Wenjun Ding
Professor, Executive Dean
College of Life Sciences
University of the Chinese Academy of Sciences
Telephone: +86-10-88256290
Fax: +86-10-88256460
Address: No.19A Yuquan Road, Beijing 100049, China


1996-1999: Ph.D. Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China


Work Experience

April 2004 ~ present, Professor of Biology, Executive Dean. College of Life Sciences, University of the Chinese Academy of Sciences (UCAS).

August 2002 ~ April 2004 (Postdoctoral Fellow), Department of Chemistry, Colorado State University, USA

July 2001 ~ August 2002 (Cooperation Researcher), Multitracer Group, Cyclotron Center, The Institute of Physical and Chemical Research (RIKEN), Japan. 

July 1999 ~ June 2001 (STA Fellowship), Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences, Japan 

July 1988 ~ September 1993 (Resident and Assistant Physician) in Institute of Hubei Provincial Geriatric Medicine, Hubei Province of Liyuan Hospital, China

Teaching Experience
Experimental Techniques of Practical Biochemistry
Application of Cell Biology Techniques in Life Science



Zhijian Liu, Wenbin Zhuang, Lingfei Hu, Rui Rong, Jinsong Li, Wenjun Ding, Na Li. Effect of equipment layout on bioaerosol temporal-spatial distribution and deposition in one BSL-3 laboratory. Building and Environment. 2020; Jul 15; 179: 106991.

Kaiquan Zhang, Zicheng Wang, Xiaoqi Hu, Jiaqi Meng, Weier Bao, Xuefei Wang, Wenjun Ding, Zhiyuan Tian. A long-wavelength turn-on fluorescent probe for intracellular nanomolar level peroxynitrite sensing with second-level response. Talanta. 2020; 219: 121354

Su Zhou, Yueyue Xi, Yingying Chen, Zezhong Zhang, Chunyan Wu, Wei Yan, Aiyue Luo, Tong Wu, Jinjin Zhang, Meng Wu, Jun Dai, Wei Shen, Wenjun Ding*, Shixuan Wang*. Ovarian dysfunction induced by chronic whole-body PM2.5 exposure. Small. 2020; DOI: 10.1002/smll.202000845

Xiaoyu Chen, Jing Guo, Yunlong Huang, Shan Liu, Ying Huang, Zezhong Zhang, Fang Zhang, Zhongbing Lu, Fang Li, Jialin C. Zheng, Wenjun Ding*. Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb. Environmental Pollution. 2020; 264: 114716

Xiao Han, Hanchen Liu, Zezhong Zhang, Wenlan Yang, Chunyan Wu, Xueying Liu, Fang Zhang, Baofa Sun, Yongliang Zhao, Guibin Jiang, Yun-Gui Yang*, Wenjun Ding*. Epitranscriptomic 5-methylcytosine profile in PM2.5-induced mouse pulmonary fibrosis. Genomics, Proteomics & Bioinformatics. 2020; 18(1):41-51

Junling Gao, Juntao Yuan, Qiao’e Wang, Tong Lei, Xiyue Shen, Bingqing Cui, Fang Zhang, Wenjun Ding*, Zhongbing Lu*. Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase ɑ2. Redox Biology. 2020; 28: 101345

Zihan Xu, Wenjun Ding*, Xiaobei Deng*. PM2.5, fine particulate matter: A novel player in the epithelial-mesenchymal transition? Frontiers in Physiology. 2019; 10: 1404

Hongyun Wang, Xiyue Shen, Jingli Liu, Chunyan Wu, Junling Gao, Zezhong Zhang, Fang Zhang, Wenjun Ding*, Zhongbing Lu*. The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: a transcriptome analysis. Redox Biology. 2019; 26:101264

Wei Feng, Tong Lei, Yue Wang, Run Feng, Juntao Yuan, Xiyue Shen, Yongguang Wu, Junling Gao, Wenjun Ding*, Zhongbing Lu*. GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress. Free Radical Biology and Medicine. 2019; 140: 128-139

Wenhui Yue, Tong Lei, Xiaohong Liu, Xinyu Weng, Xiaoyu Chen, Dongzhi Wang, Samuel C Dudley, Edward Kenneth Weir, Wenjun Ding, Zhongbing Lu, Yawei Xu, Yingjie Chen. Short-term PM2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy. Redox Biology. 2019; 22: 101161

Guoxiong Tian, Juan Wang, Zhongbing Lu, Hongyun Wang, Wei Zhang, Wenjun Ding*, Fang Zhang*. Indirect effect of PM1 on endothelial cells via inducing the release of respiratory inflammatory cytokines. Toxicology in Vitro. 2019; 57:203-210.

Zhijian Liu, Hang Yin, Shengyuan Ma, Guangya Jin, Gao Jun, Wenjun Ding. On-site assessments on variations of PM2.5, PM10, CO2 and TVOC concentrations in naturally ventilated underground parking garages with traffic volume. Environmental Pollution. 2019; 247: 626-637

Shan Liu, Wei Zhang, Fang Zhang*, Peter Roepstorff, Fuquan Yang, Zhongbing Lu, Wenjun Ding*. TMT-based quantitative proteomics analysis reveals airborne PM2.5-induced pulmonary fibrosis. International Journal of Environmental Research and Public Health. 2018; 16(1). pii: E98. doi: 10.3390/ijerph16010098.

Xiaoyu Chen, Shan Liu, Wei Zhang, Chunyan Wu, Hanchen Liu, Fang Zhang*, Zhongbing Lu, Wenjun Ding*. Nrf2 deficiency exacerbates PM2.5-induced olfactory bulb injury. Biochemical and Biophysical Research Communications. 2018; 505(4):1154-1160

Hongyun Wang, Xiyue Shen, Guoxiong Tian, Xili Shi, Wei Huang, Yongguang Wu, Lei Sun, Can Peng, Shasha Liu, Ying Huang, Xiaoyu Chen, Fang Zhang, Yingjie Chen, Wenjun Ding*, Zhongbing Lu*. AMPKɑ deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction. Free Radical Biology and Medicine. 2018; 121: 202-214

Limin Liu, Chong Wan, Wei Zhang, Longfei Guan, Guoxiong Tian, Fang Zhang*, Wenjun Ding*. MiR-146a regulates PM1-induced inflammation via NF-κB signaling pathway in BEAS-2B cells. Environmental Toxicology. 2018; 33(7):743-751

Ying Huang, Fang Liu, Fang Zhang, Pingsheng Liu, Tao Xu*, Wenjun Ding*. Vanadium(IV)-chlorodipicolinate alleviates hepatic lipid accumulation by inducing autophagy via the LKB1/AMPK signaling pathway in vitro and in vivo. Journal of Inorganic Biochemistry. 2018; 183: 66-76

Rui Han, Fang Zhang, Chong Wan, Limin Liu, Qiang Zhong*, Wenjun Ding*. Effect of perfluorooctane sulphonate-induced Kupffer cell activation on hepatocyte proliferation through the NF-κB/TNF-ɑ/IL-6-dependent pathway. Chemosphere. 2018; 200: 283-294

Rui Han, Mingxian Hu, Qiang Zhong, Chong Wan, Limin Liu, Fang Li, Fang Zhang, Wenjun Ding*. Perfluorooctane sulphonate induces oxidative hepatic damage via mitochondria-dependent and NF-κB/TNF-α-mediated pathway. Chemosphere. 2018; 191: 1056-1064

Junhui Li, Shuqiu Chen, Xiang Xiao, Yong Zhao, Wenjun Ding, Xianchang Li*. IL-9 and Th9 cells in health and diseases-From tolerance to immunopathology. Cytokine and Growth Factor Reviews. 2017; 37: 47-55

Jinxia Xu, Wei Zhang, Zhongbing Lu*, Fang Zhang, Wenjun Ding*. Airborne PM2.5 induced hepatic insulin resistance by Nrf2/JNK-mediated signaling pathway. International Journal of Environmental Research and Public Health. 2017; 14(7). pii: E787. doi: 10.3390/ijerph14070787

Qingjie Zhao, Zhulang Chu, Linnan Zhu, Tao Yang, Peng Wang, Fang Liu, Ying Huang, Fang Zhang, Xiaodong Zhang, Wenjun Ding*, Yong Zhao*. 2-deoxy-D-glucose treatment decreases anti-inflammatory M2 macrophage polarization in mice with tumor and allergic airway inflammation. Frontiers in Immunology. 2017; 8:637.

Xiaobei Deng, Nannan Feng, Min Zheng, Xiaofei Ye, Hongyan Lin, Xiao Yu, Zhihua Gan, Zheng Fang, Huan Zhang, Ming Gao, Zhijie Zheng, Herbert Yu, Wenjun Ding*, Biyun Qian. PM2.5 exposure-induced autophagy is mediated by lncRNA loc146880 which also promotes the migration and invasion of lung cancer cells. Biochimica et Biophysica Acta-General Subjects. 2017; 1861(2):112-125

Liu C, He T, Rong Y, Du F, Ma D, Wei Y, Mei Z, Wang Y, Wang H, Zhu Y, Zhang Z, Zheng L, Wu X, Liu H, Ding W. Association of mannose-binding lectin polymorphisms with Tuberculosis susceptibility among Chinese. Scientific Reports. 2016; 6:36488. doi: 10.1038/srep36488.

Yang T, Zhu L, Zhai Y, Zhao Q, Peng J, Zhang H, Yang Z, Zhang L, Ding W*, Zhao Y. TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway. Cellular & Molecular Immunology. 2016; 13(5): 640-50

Luyao Zhang, Wei Zhang, Fang Zhang*, Wenjun Ding*. Effects of protein corona on intracellular uptake and cytotoxicity of PM1. Progress in Biochemistry and Biophysics. 2016; 43(6): 624-626

Longfei Guan, Wei Rui, Ru Bai, Wei Zhang, Fang Zhang*, Wenjun Ding*. Effects of size-fractionated particulate matter on cellular oxidant radical generation in human bronchial epithelial BEAS-2B cells. International Journal of Environmental Research and Public Health. 2016; 13(5), 483; doi:10.3390/ijerph13050483

Hongyun Wang, Yuting Guo, Liming Liu, Longfei Guan, Ting Wang, Luyao Zhang, Yue Wang, Jianwei Cao, Wenjun Ding, Fang Zhang*, Zhongbing Lu*. DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells. Biochimica et Biophysica Acta-General Subjects. 2016; 1860(12): 2793-2801

Qingjie Zhao, Hui Chen, Tao Yang, Wei Rui, Fang Liu, Fang Zhang, Yong Zhao*, Wenjun Ding*. Direct effects of airborne PM2.5 exposure on macrophage polarizations. Biochimica et Biophysica Acta-General Subjects. 2016; 1860(12): 2835-2843

Ru Bai, Longfei Guan, Wei Zhang, Jinxia Xu, Wei Rui, Fang Zhang*, Wenjun Ding*. Comparative study of the effects of PM1-induced oxidative stress on autophagy and surfactant protein B and C expressions in lung alveolar type II epithelial MLE-12 cells. Biochimica et Biophysica Acta-General Subjects. 2016; 1860(12): 2782-2792

Liang Zhang, Ying Huang, Fang Liu, Fang Zhang *, Wenjun Ding*. Vanadium(IV)-chlorodipicolinate inhibits 3T3-L1 preadipocyte adipogenesis by activating LKB1/AMPK signaling pathway. Journal of Inorganic Biochemistry. 2016; 162: 1-8

Chong Wan, Rui Han, Limin Liu, Fang Zhang*, Fang Li, Mingdeng Xiang, Wenjun Ding*. Role of miR-155 in fluorooctane sulfonate-induced oxidative hepatic damage via the Nrf2-dependent pathway. Toxicology and Applied Pharmacology. 2016; 295: 85-93.

Wei Rui, Longfei Guan, Fang Zhang*, Wei Zhang, Wenjun Ding*. PM2.5-induced oxidative stress increases adhesion molecules expression in human endothelial cells through ERK/AKT/NF-κB-dependent pathway. Journal of Applied Toxicology. 2016; 36(1): 48-59.


Wenjun Ding, Fang Zhang, Fengtong Hao, Xiaoyong Cui, Tuanyao Chai, Deliang Chen, Yunjiang Yu, Chengye Sun. Qun Xu. Directory of National Environment and Heath: Chemical Pollutant II. Chinese Environmental Science Press. Beijing. 2011. (In Chinese)

Wenjun Ding, Qun Xu. Directory of National Environment and Heath: Chemical Pollutant I. Chinese Environmental Science Press. Beijing. 2009. (In Chinese)

Xiaoyong Cui, Wenjun Ding, Tuanyao Chai, Fang Zhang. Comparision of Hazard Ranking System and Risk Assessment Methodologies of Chemical Substances. Sciences Press. 2010. (In Chinese)

Xiaolin Hou, Wenjun Ding. Isotopes of Iodine in Thyroid and Urine: Source, Application, Level and Determination. In: Comprehensive Handbook of Iodine. Victor Preedy, Gerard Burrow, ed. Elsevier. 2008. ISBN-13: 978-0-12-374135-6


Research Interests

Environment and Health
Diabetes Mellitus and Obesity


  1. Wenjun Ding, Fang Zhang, Xiaoyong Cui, Tuanyao Chai. Environment pollution and risk assessment. The 6th Natioanl Conferences and Environmental Chemistry. September 21-24, 2011. Shanghai, China (Oral)
  2. Wenjun Ding, Dan Wei, Ming Li, Fang Zhang. The effect of vanadate on insulin signaling pathway in rat L6 myoblast cells. The 7th International Symposium on the Chemistry and Biological Chemistry of Vanadium. October 6-9, 2010. Toyama, Japan (Oral)
  3. Wenjun Ding, Fang Zhang, Lin Wang, Lijuan Wang. Toxic effect of ZnO nanoparticles on lung in rats. National Conference on Environment and Health. October 9-11, 2009. Guangzhou, China (Oral)
  4.  Wenjun Ding, Xiaoyong Cui. Comparison study of Chemical Pollutant on Environment and Health. The 4th Forum for Environment and Health, China 2009. September 16-17, 2009. Guangzhou, China (Oral)
  5. Wenjun Ding, Dan Wei, Ming Li. The insulin-mimetic properties of vanadium with its effects on the gene expression profiling of the insulin signaling pathway in diabetic mellitus. The 6th International Vanadium Symposium - Vanadium Chemistry and Biochemistry. July 17-19. 2008. Lisbon, Portugal (Oral)
  6. Wenjun Ding, Lijuan Wang, Lin Wang, Fang Zhang. Cytotoxicity of nano-ZnO in hippocampal neurons. The International Conference on Nano Toxicology. September 19-20, 2008. Zhenzhou, China (Oral)
  7. Lijuan Wang, Lin Wang, Fang Zhang, Wenjun Ding*. Cytotoxicity of nano-ZnO particles in hippocampal neurons cells. The International Conference on Nano Toxicology. September 19-20, 2008. Zhenzhou, China (Poster) 
  8. Han Wei, Dan Wei, Shuo Yi, Fan Qu, Fang Zhang*, Wenjun Ding*. PM2.5 particular matters induce apoptosis in H9c2 cells. The International Conference on Nano Toxicology. September 19-20, 2008. Zhenzhou, China (Poster) 
  9. Ming Li, Wenjun Ding*. The inhibitory effects of BMOV on GST-PTP1B and ALP activities in vitro. The 9th Conference on Biological Inorganic Chemistry of Chinese Chemical Society. October 19-22, 2007. Guilin, China (Oral) 
  10. Wenjun Ding, Fang Zhang, Shuo Yi, Fang Qu. Biological Effects of Transition Metals in Airborne Particulate Matter. 2007 International Workshop on Environmental Security and Health. September 7-12, 2007. Wuhan, China (Oral)