General
Prof. Gan Yong now serves as the principal investigator of the Centre for Drug Delivery Research in Shanghai institute of Materia Medica (SIMM), Chinese Academy of Science. His major interests focus on physical pharmacy. Specifically, he has designed novel drug delivery systems with further exploration of the underlying mechanisms overcoming the key physiological barriers. He has now published more than 70 peer-reviewed papers in international journals, including Science Advances, Nature Communications, PNAS, Advanced Functional Materials, Advanced Science, ACS Nano, Nano Letters, Biomaterials, Journal of Controlled Release. He has also participated in writing and editing 5 books. In the aspect of translational medicine, Prof. Gan has rationally designed a series of innovative preparations with good druggability, some of which are now undergoing clinical trials. Up to now, he holds 35 authorized patents, 15 clinical approvals for new drugs, and 5 commercial formulations.


Research Areas

1. Research on physical pharmacy;

2. Novel drug carriers design and research on the mechanism of overcoming the key physiological barriers;

3. Translational research on the innovative drug preparations. 


Education

1997.09 - 2002.06 Shenyang Pharmaceutical University, School of Pharmacy, Pharmaceutics, Ph.D.

1993.09 - 1997.06 Shenyang Pharmaceutical University, School of Pharmacy, Pharmacy Analysis, B.S.


Experience

2008.10 - Present Shanghai Institute of Materia Medica, Center for Drug Delivery, Professor

2004.10 - 2008.10 Shanghai Institute of Materia Medica, Center for Drug Delivery, Associate Professor

2002.07 - 2004.07 Shanghai Institute of Materia Medica, Postdoctoral Fellow


Publications

1.Jingyi Li, Yaqi Zhang, Miaorong Yu, Aohua Wang, Yu Qiu, Weiwei Fan, Lars Hovgaard, Mingshi Yang, Yiming Li, Rui Wang*, Xiuying Li*, Yong Gan*.The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery. Acta Pharmaceutica Sinica B. 2021.

2.Mingshu Chen#, Yunqiu Miao#, Kun Qian, Xin Zhou, Linmiao Guo, Yu Qiu, Rui Wang*, Yong Gan*, Xinxin Zhang*. Detachable Liposomes Combined Immunochemotherapy for Enhanced Triple-Negative Breast Cancer Treatment through Reprogramming of Tumor-Associated Macrophages. Nano Letters. 2021, 21(14): 6031–6041. 

3.Yan Wei#, Sha Song#, Nianxiu Duan, Feng Wang, Yuxi Wang, Yiwei Yang, Chengyuan Peng, Junjun Li, Di Nie, Xinxin Zhang, Shiyan Guo, Chunliu Zhu, Miaorong Yu, Yong Gan*. MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy. Advanced Science. 2020.

4.Aohua Wang#, Weiwei Fan#, Tiantian Yang, Shufang He, Yiwei Yang, Miaorong Yu, Li Fan, Quanlei Zhu, Shiyan Guo, Chunliu Zhu, Yong Gan*. Liver-target and glucose-responsive polymersomes toward mimicking endogenous insulin secretion with improved hepatic glucose utilization. Advanced Functional Materials. 2020, 30(13):1910168.

5.Di Nie#, Zhuo Dai#, Jialin Li#, Yiwei Yang, Ziyue Xi, Jie Wang, Wei Zhang, Kun Qian, Shiyan Guo, Chunliu Zhu, Rui Wang, Yiming Li, Miaorong Yu, Xinxin Zhang, Xinghua Shi, Yong Gan*. Cancer-cell-membrane-coated nanoparticles with a yolk-shell structure augment cancer chemotherapy. Nano Letters. 2020, 20(2):936-946. 

6.Yiwei Yang#, Falin Tian#, Di Nie#, Yuan Liu, Kun Qian, Miaorong Yu, Aohua Wang, Yaqi Zhang, Xinghua Shi*, Yong Gan*. Rapid transport of germ-mimetic nanoparticles with dual conformational polyethylene glycol chains in biological tissues. Science Advances. 2020, 6(6):eaay9937.

7.Shiyan Guo, Di Sun, Dalong Ni, Miaorong Yu, Kun Qian, Wei Zhang, Yiwei Yang, Sha Song, Yang Li, Ziyue Xi, Jie Wang, Jingyi Li, Yan Wei, Kaixian Chen*, Yong Gan*, Zhengtao Wang*. Smart tumor microenvironment-responsive nanotheranostic agent for effective cancer therapy. Advanced Functional Materials. 2020. (online)

8.Zhuo Dai#, Miaorong Yu#, Xin Yi*, Zeming Wu, Falin Tian, Yunqiu Miao, Wenyi Song, Shufang He, Ejaj Ahmad, Shiyan Guo, Chunliu Zhu, Xinxin Zhang, Yiming Li, Xinghua Shi, Rui Wang*, Yong Gan*. Chain-length- and saturation-tuned mechanics of fluid nanovesicles direct tumor delivery. ACS Nano. 2019, 13(7):7676−7689.

9.Miaorong Yu#, Wenyi Song#, Falin Tian#, Zhuo Dai, Quanlei Zhu, Ejaj Ahmad, Shiyan Guo, Chunliu Zhu, Haijun Zhong, Yongchun Yuan, Tao Zhang, Xin Yi, Xinghua Shi*, Yong Gan*, Huajian Gao*. Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels. Proceedings of the National Academy of Sciences of the United States of America. 2019, 116(12):5362-5369.

10.Miaorong Yu#, Lu Xu#, Falin Tian#, Qian Su, Nan Zheng, Yiwei Yang, Jiuling Wang, Aohua Wang, Chunliu Zhu, Shiyan Guo, Xinxin Zhang, Yong Gan*, Xinghua Shi*, Huajian Gao*. Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers. Nature Communications. 2018, 9(1):2607.