(1)   Chinese herbal medicines and drug discovery and development.

(2)   Integrative pharmacology、medicinal chemistry、preclinical research.

(3) Biotechnology R&D.

1992/9-1995/7: Institute of Chemistry, CAS, Ph.D., Physical Chemistry

1989/9-1992/7: Wuhan University, M.S., Physical Chemistry

1985/9-1989/7: Hubei University, BS, Chemistry

2024/06-present: Dalian Institute of Chemical Physics, CAS, Professor

2000/10-2024/04: Corning Incorporated, USA, Research Fellow/Technical Lead

1996/10-2000/10: Johns Hopkins University School of Medicine, USA, Postdoctoral

1995/10-1996/10: University of Vermont, USA, Postdoctoral

He had published more than 120 papers in scientific journals including Science, Nature Chemical Biology, J. Am. Chem. Soc.. He has co-authored 1 book, edited 1 book, and written nearly 30 book chapters.

代表论著：

专著

1. Fang, Y., ed. (2015) Label-free biosensor methods in drug discovery. Methods in Pharmacology and Toxicity, Vol. 53, Springer, New York.

2. 白春礼，方晔，唐有祺 (1996) 三链DNA的结构和生物学. 中国科学出版社。

论文 (*通讯联系人)

1. Peng, J., Zhao, Y., Hong, Y., Burkhalter, R.S., Hogue, C.L., Tran, E., Wei, L., Romeo, L., Dolley-Sonneville, P., Melkoumian, Z., Liang, X., Fang, Y.* (2018) Chemical identity and mechanism of action and formation of a cell growth inhibitory compound from polycarbonate flasks. Analytical Chemistry 2018, 90(7), 4603–4610.

2. Fang, Y., Eglen, R.M. (2017) Three-dimensional cell cultures in drug discovery and development. SLAS Discovery 22(5) 456–472.

3. French, J.B.*, Jones, S.A., Deng, H., Hu, H., Pedley, A.M., Kim, D., Chan, C.Y., Hu, H., Pugh, R.J., Zhao, H., Zhang, Y., Huang, T.J., Fang, Y.,* Zhuang, X.* Benkovic, S.J.* (2016) Spatial colocalization and functional link of purinosomes with mitochondria. Science 351(6274), 733-737.

4. Fang, Y.* (2012) Ligand-receptor interaction platforms and their applications for drug discovery. Expert Opinion on Drug Discovery 7, 969-988.

5. Verrier, F., An, S., Ferrie, A.M., Sun, H., Kyoung, M., Fang, Y.*, Benkovic, S.J.* (2011) GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis. Nature Chemical Biology 7, 909–915.

6. Deng, H., Hu, H., He, M., Hu, J., Niu, W., Ferrie, A.M., Fang, Y.* (2011) Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor-35 (GPR35) agonists. Journal of Medicinal Chemistry 54, 7385–7396.

7. Ferrie, A. M., Wu, Q., Fang, Y.* (2010) Resonant waveguide grating imager for live cell sensing. Applied Physics Letters 97, 223704.

8. Fang, Y.* (2006) Spreading and segregation of lipids in air-stable lipid microarrays. Journal of the American Chemical Society 128, 3158-3159.

9. Fang, Y.*, Ferrie, A.M., Fontaine, N.H., Mauro, J., Balakrishnan, J. (2006) Resonant waveguide grating biosensor for living cell sensing. Biophysical Journal 91, 1925-1940.

10. Fang, Y., Frutos, A.G., Lahiri, J.* (2002) Membrane protein microarrys. Journal of the American Chemical Society 124, 2394-2395.

11. Fang, Y. and Hoh, J.H. (1998) Early intermediates in spermidine induced DNA condensation on mica. Journal of the American Chemical Society 106, 8903-8909. 

He has 97 United States patent applications and 37 granted patents.

Chemical Biology; Receptor biology; Integrative Pharmacology; Artificial Intelligence; Drug Discovery and Development; Traditional Chinese Medicines

•         Committee member, 1st Label-free Technologies: Advances and Applications, Amsterdam, Netherlands, 2012

•         Committee member, 2nd Label-free Technologies: Advances and Applications, Boston, MA, 2015

•         Authors Choice Award, SLAS Discovery, 2020 and 2021

•         Committee member, 1st Label-free Technologies: Advances and Applications, Amsterdam, Netherlands, 2012

•         Committee member, 2nd Label-free Technologies: Advances and Applications, Boston, MA, 2015

•         Editor, Scientific Reports, 2012 - 2022

•         Associate Editor, Frontiers in Pharmacology, 2012 - 2024

•         Research Topic Editor, “Label-free technologies and pharmacology,” Pharmacological Research, 2016

•         Research Topic Editor (co-edited with Drs. Terry Kenakin and Changlu Liu), “Orphan GPCR drug targets,” Frontiers in Pharmacology, 2015

•         Guest editor, Journal of Receptor Signal Transduction Research, 2009

•         Stookey Award, Corning Incorporated, 2009

•         Second-Award, 8th National Excellent Books in Science & Technology, China, 1997

•         President Scholarship Award, Chinese Academy of Sciences, China, 1995