非编码RNA在肿瘤中的功能研究，RNA与RNA结合蛋白的相互作用在基因表达调控中的机理研究。

2023年 招收生物化学与分子生物学,细胞生物学,化学生物学 硕士研究生1名

071010-生物化学与分子生物学
071009-细胞生物学
0703Z1-化学生物学

生物化学与分子生物学,细胞生物学,化学生物学

2008-09--2012-06   中国科学技术大学   博士学位
2005-09--2008-06   西南大学   硕士学位

   

（ 1 ） 一种捕获核酸结合蛋白的方法和试剂盒, 发明专利, 2017, 第 5 作者, 专利号: CN201710080808.9

   

[1] Menghui Yin, Meidie Cheng, Chengli Liu, Keli Wu, Wei Xiong, Ji Fang, Yinxiong Li, Biliang Zhang. HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6. ISCIENCE[J]. 2021, 24(11): 103345-, [2] Hou, Linlin, Wei, Yuanjie, Lin, Yingying, Wang, Xiwei, Lai, Yiwei, Yin, Menghui, Chen, Yanpu, Guo, Xiangpeng, Wu, Senbin, Zhu, Yindi, Yuan, Jie, Tariq, Muqddas, Li, Na, Sun, Hao, Wang, Huating, Zhang, Xiaofei, Chen, Jiekai, Bao, Xichen, Jauch, Ralf. Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(7): 3869-3887, http://dx.doi.org/10.1093/nar/gkaa067.
[3] Xu, Tingting, Gan, Qingqing, Wu, Bin, Yin, Menghui, Xu, Jinxin, Shu, Xiaodong, Liu, Jinsong. Molecular Basis for PI(3,5)P-2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation. JOURNAL OF MOLECULAR BIOLOGY[J]. 2020, 432(16): 4750-4761, http://dx.doi.org/10.1016/j.jmb.2020.06.010.
[4] Bao, Xichen, Guo, Xiangpeng, Yin, Menghui, Tariq, Muqddas, Lai, Yiwei, Kanwal, Shahzina, Zhou, Jiajian, Li, Na, Lv, Yuan, PulidoQuetglas, Carlos, Wang, Xiwei, Ji, Lu, Khan, Muhammad J, Zhu, Xihua, Luo, Zhiwei, Shao, Changwei, Lim, DoHwan, Liu, Xiao, Li, Nan, Wang, Wei, He, Minghui, Liu, YuLin, Ward, Carl, Wang, Tong, Zhang, Gong, Wang, Dongye, Yang, Jianhua, Chen, Yiwen, Zhang, Chaolin, Jauch, Ralf, Yang, YunGui, Wang, Yangming, Qin, Baoming, Anko, MinnaLiisa, Hutchins, Andrew P, Sun, Hao, Wang, Huating, Fu, XiangDong, Zhang, Biliang, Esteban, Miguel A. Capturing the interactome of newly transcribed RNA. NATURE METHODS[J]. 2018, 15(3): 213-+, http://ir.siat.ac.cn:8080/handle/172644/13418.
[5] 尹梦回. Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-κB p65 to evoke reactive oxygen species generation and p53 activation. Oncogene. 2015, [6] Bao, Xichen, Wu, Haitao, Zhu, Xihua, Guo, Xiangpeng, Hutchins, Andrew P, Luo, Zhiwei, Song, Hong, Chen, Yongqiang, Lai, Keyu, Yin, Menghui, Xu, Lingxiao, Zhou, Liang, Chen, Jiekai, Wang, Dongye, Qin, Baoming, Frampton, Jon, Tse, HungFat, Pei, Duanqing, Wang, Huating, Zhang, Biliang, Esteban, Miguel A. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. CELL RESEARCH[J]. 2015, 25(1): 80-92, http://ir.gibh.ac.cn/handle/344009/616.
[7] Chen, Ke, Wang, Wei, Qu, Dezhong, Zhao, Haoting, Xiong, Wei, Luo, Caijie, Yin, Menghui, Zhang, Biliang. 2 '-O-{2,2-dimethyl-2-(2-nitrophenyl) acetyl oxy} methyl protecting group for RNA synthesis. TETRAHEDRON LETTERS[J]. 2013, 54(32): 4281-4284, http://dx.doi.org/10.1016/j.tetlet.2013.06.001.
[8] Feng, Shipeng, Cong, Shujie, Zhang, Xin, Bao, Xichen, Wang, Wei, Li, Huiping, Wang, Zhe, Wang, Guoxin, Xu, Jianzhen, Du, Bowen, Qu, Dezhong, Xiong, Wei, Yin, Menghui, Ren, Xiaoshuai, Wang, Feifei, He, Jianxing, Zhang, Biliang. MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. NUCLEIC ACIDS RESEARCH[J]. 2011, 39(15): 6669-6678, https://www.webofscience.com/wos/woscc/full-record/WOS:000294555800037.

   

（ 1 ） RNA结合蛋白HNRNPA2B1在肺癌中对miRNA功能的调控机制研究, 负责人, 国家任务, 2019-01--2022-12
（ 2 ） 长链非编码RNA在肺癌中的功能研究, 负责人, 地方任务, 2019-04--2021-03
（ 3 ） 3’UTR结合蛋白对miR-506调控靶基因CDK6的机理研究, 负责人, 研究所自选, 2018-01--2019-12

（1）RNA in life science and physics world   松山湖材料实验室氘代设施 SLDF 小型学术 研讨会   2021-05-13