEMBRANE DEVICE, 发明, 2019, 第 2 作者, 专利号: 62802527
( 2 ) FLOW DISTRIBUTION AND COLLECTION FEATURES FOR ENSURING SCALABLE UNIFORM FLOW IN A CHROMATOGRAPHY OR MEMBRANE SEPARATION DEVICE, 发明, 2019, 第 4 作者, 专利号: 62883891

出版信息

   
发表论文
[1] Chen, Guoqiang, Nikhila Butani, Raja Ghosh. Fast and high-resolution fractionation of positional isomers of a PEGylated protein using membrane chromatography. Journal of Chromatography B[J]. 2022, [2] Guoqiang Chen, John Pagano, Deqiang Yu, Sanchayita Ghose, Zhengjian Li, Raja Ghosh. Fast and high-resolution purification of a PEGylated protein using a z2 laterally-fed membrane chromatography device. Journal of Chromatography A[J]. 2021, 1652: [3] Cao, Yang, Chen, Guoqiang, Wan, Yinhua, Luo, Jianquan. Nanofiltration membrane for bio-separation: Process-oriented materials innovation. ENGINEERING IN LIFE SCIENCESnull. 2021, 21(6): 405-416, https://doaj.org/article/55faf636a9e54dd4a4b154f403cca4e1.
[4] Guoqiang Chen, Roxana Roshankhah, Raja Ghosh. A cuboid chromatography device having short bed-height gives better protein separation at a significantly lower pressure drop than a taller column having the same bed-volume. Journal of Chromatography A[J]. 2021, 1647: http://dx.doi.org/10.1016/j.chroma.2021.462167.
[5] Ghosh, Raja, Chen, Guoqiang, Roshankhah, Roxana, Umatheva, Umatheny, Gatt, Paul. A z(2) laterally-fed membrane chromatography device for fast high-resolution purification of biopharmaceuticals. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 1629: http://dx.doi.org/10.1016/j.chroma.2020.461453.
[6] Chen, Guoqiang, Raja Ghosh. Simulation and experimental study of the transport of macromolecule bands through cuboid packed-bed devices during chromatographic separations. Journal of Chromatography A[J]. 2020, [7] Ghosh, Raja, Chen, Guoqiang, Umatheva, Umatheny, Gatt, Paul. A flow distribution and collection feature for ensuring scalable uniform flow in a chromatography device. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 1618: http://dx.doi.org/10.1016/j.chroma.2020.460892.
[8] Chen, Guoqiang, Umatheva, Umatheny, Pagano, John, Yu, Deqiang, Ghose, Sanchayita, Li, Zhengjian, Ghosh, Raja. High-resolution purification of a therapeutic PEGylated protein using a cuboid packed-bed device. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 1630: http://dx.doi.org/10.1016/j.chroma.2020.461524.
[9] Chen, Guoqiang, Gerrior, Alisha, Hale, Geoffrey, Ghosh, Raja. Feasibility study of the fractionation of monoclonal antibody charge variants using a cuboid packed-bed device. BIOCHEMICAL ENGINEERING JOURNAL[J]. 2019, 147: 48-56, http://dx.doi.org/10.1016/j.bej.2019.04.003.
[10] Chen, Guoqiang, Umatheva, Umatheny, Alforque, Lionel, Shirataki, Hironobu, Ogawa, Shuichiro, Kato, Chihiro, Ghosh, Raja. An annular-flow, hollow-fiber membrane chromatography device for fast, high-resolution protein separation at low pressure. JOURNAL OF MEMBRANE SCIENCE[J]. 2019, 590: http://dx.doi.org/10.1016/j.memsci.2019.117305.
[11] Umatheva, Umatheny, Chen, Guoqiang, Ghosh, Raja. Computational fluid dynamic (CFD) simulation of a cuboid packed-bed chromatography device. CHEMICAL ENGINEERING RESEARCH & DESIGN[J]. 2019, 152: 393-401, http://dx.doi.org/10.1016/j.cherd.2019.10.005.
[12] Chen, Guoqiang, Zhitomirsky, Igor, Ghosh, Raja. Fast, low-pressure chromatographic separation of proteins using hydroxyapatite nanoparticles. TALANTA[J]. 2019, 199: 472-477, http://dx.doi.org/10.1016/j.talanta.2019.02.090.
[13] Chen Guoqiang. Efficient capture of monoclonal antibodies in the cell culture supernatant using protein-A media containing cuboid packed-bed device. Journal of Chromatography B. 2019, [14] Chen, Guoqiang, Gerrior, Alisha, Ghosh, Raja. Feasibility study for high-resolution multi-component separation of protein mixture using a cation-exchange cuboid packed-bed device. JOURNAL OF CHROMATOGRAPHY A[J]. 2018, 1549: 25-30, http://dx.doi.org/10.1016/j.chroma.2018.03.029.
[15] Chen, Guoqiang, Ghosh, Raja. Effect of the Length-to-Width Aspect Ratio of a Cuboid Packed-Bed Device on Efficiency of Chromatographic Separation. PROCESSES[J]. 2018, 6(9): https://doaj.org/article/7ec8e028241f4c6faf93509ea478eab4.
[16] Guoqiang Chen, Raja Ghosh. Effects of process parameters on the efficiency of chromatographic separations using a cuboid packed-bed device. Journal of Chromatography B. 2018, 1086: 23-28, http://dx.doi.org/10.1016/j.jchromb.2018.04.002.
[17] Ghosh, Raja, Chen, Guoqiang. Mathematical modelling and evaluation of performance of cuboid packed-bed devices for chromatographic separations. JOURNAL OF CHROMATOGRAPHY A[J]. 2017, 1515: 138-145, http://dx.doi.org/10.1016/j.chroma.2017.07.088.
[18] Chen, Guoqiang, Su, Zhiguo, Li, Feng, Liu, Hui Fang. Application of calcium phosphate flocculation in high-density cell culture fluid with high product titer of monoclonal antibody. BIOPROCESS AND BIOSYSTEMS ENGINEERING[J]. 2017, 40(5): 703-714, https://www.webofscience.com/wos/woscc/full-record/WOS:000399681900006.
[19] Chen, Guoqiang, Song, Weijie, Qi, Benkun, Ghosh, Raja, Wan, Yinhua. Separation of human serum albumin and polyethylene glycol by electro-ultrafiltration. BIOCHEMICAL ENGINEERING JOURNAL[J]. 2016, 109(MAY): 127-136, http://dx.doi.org/10.1016/j.bej.2016.01.004.
[20] Chen, Guoqiang, Song, Weijie, Qi, Benkun, Li, Jing, Ghosh, Raja, Wan, Yinhua. Separation of protein mixtures by an integrated electro-ultrafiltration-electrodialysis process. SEPARATION AND PURIFICATION TECHNOLOGY[J]. 2015, 147(JUN): 32-43, http://dx.doi.org/10.1016/j.seppur.2015.04.003.
[21] 陈国强. 电场强化超滤技术在蛋白质浓缩和分离中的应用. 2013, http://ir.ipe.ac.cn/handle/122111/8483.
[22] Chen, Guoqiang, Song, Weijie, Qi, Benkun, Lu, Jianren, Wan, Yinhua. Recycling cellulase from enzymatic hydrolyzate of acid treated wheat straw by electroultrafiltration. BIORESOURCE TECHNOLOGY[J]. 2013, 144: 186-193, http://dx.doi.org/10.1016/j.biortech.2013.06.089.
[23] Qi, Benkun, Luo, Jianquan, Chen, Guoqiang, Chen, Xiangrong, Wan, Yinhua. Application of ultrafiltration and nanofiltration for recycling cellulase and concentrating glucose from enzymatic hydrolyzate of steam exploded wheat straw. BIORESOURCE TECHNOLOGY[J]. 2012, 104: 466-472, http://dx.doi.org/10.1016/j.biortech.2011.10.049.
[24] 宋伟杰, 陈国强, 齐本坤, 苏仪, 万印华. 电场强化纤维素酶超滤过程研究. 化学工程. 2011, 39(6): 98-102, http://lib.cqvip.com/Qikan/Article/Detail?id=38270123.
[25] 陈国强. 微滤技术在发酵工艺中的应用. 生物产业技术. 2010, [26] 陈国强, 宋伟杰, 苏仪, 万印华. 超滤技术在生物分离中的应用. 生物产业技术. 2010, 69-74, http://lib.cqvip.com/Qikan/Article/Detail?id=34023694.
[27] 宋伟杰, 陈国强, 苏仪, 陈向荣, 沈飞, 万印华. 电场强化蛋白质溶液超滤过程研究. 第四届中国膜科学与技术报告会论文集null. 2010, 7-, http://www.irgrid.ac.cn/handle/1471x/717305.

科研活动

   
科研项目
( 1 ) 色谱介质及装备的开发及应用, 主持, 部委级, 2021-01--2025-01
参与会议
(1)High-resolution separation of monoclonal antibody charge variants using a cuboid packed-bed device   Guoqiang Chen   2018-03-18