‍‍‍‍2010 - 2014  B.S., School of Life Sciences, Hubei University

2014 - 2019  Ph.D., Institute of Biophysics, Chinese Academy of Sciences

2020 - 2024  Postdoctoral Fellow, National Cancer Institute, NIH

2024 -           Principle Investigator, Institute of Biophysics, CAS‍

Genomic instability is a key driver of neurodegenerative diseases, cancer, and immune-inflammatory disorders. DNA damage triggers repair mechanisms and activates intricate cellular signaling pathways that ultimately dictate cell fate-repair, apoptosis, or senescence.

Our main research topics include:

1. DNA Repair with epigenetic regulation.

2. Functional mechanisms of DNA damage in postmitotic cells like neuron and macrophage.

3. The role of non-coding RNAs and other epigenetic factors in DNA damage and repair.

(1) Dongpeng Wang; Wei Wu; Elsa Callen; Raphael Pavani; Nicholas Zolnerowich; Srikanth Kodali; Dali Zong; Nancy Wong; Santiago Noriega; William J. Nathan; Gabriel Matos-Rodrigues; Raj Chari; Michael J. Kruhlak; Ferenc Livak; Michael Ward; Keith Caldecott; Bruno Di Stefano; André Nussenzweig ; Active DNA demethylation promotes cell fate specification and the DNA damage response, Science, 2022, 378(6623): 983-989 ( first author,  highlighted by Science, Nature reviews molecular cell biology, Nature structural & molecular biology，Cancer discovery)

(2) Chong Zhang; Dongpeng Wang; Yajing Hao; Shuheng Wu; Jianjun Luo; Yuanchao Xue; Di Wang; Guohong Li; Lihui Liu; Changwei Shao; Huiyan Li; Jinfeng Yuan; Maoxiang Zhu; Xiang-Dong Fu; Xiao Yang; Runsheng Chen; Yan Teng ; LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly, Molecular Cell, 2022, 82(21): 4018-4032.e9 ( co-first author, recommanded by H1 connect )

(3) Yajing Hao; Dongpeng Wang; Shuheng Wu; Xiao Li; Changwei Shao; Peng Zhang; Jia-Yu Chen;  Do-Hwan Lim; Xiang-Dong Fu; Runsheng Chen; Shunmin He ; Active retrotransposons help maintain pericentromeric heterochromatin required for faithful cell division, Genome Research, 2020, 30(11): 1570-1582 ( co-first author )

(4) Wei Wu; Sarah E. Hill; William J. Nathan; Jacob Paiano; Elsa Callen; Dongpeng Wang; Kenta Shinoda; Niek van Wietmarschen; Jennifer M. Colón-Mercado; Dali Zong; Raffaella De Pace; Han-Yu Shih; Steve Coon; Maia Parsadanian; Raphael Pavani; Hana Hanzlikova; Solji Park; Seol Kyoung Jung; Peter J. McHugh; Andres Canela; Chongyi Chen; Rafael Casellas; Keith W. Caldecott; Michael E. Ward; André Nussenzweig ; Neuronal enhancers are hotspots for DNA single-strand break repair, Nature, 2021, 593(7859): 440-444 ( co-author，highlighted by Nature reviews molecular cell biology, )

(5) Shuheng Wu; Erzhong Wu; Dongpeng Wang*; Yiwei Niu; Haiyan Yue; Dongdong Zhang; Jianjun Luo; Di Wu ; LncRNA HRCEG, regulated by HDAC1, inhibits cells proliferation and epithelialmesenchymal- transition in gastric cancer, Cancer genetics, 2020, 241: 25-33 ( co-first author )

(6) Yanying Wang; Pingping Zhu; Jianjun Luo; Jing Wang; Zhiwei Liu; Wei Wu; Ying Du; Buqing Ye; Dongpeng Wang; Lei He; Weizheng Ren; Jianyi Wang; Xianhui Sun; Runsheng Chen; Yong Tian; Zusen Fan ; LncRNA HAND2‐AS1 promotes liver cancer stem cell self‐renewal via BMP signaling, The EMBO Journal, 2019, 38(17): e101110-e101110 ( co-author )

(7) Xiaoli Cui; Ruijin Zhang; Ye Yang; Erzhong Wu; Yiheng Tang; Zhihua Zhao; Chao Li; Lei Yang; Xueyi Teng; Yanzhen Ye; Ya Cui; Feng Xu; Zewen Su; Dongpeng Wang; Dongdong Zhang; Yan Yang; Jianyuan Sun; Jianjun Luo; Shuli Zhang; Runsheng Chen; Jianzhong Jeff Xi ; Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory, Cell Reports, 2022, 38(8): 110398 ( co-author )

(8) Lihui Liu; Ziyang Liu; Qinghua Liu; Wei Wu; Peng Lin; Xing Liu; Yuechuan Zhang; Dongpeng Wang; Briana C. Prager; Ryan C. Gimple; Jichuan Yu; Weixi Zhao; Qiulian Wu; Wei Zhang; Erzhong Wu; Xiaomin Chen; Jianjun Luo; Jeremy N. Rich; Qi Xie; Tao Jiang; Runsheng Chen ; LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2’-Omethylation, Nature Communications, 2023, 14(1) ( co-author )

(9) Zhang, Bao*; Wang, Dongpeng*; Wu, Jing*; Tang, Jun; Chen, Weixiong; Chen, Xiaomin; Zhang, Dongdong; Deng, Yanming; Guo, Mingzhou; Wang, Yuejian; Luo, Jianjun; Chen, Runsheng ; Expression Profiling and Functional Prediction of Long Noncoding RNAs in Nasopharyngeal Nonkeratinizing Carcinoma, DISCOVERY MEDICINE, 2016, 116(21): 239-250 (co-first author )

(10) Cui, Ya; Chen, Xiaowei; Niu, Yiwei; Wang, Dongpeng; Luo, Huaxia; Fan, Zhen; Wang, Dan; Wu, Wei; Teng, Xueyi; He, Shunmin; Luo, Jianjun; Chen, Runsheng ; Dynamic-BM: multispecies Dynamic BodyMap database from temporal RNA-seq data, BRIEFINGS IN BIOINFORMATICS, 2018, 6(19): 1302-1309 ( co-author )