基本信息
龚洲 男 硕导 中国科学院精密测量科学与技术创新研究院
电子邮件： gongzhou@apm.ac.cn
通信地址： 湖北省武汉市武昌区小洪山西30号中国科学院武汉物理与数学研究所综合楼
邮政编码： 430071
电子邮件： gongzhou@apm.ac.cn
通信地址： 湖北省武汉市武昌区小洪山西30号中国科学院武汉物理与数学研究所综合楼
邮政编码： 430071
招生信息
招生专业
070304-物理化学（含：化学物理）
071010-生物化学与分子生物学
071023-计算生物学
071010-生物化学与分子生物学
071023-计算生物学
招生方向
生物大分子动态学
分子模拟
多实验整合计算
分子模拟
多实验整合计算
教育背景
2007-09--2012-06 华中科技大学 理学博士学位
2003-09--2007-06 华中科技大学 理学学士学位
2003-09--2007-06 华中科技大学 理学学士学位
工作经历
工作简历
2015-06~现在, 中国科学院武汉物理与数学研究所, 副研究员
2012-07~2015-06,中国科学院武汉物理与数学研究所, 博士后
2012-07~2015-06,中国科学院武汉物理与数学研究所, 博士后
出版信息
发表论文
[1] Briefings in Bioinformatics. 2024, 通讯作者
[2] JACS Au. 2024, 第 3 作者
[3] Nat Commun. 2023, 第 3 作者
[4] Phys. Chem. Chem. Phys. 2023, 通讯作者
[5] Angew Chem Int Ed. 2023, 通讯作者
[6] Life. 2023, 通讯作者
[7] Cell Discov. 2023, 通讯作者
[8] Cell Discov. 2023, 第 7 作者
[9] Nat Commun. 2022, 第 3 作者
[10] J Phy Chem L. 2022, 第 3 作者
[11] JACS. 2022, 第 3 作者
[12] Anal Chem. 2022, 第 3 作者
[13] J Phy Chem B. 2022, 第 1 作者
[14] Anal Chem. 2022, 第 5 作者
[15] Biophys Rep. 2022, 第 2 作者
[16] Anal Chem. 2022, 第 3 作者
[17] Structure. 2020, 第 1 作者
[18] Ma, Ling, Wang, Xiang, Guan, Zeyuan, Wang, Lixia, Wang, Yidong, Zheng, Le, Gong, Zhou, Shen, Cuicui, Wang, Jing, Zhang, Delin, Liu, Zhu, Yin, Ping. Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2020, 第 7 作者27(5): 472-+, http://dx.doi.org/10.1038/s41594-020-0410-z.
[19] Tang, Chun, Gong, Zhou. Integrating Non-NMR Distance Restraints to Augment NMR Depiction of Protein Structure and Dynamics. JOURNAL OF MOLECULAR BIOLOGY. 2020, 第 2 作者432(9): 2913-2929, http://dx.doi.org/10.1016/j.jmb.2020.01.023.
[20] Gong Zhou. The conformational preference of chemical crosslinkers determins the crosslinking probability of reactive protein residues. J Phy Chem B. 2020, 第 1 作者
[21] Zhiyuan You, WenXue Jiang, LingYun Qin, Zhou Gong, Wei Wan, Jin Li, Yusha Wang, Hongtao Zhang, Chao Peng, Tianhua Zhou, Chun Tang, Wei Liu. Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. NATURE COMMUNICATIONS[J]. 2019, 第 4 作者10(1): 1-14, http://dx.doi.org/10.1038/s41467-019-13718-w.
[22] Liu, Zhu, Dong, Xu, Yi, HuaWei, Yang, Ju, Gong, Zhou, Wang, Yi, Liu, Kan, Zhang, WeiPing, Tang, Chun. Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13. CELL DISCOVERY[J]. 2019, 第 5 作者5(1): https://doaj.org/article/ea4217b35ec14714915f21e313b46cf6.
[23] Ye, ShangXiang, Gong, Zhou, Yang, Ju, An, YuXin, Liu, Zhu, Zhao, Qun, Lescop, Ewen, Dong, Xu, Tang, Chun. Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch. PROTEIN & CELL[J]. 2019, 第 2 作者10(12): 908-913, http://lib.cqvip.com/Qikan/Article/Detail?id=7100635736.
[24] Zhou Gong, Shuai Yang, QingFen Yang, YueLing Zhu, Jing Jiang, Chun Tang. Refining RNA solution structures with the integrative use of label-free paramagnetic relaxation enhancement NMR. 生物物理学报:英文版[J]. 2019, 第 1 作者5(5): 244-253, http://dx.doi.org/10.1007/s41048-019-00099-2.
[25] Tang Chun. Solution structure of the RNA recgonition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein & Cell. 2018,
[26] Zhang, Xiaoyun, Wang, JianHua, Tan, Dan, Li, Qiang, Li, Maodong, Gong, Zhou, Tang, Chun, Liu, Zhirong, Dong, MengQiu, Lei, Xiaoguang. Carboxylate-Selective Chemical Cross-Linkers for Mass Spectrometric Analysis of Protein Structures. ANALYTICAL CHEMISTRY[J]. 2018, 第 6 作者90(2): 1195-1201, https://www.webofscience.com/wos/woscc/full-record/WOS:000423011600024.
[27] Liu, Zhu, Gong, Zhou, Cao, Yong, Ding, YueHe, Dong, MengQiu, Lu, YunBi, Zhang, WeiPing, Tang, Chun. Characterizing Protein Dynamics with Integrative Use of Bulk and Single-Molecule Techniques. BIOCHEMISTRY[J]. 2018, 第 11 作者57(3): 305-313, https://www.webofscience.com/wos/woscc/full-record/WOS:000423418500008.
[28] Gong Zhou. Theory and practice of using solvent paramagnetic relaxtion enhancement to characterize protein conformational dynamics. Methods. 2018, 第 1 作者
[29] Ding, YueHe, Gong, Zhou, Dong, Xu, Liu, Kan, Liu, Zhu, Liu, Chao, He, SiMin, Dong, MengQiu, Tang, Chun. Modeling Protein Excited-state Structures from "Over-length" Chemical Cross-links. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 第 2 作者292(4): 1187-1196, http://dx.doi.org/10.1074/jbc.M116.761841.
[30] Gong, Zhou, Gu, XinHua, Guo, DaChuan, Wang, Jin, Tang, Chun. Protein Structural Ensembles Visualized by Solvent Paramagnetic Relaxation Enhancement. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 第 1 作者56(4): 1002-1006, http://dx.doi.org/10.1002/anie.201609830.
[31] Gong Zhou, Liu Zhu, Dong Xu, Ding YueHe, Dong MengQiu, Tang Chun. protocolforanalyzingproteinensemblestructuresfromchemicalcrosslinksusingdynaxl. BIOPHYSICSREPORTS[J]. 2017, 第 1 作者3(4/6): 100, http://dx.doi.org/10.1007/s41048-017-0044-9.
[32] Gong Zhou. Structural basis of nonribosomal pepetide macrocyclization in fungi. Nat Chem Biol. 2016, 第 1 作者
[33] Zhu Liu, Zhou Gong, Xu Dong, Chun Tang. Transient protein–protein interactions visualized by solution NMR. BBA - PROTEINS AND PROTEOMICS. 2016, 第 2 作者1864(1): 115-122, http://dx.doi.org/10.1016/j.bbapap.2015.04.009.
[34] Tang Chun. Visualizing the ensemble structures of protein complexes using chemical cross-linking coupled with mass spectrometry. Biophys Rept. 2016,
[35] 陈少敏, 唐淳, 龚洲. 铽离子-镧系金属结合标签的荧光探针的改进. 波谱学杂志[J]. 2016, 第 3 作者33(1): 106, http://lib.cqvip.com/Qikan/Article/Detail?id=668060229.
[36] Wang, Xiang, Feng, Jing, Xue, Yuan, Guan, Zeyuan, Zhang, Delin, Liu, Zhu, Gong, Zhou, Wang, Qiang, Huang, Jinbo, Tang, Chun, Zou, Tingting, Yin, Ping. Structural basis of N-6-adenosine methylation by the METTL3-METTL14 complex. NATURE[J]. 2016, 第 7 作者534(7608): 575-+, http://dx.doi.org/10.1038/nature18298.
[37] Zhu Liu. Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition. ELIFE SCIENCES PUBLICATIONS, LTD. 2015, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904026228108ZK.
[38] Gong, Zhou, Schwieters, Charles D, Tang, Chun. Conjoined Use of EM and NMR in RNA Structure Refinement. PLOS ONE[J]. 2015, 第 1 作者10(3): http://dx.doi.org/10.1371/journal.pone.0120445.
[39] Gong, Zhou, Zhao, Yunjie, Chen, Changjun, Duan, Yong, Xiao, Yi. Insights into Ligand Binding to PreQ(1) Riboswitch Aptamer from Molecular Dynamics Simulations. PLOS ONE[J]. 2014, 第 1 作者9(3): https://doaj.org/article/7989bf798978493e84a0259b167a29c0.
[40] Gu, XinHua, Gong, Zhou, Guo, DaChuan, Zhang, WeiPing, Tang, Chun. A decadentate Gd(III)-coordinating paramagnetic cosolvent for protein relaxation enhancement measurement. JOURNAL OF BIOMOLECULAR NMR[J]. 2014, 第 2 作者58(3): 149-154, http://dx.doi.org/10.1007/s10858-014-9817-3.
[41] Zhe Zhang. Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5. ELIFE SCIENCES PUBLICATIONS, LTD. 2014, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904029083571ZK.
[42] Liu, Zhu, Gong, Zhou, Guo, DaChuan, Zhang, WeiPing, Tang, Chun. Subtle Dynamics of holo Glutamine Binding Protein Revealed with a Rigid Paramagnetic Probe. BIOCHEMISTRY[J]. 2014, 第 2 作者53(9): 1403-1409, http://dx.doi.org/10.1021/bi4015715.
[43] Gong, Zhou, Zhao, Yunjie, Chen, Changjun, Xiao, Yi. Computational Study of Unfolding and Regulation Mechanism of preQ(1) Riboswitches. PLOS ONE[J]. 2012, 第 1 作者7(9): http://dx.doi.org/10.1371/journal.pone.0045239.
[44] Zhao, Yunjie, Huang, Yangyu, Gong, Zhou, Wang, Yanjie, Man, Jianfen, Xiao, Yi. Automated and fast building of three-dimensional RNA structures. SCIENTIFIC REPORTS[J]. 2012, 第 3 作者2: http://dx.doi.org/10.1038/srep00734.
[45] Gong, Zhou, Zhao, Yunjie, Chen, Changjun, Xiao, Yi. Role of Ligand Binding in Structural Organization of Add A-riboswitch Aptamer: A Molecular Dynamics Simulation. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2011, 第 1 作者29(2): 403-416, https://www.webofscience.com/wos/woscc/full-record/WOS:000294884000015.
[2] JACS Au. 2024, 第 3 作者
[3] Nat Commun. 2023, 第 3 作者
[4] Phys. Chem. Chem. Phys. 2023, 通讯作者
[5] Angew Chem Int Ed. 2023, 通讯作者
[6] Life. 2023, 通讯作者
[7] Cell Discov. 2023, 通讯作者
[8] Cell Discov. 2023, 第 7 作者
[9] Nat Commun. 2022, 第 3 作者
[10] J Phy Chem L. 2022, 第 3 作者
[11] JACS. 2022, 第 3 作者
[12] Anal Chem. 2022, 第 3 作者
[13] J Phy Chem B. 2022, 第 1 作者
[14] Anal Chem. 2022, 第 5 作者
[15] Biophys Rep. 2022, 第 2 作者
[16] Anal Chem. 2022, 第 3 作者
[17] Structure. 2020, 第 1 作者
[18] Ma, Ling, Wang, Xiang, Guan, Zeyuan, Wang, Lixia, Wang, Yidong, Zheng, Le, Gong, Zhou, Shen, Cuicui, Wang, Jing, Zhang, Delin, Liu, Zhu, Yin, Ping. Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2020, 第 7 作者27(5): 472-+, http://dx.doi.org/10.1038/s41594-020-0410-z.
[19] Tang, Chun, Gong, Zhou. Integrating Non-NMR Distance Restraints to Augment NMR Depiction of Protein Structure and Dynamics. JOURNAL OF MOLECULAR BIOLOGY. 2020, 第 2 作者432(9): 2913-2929, http://dx.doi.org/10.1016/j.jmb.2020.01.023.
[20] Gong Zhou. The conformational preference of chemical crosslinkers determins the crosslinking probability of reactive protein residues. J Phy Chem B. 2020, 第 1 作者
[21] Zhiyuan You, WenXue Jiang, LingYun Qin, Zhou Gong, Wei Wan, Jin Li, Yusha Wang, Hongtao Zhang, Chao Peng, Tianhua Zhou, Chun Tang, Wei Liu. Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. NATURE COMMUNICATIONS[J]. 2019, 第 4 作者10(1): 1-14, http://dx.doi.org/10.1038/s41467-019-13718-w.
[22] Liu, Zhu, Dong, Xu, Yi, HuaWei, Yang, Ju, Gong, Zhou, Wang, Yi, Liu, Kan, Zhang, WeiPing, Tang, Chun. Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13. CELL DISCOVERY[J]. 2019, 第 5 作者5(1): https://doaj.org/article/ea4217b35ec14714915f21e313b46cf6.
[23] Ye, ShangXiang, Gong, Zhou, Yang, Ju, An, YuXin, Liu, Zhu, Zhao, Qun, Lescop, Ewen, Dong, Xu, Tang, Chun. Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch. PROTEIN & CELL[J]. 2019, 第 2 作者10(12): 908-913, http://lib.cqvip.com/Qikan/Article/Detail?id=7100635736.
[24] Zhou Gong, Shuai Yang, QingFen Yang, YueLing Zhu, Jing Jiang, Chun Tang. Refining RNA solution structures with the integrative use of label-free paramagnetic relaxation enhancement NMR. 生物物理学报:英文版[J]. 2019, 第 1 作者5(5): 244-253, http://dx.doi.org/10.1007/s41048-019-00099-2.
[25] Tang Chun. Solution structure of the RNA recgonition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein & Cell. 2018,
[26] Zhang, Xiaoyun, Wang, JianHua, Tan, Dan, Li, Qiang, Li, Maodong, Gong, Zhou, Tang, Chun, Liu, Zhirong, Dong, MengQiu, Lei, Xiaoguang. Carboxylate-Selective Chemical Cross-Linkers for Mass Spectrometric Analysis of Protein Structures. ANALYTICAL CHEMISTRY[J]. 2018, 第 6 作者90(2): 1195-1201, https://www.webofscience.com/wos/woscc/full-record/WOS:000423011600024.
[27] Liu, Zhu, Gong, Zhou, Cao, Yong, Ding, YueHe, Dong, MengQiu, Lu, YunBi, Zhang, WeiPing, Tang, Chun. Characterizing Protein Dynamics with Integrative Use of Bulk and Single-Molecule Techniques. BIOCHEMISTRY[J]. 2018, 第 11 作者57(3): 305-313, https://www.webofscience.com/wos/woscc/full-record/WOS:000423418500008.
[28] Gong Zhou. Theory and practice of using solvent paramagnetic relaxtion enhancement to characterize protein conformational dynamics. Methods. 2018, 第 1 作者
[29] Ding, YueHe, Gong, Zhou, Dong, Xu, Liu, Kan, Liu, Zhu, Liu, Chao, He, SiMin, Dong, MengQiu, Tang, Chun. Modeling Protein Excited-state Structures from "Over-length" Chemical Cross-links. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 第 2 作者292(4): 1187-1196, http://dx.doi.org/10.1074/jbc.M116.761841.
[30] Gong, Zhou, Gu, XinHua, Guo, DaChuan, Wang, Jin, Tang, Chun. Protein Structural Ensembles Visualized by Solvent Paramagnetic Relaxation Enhancement. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 第 1 作者56(4): 1002-1006, http://dx.doi.org/10.1002/anie.201609830.
[31] Gong Zhou, Liu Zhu, Dong Xu, Ding YueHe, Dong MengQiu, Tang Chun. protocolforanalyzingproteinensemblestructuresfromchemicalcrosslinksusingdynaxl. BIOPHYSICSREPORTS[J]. 2017, 第 1 作者3(4/6): 100, http://dx.doi.org/10.1007/s41048-017-0044-9.
[32] Gong Zhou. Structural basis of nonribosomal pepetide macrocyclization in fungi. Nat Chem Biol. 2016, 第 1 作者
[33] Zhu Liu, Zhou Gong, Xu Dong, Chun Tang. Transient protein–protein interactions visualized by solution NMR. BBA - PROTEINS AND PROTEOMICS. 2016, 第 2 作者1864(1): 115-122, http://dx.doi.org/10.1016/j.bbapap.2015.04.009.
[34] Tang Chun. Visualizing the ensemble structures of protein complexes using chemical cross-linking coupled with mass spectrometry. Biophys Rept. 2016,
[35] 陈少敏, 唐淳, 龚洲. 铽离子-镧系金属结合标签的荧光探针的改进. 波谱学杂志[J]. 2016, 第 3 作者33(1): 106, http://lib.cqvip.com/Qikan/Article/Detail?id=668060229.
[36] Wang, Xiang, Feng, Jing, Xue, Yuan, Guan, Zeyuan, Zhang, Delin, Liu, Zhu, Gong, Zhou, Wang, Qiang, Huang, Jinbo, Tang, Chun, Zou, Tingting, Yin, Ping. Structural basis of N-6-adenosine methylation by the METTL3-METTL14 complex. NATURE[J]. 2016, 第 7 作者534(7608): 575-+, http://dx.doi.org/10.1038/nature18298.
[37] Zhu Liu. Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition. ELIFE SCIENCES PUBLICATIONS, LTD. 2015, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904026228108ZK.
[38] Gong, Zhou, Schwieters, Charles D, Tang, Chun. Conjoined Use of EM and NMR in RNA Structure Refinement. PLOS ONE[J]. 2015, 第 1 作者10(3): http://dx.doi.org/10.1371/journal.pone.0120445.
[39] Gong, Zhou, Zhao, Yunjie, Chen, Changjun, Duan, Yong, Xiao, Yi. Insights into Ligand Binding to PreQ(1) Riboswitch Aptamer from Molecular Dynamics Simulations. PLOS ONE[J]. 2014, 第 1 作者9(3): https://doaj.org/article/7989bf798978493e84a0259b167a29c0.
[40] Gu, XinHua, Gong, Zhou, Guo, DaChuan, Zhang, WeiPing, Tang, Chun. A decadentate Gd(III)-coordinating paramagnetic cosolvent for protein relaxation enhancement measurement. JOURNAL OF BIOMOLECULAR NMR[J]. 2014, 第 2 作者58(3): 149-154, http://dx.doi.org/10.1007/s10858-014-9817-3.
[41] Zhe Zhang. Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5. ELIFE SCIENCES PUBLICATIONS, LTD. 2014, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904029083571ZK.
[42] Liu, Zhu, Gong, Zhou, Guo, DaChuan, Zhang, WeiPing, Tang, Chun. Subtle Dynamics of holo Glutamine Binding Protein Revealed with a Rigid Paramagnetic Probe. BIOCHEMISTRY[J]. 2014, 第 2 作者53(9): 1403-1409, http://dx.doi.org/10.1021/bi4015715.
[43] Gong, Zhou, Zhao, Yunjie, Chen, Changjun, Xiao, Yi. Computational Study of Unfolding and Regulation Mechanism of preQ(1) Riboswitches. PLOS ONE[J]. 2012, 第 1 作者7(9): http://dx.doi.org/10.1371/journal.pone.0045239.
[44] Zhao, Yunjie, Huang, Yangyu, Gong, Zhou, Wang, Yanjie, Man, Jianfen, Xiao, Yi. Automated and fast building of three-dimensional RNA structures. SCIENTIFIC REPORTS[J]. 2012, 第 3 作者2: http://dx.doi.org/10.1038/srep00734.
[45] Gong, Zhou, Zhao, Yunjie, Chen, Changjun, Xiao, Yi. Role of Ligand Binding in Structural Organization of Add A-riboswitch Aptamer: A Molecular Dynamics Simulation. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2011, 第 1 作者29(2): 403-416, https://www.webofscience.com/wos/woscc/full-record/WOS:000294884000015.
科研活动
科研项目
（ 1 ） 建立解析非编码RNA溶液结构的新方法, 主持, 国家级, 2015-01--2017-12
（ 2 ） 生物大分子核磁共振, 参与, 国家级, 2013-01--2016-12
（ 3 ） 蛋白质机器动态结构的核磁共振研究方法及应用, 参与, 国家级, 2016-07--2021-06
（ 2 ） 生物大分子核磁共振, 参与, 国家级, 2013-01--2016-12
（ 3 ） 蛋白质机器动态结构的核磁共振研究方法及应用, 参与, 国家级, 2016-07--2021-06
参与会议
（1）溶液顺磁弛豫增强用于蛋白质结构和动态学的研究 2016-06-17