1996-1999: Ph.D. Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China

   

April 2004 ~ present, Professor of Biology, Executive Dean. College of Life Sciences, University of the Chinese Academy of Sciences (UCAS).

August 2002 ~ April 2004 (Postdoctoral Fellow), Department of Chemistry, Colorado State University, USA

July 2001 ~ August 2002 (Cooperation Researcher), Multitracer Group, Cyclotron Center, The Institute of Physical and Chemical Research (RIKEN), Japan. 

July 1999 ~ June 2001 (STA Fellowship), Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences, Japan 

July 1988 ~ September 1993 (Resident and Assistant Physician) in Institute of Hubei Provincial Geriatric Medicine, Hubei Province of Liyuan Hospital, China

Experimental Techniques of Practical Biochemistry
Application of Cell Biology Techniques in Life Science

   

Mengyao Shao, Chunjiang Li, Jingyi Li, Rulong Chen, Yuanli Wang, Jingran Su, Yikun Tu, Xiaotian Zhang*, Fang Zhang*, Wenjun Ding*. NSUN2 promotes PM_2.5-induced epithelial-mesenchymal transition through methylating chitinase 3-like-1 mRNA. Journal of Hazardous Materials. 2025. 495:138883

Jingran Su, Yikun Tu, Xiaoqi Hu, Yuanli Wang, Mo Chen, Xue Cao, Mengyao Shao, Fang Zhang, Wenjun Ding*. Ambient PM_2.5 orchestrates M1 polarization of alveolar macrophages via activating glutaminase 1-mediated glutaminolysis in acute lung injury. Environmental Pollution. 2025; 366: 125467.

Wenjiao Xu, Wenjun Ding, Liyan Jia, Kui Zhu*, Qingfeng Luo*. Esculetin combats multidrug-resistant salmonella infection and ameliorates intestinal dysfunction via the Nrf2 pathway. Antioxidants. 2024. 13: 1170.

Jingyi Li, Guodong Zeng, Zezhong Zhang, Yuanli Wang, Mengyao Shao, Chunjiang Li, Zhongbing Lu, Yong Zhao*, Fang Zhang*, Wenjun Ding*. Urban airborne PM_2.5 induces pulmonary fibrosis through triggering glycolysis and subsequent modification of histone lactylation in macrophages. Ecotoxicology and Environmental Safety. 2024; 273: 116162.

 Guodong Zeng, Jingyi Li, Yuanli Wang, Jingran Su, Zhongbing Lu, Fang Zhang, Wenjun Ding*. Polystyrene microplastic-induced oxidative stress triggers intestinal barrier dysfunction via the NF-κB/NLRP3/IL-1β/MCLK pathway. Environmental Pollution. 2024; 345: 123473.

Xiaoqi Hu, Jingran Su, Mo Chen, Yikun Tu, Chunyan Wu, Xue Cao, Xinyi Yuan, Fang Zhang*, Wenjun Ding*. Macrophage-derived exosomal TNF-α promotes pulmonary surfactant protein expression in PM_2.5-induced acute lung injury. Science of the Total Environment. 2023; 892: 164732. doi: 10.1016/j.scitotenv.2023; 892: 164732.

Wei Xing, Binjie Qi, Rulong Chen, Wenjun Ding*, Fang Zhang*. Metagenomic analysis reveals taxonomic and functional diversity of microbial communities on the deteriorated wall paintings of Qinling Tomb in the Southern Tang Dynasty, China. BMC Microbiology. 2023; 23(1):140

Yingying Chen, Yueyue Xi, Milu Li, Yaling Wu, Wei Yan, Jun Dai, Mingfu Wu, Wenjun Ding, Jinjin Zhang, Fang Zhang*, Su Zhou*, Shixuan Wang*. Maternal exposure to PM_2.5 decreases ovarian reserve in neonatal offspring mice through activating PI3K/AKT/FoxO3a pathway and ROS-dependent NF-κB pathway. Toxicology. 2022; 481: 153352.

Junling Gao, Tong Lei, Hongyun Wang, Kai Luo, Yuanli Wang, Bingqing Cui, Zhuoran Yu, Xiaoqi Hu, Fang Zhang, Yingjie Chen, Wenjun Ding*, Zhongbing Lu*. Dimethylarginine dimethylaminohydrolase 1 protects PM_2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress. Particle and Fibre Toxicology. 2022; 19: 64.

Rui Yan, Jie Ding, Yuanjie Wei, Qianlei Yang, Xiaoyun Zhang, Hairu Huang, Zhuoyue Shi, Yue Feng, Heran Li, Hengdong Zhang, Wenjun Ding*, Yan An*. Melatonin prevents NaAsO₂-induced developmental cardio-toxicity in zebrafish through regulating oxidative stress and apoptosis. Antioxidants. 2022; 11(7): 1301

Yuanli Wang, Rulong Chen, Jingyi Li, Guodong Zeng, Juntao Yuan, Jingran Su, Chunyan Wu, Zhongbing Lu, Fang Zhang, Wenjun Ding*. Vanadium(IV)-chlorodipicolinate protects against hepatic steatosis by ameliorating lipid peroxidation, endoplasmic reticulum stress, and inflammation. Antioxidants. 2022; 11(6): 1093

Xiaoqi Hu, Mo Chen, Xue Cao, Xinyi Yuan, Fang Zhang*, Wenjun Ding*. TGF-β-containing small extracellular vesicles from PM_2.5-activated macrophages induces cardiotoxicity. Frontiers in Cardiovascular Medicine. 2022; 9: 917719.

Huawen Xu, Yang Zhao, Qingjie Zhao, Mingpu Shi, Zhaoqi Zhang, Wenjun Ding*, Yong Zhao*. Tuberous sclerosis complex 1 deficiency in macrophages promotes unclassical inflammatory response to lipopolysaccharide in vitro and dextran sodium sulfate-induced colitis in mice. Aging and Disease. 2022; 13(6):1875-1890.

Tengyu Zhu, Xue Chen, Huan Qiu, Yang Liu, James mwangi, Ling Zhao, Wenjun Ding, Ren Lai*, Lin Jin*. Aspirin alleviates particulate matter induced asymptomatic orchitis of mice via suppression of cGAS-STING signaling. Frontiers in Immunology. 2021; 12:734546

Junling Gao, Juntao Yuan, Qun Liu, Yuanli Wang, Huiwen Wang, Yingjie Chen, Wenjun Ding, Guangju Ji*, Zhongbing Lu*. Adipose derived stem cells therapy effectively attenuates PM_2.5-induced lung injury. Stem Cell Research & Therapy. 2021; 12(1):355

Tengyu Zhu, Huanqiu, Qiqi Cao, Zilei Duan, Fengliang Liu, Tianzhang Song, Yang Liu, Yaqun Fang, Guangming Wu, Yongtang Zheng, Wenjun Ding*, Ren Lai, Lin Jin*. Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice. Zoological Research. 2021; 42(3):335-338. doi: 10.24272/j.issn.2095-8137.2021.088.

Zhijian Liu, Wenbin Zhuang, Xiaoqi Hu, Zhiheng Zhao, Rui Rong, Jinsong Li, Na Li, Wenjun Ding*. Potential infection risk assessment of improper bioaerosol experiment operation in one BSL-3 laboratory based on the improved Wells-Riley method. Building and Environment. 2021; 201: 107974

Zhijian Liu, Wenbin Zhuang, Xiaoqi Hu, Zhiheng Zhao, Rui Rong, Wenjun Ding, Jinsong Li, Na Li. Effect of equipment layout on bioaerosol temporal-spatial distribution and deposition in one BSL-3 laboratory. Building and Environment. 2020; 181: 107149.

Zhijian Liu, Wenbin Zhuang, Lingfei Hu, Rui Rong, Jinsong Li, Wenjun Ding, Na Li. Experimental and numerical study of potential infection risks from exposure to bioaerosols in one BSL-3 laboratory. Building and Environment. 2020; 179: 106991.

Kaiquan Zhang, Zicheng Wang, Xiaoqi Hu, Jiaqi Meng, Weier Bao, Xuefei Wang, Wenjun Ding, Zhiyuan Tian. A long-wavelength turn-on fluorescent probe for intracellular nanomolar level peroxynitrite sensing with second-level response. Talanta. 2020; 219: 121354

Su Zhou, Yueyue Xi, Yingying Chen, Zezhong Zhang, Chunyan Wu, Wei Yan, Aiyue Luo, Tong Wu, Jinjin Zhang, Meng Wu, Jun Dai, Wei Shen, Wenjun Ding*, Shixuan Wang*. Ovarian dysfunction induced by chronic whole-body PM_2.5 exposure. Small. 2020; 16(33): e2000845.

Xiaoyu Chen, Jing Guo, Yunlong Huang, Shan Liu, Ying Huang, Zezhong Zhang, Fang Zhang, Zhongbing Lu, Fang Li, Jialin C. Zheng, Wenjun Ding*. Urban airborne PM_2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb. Environmental Pollution. 2020; 264: 114716

Xiao Han, Hanchen Liu, Zezhong Zhang, Wenlan Yang, Chunyan Wu, Xueying Liu, Fang Zhang, Baofa Sun, Yongliang Zhao, Guibin Jiang, Yun-Gui Yang*, Wenjun Ding*. Epitranscriptomic 5-methylcytosine profile in PM_2.5-induced mouse pulmonary fibrosis. Genomics, Proteomics & Bioinformatics. 2020; 18(1):41-51

Junling Gao, Juntao Yuan, Qiao’e Wang, Tong Lei, Xiyue Shen, Bingqing Cui, Fang Zhang, Wenjun Ding*, Zhongbing Lu*. Metformin protects against PM_2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase ɑ2. Redox Biology. 2020; 28: 101345

Zihan Xu, Wenjun Ding*, Xiaobei Deng*. PM_2.5, fine particulate matter: A novel player in the epithelial-mesenchymal transition? Frontiers in Physiology. 2019; 10: 1404

Hongyun Wang, Xiyue Shen, Jingli Liu, Chunyan Wu, Junling Gao, Zezhong Zhang, Fang Zhang, Wenjun Ding*, Zhongbing Lu*. The effect of exposure time and concentration of airborne PM_2.5 on lung injury in mice: a transcriptome analysis. Redox Biology. 2019; 26:101264

Wei Feng, Tong Lei, Yue Wang, Run Feng, Juntao Yuan, Xiyue Shen, Yongguang Wu, Junling Gao, Wenjun Ding*, Zhongbing Lu*. GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress. Free Radical Biology and Medicine. 2019; 140: 128-139

Wenhui Yue, Tong Lei, Xiaohong Liu, Xinyu Weng, Xiaoyu Chen, Dongzhi Wang, Samuel C Dudley, Edward Kenneth Weir, Wenjun Ding, Zhongbing Lu, Yawei Xu, Yingjie Chen. Short-term PM_2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy. Redox Biology. 2019; 22: 101161

Guoxiong Tian, Juan Wang, Zhongbing Lu, Hongyun Wang, Wei Zhang, Wenjun Ding*, Fang Zhang*. Indirect effect of PM₁ on endothelial cells via inducing the release of respiratory inflammatory cytokines. Toxicology in Vitro. 2019; 57: 203-210

Zhijian Liu, Hang Yin, Shengyuan Ma, Guangya Jin, Gao Jun, Wenjun Ding. On-site assessments on variations of PM_2.5, PM₁₀, CO₂ and TVOC concentrations in naturally ventilated underground parking garages with traffic volume. Environmental Pollution. 2019; 247: 626-637

Environment and Health
Diabetes Mellitus and Obesity

1. Wenjun Ding, Fang Zhang, Xiaoyong Cui, Tuanyao Chai. Environment pollution and risk assessment. The 6th Natioanl Conferences and Environmental Chemistry. September 21-24, 2011. Shanghai, China (Oral)
2. Wenjun Ding, Dan Wei, Ming Li, Fang Zhang. The effect of vanadate on insulin signaling pathway in rat L6 myoblast cells. The 7th International Symposium on the Chemistry and Biological Chemistry of Vanadium. October 6-9, 2010. Toyama, Japan (Oral)
3. Wenjun Ding, Fang Zhang, Lin Wang, Lijuan Wang. Toxic effect of ZnO nanoparticles on lung in rats. National Conference on Environment and Health. October 9-11, 2009. Guangzhou, China (Oral)
4.  Wenjun Ding, Xiaoyong Cui. Comparison study of Chemical Pollutant on Environment and Health. The 4th Forum for Environment and Health, China 2009. September 16-17, 2009. Guangzhou, China (Oral)
5. Wenjun Ding, Dan Wei, Ming Li. The insulin-mimetic properties of vanadium with its effects on the gene expression profiling of the insulin signaling pathway in diabetic mellitus. The 6th International Vanadium Symposium - Vanadium Chemistry and Biochemistry. July 17-19. 2008. Lisbon, Portugal (Oral)
6. Wenjun Ding, Lijuan Wang, Lin Wang, Fang Zhang. Cytotoxicity of nano-ZnO in hippocampal neurons. The International Conference on Nano Toxicology. September 19-20, 2008. Zhenzhou, China (Oral)
7. Lijuan Wang, Lin Wang, Fang Zhang, Wenjun Ding*. Cytotoxicity of nano-ZnO particles in hippocampal neurons cells. The International Conference on Nano Toxicology. September 19-20, 2008. Zhenzhou, China (Poster) 
8. Han Wei, Dan Wei, Shuo Yi, Fan Qu, Fang Zhang*, Wenjun Ding*. PM2.5 particular matters induce apoptosis in H9c2 cells. The International Conference on Nano Toxicology. September 19-20, 2008. Zhenzhou, China (Poster) 
9. Ming Li, Wenjun Ding*. The inhibitory effects of BMOV on GST-PTP1B and ALP activities in vitro. The 9th Conference on Biological Inorganic Chemistry of Chinese Chemical Society. October 19-22, 2007. Guilin, China (Oral) 
10. Wenjun Ding, Fang Zhang, Shuo Yi, Fang Qu. Biological Effects of Transition Metals in Airborne Particulate Matter. 2007 International Workshop on Environmental Security and Health. September 7-12, 2007. Wuhan, China (Oral)