基本信息
杜玉涛 女 硕导 其他
电子邮件： duyt@genomics.cn
通信地址： 深圳市盐田区北山工业区11栋
邮政编码： 518083
电子邮件： duyt@genomics.cn
通信地址： 深圳市盐田区北山工业区11栋
邮政编码： 518083
研究领域
从事家猪体外受精，手工克隆，玻璃化冷冻等技术的完善和优化，成功得到世界第一批手工克隆猪后代，后又将“手工克隆技术在家猪的应用”引进国内，研发出了国内首批“手工克隆猪”，效率达国际先进水平，2009年研发出世界首例“手工克隆绵羊”。2008年获得深圳“双百计划”支持、2009年获得广东省地方领军人物,成功研究出“迷你发光猪”、“克隆猪坚强”等前沿技术。完成了973项目“iPS克隆猪高效创建”，与中科院广州生物医药健康研究院等合作单位获得2015年广东省科学技术奖一等奖。带领团队研发了大规模测序的植入前筛查（PGS）技术，并于2012年与湖南中信湘雅生殖与遗传专科医院卢光琇团队合作陆续诞生了世界首批全基因组测序的试管婴儿。
招生信息
招生专业
086000-生物与医药
招生方向
辅助生殖
基因组学医学应用
胚胎发育
基因组学医学应用
胚胎发育
教育背景
2004-10--2008-06 丹麦奥尔胡斯大学 博士
2000-09--2003-07 河北医科大学 硕士
1995-09--2000-06 河北医科大学 学士
2000-09--2003-07 河北医科大学 硕士
1995-09--2000-06 河北医科大学 学士
工作经历
工作简历
2018-03~现在, 深圳华大基因科技有限公司，深圳华大基因股份有限公司, 执行副总裁，常务副总裁
2017-09~2018-03,深圳华大基因股份有限公司, 常务副总裁
2016-09~2017-09,深圳华大运动控股有限责任公司, 首席科学家
2013-01~2016-09,深圳华大基因科技有限公司, 健康事业部副总裁
2011-01~现在, 深圳华大生命科学研究院（原深圳华大基因研究院）, 党委书记
2009-07~2012-12,深圳华大方舟生物技术有限公司, 总经理
2007-07~2009-06,深圳华大基因研究院, 克隆与基因工程平台主管
2003-09~2004-09,丹麦Aarhus大学人类遗传所, 访问学者
1999-10~2003-08,北京华大基因研究中心, 客座硕士研究生
2017-09~2018-03,深圳华大基因股份有限公司, 常务副总裁
2016-09~2017-09,深圳华大运动控股有限责任公司, 首席科学家
2013-01~2016-09,深圳华大基因科技有限公司, 健康事业部副总裁
2011-01~现在, 深圳华大生命科学研究院（原深圳华大基因研究院）, 党委书记
2009-07~2012-12,深圳华大方舟生物技术有限公司, 总经理
2007-07~2009-06,深圳华大基因研究院, 克隆与基因工程平台主管
2003-09~2004-09,丹麦Aarhus大学人类遗传所, 访问学者
1999-10~2003-08,北京华大基因研究中心, 客座硕士研究生
社会兼职
2011-01-01-2013-05-22,广东省深圳市盐田区区委, 区委委员
2009-03-01-2013-05-22,深圳华大基因研究院党委, 党委书记
2009-03-01-2013-05-22,深圳华大基因研究院党委, 党委书记
教授课程
胚胎发育学与动物克隆
专利与奖励
奖励信息
（1） 猪基因技术突变创新及基因修饰猪模型的建立, 一等奖, 省级, 2015
（2） 全国五一巾帼标兵, 国家级, 2013
（3） 广东省地方领军人才, , 省级, 2009
（4） 深圳双百计划高端科技人才, , 市地级, 2008
（2） 全国五一巾帼标兵, 国家级, 2013
（3） 广东省地方领军人才, , 省级, 2009
（4） 深圳双百计划高端科技人才, , 市地级, 2008
专利成果
（ 1 ） 一种猪卵母细胞体外培养成熟方法, 发明, 2008, 第 5 作者, 专利号: ZL200910107266.5
（ 2 ） 一种细胞核移植方法, 发明, 2012, 第 1 作者, 专利号: CN 101580828 B
（ 3 ） 一种染色体标本滴片装置, 实用新型, 2011, 第 2 作者, 专利号: CN 101580828 B
（ 4 ） Cell nuclear transfer, 发明, 2005, 第 1 作者, 专利号: P1094DK00
（ 5 ） 一种用于胚胎或细胞的冷冻液及其用途, 发明, 2014, 第 2 作者, 专利号: CN 101580828 B
（ 6 ） 一种人工透明带及其制备方法和用途, 发明, 2014, 第 2 作者, 专利号: CN 102899283 B
（ 7 ） 转基因动物及其制备方法, 发明, 2015, 第 4 作者, 专利号: CN 102367454 B
（ 8 ） 猪假attp位点及其用途, 发明, 2014, 第 5 作者, 专利号: CN 102533741 B
（ 9 ） 一种突变型隐色素基因1和突变型隐色素基因1的转基因猪, 发明, 2015, 第 5 作者, 专利号: CN 103145824 B
（ 10 ） 构建体及其应用, 发明, 2015, 第 5 作者, 专利号: CN 103255168 B
（ 11 ） 封装胚胎的装置及方法, 发明, 2016, 第 2 作者, 专利号: CN 104206375 B
（ 12 ） 从血液中分离、培养细胞的方法及进行克隆非人动物的方法, 发明, 2018, 第 4 作者, 专利号: CN 104513807 B
（ 13 ） 制备克隆小型动物胚胎的方法, 发明, 2019, 第 5 作者, 专利号: CN 105087653 B
（ 14 ） SNP标记及其应用, 发明, 2019, 第 5 作者, 专利号: CN 105821037 B
（ 2 ） 一种细胞核移植方法, 发明, 2012, 第 1 作者, 专利号: CN 101580828 B
（ 3 ） 一种染色体标本滴片装置, 实用新型, 2011, 第 2 作者, 专利号: CN 101580828 B
（ 4 ） Cell nuclear transfer, 发明, 2005, 第 1 作者, 专利号: P1094DK00
（ 5 ） 一种用于胚胎或细胞的冷冻液及其用途, 发明, 2014, 第 2 作者, 专利号: CN 101580828 B
（ 6 ） 一种人工透明带及其制备方法和用途, 发明, 2014, 第 2 作者, 专利号: CN 102899283 B
（ 7 ） 转基因动物及其制备方法, 发明, 2015, 第 4 作者, 专利号: CN 102367454 B
（ 8 ） 猪假attp位点及其用途, 发明, 2014, 第 5 作者, 专利号: CN 102533741 B
（ 9 ） 一种突变型隐色素基因1和突变型隐色素基因1的转基因猪, 发明, 2015, 第 5 作者, 专利号: CN 103145824 B
（ 10 ） 构建体及其应用, 发明, 2015, 第 5 作者, 专利号: CN 103255168 B
（ 11 ） 封装胚胎的装置及方法, 发明, 2016, 第 2 作者, 专利号: CN 104206375 B
（ 12 ） 从血液中分离、培养细胞的方法及进行克隆非人动物的方法, 发明, 2018, 第 4 作者, 专利号: CN 104513807 B
（ 13 ） 制备克隆小型动物胚胎的方法, 发明, 2019, 第 5 作者, 专利号: CN 105087653 B
（ 14 ） SNP标记及其应用, 发明, 2019, 第 5 作者, 专利号: CN 105821037 B
出版信息
发表论文
[1] 高会霞, 杨林, 郭云, 王逸丛, 刘玉珍, 唐岳, 赫章, 梁鑫明, 黄顺楷, 高鹏, 黄颖, 戴慕巍, 张志, 胡倩, 王瑜玲, 陈芳, 戴二黑, 江平, 杜玉涛. 石家庄新型冠状病毒肺炎疫情新型冠状病毒分子流行病学特征. 中华检验医学杂志[J]. 2022, 45(6): 637-641, http://lib.cqvip.com/Qikan/Article/Detail?id=7107659672.
[2] 高会霞, 杨林, 郭云, 王逸丛, 刘玉珍, 唐岳, 赫章, 梁鑫明, 黄顺楷, 高鹏, 黄颖, 戴慕巍, 张志, 胡倩, 王瑜玲, 陈芳, 戴二黑, 江平, 杜玉涛. 石家庄新型冠状病毒肺炎疫情新型冠状病毒分子流行病学特征. 中华检验医学杂志[J]. 2022, 45(6): 637-641, http://lib.cqvip.com/Qikan/Article/Detail?id=7107659672.
[3] Sjostedt, Evelina, Zhong, Wen, Fagerberg, Linn, Karlsson, Max, Mitsios, Nicholas, Adori, Csaba, Oksvold, Per, Edfors, Fredrik, Limiszewska, Agnieszka, Hikmet, Feria, Huang, Jinrong, Du, Yutao, Lin, Lin, Dong, Zhanying, Yang, Ling, Liu, Xin, Jiang, Hui, Xu, Xun, Wang, Jian, Yang, Huanming, Bolund, Lars, Mardinoglu, Adil, Zhang, Cheng, von Feilitzen, Kalle, Lindskog, Cecilia, Ponten, Fredrik, Luo, Yonglun, Hokfelt, Tomas, Uhlen, Mathias, Mulder, Jan. An atlas of the protein-coding genes in the human, pig, and mouse brain. SCIENCE[J]. 2020, 367(6482): 1090-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000520018400034.
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[5] Jian Liu, Xuemei Qiu, Daoming Wang, Yantao Li, Yang Zong, Yichen Liu, Yue Zhang, Ping Yang, Yong Zuo, Huanming Yang, Jian Wang, Yutao Du, Jin Zi. Quantification of 10 steroid hormones in human saliva from Chinese adult volunteers. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH[J]. 2018, 46(4): 1414-1427, https://www.webofscience.com/wos/woscc/full-record/WOS:000429878200013.
[6] Jian Liu, Xuemei Qiu, Daoming Wang, Yantao Li, Yang Zong, Yichen Liu, Yue Zhang, Ping Yang, Yong Zuo, Huanming Yang, Jian Wang, Yutao Du, Jin Zi. Quantification of 10 steroid hormones in human saliva from Chinese adult volunteers. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH[J]. 2018, 46(4): 1414-1427, https://www.webofscience.com/wos/woscc/full-record/WOS:000429878200013.
[7] Dong, Guoyi, Shang, Zhouchun, Liu, Longqi, Liu, Chuanyu, Ge, Yuping, Wang, Quanlei, Wu, Liang, Chen, Fang, Li, Baolin, Liu, Xin, Xu, Xun, Yang, Huanming, Du, Yutao, Jiang, Hui. Retinoic acid combined with spermatogonial stem cell conditions facilitate the generation of mouse germ-like cells. BIOSCIENCE REPORTS[J]. 2017, 37(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000406241300033.
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[9] Yang, Zhenzhen, Vajta, Gabor, Xu, Ying, Luan, Jing, Lin, Mufei, Liu, Cong, Tian, Jianing, Dou, Hongwei, Li, Yong, Liu, Tianbin, Zhang, Yijie, Li, Lin, Yang, Wenxian, Bolund, Lars, Yang, Huanming, Du, Yutao. Production of Pigs by Hand-Made Cloning Using Mesenchymal Stem Cells and Fibroblasts. CELLULAR REPROGRAMMING[J]. 2016, 18(4): 256-263, https://www.webofscience.com/wos/woscc/full-record/WOS:000380847100007.
[10] Yang, Zhenzhen, Vajta, Gabor, Xu, Ying, Luan, Jing, Lin, Mufei, Liu, Cong, Tian, Jianing, Dou, Hongwei, Li, Yong, Liu, Tianbin, Zhang, Yijie, Li, Lin, Yang, Wenxian, Bolund, Lars, Yang, Huanming, Du, Yutao. Production of Pigs by Hand-Made Cloning Using Mesenchymal Stem Cells and Fibroblasts. CELLULAR REPROGRAMMING[J]. 2016, 18(4): 256-263, https://www.webofscience.com/wos/woscc/full-record/WOS:000380847100007.
[11] Liu, Tianbin, Dou, Hongwei, Xiang, Xi, Li, Lin, Li, Yong, Lin, Lin, Pang, Xinzhi, Zhang, Yijie, Chen, Yu, Luan, Jing, Xu, Ying, Yang, Zhenzhen, Yang, Wenxian, Liu, Huan, Li, Feida, Wang, Hui, Yang, Huanming, Bolund, Lars, Vajta, Gabor, Du, Yutao. Factors Determining the Efficiency of Porcine Somatic Cell Nuclear Transfer: Data Analysis with Over 200,000 Reconstructed Embryos. CELLULAR REPROGRAMMING[J]. 2015, 17(6): 463-471, https://www.webofscience.com/wos/woscc/full-record/WOS:000366311300006.
[12] Li, Feida, Li, Yong, Liu, Huan, Zhang, Xingju, Liu, Chuxin, Tian, Kai, Bolund, Lars, Dou, Hongwei, Yang, Wenxian, Yang, Huanming, Staunstrup, Nicklas Heine, Du, Yutao. Transgenic Wuzhishan minipigs designed to express a dominant-negative porcine growth hormone receptor display small stature and a perturbed insulin/IGF-1 pathway. TRANSGENIC RESEARCH[J]. 2015, 24(6): 1029-1042, https://www.webofscience.com/wos/woscc/full-record/WOS:000365007800009.
[13] Liu, Tianbin, Dou, Hongwei, Xiang, Xi, Li, Lin, Li, Yong, Lin, Lin, Pang, Xinzhi, Zhang, Yijie, Chen, Yu, Luan, Jing, Xu, Ying, Yang, Zhenzhen, Yang, Wenxian, Liu, Huan, Li, Feida, Wang, Hui, Yang, Huanming, Bolund, Lars, Vajta, Gabor, Du, Yutao. Factors Determining the Efficiency of Porcine Somatic Cell Nuclear Transfer: Data Analysis with Over 200,000 Reconstructed Embryos. CELLULAR REPROGRAMMING[J]. 2015, 17(6): 463-471, https://www.webofscience.com/wos/woscc/full-record/WOS:000366311300006.
[14] Li, Feida, Li, Yong, Liu, Huan, Zhang, Xingju, Liu, Chuxin, Tian, Kai, Bolund, Lars, Dou, Hongwei, Yang, Wenxian, Yang, Huanming, Staunstrup, Nicklas Heine, Du, Yutao. Transgenic Wuzhishan minipigs designed to express a dominant-negative porcine growth hormone receptor display small stature and a perturbed insulin/IGF-1 pathway. TRANSGENIC RESEARCH[J]. 2015, 24(6): 1029-1042, https://www.webofscience.com/wos/woscc/full-record/WOS:000365007800009.
[15] 李剑, Gábor, Vajta, 杜玉涛. 植入前遗传学诊断和筛查的最新进展. 中国产前诊断杂志（电子版）[J]. 2014, 34-41, http://lib.cqvip.com/Qikan/Article/Detail?id=1005330911.
[16] Tan, Yueqiu, Yin, Xuyang, Zhang, Shuoping, Jiang, Hui, Tan, Ke, Li, Jian, Xiong, Bo, Gong, Fei, Zhang, Chunlei, Pan, Xiaoyu, Chen, Fang, Chen, Shengpei, Gong, Chun, Lu, Changfu, Luo, Keli, Gu, Yifan, Zhang, Xiuqing, Wang, Wei, Xu, Xun, Vajta, Gabor, Bolund, Lars, Yang, Huanming, Lu, Guangxiu, Du, Yutao, Lin, Ge. Clinical outcome of preimplantation genetic diagnosis and screening using next generation sequencing. GIGASCIENCE[J]. 2014, 3(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000365658900001.
[17] 李剑, Gábor, Vajta, 杜玉涛. 植入前遗传学诊断和筛查的最新进展. 中国产前诊断杂志（电子版）[J]. 2014, 34-41, http://lib.cqvip.com/Qikan/Article/Detail?id=1005330911.
[18] Tan, Yueqiu, Yin, Xuyang, Zhang, Shuoping, Jiang, Hui, Tan, Ke, Li, Jian, Xiong, Bo, Gong, Fei, Zhang, Chunlei, Pan, Xiaoyu, Chen, Fang, Chen, Shengpei, Gong, Chun, Lu, Changfu, Luo, Keli, Gu, Yifan, Zhang, Xiuqing, Wang, Wei, Xu, Xun, Vajta, Gabor, Bolund, Lars, Yang, Huanming, Lu, Guangxiu, Du, Yutao, Lin, Ge. Clinical outcome of preimplantation genetic diagnosis and screening using next generation sequencing. GIGASCIENCE[J]. 2014, 3(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000365658900001.
[19] Huan Liu, Yong Li, Qiang Wei, Chunxin Liu, Lars Bolund, Gbor Vajta, Hongwei Dou, Wenxian Yang, Ying Xu, Jing Luan, Jun Wang, Huanming Yang, Nicklas Heine Staunstrup, Yutao Du. Development of Transgenic Minipigs with Expression of Antimorphic Human Cryptochrome 1. PLOS ONE[J]. 2013, 8(10): https://doaj.org/article/fb16aa19bbcd42aab18cc51ca70f86a8.
[20] Zhang, Peng, Liu, Peng, Dou, Hongwei, Chen, Lei, Chen, Longxin, Lin, Lin, Tan, Pingping, Vajta, Gabor, Gao, Jianfeng, Du, Yutao, Ma, Runlin Z. Handmade Cloned Transgenic Sheep Rich in Omega-3 Fatty Acids. PLOS ONE[J]. 2013, 8(2): http://dx.doi.org/10.1371/journal.pone.0055941.
[21] Fan, Nana, Chen, Jijun, Shang, Zhouchun, Dou, Hongwei, Ji, Guangzhen, Zou, Qingjian, Wu, Lu, He, Lixiazi, Wang, Fang, Liu, Kai, Liu, Na, Han, Jianyong, Zhou, Qi, Pan, Dengke, Yang, Dongshan, Zhao, Bentian, Ouyang, Zhen, Liu, Zhaoming, Zhao, Yu, Lin, Lin, Zhong, Chongming, Wang, Quanlei, Wang, Shouqi, Xu, Ying, Luan, Jing, Liang, Yu, Yang, Zhenzhen, Li, Jing, Lu, Chunxia, Vajta, Gabor, Li, Ziyi, Ouyang, Hongsheng, Wang, Huayan, Wang, Yong, Yang, Yang, Liu, Zhonghua, Wei, Hong, Luan, Zhidong, Esteban, Miguel A, Deng, Hongkui, Yang, Huanming, Pei, Duanqing, Li, Ning, Pei, Gang, Liu, Lin, Du, Yutao, Xiao, Lei, Lai, Liangxue. Piglets cloned from induced pluripotent stem cells. CELL RESEARCH. 2013, 23(1): 162-166, https://www.webofscience.com/wos/woscc/full-record/WOS:000313194700019.
[22] Huan Liu, Yong Li, Qiang Wei, Chunxin Liu, Lars Bolund, Gbor Vajta, Hongwei Dou, Wenxian Yang, Ying Xu, Jing Luan, Jun Wang, Huanming Yang, Nicklas Heine Staunstrup, Yutao Du. Development of Transgenic Minipigs with Expression of Antimorphic Human Cryptochrome 1. PLOS ONE[J]. 2013, 8(10): https://doaj.org/article/fb16aa19bbcd42aab18cc51ca70f86a8.
[23] Zhang, Peng, Liu, Peng, Dou, Hongwei, Chen, Lei, Chen, Longxin, Lin, Lin, Tan, Pingping, Vajta, Gabor, Gao, Jianfeng, Du, Yutao, Ma, Runlin Z. Handmade Cloned Transgenic Sheep Rich in Omega-3 Fatty Acids. PLOS ONE[J]. 2013, 8(2): http://dx.doi.org/10.1371/journal.pone.0055941.
[24] Fan, Nana, Chen, Jijun, Shang, Zhouchun, Dou, Hongwei, Ji, Guangzhen, Zou, Qingjian, Wu, Lu, He, Lixiazi, Wang, Fang, Liu, Kai, Liu, Na, Han, Jianyong, Zhou, Qi, Pan, Dengke, Yang, Dongshan, Zhao, Bentian, Ouyang, Zhen, Liu, Zhaoming, Zhao, Yu, Lin, Lin, Zhong, Chongming, Wang, Quanlei, Wang, Shouqi, Xu, Ying, Luan, Jing, Liang, Yu, Yang, Zhenzhen, Li, Jing, Lu, Chunxia, Vajta, Gabor, Li, Ziyi, Ouyang, Hongsheng, Wang, Huayan, Wang, Yong, Yang, Yang, Liu, Zhonghua, Wei, Hong, Luan, Zhidong, Esteban, Miguel A, Deng, Hongkui, Yang, Huanming, Pei, Duanqing, Li, Ning, Pei, Gang, Liu, Lin, Du, Yutao, Xiao, Lei, Lai, Liangxue. Piglets cloned from induced pluripotent stem cells. CELL RESEARCH. 2013, 23(1): 162-166, https://www.webofscience.com/wos/woscc/full-record/WOS:000313194700019.
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[17] 李剑, Gábor, Vajta, 杜玉涛. 植入前遗传学诊断和筛查的最新进展. 中国产前诊断杂志（电子版）[J]. 2014, 34-41, http://lib.cqvip.com/Qikan/Article/Detail?id=1005330911.
[18] Tan, Yueqiu, Yin, Xuyang, Zhang, Shuoping, Jiang, Hui, Tan, Ke, Li, Jian, Xiong, Bo, Gong, Fei, Zhang, Chunlei, Pan, Xiaoyu, Chen, Fang, Chen, Shengpei, Gong, Chun, Lu, Changfu, Luo, Keli, Gu, Yifan, Zhang, Xiuqing, Wang, Wei, Xu, Xun, Vajta, Gabor, Bolund, Lars, Yang, Huanming, Lu, Guangxiu, Du, Yutao, Lin, Ge. Clinical outcome of preimplantation genetic diagnosis and screening using next generation sequencing. GIGASCIENCE[J]. 2014, 3(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000365658900001.
[19] Huan Liu, Yong Li, Qiang Wei, Chunxin Liu, Lars Bolund, Gbor Vajta, Hongwei Dou, Wenxian Yang, Ying Xu, Jing Luan, Jun Wang, Huanming Yang, Nicklas Heine Staunstrup, Yutao Du. Development of Transgenic Minipigs with Expression of Antimorphic Human Cryptochrome 1. PLOS ONE[J]. 2013, 8(10): https://doaj.org/article/fb16aa19bbcd42aab18cc51ca70f86a8.
[20] Zhang, Peng, Liu, Peng, Dou, Hongwei, Chen, Lei, Chen, Longxin, Lin, Lin, Tan, Pingping, Vajta, Gabor, Gao, Jianfeng, Du, Yutao, Ma, Runlin Z. Handmade Cloned Transgenic Sheep Rich in Omega-3 Fatty Acids. PLOS ONE[J]. 2013, 8(2): http://dx.doi.org/10.1371/journal.pone.0055941.
[21] Fan, Nana, Chen, Jijun, Shang, Zhouchun, Dou, Hongwei, Ji, Guangzhen, Zou, Qingjian, Wu, Lu, He, Lixiazi, Wang, Fang, Liu, Kai, Liu, Na, Han, Jianyong, Zhou, Qi, Pan, Dengke, Yang, Dongshan, Zhao, Bentian, Ouyang, Zhen, Liu, Zhaoming, Zhao, Yu, Lin, Lin, Zhong, Chongming, Wang, Quanlei, Wang, Shouqi, Xu, Ying, Luan, Jing, Liang, Yu, Yang, Zhenzhen, Li, Jing, Lu, Chunxia, Vajta, Gabor, Li, Ziyi, Ouyang, Hongsheng, Wang, Huayan, Wang, Yong, Yang, Yang, Liu, Zhonghua, Wei, Hong, Luan, Zhidong, Esteban, Miguel A, Deng, Hongkui, Yang, Huanming, Pei, Duanqing, Li, Ning, Pei, Gang, Liu, Lin, Du, Yutao, Xiao, Lei, Lai, Liangxue. Piglets cloned from induced pluripotent stem cells. CELL RESEARCH. 2013, 23(1): 162-166, https://www.webofscience.com/wos/woscc/full-record/WOS:000313194700019.
[22] Huan Liu, Yong Li, Qiang Wei, Chunxin Liu, Lars Bolund, Gbor Vajta, Hongwei Dou, Wenxian Yang, Ying Xu, Jing Luan, Jun Wang, Huanming Yang, Nicklas Heine Staunstrup, Yutao Du. Development of Transgenic Minipigs with Expression of Antimorphic Human Cryptochrome 1. PLOS ONE[J]. 2013, 8(10): https://doaj.org/article/fb16aa19bbcd42aab18cc51ca70f86a8.
[23] Zhang, Peng, Liu, Peng, Dou, Hongwei, Chen, Lei, Chen, Longxin, Lin, Lin, Tan, Pingping, Vajta, Gabor, Gao, Jianfeng, Du, Yutao, Ma, Runlin Z. Handmade Cloned Transgenic Sheep Rich in Omega-3 Fatty Acids. PLOS ONE[J]. 2013, 8(2): http://dx.doi.org/10.1371/journal.pone.0055941.
[24] Fan, Nana, Chen, Jijun, Shang, Zhouchun, Dou, Hongwei, Ji, Guangzhen, Zou, Qingjian, Wu, Lu, He, Lixiazi, Wang, Fang, Liu, Kai, Liu, Na, Han, Jianyong, Zhou, Qi, Pan, Dengke, Yang, Dongshan, Zhao, Bentian, Ouyang, Zhen, Liu, Zhaoming, Zhao, Yu, Lin, Lin, Zhong, Chongming, Wang, Quanlei, Wang, Shouqi, Xu, Ying, Luan, Jing, Liang, Yu, Yang, Zhenzhen, Li, Jing, Lu, Chunxia, Vajta, Gabor, Li, Ziyi, Ouyang, Hongsheng, Wang, Huayan, Wang, Yong, Yang, Yang, Liu, Zhonghua, Wei, Hong, Luan, Zhidong, Esteban, Miguel A, Deng, Hongkui, Yang, Huanming, Pei, Duanqing, Li, Ning, Pei, Gang, Liu, Lin, Du, Yutao, Xiao, Lei, Lai, Liangxue. Piglets cloned from induced pluripotent stem cells. CELL RESEARCH. 2013, 23(1): 162-166, https://www.webofscience.com/wos/woscc/full-record/WOS:000313194700019.
[25] Yutao Du, Songgang Li, Shutang Feng, Jian Wang, Huanming Yang, Lars Bolund, Jun Wang, Yingrui Li, Guojie Zhang, Liangxue Lai, Shulin Yang, Guangbiao Wang, Kui Li, Juan Wang, Chuxin Liu, Lijie Ren, Likai Mao, Dingding Fan, Huan Liu, Lan Yang, Zhiqiang Xiong, Xiaoqing Sun, Wei Zhao, Xuanting Jiang, Yuanxin Chen, Yue Feng, Yanfeng Zhang, Lijuan Han, Yong Li, Zhiyong Huang, Yulian Mou, Xiaodong Fang. The sequence and analysis of a Chinese pig genome. 2012, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201706309352780ZK.
[26] Cheng, Linzhao, Hansen, Nancy F, Zhao, Ling, Du, Yutao, Zou, Chunlin, Donovan, Frank X, Chou, BinKuan, Zhou, Guangyu, Li, Shijie, Dowey, Sarah N, Ye, Zhaohui, Chandrasekharappa, Settara C, Yang, Huanming, Mullikin, James C, Liu, P Paul, NISC Comparative Sequencing Progra. Low Incidence of DNA Sequence Variation in Human Induced Pluripotent Stem Cells Generated by Nonintegrating Plasmid Expression. CELL STEM CELL[J]. 2012, 10(3): 337-344, http://dx.doi.org/10.1016/j.stem.2012.01.005.
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[28] Yutao Du, Songgang Li, Shutang Feng, Jian Wang, Huanming Yang, Lars Bolund, Jun Wang, Yingrui Li, Guojie Zhang, Liangxue Lai, Shulin Yang, Guangbiao Wang, Kui Li, Juan Wang, Chuxin Liu, Lijie Ren, Likai Mao, Dingding Fan, Huan Liu, Lan Yang, Zhiqiang Xiong, Xiaoqing Sun, Wei Zhao, Xuanting Jiang, Yuanxin Chen, Yue Feng, Yanfeng Zhang, Lijuan Han, Yong Li, Zhiyong Huang, Yulian Mou, Xiaodong Fang. The sequence and analysis of a Chinese pig genome. 2012, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201706309352780ZK.
[29] Cheng, Linzhao, Hansen, Nancy F, Zhao, Ling, Du, Yutao, Zou, Chunlin, Donovan, Frank X, Chou, BinKuan, Zhou, Guangyu, Li, Shijie, Dowey, Sarah N, Ye, Zhaohui, Chandrasekharappa, Settara C, Yang, Huanming, Mullikin, James C, Liu, P Paul, NISC Comparative Sequencing Progra. Low Incidence of DNA Sequence Variation in Human Induced Pluripotent Stem Cells Generated by Nonintegrating Plasmid Expression. CELL STEM CELL[J]. 2012, 10(3): 337-344, http://dx.doi.org/10.1016/j.stem.2012.01.005.
[30] Zhang, Peng, Zhang, Yidi, Dou, Hongwei, Yin, Jingdong, Chen, Yu, Pang, Xinzhi, Vajta, Gabor, Bolund, Lars, Du, Yutao, Ma, Runlin Z. Handmade Cloned Transgenic Piglets Expressing the Nematode Fat-1 Gene. CELLULAR REPROGRAMMING[J]. 2012, 14(3): 258-266, http://dx.doi.org/10.1089/cell.2011.0073.
[31] Fei Gao, Yonglun Luo, Shengting Li, Jian Li, Lin Lin, Anders Lade Nielsen, Charlotte Brandt Srensen, Gbor Vajta, Jun Wang, Xiuqing Zhang, Yutao Du, Huanming Yang, Lars Bolund. Comparison of Gene Expression and Genome-Wide DNA Methylation Profiling between Phenotypically Normal Cloned Pigs and Conventionally Bred Controls. PLOS ONE[J]. 2011, 6(10): http://dx.doi.org/10.1371/journal.pone.0025901.
[32] Luo, Yonglun, Li, Juan, Liu, Ying, Lin, Lin, Du, Yutao, Li, Shengting, Yang, Huanming, Vajta, Gabor, Callesen, Henrik, Bolund, Lars, Sorensen, Charlotte Brandt. High efficiency of BRCA1 knockout using rAAV-mediated gene targeting: developing a pig model for breast cancer. TRANSGENIC RESEARCH[J]. 2011, 20(5): 975-988, https://www.webofscience.com/wos/woscc/full-record/WOS:000296786900002.
[33] Fei Gao, Yonglun Luo, Shengting Li, Jian Li, Lin Lin, Anders Lade Nielsen, Charlotte Brandt Srensen, Gbor Vajta, Jun Wang, Xiuqing Zhang, Yutao Du, Huanming Yang, Lars Bolund. Comparison of Gene Expression and Genome-Wide DNA Methylation Profiling between Phenotypically Normal Cloned Pigs and Conventionally Bred Controls. PLOS ONE[J]. 2011, 6(10): http://dx.doi.org/10.1371/journal.pone.0025901.
[34] Luo, Yonglun, Li, Juan, Liu, Ying, Lin, Lin, Du, Yutao, Li, Shengting, Yang, Huanming, Vajta, Gabor, Callesen, Henrik, Bolund, Lars, Sorensen, Charlotte Brandt. High efficiency of BRCA1 knockout using rAAV-mediated gene targeting: developing a pig model for breast cancer. TRANSGENIC RESEARCH[J]. 2011, 20(5): 975-988, https://www.webofscience.com/wos/woscc/full-record/WOS:000296786900002.
[35] Lin, Lin, Pribenszky, Csaba, Molnar, Miklos, Kragh, Peter M, Du, Yutao, Zhang, Xiuqing, Yang, Huanming, Bolund, Lars, Callesen, Henrik, Machaty, Zoltan, Vajta, Gabor. High Hydrostatic Pressure Treatment of Porcine Oocytes Induces Parthenogenetic Activation. CELLULAR REPROGRAMMING[J]. 2010, 12(4): 475-480, https://www.webofscience.com/wos/woscc/full-record/WOS:000280329200010.
[36] Pribenszky, Csaba, Vajta, Gabor, Molnar, Miklos, Du, Yutao, Lin, Lin, Bolund, Lars, Yovich, John. Stress for Stress Tolerance? A Fundamentally New Approach in Mammalian Embryology. BIOLOGY OF REPRODUCTIONnull. 2010, 83(5): 690-697, https://www.webofscience.com/wos/woscc/full-record/WOS:000283398900002.
[37] Lin, Lin, Pribenszky, Csaba, Molnar, Miklos, Kragh, Peter M, Du, Yutao, Zhang, Xiuqing, Yang, Huanming, Bolund, Lars, Callesen, Henrik, Machaty, Zoltan, Vajta, Gabor. High Hydrostatic Pressure Treatment of Porcine Oocytes Induces Parthenogenetic Activation. CELLULAR REPROGRAMMING[J]. 2010, 12(4): 475-480, https://www.webofscience.com/wos/woscc/full-record/WOS:000280329200010.
[38] Pribenszky, Csaba, Vajta, Gabor, Molnar, Miklos, Du, Yutao, Lin, Lin, Bolund, Lars, Yovich, John. Stress for Stress Tolerance? A Fundamentally New Approach in Mammalian Embryology. BIOLOGY OF REPRODUCTIONnull. 2010, 83(5): 690-697, https://www.webofscience.com/wos/woscc/full-record/WOS:000283398900002.
[39] Lin, Lin, Kragh, Peter M, Purup, Stig, Kuwayama, Masashige, Du, Yutao, Zhang, Xiuqing, Yang, Huanming, Bolund, Lars, Callesen, Henrik, Vajta, Gabor. Osmotic stress induced by sodium chloride, sucrose or trehalose improves cryotolerance and developmental competence of porcine oocytes. REPRODUCTION FERTILITY AND DEVELOPMENT[J]. 2009, 21(2): 338-344, https://www.webofscience.com/wos/woscc/full-record/WOS:000262811400009.
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[41] Lin, Lin, Kragh, Peter M, Purup, Stig, Kuwayama, Masashige, Du, Yutao, Zhang, Xiuqing, Yang, Huanming, Bolund, Lars, Callesen, Henrik, Vajta, Gabor. Osmotic stress induced by sodium chloride, sucrose or trehalose improves cryotolerance and developmental competence of porcine oocytes. REPRODUCTION FERTILITY AND DEVELOPMENT[J]. 2009, 21(2): 338-344, https://www.webofscience.com/wos/woscc/full-record/WOS:000262811400009.
[42] Lin, Lin, Du, Yutao, Liu, Ying, Kragh, Peter M, Li, Juan, Purup, Stig, Kuwayama, Masashige, Zhang, Xiuqing, Yang, Huanming, Bolund, Lars, Vajta, Gabor. Elevated NaCl concentration improves cryotolerance and developmental competence of porcine oocytes. REPRODUCTIVE BIOMEDICINE ONLINE[J]. 2009, 18(3): 360-366, http://dx.doi.org/10.1016/S1472-6483(10)60094-6.
[43] Du, Yutao, Lin, Lin, Schmidt, Mette, Bogh, Ingrid B, Kragh, Peter M, Sorensen, Charlotte B, Li, Juan, Purup, Stig, Pribenszky, Csaba, Molnar, Molnar, Kuwayama, Masaabc, Zhang, Xiuqing, Yang, Huanming, Bolund, Lars, Vajta, Gabor. High hydrostatic pressure treatment of porcine oocytes before handmade cloning improves developmental competence and cryosurvival. CLONING AND STEM CELLS[J]. 2008, 10(3): 325-330, https://www.webofscience.com/wos/woscc/full-record/WOS:000259313100004.
[44] Liu, Ying, Du, Yutao, Lin, Lin, Li, Juan, Kragh, Peter M, Kuwayama, Masashige, Bolund, Lars, Yang, Huanming, Vajta, Gabor. Comparison of efficiency of open pulled straw (OPS) and Cryotop vitrification for cryopreservation of in vitro matured pig oocytes. CRYOLETTERS[J]. 2008, 29(4): 315-320, https://www.webofscience.com/wos/woscc/full-record/WOS:000258850300006.
[45] Du, Y, Pribenszky, C S, Molnar, M, Zhang, X, Yang, H, Kuwayama, M, Pedersen, A M, Villemoes, K, Bolund, L, Vajta, G. High hydrostatic pressure: a new way to improve in vitro developmental competence of porcine matured oocytes after vitrification. REPRODUCTION[J]. 2008, 135(1): 13-17, https://www.webofscience.com/wos/woscc/full-record/WOS:000252309100002.
[46] Vajta, Gabor, Korosi, Tamas, Du, Yutao, Nakata, Kumiko, Ieda, Shoko, Kuwayama, Masashige, Nagy, Zsolt Peter. The Well-of-the-Well system: an efficient approach to improve embryo development. REPRODUCTIVE BIOMEDICINE ONLINE[J]. 2008, 17(1): 73-81, http://dx.doi.org/10.1016/S1472-6483(10)60296-9.
[47] Du, Yutao, Lin, Lin, Schmidt, Mette, Bogh, Ingrid B, Kragh, Peter M, Sorensen, Charlotte B, Li, Juan, Purup, Stig, Pribenszky, Csaba, Molnar, Molnar, Kuwayama, Masaabc, Zhang, Xiuqing, Yang, Huanming, Bolund, Lars, Vajta, Gabor. High hydrostatic pressure treatment of porcine oocytes before handmade cloning improves developmental competence and cryosurvival. CLONING AND STEM CELLS[J]. 2008, 10(3): 325-330, https://www.webofscience.com/wos/woscc/full-record/WOS:000259313100004.
[48] Liu, Ying, Du, Yutao, Lin, Lin, Li, Juan, Kragh, Peter M, Kuwayama, Masashige, Bolund, Lars, Yang, Huanming, Vajta, Gabor. Comparison of efficiency of open pulled straw (OPS) and Cryotop vitrification for cryopreservation of in vitro matured pig oocytes. CRYOLETTERS[J]. 2008, 29(4): 315-320, https://www.webofscience.com/wos/woscc/full-record/WOS:000258850300006.
[49] Du, Y, Pribenszky, C S, Molnar, M, Zhang, X, Yang, H, Kuwayama, M, Pedersen, A M, Villemoes, K, Bolund, L, Vajta, G. High hydrostatic pressure: a new way to improve in vitro developmental competence of porcine matured oocytes after vitrification. REPRODUCTION[J]. 2008, 135(1): 13-17, https://www.webofscience.com/wos/woscc/full-record/WOS:000252309100002.
[50] Vajta, Gabor, Korosi, Tamas, Du, Yutao, Nakata, Kumiko, Ieda, Shoko, Kuwayama, Masashige, Nagy, Zsolt Peter. The Well-of-the-Well system: an efficient approach to improve embryo development. REPRODUCTIVE BIOMEDICINE ONLINE[J]. 2008, 17(1): 73-81, http://dx.doi.org/10.1016/S1472-6483(10)60296-9.
[51] Du, Yutao, Li, Juan, Kragh, Peter M, Zhang, Yunhai, Schmidt, Mette, Bogh, Ingrid B, Zhang, Xiuqing, Purup, Stig, Kuwayama, M, Jorgensen, Arne L, Pedersen, Anette M, Villemoes, Klaus, Yang, Huanming, Bolund, Lars, Vajtai, Gabor. Piglets born from vitrified cloned blastocysts produced with a simplified method of delipation and nuclear transfer. CLONING AND STEM CELLS[J]. 2007, 9(4): 469-476, https://www.webofscience.com/wos/woscc/full-record/WOS:000252027800003.
[52] Du, Y, Kragh, P M, Zhang, Y, Li, J, Schmidt, M, Bogh, I B, Zhang, X, Purup, S, Jorgensen, A L, Pedersen, A M, Villemoes, K, Yang, H, Bolund, L, Vajta, G. Piglets born from handmade cloning, an innovative cloning method without micromanipulation. THERIOGENOLOGY[J]. 2007, 68(8): 1104-1110, http://dx.doi.org/10.1016/j.theriogenology.2007.07.021.
[53] Du, Y, Zhang, Y, Li, J, Kragh, P M, Kuwayama, M, Ieda, S, Zhang, X, Schmidt, M, Bogh, I B, Purup, S, Pedersen, A M, Villemoes, K, Yang, H, Bolund, L, Vajta, G. Simplified cryopreservation of porcine cloned blastocysts. CRYOBIOLOGY[J]. 2007, 54(2): 181-187, http://dx.doi.org/10.1016/j.cryobiol.2007.01.001.
[54] Du, Yutao, Li, Juan, Kragh, Peter M, Zhang, Yunhai, Schmidt, Mette, Bogh, Ingrid B, Zhang, Xiuqing, Purup, Stig, Kuwayama, M, Jorgensen, Arne L, Pedersen, Anette M, Villemoes, Klaus, Yang, Huanming, Bolund, Lars, Vajtai, Gabor. Piglets born from vitrified cloned blastocysts produced with a simplified method of delipation and nuclear transfer. CLONING AND STEM CELLS[J]. 2007, 9(4): 469-476, https://www.webofscience.com/wos/woscc/full-record/WOS:000252027800003.
[55] Du, Y, Kragh, P M, Zhang, Y, Li, J, Schmidt, M, Bogh, I B, Zhang, X, Purup, S, Jorgensen, A L, Pedersen, A M, Villemoes, K, Yang, H, Bolund, L, Vajta, G. Piglets born from handmade cloning, an innovative cloning method without micromanipulation. THERIOGENOLOGY[J]. 2007, 68(8): 1104-1110, http://dx.doi.org/10.1016/j.theriogenology.2007.07.021.
[56] Du, Y, Zhang, Y, Li, J, Kragh, P M, Kuwayama, M, Ieda, S, Zhang, X, Schmidt, M, Bogh, I B, Purup, S, Pedersen, A M, Villemoes, K, Yang, H, Bolund, L, Vajta, G. Simplified cryopreservation of porcine cloned blastocysts. CRYOBIOLOGY[J]. 2007, 54(2): 181-187, http://dx.doi.org/10.1016/j.cryobiol.2007.01.001.
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[58] Du, Y, Kragh, PM, Zhang, X, Purup, S, Yang, H, Bolund, L, Vajta, G. High overall in vitro efficiency of porcine handmade cloning (HMC) combining partial zona digestion and oocyte trisection with sequential culture. CLONING AND STEM CELLS[J]. 2005, 7(3): 199-205, [59] Du Yutao. Post-hatching development of the porcine and bovine embryo--defining criteria for expected development in vivo and in vitro. Theriogenology. 2005, [60] Kragh, PM, Du, Y, Corydon, TJ, Purup, S, Bolund, L, Vajta, G. Efficient in vitro production of porcine blastocysts by handmade cloning with a combined electrical and chemical activation. THERIOGENOLOGY[J]. 2005, 64(7): 1536-1545, http://dx.doi.org/10.1016/j.theriogenology.2005.03.021.
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科研活动
科研项目
（ 1 ） 项目“发育与生殖重要哺乳动物模型的建立”课题—小型猪基因组学研究, 参与, 国家级, 2011-01--2015-12
（ 2 ） 无标记定点整合动物转基因技术研究, 主持, 省级, 2012-11--2014-10
（ 3 ） 手工克隆小鼠项目研究, 主持, 省级, 2013-01--2015-01
（ 4 ） 手工克隆技术产业化推广项目, 主持, 省级, 2012-04--2014-03
（ 5 ） 超小型迷你猪转基因项目研究, 主持, 省级, 2011-02--2014-04
（ 6 ） 特异们点整合的安全高效转基因技术开发, 主持, 国家级, 2014-01--2016-12
（ 7 ） 干细胞与生殖细胞保存应用技术开发暨临床应用级（干）细胞库的建立, 主持, 省级, 2013-07--2015-07
（ 8 ） 基于Cas9-guid RNA共表达系统构建乳腺特异性敲除BRCA1基因小鼠的研究, 主持, 省级, 2014-12--2017-08
（ 9 ） 深圳动物基因组辅助育种工程实验室提升, 主持, 省级, 2016-07--2019-06
（ 10 ） 脑疾病患者多潜能干细胞模型的建立和应用研究, 主持, 省级, 2019-06--2022-06
（ 2 ） 无标记定点整合动物转基因技术研究, 主持, 省级, 2012-11--2014-10
（ 3 ） 手工克隆小鼠项目研究, 主持, 省级, 2013-01--2015-01
（ 4 ） 手工克隆技术产业化推广项目, 主持, 省级, 2012-04--2014-03
（ 5 ） 超小型迷你猪转基因项目研究, 主持, 省级, 2011-02--2014-04
（ 6 ） 特异们点整合的安全高效转基因技术开发, 主持, 国家级, 2014-01--2016-12
（ 7 ） 干细胞与生殖细胞保存应用技术开发暨临床应用级（干）细胞库的建立, 主持, 省级, 2013-07--2015-07
（ 8 ） 基于Cas9-guid RNA共表达系统构建乳腺特异性敲除BRCA1基因小鼠的研究, 主持, 省级, 2014-12--2017-08
（ 9 ） 深圳动物基因组辅助育种工程实验室提升, 主持, 省级, 2016-07--2019-06
（ 10 ） 脑疾病患者多潜能干细胞模型的建立和应用研究, 主持, 省级, 2019-06--2022-06