070304-物理化学（含：化学物理）
071010-生物化学与分子生物学
071023-计算生物学

生物大分子动态学
分子模拟
多实验整合计算

2007-09--2012-06   华中科技大学   理学博士学位
2003-09--2007-06   华中科技大学   理学学士学位

   

2015-06~现在, 中国科学院武汉物理与数学研究所, 副研究员
2012-07~2015-06,中国科学院武汉物理与数学研究所, 博士后

   

[1] Ma, Ling, Wang, Xiang, Guan, Zeyuan, Wang, Lixia, Wang, Yidong, Zheng, Le, Gong, Zhou, Shen, Cuicui, Wang, Jing, Zhang, Delin, Liu, Zhu, Yin, Ping. Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2020, 27(5): 472-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000532487100009.
[2] Tang, Chun, Gong, Zhou. Integrating Non-NMR Distance Restraints to Augment NMR Depiction of Protein Structure and Dynamics. JOURNAL OF MOLECULAR BIOLOGYnull. 2020, 432(9): 2913-2929, http://dx.doi.org/10.1016/j.jmb.2020.01.023.
[3] Gong Zhou. The conformational preference of chemical crosslinkers determins the crosslinking probability of reactive protein residues. J Phy Chem B. 2020, [4] Zhiyuan You, WenXue Jiang, LingYun Qin, Zhou Gong, Wei Wan, Jin Li, Yusha Wang, Hongtao Zhang, Chao Peng, Tianhua Zhou, Chun Tang, Wei Liu. Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-14, http://dx.doi.org/10.1038/s41467-019-13718-w.
[5] Liu, Zhu, Dong, Xu, Yi, HuaWei, Yang, Ju, Gong, Zhou, Wang, Yi, Liu, Kan, Zhang, WeiPing, Tang, Chun. Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13. CELL DISCOVERY[J]. 2019, 5(1): https://doaj.org/article/ea4217b35ec14714915f21e313b46cf6.
[6] Ye, ShangXiang, Gong, Zhou, Yang, Ju, An, YuXin, Liu, Zhu, Zhao, Qun, Lescop, Ewen, Dong, Xu, Tang, Chun. Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch. PROTEIN & CELL[J]. 2019, 10(12): 908-913, http://lib.cqvip.com/Qikan/Article/Detail?id=7100635736.
[7] Zhou Gong, Shuai Yang, QingFen Yang, YueLing Zhu, Jing Jiang, Chun Tang. Refining RNA solution structures with the integrative use of label-free paramagnetic relaxation enhancement NMR. 生物物理学报:英文版[J]. 2019, 5(5): 244-253, http://dx.doi.org/10.1007/s41048-019-00099-2.
[8] Tang Chun. Solution structure of the RNA recgonition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein & Cell. 2018, [9] Zhang, Xiaoyun, Wang, JianHua, Tan, Dan, Li, Qiang, Li, Maodong, Gong, Zhou, Tang, Chun, Liu, Zhirong, Dong, MengQiu, Lei, Xiaoguang. Carboxylate-Selective Chemical Cross-Linkers for Mass Spectrometric Analysis of Protein Structures. ANALYTICAL CHEMISTRY[J]. 2018, 90(2): 1195-1201, https://www.webofscience.com/wos/woscc/full-record/WOS:000423011600024.
[10] Liu, Zhu, Gong, Zhou, Cao, Yong, Ding, YueHe, Dong, MengQiu, Lu, YunBi, Zhang, WeiPing, Tang, Chun. Characterizing Protein Dynamics with Integrative Use of Bulk and Single-Molecule Techniques. BIOCHEMISTRY[J]. 2018, 57(3): 305-313, https://www.webofscience.com/wos/woscc/full-record/WOS:000423418500008.
[11] Gong Zhou. Theory and practice of using solvent paramagnetic relaxtion enhancement to characterize protein conformational dynamics. Methods. 2018, [12] Ding, YueHe, Gong, Zhou, Dong, Xu, Liu, Kan, Liu, Zhu, Liu, Chao, He, SiMin, Dong, MengQiu, Tang, Chun. Modeling Protein Excited-state Structures from "Over-length" Chemical Cross-links. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 292(4): 1187-1196, http://dx.doi.org/10.1074/jbc.M116.761841.
[13] Gong, Zhou, Gu, XinHua, Guo, DaChuan, Wang, Jin, Tang, Chun. Protein Structural Ensembles Visualized by Solvent Paramagnetic Relaxation Enhancement. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(4): 1002-1006, http://dx.doi.org/10.1002/anie.201609830.
[14] Gong Zhou, Liu Zhu, Dong Xu, Ding YueHe, Dong MengQiu, Tang Chun. protocolforanalyzingproteinensemblestructuresfromchemicalcrosslinksusingdynaxl. BIOPHYSICSREPORTS[J]. 2017, 3(4/6): 100-, http://dx.doi.org/10.1007/s41048-017-0044-9.
[15] Gong Zhou. Structural basis of nonribosomal pepetide macrocyclization in fungi. Nat Chem Biol. 2016, [16] Zhu Liu, Zhou Gong, Xu Dong, Chun Tang. Transient protein–protein interactions visualized by solution NMR. BBA - PROTEINS AND PROTEOMICS. 2016, 1864(1): 115-122, http://dx.doi.org/10.1016/j.bbapap.2015.04.009.
[17] Tang Chun. Visualizing the ensemble structures of protein complexes using chemical cross-linking coupled with mass spectrometry. Biophys Rept. 2016, [18] 陈少敏, 唐淳, 龚洲. 铽离子-镧系金属结合标签的荧光探针的改进. 波谱学杂志[J]. 2016, 33(1): 106-, http://lib.cqvip.com/Qikan/Article/Detail?id=668060229.
[19] Wang, Xiang, Feng, Jing, Xue, Yuan, Guan, Zeyuan, Zhang, Delin, Liu, Zhu, Gong, Zhou, Wang, Qiang, Huang, Jinbo, Tang, Chun, Zou, Tingting, Yin, Ping. Structural basis of N-6-adenosine methylation by the METTL3-METTL14 complex. NATURE[J]. 2016, 534(7608): 575-+, http://dx.doi.org/10.1038/nature18298.
[20] Zhu Liu. Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition. ELIFE SCIENCES PUBLICATIONS, LTD. 2015, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904026228108ZK.
[21] Gong, Zhou, Schwieters, Charles D, Tang, Chun. Conjoined Use of EM and NMR in RNA Structure Refinement. PLOS ONE[J]. 2015, 10(3): http://dx.doi.org/10.1371/journal.pone.0120445.
[22] Gong, Zhou, Zhao, Yunjie, Chen, Changjun, Duan, Yong, Xiao, Yi. Insights into Ligand Binding to PreQ(1) Riboswitch Aptamer from Molecular Dynamics Simulations. PLOS ONE[J]. 2014, 9(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000333459900047.
[23] Gu, XinHua, Gong, Zhou, Guo, DaChuan, Zhang, WeiPing, Tang, Chun. A decadentate Gd(III)-coordinating paramagnetic cosolvent for protein relaxation enhancement measurement. JOURNAL OF BIOMOLECULAR NMR[J]. 2014, 58(3): 149-154, http://dx.doi.org/10.1007/s10858-014-9817-3.
[24] Zhe Zhang. Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5. ELIFE SCIENCES PUBLICATIONS, LTD. 2014, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904029083571ZK.
[25] Liu, Zhu, Gong, Zhou, Guo, DaChuan, Zhang, WeiPing, Tang, Chun. Subtle Dynamics of holo Glutamine Binding Protein Revealed with a Rigid Paramagnetic Probe. BIOCHEMISTRY[J]. 2014, 53(9): 1403-1409, http://dx.doi.org/10.1021/bi4015715.
[26] Gong, Zhou, Zhao, Yunjie, Chen, Changjun, Xiao, Yi. Computational Study of Unfolding and Regulation Mechanism of preQ(1) Riboswitches. PLOS ONE[J]. 2012, 7(9): https://doaj.org/article/5c0a65495bec4dd098ce8770af6e133a.
[27] Zhao, Yunjie, Huang, Yangyu, Gong, Zhou, Wang, Yanjie, Man, Jianfen, Xiao, Yi. Automated and fast building of three-dimensional RNA structures. SCIENTIFIC REPORTS[J]. 2012, 2: https://www.webofscience.com/wos/woscc/full-record/WOS:000309957800001.
[28] Gong, Zhou, Zhao, Yunjie, Chen, Changjun, Xiao, Yi. Role of Ligand Binding in Structural Organization of Add A-riboswitch Aptamer: A Molecular Dynamics Simulation. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2011, 29(2): 403-416, https://www.webofscience.com/wos/woscc/full-record/WOS:000294884000015.

   

（ 1 ） 建立解析非编码RNA溶液结构的新方法, 主持, 国家级, 2015-01--2017-12
（ 2 ） 生物大分子核磁共振, 参与, 国家级, 2013-01--2016-12
（ 3 ） 蛋白质机器动态结构的核磁共振研究方法及应用, 参与, 国家级, 2016-07--2021-06

（1）溶液顺磁弛豫增强用于蛋白质结构和动态学的研究   2016-06-17