1. 肺部分子影像

2. 可吸入药物/核酸递送

   

070302-分析化学
0703J1-纳米科学与技术

分子影像，药物/核酸递送

2010-09--2015-07   中国科学院大学   博士
2006-09--2010-07   华中师范大学   学士

   

2022-12~现在, 中国科学院精密测量科学与技术创新研究院, 研究员
2021-12~2022-11,Pure Tech Health公司, 高级研究员
2017-12~2021-11,约翰霍普金斯大学医学院, 博士后
2015-09~2017-11,密歇根大学安娜堡分校, 博士后

   

（1） Center for Molecular Imaging Innovation & Translation Young Investigato r Award, 二等奖, 其他, 2017
（2） SNMMI Annual Meeting Travel Award, 其他, 2017
（3） Berson-Yalow Award, 其他, 2016

（ 1 ） 用于转染的纳米复合物载体、核酸纳米药物及其制备方法和应用, 发明专利, 2021, 第 5 作者, 专利号: CN113262307A

（ 2 ） 一种硫缩酮聚合物及其制备方法与应用, 2017, 第 2 作者, 专利号: CN104629054B

   

（1） Fullerene-based nanocomplex assists pulmonary delivery of siRNA for treating metastatic lung cancer, NANO TODAY, 2023, 第 4 作者
（2） Telmisartan Nanosuspension for Inhaled Therapy of COVID-19 Lung Disease and Other Respiratory Infections, MOLECULAR PHARMACEUTICS, 2022, 第 1 作者
（3） Enhancing nanoparticle penetration through airway mucus to improve drug delivery efficacy in the lung, EXPERT OPINION ON DRUG DELIVERY, 2021, 第 1 作者
（4） A Two-Pronged Pulmonary Gene Delivery Strategy: A Surface-Modified Fullerene Nanoparticle and a Hypotonic Vehicle, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 第 1 作者
（5） Engineered Antibody Fragment against the Urokinase Plasminogen Activator for Fast Delineation of Triple-Negative Breast Cancer by Positron Emission Tomography, MOLECULAR PHARMACEUTICS, 2021, 第 4 作者
（6） Fullerene nanoparticles: a promising candidate for the alleviation of silicosis-associated pulmonary inflammation, NANOSCALE, 2020, 第 2 作者
（7） AAV8-vectored suprachoroidal gene transfer produces widespread ocular transgene expression, JOURNAL OF CLINICAL INVESTIGATION, 2019, 第 8 作者
（8） Photo-triggered gadofullerene:enhanced cancer therapy by combining tumor vascular disruption and stimulation of anti-tumor immune responses, BIOMATERIALS, 2019, 第 4 作者
（9） Positron Emission Tomography/Magnetic Resonance Imaging of Glioblastoma Using a Functionalized Gadofullerene Nanoparticle, ACS APPLIED MATERIALS & INTERFACES, 2019, 第 1 作者
（10） Biodegradable, Hydrogen Peroxide, and Glutathione Dual Responsive Nanoparticles for Potential Programmable Paclitaxel Release, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 1 作者
（11） In Vivo Targeting and Positron Emission Tomography Imaging of Tumor with Intrinsically Radioactive Metal–Organic Frameworks Nanomaterials, ACS NANO, 2017, 第 1 作者
（12） Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy, BIOMATERIALS, 2016, 第 5 作者
（13） A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals, ADVANCED HEALTHCARE MATERIALS, 2016, 第 5 作者
（14） Antibody-based PET of uPA/uPAR signaling with broad applicability for cancer imaging, ONCOTARGET, 2016, 第 5 作者
（15） Radioactive Nanomaterials for Multimodality Imaging, TOMOGRAPHY : A JOURNAL FOR IMAGING RESEARCH, 2016, 第 1 作者
（16） Synergistic Effect of Human Serum Albumin and Fullerene on Gd-DO3A for Tumor-Targeting Imaging, ACS APPLIED MATERIALS & INTERFACES, 2016, 第 5 作者
（17） Invivo targeting of metastatic breast cancer via tumor vasculature-specific nano-graphene oxide, BIOMATERIALS, 2016, 第 5 作者
（18） Ultrasmall Pd/Au bimetallic nanocrystals embedded in hydrogen-bonded supramolecular structures: facile synthesis and catalytic activities in the reduction of 4-nitrophenol, JOURNAL OF MATERIALS CHEMISTRY A, 2015, 第 6 作者
（19） Amphiphilic trismethylpyridylporphyrin-fullerene (C-70) dyad: an efficient photosensitizer under hypoxia conditions, JOURNALOFMATERIALSCHEMISTRYB, 2015, 第 6 作者
（20） Theranostic applications of carbon nanomaterials in cancer: Focus on imaging and cargo delivery, JOURNAL OF CONTROLLED RELEASE, 2015, 第 1 作者
（21） The effect of hemiketals on the relaxivity of endohedral gadofullerenols, RSC ADVANCES, 2015, 第 4 作者
（22） Multifunctional upconversion-nanoparticles-trismethylpyridylporphyrin- fullerene nanocomposite: a near-infrared light-triggered theranostic platform for imaging-guided photodynamic therapy, NPG ASIA MATERIALS, 2015, 第 4 作者
（23） The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation, DALTON TRANSACTIONS, 2015, 第 3 作者
（24） In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system, JOURNAL OF MATERIALS CHEMISTRY B, 2014, 第 1 作者
（25） G-quadruplex DNAzymes-induced highly selective and sensitive colorimetric sensing of free heme in rat brain, ANALYST, 2014, 第 6 作者
（26） Photoacoustic Imaging Guided Near-Infrared Photothermal Therapy Using Highly Water-Dispersible Single-Walled Carbon Nanohorns as Theranostic Agents, ADVANCED FUNCTIONAL MATERIALS, 2014, 通讯作者
（27） Eco-friendly synthesis of size-controllable amine-functionalized graphene quantum dots with antimycoplasma properties, NANOSCALE, 2013, 第 2 作者
（28） pH-Responsive Mechanism of a Deoxycholic Acid and Folate Comodified Chitosan Micelle under Cancerous Environment, JOURNAL OF PHYSICAL CHEMISTRY B, 2013, 第 1 作者
（29） A novel glucose colorimetric sensor based on intrinsic peroxidase-like activity of C60-carboxyfullerenes, BIOSENSORS AND BIOELECTRONICS, 2013, 第 4 作者
（30） Detection of Organophosphate Pesticide Using Polyaniline and Carbon Nanotubes Composite Based on Acetylcholinesterase Inhibition, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2010, 第 1 作者

（1） Surface modification of radionanomedicine, Springer, 2018-09, 第 1 作者

   

（ 1 ） 可吸入纳米药物用于重大肺部疾病的诊疗, 负责人, 国家任务, 2023-01--2026-12

（1）PET-guided cancer targeting by a fullerene-based nanoplatform with fast renal clearance   2017-06-07
（2）An intrinsically radioactive metal-organic framework (MOF) nanomaterial as a Cerenkov luminescence-excitable PDT agent: focused on deep-tissue and metastatic tumors   2017-06-07
（3）An intrinsically radioactive metal-organic frameworks (MOF) nanomaterial as tumor-targeted, PET-guidable cargo delivery nanoplatform   2017-06-07
（4）A biomolecule coordination complex nanotube with inherent tumor theranostic characteristics: in vivo investigation by PET   2017-06-07
（5）A monosaccharide derivative as a positron emission tomography (PET) imaging probe for glioblastoma   2017-06-07
（6）A monosaccharide derivative as a positron emission tomography (PET) imaging probe for glioblastoma   2017-06-07
（7）Positron emission tomography imaging of glioblastoma with a monosaccharide-based contrast agent   2017-06-07
（8）Dual functional piscidin 1: a natural chelating ligand for 64Cu and an anti-cancer peptide   2017-06-07
（9）ImmunoPET of urokinase plasminogen activator (uPA) system: broad applicability in cancer imaging   2016-06-07
（10）Tumor vasculature-targeted nano-graphene as a multimodality imaging guidable drug delivery platform for metastatic breast cancer   2016-06-07
（11）ImmunoPET of CXCR7: a pilot imaging study in breast cancer   2016-06-07
（12）ImmunoPET of uPA/uPAR signaling: broad applicability in cancer imaging   2016-06-07
（13）Photothermal Effect of Single-walled Carbon Nanohorns   2013-06-07
（14）Application of Carbonaceous Nanomaterials in Biomedicine   2012-06-07