植物-微生物共生互作

本课题组以模式豆科植物为材料，从宿主植物的角度探索豆科植物与根瘤菌共生固氮的分子机理，通过遗传、生化、细胞生物学等手段研究共生固氮过程中宿主植物是怎样调控根瘤菌侵染，根瘤器官的形成。欢迎对植物-微生物互作研究有兴趣、有志从事科研工作对同学包括。

071007-遗传学

豆科植物-根瘤菌共生固氮
植物-微生物互作
器官发育

2002-09--2007-09   中科院上海生命科学院   博士

   

2012-05~现在, 中科院上海生命科学院, PI
2007-09~2011-09,英国 John Innes Centre, 博士后

   

[1] Ning Zhou, Xiaolin Li, Zhiqiong Zheng, Jing Liu, J. Allan Downie, Fang Xie. RinRK1 enhances NF receptors accumulation in nanodomain-like structures at root-hair tip. NATURE COMMUNICATIONS[J]. 2024, 第 6 作者  通讯作者  15(1): http://dx.doi.org/10.1038/s41467-024-47794-4.
[2] Mengdi Fu, Xiaolei Yao, Xiaolin Li, Jing Liu, Mengyan Bai, Zijun Fang, Jiming Gong, Yuefeng Guan and Fang Xie. GmNLP1 and GmNLP4 activate nitrate-induced CLE peptides NIC1a/b to mediate nitrate-regulated root nodulation. The Plant Journal[J]. 2024, 
[3] Xiaolin Li, Miaoxia Liu, Min Cai, David Chiasson, Martin Groth, Anne B Heckmann, Trevor L Wang, Martin Parniske, J Allan Downie, Fang Xie. RPG interacts with E3-ligase CERBERUS to mediate rhizobial infection in Lotus japonicus. PLOS GENETICS[J]. 2023, 第 10 作者  通讯作者  19(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931111/.
[4] Liu, Haiyue, Lin, JieShun, Luo, Zhenpeng, Sun, Jongho, Huang, Xiaowei, Yang, Yang, Xu, Ji, Wang, YongFei, Zhang, Peng, Oldroyd, Giles E D, Xie, Fang. Constitutive activation of a nuclear-localized calcium channel complex in Medicago truncatula. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 第 11 作者  通讯作者  119(34): http://dx.doi.org/10.1073/pnas.2205920119.
[5] Luo, Zhenpeng, Moreau, Corentin, Wang, Jiang, Frugier, Florian, Xie, Fang. NLP1 binds the CEP1 signalling peptide promoter to repress its expression in response to nitrate. NEW PHYTOLOGIST[J]. 2022, 第 5 作者  通讯作者  234(5): 1547-1552, http://dx.doi.org/10.1111/nph.18062.
[6] Luo, Zhenpeng, Wang, Jiang, Li, Fuyu, Lu, Yuting, Fang, Zijun, Fu, Mengdi, Mysore, Kirankumar S, Wen, Jiangqi, Gong, Jiming, Murray, Jeremy D, Xie, Fang. The small peptide CEP1 and the NIN-like protein NLP1 regulate NRT2.1 to mediate root nodule formation across nitrate concentrations. PLANT CELL. 2022, 第 11 作者  通讯作者  35(2): 776-794, 
[7] Luo, Zhenpeng, Lin, JieShun, Zhu, Yali, Fu, Mengdi, Li, Xiaolin, Xie, Fang. NLP1 reciprocally regulates nitrate inhibition of nodulation through SUNN-CRA2 signaling in Medicago truncatula. PLANT COMMUNICATIONS[J]. 2021, 第 6 作者  通讯作者  2(3): 117-129, http://dx.doi.org/10.1016/j.xplc.2021.100183.
[8] Mengdi Fu, Jiafeng Sun, Xiaolin Li, Yuefeng Guan, Fang Xie. Asymmetric redundancy of soybean Nodule Inception ( NIN ) genes in root nodule symbiosis. PLANT PHYSIOLOGY. 2021, 第 5 作者188(1): 477-489, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774708/.
[9] Jing Liu, Miao Xia Liu, Li Ping Qiu, Fang Xie. SPIKE1 Activates the GTPase ROP6 to Guide the Polarized Growth of Infection Threads in Lotus japonicus OPEN. THE PLANT CELL. 2020, 第 4 作者32(12): 3774-3791, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721321/.
[10] Han, Fang, He, Xueqian, Chen, Wenwen, Gai, Haoyu, Bai, Xuemei, He, Yongxing, Takeshima, Keisuke, Ohwada, Takuji, Wei, Min, Xie, Fang. Involvement of a Novel TetR-Like Regulator (BdtR) of Bradyrhizobium diazoefficiens in the Efflux of Isoflavonoid Genistein. MOLECULAR PLANT-MICROBE INTERACTIONS[J]. 2020, 第 10 作者33(12): 1411-1423, http://dx.doi.org/10.1094/MPMI-08-20-0243-R.
[11] Liu, Miaoxia, Jia, Ning, Li, Xiaolin, Liu, Ruijun, Xie, Qi, Murray, Jeremy D, Downie, J Allan, Xie, Fang. CERBERUS is critical for stabilization of VAPYRIN during rhizobial infection in Lotus japonicus. NEW PHYTOLOGIST. 2020, 第 8 作者  通讯作者  https://www.webofscience.com/wos/woscc/full-record/WOS:000582535700001.
[12] Liu, Jing, Liu, Miao Xia, Qiu, Li Ping, Xie, Fang. SPIKE1 Activates the GTPase ROP6 to Guide the Polarized Growth of Infection Threads in Lotus japonicus. PLANT CELL[J]. 2020, 第 4 作者  通讯作者  32(12): 3774-3791, http://dx.doi.org/10.1105/tpc.20.00109.
[13] Li, Xiaolin, Zheng, Zhiqiong, Kong, Xiangxiao, Xu, Ji, Qiu, Liping, Sun, Jongho, Reid, Dugald, Jin, Haojie, Andersen, Stig U, Oldroyd, Giles E D, Stougaard, Jens, Downie, J Allan, Xie, Fang. Atypical Receptor Kinase RINRK1 Required for Rhizobial Infection But Not Nodule Development in Lotus japonicus. PLANT PHYSIOLOGY[J]. 2019, 第 13 作者  通讯作者  181(2): 804-816, https://www.webofscience.com/wos/woscc/full-record/WOS:000488973400033.
[14] Lin, Jieshun, Li, Xiaolin, Luo, Zhenpeng, Mysore, Kirankumar S, Wen, Jiangqi, Xie, Fang. NIN interacts with NLPs to mediate nitrate inhibition of nodulation in Medicago truncatula. NATURE PLANTS[J]. 2018, 第 6 作者  通讯作者  4(11): 942-+, http://dx.doi.org/10.1038/s41477-018-0261-3.
[15] Jia, Ning, Zhu, Yali, Xie, Fang. An Efficient Protocol for Model Legume Root Protoplast Isolation and Transformation. FRONTIERS IN PLANT SCIENCE[J]. 2018, 第 3 作者  通讯作者  9: https://doaj.org/article/9408143111a9486ab5c0a5f8d438bf8f.
[16] Cerri, Marion R, Wang, Quanhui, Stolz, Paul, Folgmann, Jessica, Frances, Lisa, Katzer, Katja, Li, Xiaolin, Heckmann, Anne B, Wang, Trevor L, Downie, J Allan, Klingl, Andreas, de CarvalhoNiebel, Fernanda, Xie, Fang, Parniske, Martin. The ERN1 transcription factor gene is a target of the CCaMK/CYCLOPS complex and controls rhizobial infection in Lotus japonicus. NEW PHYTOLOGIST[J]. 2017, 第 13 作者  通讯作者  215(1): 323-337, http://dx.doi.org/10.1111/nph.14547.
[17] Qiu, Liping, Lin, Jieshun, Xu, Ji, Sato, Shusei, Parniske, Martin, Wang, Trevor L, Downie, J Allan, Xie, Fang. SCARN a Novel Class of SCAR Protein That Is Required for Root-Hair Infection during Legume Nodulation. PLOS GENETICS[J]. 2015, 第 8 作者11(10): http://dx.doi.org/10.1371/journal.pgen.1005623.
[18] Xie, Fang, Murray, Jeremy D, Kim, Jiyoung, Heckmann, Anne B, Edwards, Anne, Oldroyd, Giles E D, Downie, Allan. Legume pectate lyase required for root infection by rhizobia. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 第 1 作者109(2): 633-638, https://www.webofscience.com/wos/woscc/full-record/WOS:000298950200059.
[19] Zhenpeng Luo, Jieshun Lin, Yali Zhu, Mengdi Fu, Xiaolin Li, Fang Xie. NLP1 reciprocally regulates nitrate inhibition of nodulation through SUNN-CRA2 signaling in Medicago truncatula. PLANT COMMUNICATIONS. 第 6 作者http://dx.doi.org/10.1016/j.xplc.2021.100183.

   

（ 1 ） 类受体蛋白ITD4参与百脉根结瘤因子受体信号输出的分子机理研究, 主持, 国家级, 2015-01--2018-12
（ 2 ） 硝态氮抑制苜蓿根瘤形成的分子机制研究, 主持, 国家级, 2017-01--2020-12
（ 3 ） 大豆高效生物固氮关键基因克隆及其调控机制, 参与, 国家级, 2016-01--2020-12
（ 4 ） 共生识别与固氮蛋白质机器, 主持, 国家级, 2016-07--2021-06

已指导学生

孔祥晓  博士研究生  071007-遗传学  

王全慧  博士研究生  071007-遗传学  

林杰顺  博士研究生  071007-遗传学  

现指导学生

刘苗霞  博士研究生  071007-遗传学  

朱亚丽  博士研究生  071007-遗传学  

李雨爽  博士研究生  071007-遗传学  

刘静  博士研究生  071007-遗传学  

郑志琼  博士研究生  071007-遗传学  

刘海月  博士研究生  071007-遗传学  

罗振鹏  博士研究生  071007-遗传学  

周宁  硕士研究生  071007-遗传学