基本信息
范克龙 男 博导 中国科学院生物物理研究所
电子邮件: fankelong@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码:
电子邮件: fankelong@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码:
研究领域
研究方向为纳米酶的仿生合成及其生物医学应用。取得的主要学术成果如下:
①首次提出模拟天然酶活性中心,仿生设计纳米酶的新理念,实现高活性单原子纳米酶的设计合成。
②发明铁蛋白纳米酶:发现铁蛋白独特的新功能,识别肿瘤标志分子TfR1及穿越血脑屏障。据此,仿生设计铁蛋白纳米酶,结合铁蛋白新特性,实现纳米酶在肿瘤诊断和催化治疗领域的突破,研究成果入选中国十大科学进展。
③发现铁蛋白存在温度敏感型药物通道,突破药物装载技术瓶颈,发展了铁蛋白药物载体。
上述成果以第一/共通讯发表在Nat Nano, Nat Commun, Angew Chem, ACS Nano等权威期刊,发明专利授权并转让6000万。获得贝时璋青年生物物理学家奖(2019),全国创新创业好青年(2019),中国科学院优秀博士毕业论文(2015)等奖项。
招生信息
本课题组将招收至少一位硕博连读生。欢迎对铁蛋白或纳米酶的仿生设计领域感兴趣的本科应届毕业生推免或者报考
招生专业
071010-生物化学与分子生物学083100-生物医学工程0703Z1-化学生物学
招生方向
纳米生物学与纳米医学纳米酶的仿生设计蛋白质药物载体
教育背景
2009-09--2014-07 中国科学院大学 博士2005-09--2009-07 中国矿业大学(北京) 学士
工作经历
工作简历
2019-07~现在, 中国科学院生物物理研究所, 研究员2018-02~2019-07,中国科学院生物物理研究所, 副研究员2014-08~2018-01,中国科学院生物物理研究所, 博士后,副研究员(资格)
社会兼职
2022-05-01-今,Frontiers in Chemistry 副主编, 副主编
2021-03-31-2023-04-30,Exploration杂志, 副主编
2019-07-01-2022-07-01,中国生物物理学会纳米酶分会, 副秘书长
2021-03-31-2023-04-30,Exploration杂志, 副主编
2019-07-01-2022-07-01,中国生物物理学会纳米酶分会, 副秘书长
专利与奖励
奖励信息
(1) 贝时璋青年生物物理学家奖, 其他, 2019(2) 全国向上向善好青年, 国家级, 2019(3) 中国医师协会优秀青年科技工作者, 其他, 2019(4) 中国科学院优秀博士学位论文, 院级, 2015(5) 中国科学院院长特别奖, 院级, 2013
专利成果
[1] 阎锡蕴, 高利增, 范克龙, 孟祥芹. 硫铁矿纳米酶、抗肿瘤药物及应用. CN: CN112791099A, 2021-05-14.[2] 阎锡蕴, 范克龙, 赵帅. 一种用于恶性脑疟治疗的新型试剂及方法. CN: CN111840250A, 2020-10-30.[3] 阎锡蕴, 江冰, 范克龙. 一种用于肝癌诊断的特异性靶点及诊断试剂. CN: CN109852666A, 2019-06-07.[4] 阎锡蕴, 范克龙, 江冰. 一种装载抗肿瘤药物的纳米药物载体、其制备方法及应用. CN: CN109512799A, 2019-03-26.[5] 阎锡蕴, 丁辉, 范克龙, 杨明. 纳米酶小体在催化光声成像中的应用. CN: CN109364272A, 2019-02-22.[6] 阎锡蕴, 范克龙, 高利增, 段德民. 优化纳米酶颗粒活性的方法. CN: CN108067309A, 2018-05-25.[7] 阎锡蕴, 范克龙, 高利增, 段德民, 张德玺, 桑建彬. 一种具有止血、杀菌功能的纳米酶止血剂及其应用. CN: CN107496449A, 2017-12-22.[8] 史桂芝, 范克龙, 张德玺, 桑建彬, 阎锡蕴. 分子标记物CD71及在子宫内膜癌诊断、分期及预后中的应用. CN: CN107102141A, 2017-08-29.[9] 阎锡蕴, Fan Kelong, Liang Minmin, Wang Fei, Duan Demin, Zhang Dexi, Feng Jing, Yang Dongling. DRUG CARRIER FOR TUMOR-SPECIFIC TARGETED DRUG DELIVERY AND USE THEREOF. CN: US20170189343A1, 2017-07-06.[10] 阎锡蕴, 范克龙, 梁敏敏, 郑继燕, 冯静, 杨东玲. 一种肿瘤特异性靶向给药的药物载体及其应用. CN: CN104013599A, 2014-09-03.[11] 阎锡蕴, 梁敏敏, 范克龙, 潘永信, 曹长乾, 杨东玲, 卢迪, 冯静. 一种双功能肿瘤诊断试剂及方法. CN: CN102778567A, 2012-11-14.[12] 阎锡蕴, 高利增, 范克龙, 孟祥芹. 硫铁矿纳米酶、抗肿瘤药物及应用. CN: CN112791099B, 2022-02-18.[13] 阎锡蕴, 范克龙, 赵帅. 一种用于恶性脑疟治疗的新型试剂及方法. CN: CN111840250B, 2023-07-04.
出版信息
发表论文
[1] Fan, Huizhen, Zheng, Jiajia, Xie, Jiaying, Liu, Juewen, Gao, Xingfa, Yan, Xiyun, Fan, Kelong, Gao, Lizeng. Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay. ADVANCED MATERIALS[J]. 2024, 第 7 作者36(null): 2300387, [2] Fang, Long, Zhang, Ruofei, Shi, Lin, Xie, Jiaying, Ma, Long, Yang, Yili, Yan, Xiyun, Fan, Kelong. Protein-Nanocaged Selenium Induces t(8;21) Leukemia Cell Differentiation via Epigenetic Regulation. ADVANCED SCIENCE[J]. 2023, 第 8 作者 通讯作者 10(35): http://dx.doi.org/10.1002/advs.202300698.[3] Li, Yucong, Zhang, Ruofei, Yan, Xiyun, Fan, Kelong. Machine learning facilitating the rational design of nanozymes. JOURNAL OF MATERIALS CHEMISTRY B. 2023, 第 4 作者 通讯作者 11(28): 6466-6477, http://dx.doi.org/10.1039/d3tb00842h.[4] Wang, Jia, Xie, Qingpeng, Song, Haoyue, Chen, Xiaohang, Zhang, Xiaoxuan, Zhao, Xiangyu, Hao, Yujia, Zhang, Yuan, Li, Huifei, Li, Na, Fan, Kelong, Wang, Xing. Utilizing nanozymes for combating COVID-19: advancements in diagnostics, treatments, and preventative measures. JOURNAL OF NANOBIOTECHNOLOGY. 2023, 第 11 作者 通讯作者 21(1): http://dx.doi.org/10.1186/s12951-023-01945-9.[5] 范克龙, 高利增, 魏辉, 江冰, 王大吉, 张若飞, 贺久洋, 孟祥芹, 王卓然, 樊慧真, 温涛, 段德民, 陈雷, 姜伟, 芦宇, 蒋冰, 魏咏华, 李唯, 袁野, 董海姣, 张鹭, 洪超仪, 张紫霞, 程苗苗, 耿欣, 侯桐阳, 侯亚欣, 李建茹, 汤国恒, 赵越, 赵菡卿, 张帅, 谢佳颖, 周子君, 任劲松, 黄兴禄, 高兴发, 梁敏敏, 张宇, 许海燕, 曲晓刚, 阎锡蕴. 纳米酶. 化学进展[J]. 2023, 第 1 作者35(1): 1-87, http://lib.cqvip.com/Qikan/Article/Detail?id=7109514304.[6] Li, Jianru, Zhang, Zixia, Zhang, Baoli, Yan, Xiyun, Fan, Kelong. Transferrin receptor 1 targeted nanomedicine for brain tumor therapy. BIOMATERIALS SCIENCE. 2023, 第 5 作者 通讯作者 11(10): http://dx.doi.org/10.1039/d2bm02152h.[7] Li, Jingqi, Cai, Xinda, Jiang, Peng, Wang, Huayuan, Zhang, Shiwei, Sun, Tiedong, Chen, Chunxia, Fan, Kelong. Co-based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences. ADVANCED MATERIALS. 2023, 第 8 作者 通讯作者 http://dx.doi.org/10.1002/adma.202307337.[8] 吴雪彤, 张若飞, 阎锡蕴, 范克龙. 纳米酶: 一种抗微生物感染新方法. 无机材料学报[J]. 2023, 第 4 作者38(1): 43-54, https://www.jim.org.cn/CN/10.15541/jim20220578.[9] Wenhui Gao, Jiuyang He, Lei Chen, Xiangqin Meng, Yana Ma, Liangliang Cheng, Kangsheng Tu, Xingfa Gao, Cui Liu, Mingzhen Zhang, Kelong Fan, Dai-Wen Pang, Xiyun Yan. Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme. NATURE COMMUNICATIONS[J]. 2023, 第 11 作者 通讯作者 14(1): 1-15, http://dx.doi.org/10.1038/s41467-023-35828-2.[10] Liu, Cui, Fan, Wenbin, Cheng, WenXiang, Gu, Yiping, Chen, Yiming, Zhou, Wenhua, Yu, XueFeng, Chen, Minghai, Zhu, Minrong, Fan, Kelong, Luo, QingYing. Red Emissive Carbon Dot Superoxide Dismutase Nanozyme for Bioimaging and Ameliorating Acute Lung Injury. ADVANCED FUNCTIONAL MATERIALS[J]. 2023, 第 10 作者 通讯作者 [11] Wang, Zhuoran, Zhao, Yue, Hou, Yaxin, Tang, Guoheng, Zhang, Ruofei, Yang, Yili, Yan, Xiyun, Fan, Kelong. A Thrombin-Activated Peptide-Templated Nanozyme for Remedying Ischemic Stroke via Thrombolytic and Neuroprotective Actions. ADVANCED MATERIALS. 2023, 第 8 作者 通讯作者 http://dx.doi.org/10.1002/adma.202210144.[12] 谢佳颖, 金奕良, 范克龙. 铁蛋白:疫苗设计新平台. 科学. 2022, 第 3 作者74(4): 44-48, http://lib.cqvip.com/Qikan/Article/Detail?id=7107917611.[13] Zhang, Baoli, Chen, Xuehui, Tang, Guoheng, Zhang, Ruofei, Li, Jingyun, Sun, Guoming, Yan, Xiyun, Fan, Kelong. Constructing a nanocage-based universal carrier for delivering TLR- activating nucleic acids to enhance antitumor immunotherapy. NANO TODAY[J]. 2022, 第 8 作者 通讯作者 46: http://dx.doi.org/10.1016/j.nantod.2022.101564.[14] Pang, Jing, Feng, Xu, Liang, Qian, Zheng, Xiaoyan, Duan, Yiman, Zhang, Xin, Zhang, Jubiao, Chen, Yang, Fan, Kelong, Gao, Lizeng, Li, Juxue. Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model. ACS NANO[J]. 2022, 第 9 作者 通讯作者 16(3): 4175-4185, http://dx.doi.org/10.1021/acsnano.1c10029.[15] Jiang, Bing, Jia, Xiaohua, Ji, Tianjiao, Zhou, Meng, He, Jiuyang, Wang, Kun, Tian, Jie, Yan, Xiyun, Fan, Kelong. Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 第 9 作者 通讯作者 65(2): 328-340, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000693359700004.[16] Zhang, Ruofei, Xue, Bai, Tao, Yanhong, Zhao, Hanqing, Zhang, Zixia, Wang, Xiaonan, Zhou, Xinyao, Jiang, Bing, Yang, Zhenglin, Yan, Xiyun, Fan, Kelong. Edge-Site Engineering of Defective Fe-N-4 Nanozymes with Boosted Catalase-Like Performance for Retinal Vasculopathies. ADVANCED MATERIALS[J]. 2022, 第 11 作者 通讯作者 34(39): http://dx.doi.org/10.1002/adma.202205324.[17] Zhu, Daoming, Chen, Hao, Huang, Chunyu, Li, Guoxin, Wang, Xing, Jiang, Wei, Fan, Kelong. H2O2 Self-Producing Single-Atom Nanozyme Hydrogels as Light-Controlled Oxidative Stress Amplifier for Enhanced Synergistic Therapy by Transforming "Cold" Tumors. ADVANCED FUNCTIONAL MATERIALS[J]. 2022, 第 7 作者 通讯作者 32(16): http://dx.doi.org/10.1002/adfm.202110268.[18] Hong, Chaoyi, Meng, Xiangqin, He, Jiuyang, Fan, Kelong, Yan, Xiyun. Nanozyme: A promising tool from clinical diagnosis and environmental monitoring to wastewater treatment. PARTICUOLOGY. 2022, 第 4 作者 通讯作者 71(12): 90-107, http://dx.doi.org/10.1016/j.partic.2022.02.001.[19] 范克龙, 魏辉, 许华平, 王树涛, 曲晓刚, 张灿. 生物活性纳米材料用于重大疾病治疗的研究进展. 中国基础科学[J]. 2022, 第 1 作者57-67, http://lib.cqvip.com/Qikan/Article/Detail?id=00002EGM55987JP0MLDO8JP1MDR.[20] Zhang, Shuai, Zhang, Ruofei, Yan, Xiyun, Fan, Kelong. Nanozyme-Based Artificial Organelles: An Emerging Direction for Artificial Organelles. SMALL. 2022, 第 4 作者 通讯作者 18(33): http://dx.doi.org/10.1002/smll.202202294.[21] Meng, Xiangqin, Li, Dandan, Chen, Lei, He, Helen, Wang, Qian, Hong, Chaoyi, He, Jiuyang, Gao, Xingfa, Yang, Yili, Jiang, Bing, Nie, Guohui, Yan, Xiyun, Gao, Lizeng, Fan, Kelong. High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis-Ferroptosis Synergistic Tumor Therapy. ACS NANO[J]. 2021, 第 14 作者 通讯作者 15(3): 5735-5751, http://dx.doi.org/10.1021/acsnano.1c01248.[22] Xi, Juqun, Zhang, Ruofei, Wang, Liming, Xu, Wei, Liang, Qian, Li, Jingyun, Jiang, Jian, Yang, Yili, Yan, Xiyun, Fan, Kelong, Gao, Lizeng. A Nanozyme-Based Artificial Peroxisome Ameliorates Hyperuricemia and Ischemic Stroke. ADVANCED FUNCTIONAL MATERIALS[J]. 2021, 第 10 作者 通讯作者 31(9): http://dx.doi.org/10.1002/adfm.202007130.[23] Zeng, Li, Cheng, Hui, Dai, Yuwei, Su, Zhipeng, Wang, Chengde, Lei, Lei, Lin, Deqing, Li, Xingyi, Chen, Hao, Fan, Kelong, Shi, Shuai. In Vivo Regenerable Cerium Oxide Nanozyme-Loaded pH/H2O2-Responsive Nanovesicle for Tumor-Targeted Photothermal and Photodynamic Therapies. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 第 10 作者 通讯作者 13(1): 233-244, https://www.webofscience.com/wos/woscc/full-record/WOS:000611066000018.[24] Wu, Chunling, Shi, Huigang, Zhu, Dongjie, Fan, Kelong, Zhang, Xinzheng. Low-cooling-rate freezing in biomolecular cryo-electron microscopy for recovery of initial frames. QRB Discovery[J]. 2021, 第 4 作者[25] Wang, Daji, Zhang, Bin, Ding, Hui, Liu, Dan, Xiang, Jianquan, Gao, Xuejiao J, Chen, Xuehui, Li, Zhongjun, Yang, Lei, Duan, Hongxia, Zheng, Jiyan, Liu, Zheng, Jiang, Bing, Liu, Yang, Xie, Ni, Zhang, Han, Yan, Xiyun, Fan, Kelong, Nie, Guohui. TiO2 supported single Ag atoms nanozyme for elimination of SARS-CoV2. NANO TODAY[J]. 2021, 第 18 作者 通讯作者 40: 101243-101243, http://dx.doi.org/10.1016/j.nantod.2021.101243.[26] 向建全, 周彩玉, 张若飞, 曾凡才, 范克龙. 铁蛋白装载“铁-阿霉素”新策略. 中国科学:生命科学[J]. 2021, 第 5 作者51(7): 871-878, https://www.sciengine.com/doi/10.1360/SSV-2021-0134.[27] Zhang, Yanan, Li, Yingni, Zhang, Jianlin, Chen, Xuehui, Zhang, Ruofei, Sun, Guoming, Jiang, Bing, Fan, Kelong, Li, Zhanguo, Yan, Xiyun. Nanocage-Based Capture-Detection System for the Clinical Diagnosis of Autoimmune Disease. SMALL[J]. 2021, 第 8 作者 通讯作者 17(25): http://dx.doi.org/10.1002/smll.202101655.[28] Jiang, Bing, Jia, Xiaohua, Ji, Tianjiao, Zhou, Meng, He, Jiuyang, Wang, Kun, Tian, Jie, Yan, Xiyun, Fan, Kelong. Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 第 9 作者65: 13, https://www.sciengine.com/doi/10.1007/s11427-021-1976-0.[29] Fan, Kelong, Lin, Youhui, Bansal, Vipul. Editorial: Nanozymes: From Rational Design to Biomedical Applications. FRONTIERS IN CHEMISTRY[J]. 2021, 第 1 作者 通讯作者 9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042218/.[30] Wang, Zhuoran, Zhang, Shuai, Zhang, Ruofei, Chen, Xuehui, Sun, Guoming, Zhou, Meng, Han, Qiubai, Zhang, Baoli, Zhao, Yue, Jiang, Bing, Yang, Yili, Yan, Xiyun, Fan, Kelong. Bioengineered Dual-Targeting Protein Nanocage for Stereoscopically Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy. ADVANCED FUNCTIONAL MATERIALS[J]. 2021, 第 13 作者 通讯作者 31(29): http://dx.doi.org/10.1002/adfm.202102004.[31] 赵越, 孟祥芹, 阎锡蕴, 范克龙. 纳米酶:一种新型的生物安全材料. 应用化学[J]. 2021, 第 4 作者38(5): 524-545, http://yyhx.ciac.jl.cn/CN/10.19894/j.issn.1000-0518.210174.[32] Zhang, Baoli, Tang, Guoheng, He, Jiuyang, Yan, Xiyun, Fan, Kelong. Ferritin nanocage: A promising and designable multi-module platform for constructing dynamic nanoassembly-based drug nanocarrier. ADVANCED DRUG DELIVERY REVIEWS. 2021, 第 5 作者 通讯作者 176: http://dx.doi.org/10.1016/j.addr.2021.113892.[33] 焦健, 范克龙, 胡志刚, 杜鹏. 纳米生物学的研究现状与关键科学问题. 中国科学:生命科学[J]. 2020, 第 2 作者50(7): 778-787, https://www.sciengine.com/doi/10.1360/SSV-2019-0296.[34] Zhang, Ruofei, Fan, Kelong, Yan, Xiyun. Nanozymes: created by learning from nature. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 第 2 作者 通讯作者 63(8): 1183-1200, http://lib.cqvip.com/Qikan/Article/Detail?id=7102433154.[35] Liang, Qian, Xi, Juqun, Gao, Xuejiao J, Zhang, Ruofei, Yang, Yili, Gao, Xingfa, Yan, Xiyun, Gao, Lizeng, Fan, Kelong. A metal-free nanozyme-activated prodrug strategy for targeted tumor catalytic therapy. NANO TODAY[J]. 2020, 第 9 作者 通讯作者 35: http://dx.doi.org/10.1016/j.nantod.2020.100935.[36] Jiaying Xie, Yiliang Jin, Kelong Fan, Xiyun Yan. The prototypes of nanozyme-based nanorobots. 生物物理学报:英文版[J]. 2020, 第 3 作者6(6): 223-244, http://lib.cqvip.com/Qikan/Article/Detail?id=7103702509.[37] 侯亚欣, 张若飞, 阎锡蕴, 范克龙. 纳米酶:疾病治疗新选择. 中国科学:生命科学[J]. 2020, 第 4 作者50(3): 311-328, https://www.sciengine.com/doi/10.1360/SSV-2019-0216.[38] Zhu, Daoming, Lyu, Meng, Huang, Qinqin, Suo, Meng, Liu, Ying, Jiang, Wei, Duo, Yanhong, Fan, Kelong. Stellate Plasmonic Exosomes for Penetrative Targeting Tumor NIR-II Thermo-Radiotherapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 第 8 作者 通讯作者 12(33): 36928-36937, https://www.webofscience.com/wos/woscc/full-record/WOS:000563074900011.[39] Yang, Yang, Zhu, Daoming, Liu, Ying, Jiang, Bing, Jiang, Wei, Yan, Xiyun, Fan, Kelong. Platinum-carbon-integrated nanozymes for enhanced tumor photodynamic and photothermal therapy. NANOSCALE[J]. 2020, 第 7 作者 通讯作者 12(25): 13548-13557, http://dx.doi.org/10.1039/d0nr02800b.[40] Jiang, Bing, Chen, Xuehui, Sun, Guoming, Chen, Xiangru, Yin, Yufang, Jin, Yiliang, Mi, Qian, Ma, Long, Yang, Yili, Yan, Xiyun, Fan, Kelong. A natural drug entry channel in the ferritin nanocage. NANO TODAY[J]. 2020, 第 11 作者 通讯作者 35: http://dx.doi.org/10.1016/j.nantod.2020.100948.[41] Jia, Xiaohua, Fan, Kelong, Zhang, Ruofei, Zhang, Dan, Zhang, Jianjun, Gao, Yuan, Zhang, Tao, Li, Wanjun, Li, Junlai, Yan, Xiyun, Tian, Jie. Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE[J]. 2020, 第 2 作者27: http://dx.doi.org/10.1016/j.nano.2020.102204.[42] Hu, Xi, Li, Fangyuan, Xia, Fan, Guo, Xia, Wang, Nan, Liang, Lili, Yang, Bo, Fan, Kelong, Yan, Xiyun, Ling, Daishun. Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 第 8 作者142(3): 1636-1644, http://dx.doi.org/10.1021/jacs.9b13586.[43] Wang, Zhuoran, Zhang, Ruofei, Yan, Xiyun, Fan, Kelong. Structure and activity of nanozymes: Inspirations for de novo design of nanozymes. MATERIALS TODAY. 2020, 第 4 作者 通讯作者 41: 81-119, http://dx.doi.org/10.1016/j.mattod.2020.08.020.[44] Shen, Xinyu, Ma, Ruonan, Huang, Yixin, Chen, Lei, Xu, Zhuobin, Li, Dandan, Meng, Xiangqin, Fan, Kelong, Xi, Juqun, Yan, Xiyun, Koo, Hyun, Yang, Yili, Jiang, Jing, Gao, Lizeng. Nano-decocted ferrous polysulfide coordinates ferroptosis-like death in bacteria for anti-infection therapy. NANO TODAY[J]. 2020, 第 8 作者35: http://dx.doi.org/10.1016/j.nantod.2020.100981.[45] Meng, Xiangqin, Zare, Iman, Yan, Xiyun, Fan, Kelong. Protein-protected metal nanoclusters: An emerging ultra-small nanozyme. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY. 2020, 第 4 作者 通讯作者 12(3): http://dx.doi.org/10.1002/wnan.1602.[46] 马龙, 范克龙. 纳米酶和铁蛋白新特性的发现和应用. 自然杂志[J]. 2020, 第 2 作者42(1): 1-11, http://lib.cqvip.com/Qikan/Article/Detail?id=7101105425.[47] Jiang, Bing, Fang, Long, Wu, Kongming, Yan, Xiyun, Fan, Kelong. Ferritins as natural and artificial nanozymes for theranostics. THERANOSTICS. 2020, 第 5 作者 通讯作者 10(2): 687-706, http://dx.doi.org/10.7150/thno.39827.[48] Qin, Tao, Ma, Ruonan, Yin, Yinyan, Miao, Xinyu, Chen, Sujuan, Fan, Kelong, Xi, Juqun, Liu, Qi, Gu, Yunhao, Yin, Yuncong, Hu, Jiao, Liu, Xiufan, Peng, Daxin, Gao, Lizeng. Catalytic inactivation of influenza virus by iron oxide nanozyme. THERANOSTICS[J]. 2019, 第 6 作者9(23): 6920-6935, https://www.webofscience.com/wos/woscc/full-record/WOS:000487830500013.[49] Zhao, Shuai, Duan, Hongxia, Yang, Yili, Yan, Xiyun, Fan, Kelong. Fenozyme Protects the Integrity of the Blood-Brain Barrier against Experimental Cerebral Malaria. NANO LETTERS[J]. 2019, 第 5 作者 通讯作者 19(12): 8887-8895, [50] Xu, Bolong, Wang, Hui, Wang, Weiwei, Gao, Lizeng, Li, Shanshan, Pan, Xueting, Wang, Hongyu, Yang, Hailong, Meng, Xiangqin, Wu, Qiuwen, Zheng, Lirong, Chen, Shenming, Shi, Xinghua, Fan, Kelong, Yan, Xiyun, Liu, Huiyu. A Single-Atom Nanozyme for Wound Disinfection Applications. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 第 14 作者 通讯作者 58(15): 4911-4916, https://www.webofscience.com/wos/woscc/full-record/WOS:000463739900018.[51] Jiang, Bing, Zhang, Ruofei, Zhang, Jianlin, Hou, Yaxin, Chen, Xuehui, Zhou, Meng, Tian, Xiuyun, Hao, Chunyi, Fan, Kelong, Yan, Xiyun. GRP78-targeted ferritin nanocaged ultra-high dose of doxorubicin for hepatocellular carcinoma therapy. THERANOSTICS[J]. 2019, 第 9 作者 通讯作者 9(8): 2167-2182, https://www.webofscience.com/wos/woscc/full-record/WOS:000464623500004.[52] Tao Wang, Jiuyang He, Demin Duan, Bing Jiang, Peixia Wang, Kelong Fan, Minmin Liang, Xiyun Yan. Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans. 纳米研究:英文版[J]. 2019, 第 6 作者12(4): 863-868, http://lib.cqvip.com/Qikan/Article/Detail?id=7001880742.[53] Jin, Yiliang, He, Jiuyang, Fan, Kelong, Yan, Xiyun. Ferritin variants: inspirations for rationally designing protein nanocarriers. NANOSCALE. 2019, 第 3 作者 通讯作者 11(26): 12449-12459, https://www.webofscience.com/wos/woscc/full-record/WOS:000474160000002.[54] Fan, Kelong, Yan, Xiyun. Nanozyme based tumor catalytic theranostics. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2019, 第 1 作者258: https://www.webofscience.com/wos/woscc/full-record/WOS:000525055501290.[55] Zhang, Ruofei, Zhou, Yunlong, Yan, Xiyun, Fan, Kelong. Advances in chiral nanozymes: a review. MICROCHIMICA ACTA. 2019, 第 4 作者 通讯作者 186(12): https://www.webofscience.com/wos/woscc/full-record/WOS:000498188200006.[56] He, Jiuyang, Fan, Kelong, Yan, Xiyun. Ferritin drug carrier (FDC) for tumor targeting therapy. JOURNAL OF CONTROLLED RELEASE. 2019, 第 2 作者 通讯作者 311: 288-300, http://dx.doi.org/10.1016/j.jconrel.2019.09.002.[57] Ding, Hui, Cai, Yanjuan, Gao, Lizeng, Liang, Minmin, Miao, Beiping, Wu, Hanwei, Liu, Yang, Xie, Ni, Tang, Aifa, Fan, Kelong, Yan, Xiyun, Nie, Guohui. Exosome-like Nanozyme Vesicles for H2O2-Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma. NANO LETTERS[J]. 2019, 第 10 作者 通讯作者 19(1): 203-209, https://www.webofscience.com/wos/woscc/full-record/WOS:000455561300025.[58] 焦健, 范克龙, 胡志刚, 阎锡蕴, 杜鹏. 纳米酶的发展态势与优先领域分析. 中国科学:化学[J]. 2019, 第 2 作者49(12): 1442-1453, https://www.sciengine.com/doi/10.1360/SSC-2019-0138.[59] Meng, Xiangqin, Fan, Kelong, Yan, Xiyun. Nanozymes: an emerging field bridging nanotechnology and enzymology. SCIENCE CHINA-LIFE SCIENCES[J]. 2019, 第 2 作者 通讯作者 62(11): 1543-1546, https://www.sciengine.com/doi/10.1007/s11427-019-1557-8.[60] Jiang, Bing, Yan, Liang, Zhang, Jianlin, Zhou, Meng, Shi, Guizhi, Tian, Xiuyun, Fan, Kelong, Hao, Chunyi, Yan, Xiyun. Biomineralization Synthesis of the Cobalt Nanozyme in SP94-Ferritin Nanocages for Prognostic Diagnosis of Hepatocellular Carcinoma. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 第 7 作者 通讯作者 11(10): 9747-9755, [61] Wang Tao, He Jiuyang, Duan Demin, Jiang Bing, Wang Peixia, Fan Kelong, Liang Minmin, Yan Xiyun. Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans. NANO RESEARCH[J]. 2019, 第 6 作者12(4): 863-868, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6455367&detailType=1.[62] Yanan Zhang, Yiliang Jin, Haixia Cui, Xiyun Yan, Kelong Fan. Nanozyme-based catalytic theranostics. RSC ADVANCES. 2019, 第 5 作者10(1): 10-20, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048033/.[63] Du, Yang, Fan, Kelong, Zhang, Hejun, Li, Li, Wang, Peixia, He, Jiuyang, Ding, Shigang, Yan, Xiyun, Tian, Jie. Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE[J]. 2018, 第 2 作者14(7): 2259-2270, http://ir.ia.ac.cn/handle/173211/23046.[64] Fan, Kelong, Jiang, Bing, Guan, Zhe, He, Jiuyang, Yang, Dongling, Xie, Ni, Nie, Guohui, Xie, Can, Yan, Xiyun. Fenobody: A Ferritin-Displayed Nanobody with High Apparent Affinity and Half-Life Extension. ANALYTICALCHEMISTRY[J]. 2018, 第 1 作者 通讯作者 90(9): 5671-5677, https://www.webofscience.com/wos/woscc/full-record/WOS:000431464400023.[65] Liang, Minmin, Tan, Hui, Zhou, Jun, Wang, Tao, Duan, Demin, Fan, Kelong, He, Jiuyang, Cheng, Dengfeng, Shi, Hongcheng, Choi, Hak Soo, Yan, Xiyun. Bioengineered H-Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosis. ACS NANO[J]. 2018, 第 6 作者12(9): 9300-9308, https://www.webofscience.com/wos/woscc/full-record/WOS:000445972400048.[66] Fan, Kelong, Jia, Xiaohua, Zhou, Meng, Wang, Kun, Conde, Joao, He, Jiuyang, Tian, Jie, Yan, Xiyun. Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma. ACS NANO[J]. 2018, 第 1 作者12(5): 4105-4115, https://www.webofscience.com/wos/woscc/full-record/WOS:000433404500005.[67] Zhuobin Xu, Zhiyue Qiu, Qi Liu, Yixin Huang, Dandan Li, Xinggui Shen, Kelong Fan, Juqun Xi, Yunhao Gu, Yan Tang, Jing Jiang, Jialei Xu, Jinzhi He, Xingfa Gao, Yuan Liu, Hyun Koo, Xiyun Yan, Lizeng Gao. Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections. NATURE COMMUNICATIONS[J]. 2018, 第 7 作者9(1): http://dx.doi.org/10.1038/s41467-018-06164-7.[68] Kelong Fan, Juqun Xi, Lei Fan, Peixia Wang, Chunhua Zhu, Yan Tang, Xiangdong Xu, Minmin Liang, Bing Jiang, Xiyun Yan, Lizeng Gao. In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy. NATURE COMMUNICATIONS[J]. 2018, 第 1 作者9(1): https://doaj.org/article/f55c3e0f0c44429490f4f7081e46bd02.[69] Jiang, Bing, Duan, Demin, Gao, Lizeng, Zhou, Mengjie, Fan, Kelong, Tang, Yan, Xi, Juqun, Bi, Yuhai, Tong, Zhou, Gao, George Fu, Xie, Ni, Tango, Aifa, Nie, Guohui, Liang, Minmin, Yan, Xiyun. Standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes. NATURE PROTOCOLS[J]. 2018, 第 5 作者13(7): 1506-1520, https://www.webofscience.com/wos/woscc/full-record/WOS:000439317300003.[70] Meng XiangQin, Fan KeLong. Application of Nanozymes in Disease Diagnosis. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2018, 第 2 作者 通讯作者 45(2): 218-236, http://dx.doi.org/10.16476/j.pibb.2018.0039.[71] Fan, Kelong, Zhou, Meng, Yan, Xiyun. Questions about horse spleen ferritin crossing the blood brain barrier via mouse transferrin receptor 1. PROTEIN & CELL[J]. 2017, 第 1 作者8(11): 788-790, https://doaj.org/article/c2bcc5fde77f442e986dce4db79efab1.[72] Gao, Lizeng, Fan, Kelong, Yan, Xiyun. Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetic for Biomedical Applications. THERANOSTICS. 2017, 第 2 作者7(13): 3207-3227, http://dx.doi.org/10.7150/thno.19738.[73] Fan, Xiao, Zhao, Lingyun, Liu, Chuan, Zhang, JinCan, Fan, Kelong, Yan, Xiyun, Peng, HaiLin, Lei, Jianlin, Wang, HongWei. Near-Atomic Resolution Structure Determination in Over-Focus with Volta Phase Plate by Cs-Corrected Cryo-EM. STRUCTURE[J]. 2017, 第 5 作者25(10): 1623-+, http://dx.doi.org/10.1016/j.str.2017.08.008.[74] Fan, Kelong, Wang, Hui, Xi, Juqun, Liu, Qi, Meng, Xiangqin, Duan, Demin, Gao, Lizeng, Yan, Xiyun. Optimization of Fe3O4 nanozyme activity via single amino acid modification mimicking an enzyme active site. CHEMICAL COMMUNICATIONS[J]. 2017, 第 1 作者53(2): 424-427, https://www.webofscience.com/wos/woscc/full-record/WOS:000391736100031.[75] Zhao, Yanzhao, Liang, Minmin, Li, Xiao, Fan, Kelong, Xiao, Jie, Li, Yanli, Shi, Hongcheng, Wang, Fei, Choi, Hak Soo, Cheng, Dengfeng, Yan, Xiyun. Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging. ACS NANO[J]. 2016, 第 4 作者10(4): 4184-4191, https://www.webofscience.com/wos/woscc/full-record/WOS:000375245000034.[76] Duan, Demin, Fan, Kelong, Zhang, Dexi, Tan, Shuguang, Liang, Mifang, Liu, Yang, Zhang, Jianlin, Zhang, Panhe, Liu, Wei, Qiu, Xiangguo, Kobinger, Gary P, Gao, George Fu, Yan, Xiyun. Nanozyme-strip for rapid local diagnosis of Ebola. BIOSENSORS & BIOELECTRONICS[J]. 2015, 第 2 作者74: 134-141, http://dx.doi.org/10.1016/j.bios.2015.05.025.[77] Liang, Minmin, Fan, Kelong, Zhou, Meng, Duan, Demin, Zheng, Jiyan, Yang, Dongling, Feng, Jing, Yan, Xiyun. H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 第 2 作者111(41): 14900-14905, https://www.webofscience.com/wos/woscc/full-record/WOS:000342922000066.[78] 范克龙, 周萌, 阎锡蕴. 细菌生产人铁蛋白的新功能及应用. 微生物学通报[J]. 2014, 第 1 作者41(3): 520-538, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb14030520?st=article_issue.[79] Duan, Hongxia, Xing, Shu, Luo, Yongting, Feng, Liqun, Gramaglia, Irene, Zhang, Ying, Lu, Di, Zeng, Qiqun, Fan, Kelong, Feng, Jing, Yang, Dongling, Qin, Zhihai, Couraud, PierreOlivier, Romero, Ignacio A, Weksler, Babette, Yan, Xiyun. Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS. SCIENTIFIC REPORTS[J]. 2013, 第 9 作者3: http://www.irgrid.ac.cn/handle/1471x/756579.[80] Fan, Kelong, Gao, Lizeng, Yan, Xiyun. Human ferritin for tumor detection and therapy. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY[J]. 2013, 第 1 作者5(4): 287-298, http://www.irgrid.ac.cn/handle/1471x/756682.[81] Liang, Minmin, Fan, Kelong, Pan, Yong, Jiang, Hui, Wang, Fei, Yang, Dongling, Lu, Di, Feng, Jing, Zhao, Jianjun, Yang, Liu, Yan, Xiyun. Fe3O4 Magnetic Nanoparticle Peroxidase Mimetic-Based Colorimetric Assay for the Rapid Detection of Organophosphorus Pesticide and Nerve Agent. ANALYTICAL CHEMISTRY[J]. 2013, 第 2 作者85(1): 308-312, http://www.irgrid.ac.cn/handle/1471x/756582.[82] Fan, Kelong, Cao, Changqian, Pan, Yongxin, Lu, Di, Yang, Dongling, Feng, Jing, Song, Lina, Liang, Minmin, Yan, Xiyun. Magnetoferritin nanoparticles for targeting and visualizing tumour tissues. NATURE NANOTECHNOLOGY[J]. 2012, 第 1 作者 通讯作者 7(7): 459-464, http://www.irgrid.ac.cn/handle/1471x/756843.[83] Zhuang, Jie, Fan, Kelong, Gao, Lizeng, Lu, Di, Feng, Jing, Yang, Dongling, Gu, Ning, Zhang, Yu, Liang, Minmin, Yan, Xiyun. Ex Vivo Detection of Iron Oxide Magnetic Nanoparticles in Mice Using Their Intrinsic Peroxidase-Mimicking Activity. MOLECULAR PHARMACEUTICS[J]. 2012, 第 2 作者9(7): 1983-1989, http://www.irgrid.ac.cn/handle/1471x/756791.[84] 阎锡蕴. CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. BLOOD[J]. 2012, 120(11): 2330-2339, http://dx.doi.org/10.1182/blood-2012-01-406108.[85] Iman Zare, Daniel M Chevrier, Anna CifuentesRius, Nasrin Moradi, Yunlei Xianyu, Subhadip Ghosh, Laura TrapiellaAlfonso, Ye Tian, Alireza ShourangizHaghighi, Saptarshi Mukherjee, Kelong Fan, Michael R Hamblin. Protein-protected metal nanoclusters as diagnostic and therapeutic platforms for biomedical applications. MATERIALS TODAY. 第 11 作者 通讯作者 http://dx.doi.org/10.1016/j.mattod.2020.10.027.
科研活动
科研项目
( 1 ) 中国科学院创新交叉团队, 主持, 部委级, 2021-01--2023-12( 2 ) 一种肝细胞肝癌特异性靶分子的鉴定及其靶向纳米药物载体的设计, 主持, 国家级, 2019-01--2020-12( 3 ) 一种可实现肿瘤超早期成像的多模靶向纳米探针, 主持, 国家级, 2020-01--2022-12( 4 ) 纳米酶的仿生设计及其生物医学应用, 主持, 国家级, 2022-01--2024-12( 5 ) 肿瘤微环境的免疫抑制关键机制研究和精准纳米基因治疗, 主持, 国家级, 2021-12--2026-11
指导学生
现指导学生
谢佳颖 硕士研究生 071010-生物化学与分子生物学
张宝丽 博士研究生 071010-生物化学与分子生物学
向建全 博士研究生 071010-生物化学与分子生物学
李建茹 博士研究生 071010-生物化学与分子生物学