​The Pathological Mechanism of Neurological Diseases

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September 2012 - July 2016: University of Chinese Academy of Sciences, Ph.D.

September 2009 - March 2012: Shanghai Jiao Tong University, Master of Engineering

September 2005 - July 2009: Hainan University, Bachelor of Science

   

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November 2023 - August 2024: National Institutes of Health (NIH), Research Fellow

June 2022 - October 2023: National Institutes of Health (NIH), Assistant Researcher

June 2017 - June 2022: National Institutes of Health (NIH), Postdoctoral Researcher

July 2016 - January 2017: Duke-NUS Medical School, Postdoctoral Researcher

Wang G, Peng S, Reyes Mendez M, Keramidas A, Castellano D, Wu K, Han W, Tian Q, Dong L, Li Y, Lu W. The TMEM132B-GABAA receptor complex controls alcohol actions in the brain. Cell. 2024. 187(23):6649-6668.e35.doi: 10.1016/j.cell.2024.09.006. 

Wang G*, Jin S*, Liu J, Li X, Dai P, Wang Y, Hou XS. A Neuron-Immune Circuit Regulates Neurodegeneration in the Hindbrain and Spinal cord of ARF1-Ablated Mice. National Science Review. 2023. nwad222. (Co-first author)

 

Wang G^#, Yin W, Shin H, Tian Q, Lu W^#, Hou SX^#. Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome. Nat Aging. 2021. 1:1024–1037. 

 

Wang G, Xu J, Zhao J, Yin W, Liu D, Chen W, Hou SX. Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice. Nat Commun. 2020, 11: 220.

 

Wang G, Liu X, Gaertig MA, Li S, Li XJ. Ablation of huntingtin in adult neurons is non-deleterious but its depletion in young mice causes acute pancreatitis. Proc Natl Acad Sci U S A. 2016, 113(12):3359-3364.

 

Wang G*, Yang H*, Yan S*, Wang CE, Liu X, Zhao B, Ouyang Z, Yin P, Liu Z, Zhao Y, Liu T, Fan N, Guo L, Li S, Li XJ, Lai L. Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain. Mol Neurodegener. 2015, 10: 42. (Co-first author)

 

Wang G, Yin P, Zhang W, Fernandez CG, Xu X. Editorial: The relationship of neuroinflammation with aging and neurodegenerative diseases. Front. Aging Neurosci. 2022. 14, 1102613.

 

Yang H*, Wang G*, Sun H*, Shu R*, Liu T, Wang CE, Liu Z, Zhao Y, Zhao B, Ouyang Z, Yang D, Huang J, Zhou Y, Li S, Jiang X, Xiao Z, Li XJ, Lai L. Species-dependent neuropathology in transgenic SOD1 pigs. Cell Res. 2014, 24(4):464-481. (Co-first author)

 

Yang W*, Wang G*, Wang CE*, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ. Mutant alpha-Synuclein causes age-dependent neuropathology in monkey brain. J Neurosci. 2015, 35(21):8345-8358. (Co-first author)

 

Huang B, Wei W, Wang G, Gaertig MA, Feng Y, Wang W, Li XJ, Li S. Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron. 2015, 85(6):1212-1226.

 

Liu X, Wang CE, Hong Y, Zhao T, Wang G, Gaertig MA, Sun M, Li S, Li XJ. N-terminal huntingtin knock-in mice: Implications of removing the N-terminal region of huntingtin for therapy. PLoS Genet. 2016, 12(5): e1006083.

 

Wang G, Huang X, Li S, Huang J, Wei X, Li Y, Xu Y. The RNA chaperone Hfq regulates antibiotic biosynthesis in the rhizobacterium Pseudomonas aeruginosa M18. J Bacterial. 2012, 194(10):2443-2457.

Neurological disorders, Synapse and neurocircuits, Generations of neuroligical disorders' animal models

2023-2024, SFN meetting

现指导学生

赵楚芸  硕士研究生  071002-动物学  

FARE Award, NIH, USA                                                         2021

FARE Award, NIH, USA                                                         2020

CGS Fellowship, NCI, NIH, USA                                                       2017-2018

Excellent Graduate of Beijing Award, Beijing, China                                    2016    

Excellent Graduate Award, Chinese Academy of Sciences                               2016    

Fellowship of President of Chinese Academy of Sciences Award, Chinese Academy of Sciences 2016