基本信息
冯婕  女  博导  中国科学院微生物研究所
电子邮件: fengj@im.ac.cn
通信地址: 北京朝阳区北辰西路1号院3号A714
邮政编码: 100101

研究领域

致力于了解环境中耐药基因的分布,对生态环境的影响,评估抗生素污染对环境造成的影响;发现环境中新的耐药机制,探讨这些新的耐药机制是否能通过基因水平转移传递给病原微生物;研究细菌移动元件,发现基因水平转移的一些新规律,为有效控制微生物耐药迅速传播提供理论依据。
目前本组的研究主要涉及以下内容:1)海水养殖环境中微生物耐药基因调查;2)环境微生物的耐药机制;3)携带耐药基因的可移动遗传元件主要包括整合子和质粒的研究。

招生信息

   
招生专业
071005-微生物学
招生方向
微生物耐药机制

教育背景

2002-09--2006-03   中国科学院微生物研究所   博士
1998-09--2001-07   山东农业大学   硕士

工作经历

   
工作简历
2017-10~现在, 中国科学院微生物研究所, 研究员
2016-10~2017-09,中国科学院微生物研究所, 项目研究员
2009-08~2016-10,中国科学院微生物研究所, 副研究员
2006-07~2009-07,Laval University,Canada, 博士后
2001-09~2002-07,河北大学, 讲师

教授课程

微生物生态学

专利与奖励

   
专利成果
[1] 王超, 田井井, 冯婕, 张刚. β-内酰胺酶及其编码基因以及它们的应用. CN: CN110157699B, 2021-07-23.

[2] 刘双江, 朱愿, 刘志培, 冯婕, 姜成英, 魏大伟, 彭潇, 柳晓东, 高喜燕, 刘缨, 吴梦茹. 一种用于水环境治理的复合微生物菌剂及其应用. CN: CN110217895B, 2020-09-29.

[3] 冯婕, 杜晓辰. 一种快速检测水产病原菌的组合物及其制备方法. CN: CN105969853B, 2020-01-21.

[4] 王超, 冯婕, 杜晓辰. 用于检测沙门氏菌的引物系统和试剂盒以及他们的应用和检测沙门氏菌的方法. CN: CN109402271A, 2019-03-01.

[5] 刘双江, 冯婕, 周培瑾, 刘志培. 一种生产视紫红质蛋白的方法及其专用菌株. 中国: CN1300303, 2007-02-14.

[6] 张利平, 冯婕, 吕志堂, 朱路甲, 吴继标, 郭立格, 陈冠华, 王来福, 王清州. 利用酵母菌发酵制备木糖醇的方法. 中国: CN1400311, 2003-03-05.

出版信息

   
发表论文
[1] Tang Na, Hu J, Zhao Y, Song Y, Wang C, Zhang Gang, Wei D, Fang H, Li C, Jia R, Feng Jie. In vivo evolution of carbapenem resistance in hypervirulent Klebsiella pneumoniae in a patient undergoing long-term treatment. Journal of Antimicrobial Chemotherapy[J]. 2022, 77(2): [2] Song Y, Wang Z, Wang C, Zhang Gang, Li J, Jie Feng. An urban soil environmental E. coli ST354 isolate co-harbouring mcr-1 and bla NDM-9. Journal of Global Antimicrobial Resistance[J]. 2022, 29: [3] DaWei Wei, NaiKei Wong, Yuqin Song, Gang Zhang, Chao Wang, Juan Li, Jie Feng. IS 26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics. mBio[J]. 2022, 13(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822349/.
[4] 胡金树, 刘伟, 贾汝福, 宋宇琴, 王超, 唐娜, 冯婕. 耐碳青霉烯鲍曼不动杆菌的临床分布及基因组流行病学分析. 微生物学通报. 2022, 270-282, https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2022&filename=WSWT202201022&v=MDQxNjIxTHV4WVM3RGgxVDNxVHJXTTFGckNVUjdpZlpPZHZGaXJrVUwzQU1qN2Nlckc0SE5QTXJvOUhab1I4ZVg=.
[5] Chao Wang, Yuan Zeng, Mengyu Wei, Lanqing Cui, Yuqin Song, Gang Zhang, Yun Li, Jie Feng. Streptococcus sputorum , a Novel Member of Streptococcus with Multidrug Resistance, Exhibits Cytotoxicity. Antibiotics[J]. 2021, 10(12): [6] Wang, Chao, Song, Yuqin, Tang, Na, Zhang, Gang, Leclercq, Sebastien Olivier, Feng, Jie. The Shared Resistome of Human and Pig Microbiota Is Mobilized by Distinct Genetic Elements. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2021, 87(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000618054600001.
[7] Zhao, Yingying, Yang, Yunzhen, He, Fei, Wang, Chao, Feng, Jie, Zhang, Xiumin. Pseudomonas xionganensis sp. nov., isolated from Baiyangdian Lake in Xiong'an New Area. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2020, 70(12): 6052-6059, https://www.webofscience.com/wos/woscc/full-record/WOS:000608418900004.
[8] Songzhe Fu, Dawei Wei, Qian Yang, Guosi Xie, Bo Pang, Yongjie Wang, Ruiting Lan, Qingyao Wang, Xuan Dong, Xiaojun Zhang, Jie Huang, Jie Feng, Ying Liu. Horizontal Plasmid Transfer Promotes the Dissemination of Asian Acute Hepatopancreatic Necrosis Disease and Provides a Novel Mechanism for Genetic Exchange and Environmental Adaptation. MSYSTEMS[J]. 2020, 5(2): https://doaj.org/article/e8548f4566dc4f6fa748e764fb92239e.
[9] Yang, Yunzhen, Chen, Jifeng, Huang, Wanru, Zhang, Ranran, Liu, Shuangjiang, Wang, Chao, Feng, Jie. Rufibacter latericius sp. nov., isolated from Baiyang Lake. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2020, 70(11): 5943-5949, https://www.webofscience.com/wos/woscc/full-record/WOS:000608414600040.
[10] Zhang, Chaodong, Ju, Yingjiao, Tang, Na, Li, Yun, Zhang, Gang, Song, Yuqin, Fang, Hailing, Yang, Liang, Feng, Jie. Systematic analysis of supervised machine learning as an effective approach to predicate beta-lactam resistance phenotype in Streptococcus pneumoniae. BRIEFINGS IN BIOINFORMATICS[J]. 2020, 21(4): 1347-1355, http://dx.doi.org/10.1093/bib/bbz056.
[11] Zhang, Gang, Li, Jianjuan, Ai, Guomin, He, Jialiang, Wang, Chao, Feng, Jie. A new intrinsic aminoglycoside 6 '-N-acetyltransferase subclass, AAC(6 ')-III, in Burkholderia pseudomallei, Burkholderia mallei and Burkholderia oklahomensis. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPYnull. 2020, 75(5): 1352-1353, https://www.webofscience.com/wos/woscc/full-record/WOS:000537415500039.
[12] Gong, Lin, Tang, Na, Chen, Dongke, Sun, Kaiwen, Lan, Ruiting, Zhang, Wen, Zhou, Haijian, Yuan, Min, Chen, Xia, Zhao, Xiaofei, Che, Jie, Bai, Xuemei, Zhang, Yunfei, Xu, Hongtao, Walsh, Timothy R, Lu, Jinxing, Xu, Jianguo, Li, Juan, Feng, Jie. A Nosocomial Respiratory Infection Outbreak of Carbapenem-ResistantEscherichia coliST131 With Multiple Transmissiblebla(KPC-2)Carrying Plasmids. FRONTIERS IN MICROBIOLOGY[J]. 2020, 11: https://doaj.org/article/5cd5d2a09e9e4de1b270592ad806c309.
[13] Chang Liu, Nan Zhou, MengXuan Du, YuTong Sun, Kai Wang, YuJing Wang, DanHua Li, HaiYing Yu, Yuqin Song, BingBing Bai, Yuhua Xin, Linhuan Wu, ChengYing Jiang, Jie Feng, Hua Xiang, Yuguang Zhou, Juncai Ma, Jun Wang, HongWei Liu, ShuangJiang Liu. The Mouse Gut Microbial Biobank expands the coverage of cultured bacteria. Nature Communications[J]. 2020, 11(1): 1-12, http://dx.doi.org/10.1038/s41467-019-13836-5.
[14] Zhao, Yingying, Tang, Na, Jia, Rufu, Hu, Jinshu, Liu, Wei, Sun, Yan, Zhang, Gang, Song, Yuqin, Feng, Jie, Wang, Chao. Co-existence of the carbapenem resistance genes bla(KPC-2) and bla(NDM-1) in a Raoultella planticola isolate in China. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCEnull. 2020, 23: 327-328, http://dx.doi.org/10.1016/j.jgar.2020.09.015.
[15] Zhang, Gang, Sun, Kaiwen, Ai, Guomin, Li, Jianjuan, Tang, Na, Song, Yuqin, Wang, Chao, Feng, Jie. A novel family of intrinsic chloramphenicol acetyltransferase CATC in Vibrio parahaemolyticus : Naturally occurring variants reveal diverse resistance levels against chloramphenicol. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS[J]. 2019, 54(1): 75-79, http://dx.doi.org/10.1016/j.ijantimicag.2019.03.012.
[16] Yang, Yunzhen, Zhang, RanRan, Feng, Jie, Wang, Chao, Chen, Jifeng. Azospirillum griseum sp. nov., isolated from lakewater. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2019, 69(12): 3676-3681, https://www.webofscience.com/wos/woscc/full-record/WOS:000500924000003.
[17] Liu, Sha, Feng, Jie, Pu, Ji, Xu, Xuefang, Lu, Shan, Yang, Jing, Wang, Yiting, Jin, Dong, Du, Xiaochen, Meng, Xiangli, Luo, Xia, Sun, Hui, Xiong, Yanwen, Ye, Changyun, Lan, Ruiting, Xu, Jianguo. Genomic and molecular characterisation of Escherichia marmotae from wild rodents in Qinghai-Tibet plateau as a potential pathogen. SCIENTIFIC REPORTS[J]. 2019, 9(1): http://dx.doi.org/10.1038/s41598-019-46831-3.
[18] Zhou Huang, YunHao Wang, HaiZhen Zhu, Ekaterina P Andrianova, ChengYing Jiang, Defeng Li, Luyan Ma, Jie Feng, ZhiPei Liu, Hua Xiang, Igor B Zhulin, ShuangJiang Liu. Cross Talk between Chemosensory Pathways That Modulate Chemotaxis and Biofilm Formation. mBio[J]. 2019, 10(1): https://doaj.org/article/8de476d42ca74d7ca235f0d3d07dcf7c.
[19] Du, Xiaochen, Bayliss, Sion C, Feil, Edward J, Liu, Ying, Wang, Chao, Zhang, Gang, Zhou, Dongsheng, Wei, Dawei, Tang, Na, Leclercq, Sebastien O, Feng, Jie. Real time monitoring of Aeromonas salmonicida evolution in response to successive antibiotic therapies in a commercial fish farm. ENVIRONMENTAL MICROBIOLOGY[J]. 2019, 21(3): 1113-1123, https://www.webofscience.com/wos/woscc/full-record/WOS:000461231300017.
[20] 郭瑞亮, 张刚, 崔钦娜, 冯婕, 陈继峰. 细菌中基因组岛的转移与调控机制研究进展. 微生物学通报[J]. 2018, 45(10): 2234-2242, http://lib.cqvip.com/Qikan/Article/Detail?id=676588791.
[21] Tian, Jingjing, Zhang, Gang, Ju, Yingjiao, Tang, Na, Li, Jianjuan, Jia, Rufu, Feng, Jie. Five novel carbapenem-hydrolysing OXA-type beta-lactamase groups are intrinsic in Acinetobacter spp.. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY[J]. 2018, 73(12): 3279-3284, https://www.webofscience.com/wos/woscc/full-record/WOS:000452916600008.
[22] Liao, Shenglong, Tao, Xinglei, Ju, Yingjiao, Feng, Jie, Du, Wenbin, Wang, Yapei. Multichannel Dynamic Interfacial Printing: An Alternative Multicomponent Droplet Generation Technique for Lab in a Drop. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(50): 43545-43552, https://www.webofscience.com/wos/woscc/full-record/WOS:000418783700016.
[23] Zhang, Gang, Leclercq, Sebastien Olivier, Tian, Jingjing, Wang, Chao, Yahara, Koji, Ai, Guomin, Liu, Shuangjiang, Feng, Jie. A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, is horizontally transferred among Acinetobacter spp. by homologous recombination. PLOS GENETICS[J]. 2017, 13(2): https://doaj.org/article/bd6e44c85065423099b317982927bfd7.
[24] Xu, Yixiang, Wang, Chao, Zhang, Gang, Tian, Jingjing, Liu, Ying, Shen, Xihui, Feng, Jie. ISCR2 is associated with the dissemination of multiple resistance genes among Vibrio spp. and Pseudoalteromonas spp. isolated from farmed fish. ARCHIVES OF MICROBIOLOGY[J]. 2017, 199(6): 891-896, http://ir.qdio.ac.cn/handle/337002/137034.
[25] 张刚, 冯婕. 细菌固有耐药的研究进展. 遗传[J]. 2016, 38(10): 872-880, http://lib.cqvip.com/Qikan/Article/Detail?id=670388088.
[26] Zhang, Gang, Tian, Jingjing, Wang, Chao, Chen, Jifeng, Feng, Jie. Identification of Novel Cryptic Aminoglycoside Phosphotransferases in Pseudomonas aeruginosa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPYnull. 2016, 60(11): 6983-6985, https://www.webofscience.com/wos/woscc/full-record/WOS:000389063500077.
[27] Leclercq, Sebastien Olivier, Wang, Chao, Zhu, Yaxin, Wu, Hai, Du, Xiaochen, Liu, Zhipei, Feng, Jie. Diversity of the Tetracycline Mobilome within a Chinese Pig Manure Sample. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2016, 82(21): 6454-6462, https://www.webofscience.com/wos/woscc/full-record/WOS:000386072300017.
[28] Leclercq, Sebastien Olivier, Wang, Chao, Sui, Zhihai, Wu, Hai, Zhu, Baoli, Deng, Ye, Feng, Jie. A multiplayer game: species of Clostridium, Acinetobacter, and Pseudomonas are responsible for the persistence of antibiotic resistance genes in manure-treated soils. ENVIRONMENTAL MICROBIOLOGY[J]. 2016, 18(10): 3494-3508, https://www.webofscience.com/wos/woscc/full-record/WOS:000388613200022.
[29] Zhang, Gang, Wang, Chao, Sui, Zhihai, Feng, Jie. Insights into the evolutionary trajectories of fluoroquinolone resistance in Streptococcus pneumoniae. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY[J]. 2015, 70(9): 2499-2506, https://www.webofscience.com/wos/woscc/full-record/WOS:000363248300009.
[30] Wang, Chao, Sui, Zhihai, Leclercq, Sebastien Olivier, Zhang, Gang, Zhao, Meilin, Chen, Weiqi, Feng, Jie. Functional characterization and phylogenetic analysis of acquired and intrinsic macrolide phosphotransferases in the Bacillus cereus group. ENVIRONMENTAL MICROBIOLOGY[J]. 2015, 17(5): 1560-1573, https://www.webofscience.com/wos/woscc/full-record/WOS:000353507100008.
[31] Zhou, Wenqing, Yao, Kaihu, Zhang, Gang, Yang, Yonghong, Li, Yun, Lv, Yuan, Feng, Jie. Mechanism for transfer of transposon Tn2010 carrying macrolide resistance genes in Streptococcus pneumoniae and its effects on genome evolution. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY[J]. 2014, 69(6): 1470-1473, https://www.webofscience.com/wos/woscc/full-record/WOS:000336506300005.
[32] Yang, Jing, Wang, Chao, Wu, Jinyu, Liu, Li, Zhang, Gang, Feng, Jie. Characterization of a Multiresistant Mosaic Plasmid from a Fish Farm Sediment Exiguobacterium sp Isolate Reveals Aggregation of Functional Clinic-Associated Antibiotic Resistance Genes. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2014, 80(4): 1482-1488, https://www.webofscience.com/wos/woscc/full-record/WOS:000331625100029.
[33] 张刚, 冯婕. 肺炎链球菌对氟喹诺酮类抗生素耐药研究进展. 中国实用内科杂志[J]. 2014, 34(11): 1126-1130, [34] Yang, Jing, Wang, Chao, Shu, Chang, Liu, Li, Geng, Jianing, Hu, Songnian, Feng, Jie. Marine Sediment Bacteria Harbor Antibiotic Resistance Genes Highly Similar to Those Found in Human Pathogens. MICROBIAL ECOLOGY[J]. 2013, 65(4): 975-981, https://www.webofscience.com/wos/woscc/full-record/WOS:000318183800021.
[35] Zhang, Gang, Tian, Wenyu, Wang, Chao, Feng, Jie. Identification of a novel resistance mutation in parE that confers high-level resistance to moxifloxacin in Streptococcus pneumoniae. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPYnull. 2012, 67(11): 2773-2774, https://www.webofscience.com/wos/woscc/full-record/WOS:000309923800033.
[36] Billal, Dewan S, Feng, Jie, Leprohon, Philippe, Legare, Danielle, Ouellette, Marc. Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations. BMC GENOMICS[J]. 2011, 12(1): 512-512, http://dx.doi.org/10.1186/1471-2164-12-512.
[37] Feng, Jie, Billal, Dewan S, Lupien, Andreanne, Racine, Gina, Winstall, Eric, Legare, Danielle, Leprohon, Philippe, Ouellette, Marc. Proteomic and Transcriptomic Analysis of Linezolid Resistance in Streptococcus pneumoniae. JOURNAL OF PROTEOME RESEARCH[J]. 2011, 10(10): 4439-4452, https://www.webofscience.com/wos/woscc/full-record/WOS:000295602700008.
[38] Feng, Jie, Lupien, Andreanne, Gingras, Helene, Wasserscheid, Jessica, Dewar, Ken, Legare, Danielle, Ouellette, Marc. Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. GENOME RESEARCH[J]. 2009, 19(7): 1214-1223, https://www.webofscience.com/wos/woscc/full-record/WOS:000267786900008.
[39] Feng J, Che Y, Milse J, Yin YJ, Liu L, Rückert C, Shen XH, Qi SW, Kalinowski J, Liu SJ. The gene ncgl2918 encoding a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum. J Biol Chem[J]. 2006, [40] Feng, J, Liu, HC, Chu, JF, Zhou, PJ, Tang, JA, Liu, SJ. Genetic cloning and functional expression in Escherichia coli of an archaerhodopsin gene from Halorubrum xinjiangense. EXTREMOPHILES[J]. 2006, 10(1): 29-33, http://124.16.144.217/handle/311023/2954.
[41] Feng J, Zhou P, Zhou YG, Liu SJ. Halorubrum alkaliphlilum sp. nov., a novel haloalkaliphile isolated from a soda lake in Xinjiang, China. Int J Syst Evol Microbiol[J]. 2005, [42] Feng, J, Zhou, PJ, Liu, SJ. Halorubrum xinjiangense sp nov., a novel halophile isolated from saline lakes in China. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2004, 54: 1789-1791, http://124.16.144.217/handle/311023/1894.
[43] 冯婕, 张利平. 发酵生产木糖酶的影响因素. 食品与发酵工业. 2001, 27(3): 66-70, http://lib.cqvip.com/Qikan/Article/Detail?id=5135478.

科研活动

   
科研项目
( 1 ) 重要病原细菌关键生物学特性适应性进化机制的研究, 参与, 国家级, 2015-01--2019-12
( 2 ) 海水养殖鱼类病害防控生物制品研发与应用, 参与, 省级, 2014-01--2016-12
( 3 ) 肺炎链球菌莫西沙星耐药的进化路径, 主持, 研究所(学校), 2014-01--2015-12
( 4 ) 生命科学领域前沿技术培育--细菌耐药快速检测用流控芯片研制, 参与, 省级, 2016-01--2018-12
( 5 ) 湖泊微生物物种分离与物种资源库建设, 主持, 国家级, 2017-02--2022-01
( 6 ) 肺炎链球菌对头孢类抗生素耐药的协同机制研究的非干预性研究, 主持, 院级, 2016-09--2017-09
( 7 ) 家养动物肠道微生物分离培养及代谢分析, 主持, 部委级, 2017-10--2019-09
( 8 ) GIsul2基因岛与耐药元件ISCR2协同转移机制及其在耐药传播中的作用, 主持, 国家级, 2019-01--2022-12
( 9 ) 白洋淀健康水环境本土菌剂开发项目, 主持, 院级, 2018-07--2019-06
( 10 ) 肠杆菌科细菌广泛耐药株/耐药基因在健康人群及社区环境的传播及危害研究, 参与, 国家级, 2019-01--2022-12
( 11 ) 弱电能介入型生物强化处理系统中毒害性有机污染物的定向转化机调控机制, 参与, 国家级, 2019-01--2022-12
( 12 ) 细菌耐药数字化诊断的机器学习研究, 主持, 研究所(学校), 2020-03--2023-06

指导学生

已指导学生

杨晶  硕士研究生  430139-生物工程  

周文清  硕士研究生  071005-微生物学  

隋智海  硕士研究生  085238-生物工程  

田井井  硕士研究生  071005-微生物学  

崔钦娜  硕士研究生  071005-微生物学  

杜晓辰  硕士研究生  071005-微生物学  

句英娇  硕士研究生  071005-微生物学  

现指导学生

李建娟  硕士研究生  085238-生物工程  

黄婉茹  硕士研究生  085238-生物工程  

武歆怡  硕士研究生  071007-遗传学  

唐娜  博士研究生  071005-微生物学  

曾元  硕士研究生  071007-遗传学  

魏大伟  博士研究生  071007-遗传学