基本信息
丁楠  男  硕导  中国科学院近代物理研究所
电子邮件: dn@impcas.ac.cn
通信地址: 甘肃省兰州市南昌路509号
邮政编码: 730000

研究领域

1. 辐射旁效应及其机理研究

2. 空间辐射的生物学效应研究;

3. 重离子辐射的肿瘤杀伤效应研究

招生信息

   
招生专业
071011-生物物理学
086000-生物与医药
招生方向
辐射生物学
生物与医药

教育背景

2009-09--2013-12   兰州大学   理学博士
2004-09--2007-06   兰州大学   理学硕士
1999-09--2003-06   兰州大学   理学学士

工作经历

   
工作简历
2017-08~2018-10,俄亥俄州立大学,哥伦布,美国, 访问学者
2011-10~2012-04,国立放射医学研究所,千叶,日本, 访问学者
2007-07~现在, 中国科学院近代物理研究所, 科研

专利与奖励

   
专利成果
( 1 ) miR-197在作为肝癌检测标志物中的应用, 发明专利, 2016, 第 1 作者, 专利号: CN105238863A

( 2 ) 循环血miR-34a作为辐射生物标志物在辐射监控中的应用, 发明专利, 2015, 第 4 作者, 专利号: CN104977398A

( 3 ) CD73作为肾透明细胞癌干细胞表面标志物的应用, 发明专利, 2013, 第 7 作者, 专利号: CN103278634A

( 4 ) hsa-miR-185的新用途, 发明专利, 2011, 第 5 作者, 专利号: CN102102102A

出版信息

   
发表论文
[1] Yang, Pengfei, Feng, Xiu, Li, Jin, Zhang, Tianyi, Sheng, Chengyan, Zhang, Liying, Hua, Junrui, Wei, Wenjun, Ding, Nan, He, Jinpeng, Zhang, Yanan, Wang, Jufang, Zhou, Heng. Ionizing radiation downregulates estradiol synthesis via endoplasmic reticulum stress and inhibits the proliferation of estrogen receptor-positive breast cancer cells. CELL DEATH & DISEASE[J]. 2021, 12(11): http://dx.doi.org/10.1038/s41419-021-04328-w.
[2] Li, Xin, Chen, Lei, Zhou, Haitao, Gu, Shaobin, Wu, Ying, Wang, Bing, Zhang, Miaomiao, Ding, Nan, Sun, Jiaju, Pang, Xinyue, Lu, Dong. LsrB, the hub of ABC transporters involved in the membrane damage mechanisms of heavy ion irradiation in Escherichia coli. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY[J]. 2021, 97(12): 1731-1740, [3] 李洋洋, 张苡铭, 魏孔熙, 周婷, 何进鹏, 丁楠, 周谷城, 史桐凡, 柯宜诚, 牛帆, 刘永琦, 张利英. 黄芪不同有效成分对电离辐射致BMSCs DNA损伤防护作用的比较研究. 中国药房. 2020, 31(24): 2987-2992, http://lib.cqvip.com/Qikan/Article/Detail?id=7103607313.
[4] Ding, Nan, Hua, Junrui, He, Jinpeng, Lu, Dong, Wei, Wenjun, Zhang, Yanan, Zhou, Heng, Zhang, Liying, Liu, Yongqi, Zhou, Guangming, Wang, Jufang. The Role of MiR-5094 as a Proliferation Suppressor during Cellular Radiation Response via Downregulating STAT5b. JOURNAL OF CANCER[J]. 2020, 11(8): 2222-2233, https://www.webofscience.com/wos/woscc/full-record/WOS:000512898800022.
[5] LiYing Zhang, Ting Zhou, YiMing Zhang, XiaoMin Xu, YangYang Li, KongXi Wei, JinPeng He, Nan Ding, Heng Zhou, YongQi Liu. Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE[J]. 2020, 2020: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591278/.
[6] Zhu, Qianzheng, Ding, Nan, Wei, Shengcai, Li, Ping, Wani, Gulzar, He, Jinshan, Wani, Altaf A. USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage. CELL CYCLE[J]. 2020, 19(1): 124-141, https://www.webofscience.com/wos/woscc/full-record/WOS:000499046400001.
[7] Wei, Wenjun, Bai, Hao, Feng, Xiu, Hua, Junrui, Long, Kaiqin, He, Jinpeng, Zhang, Yanan, Ding, Nan, Wang, Jufang, Zhou, Heng. Serum Proteins as New Biomarkers for Whole-Body Exposure to High- and Low-LET Ionizing Radiation. DOSE-RESPONSE[J]. 2020, 18(1): https://doaj.org/article/7295872fd1694d16ae1f0e223c21de13.
[8] 马季, 叶才勇, 丁楠, 朱佳赟, 胡文涛. DNA—PKcs在细胞辐射超敏感性中的作用研究. 中华放射医学与防护杂志[J]. 2018, 38(7): 489-493, http://lib.cqvip.com/Qikan/Article/Detail?id=675679778.
[9] 张利英, 王磊, 张丽昕, 张苡铭, 许小敏, 丁楠, 华君瑞, 刘永琦. 黄芪多糖对重离子辐射BMSCs防护作用及与NF-κB相关机制研究. 中华中医药杂志[J]. 2018, 33(12): 5576-5580, [10] Ding, Nan, Zhu, Qianzheng. Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4. TRANSLATIONAL CANCER RESEARCHnull. 2018, 7: S495-S499, https://www.webofscience.com/wos/woscc/full-record/WOS:000431843600017.
[11] Ding, Nan, Hua, Junrui, He, Jinpeng, Wei, Wenjun, Pei, Hailong, Zhou, Guangming, Wang, Jufang, Wani, Altaf A, Zhu, Qianzheng. Radiation-induced miR-5094 expression inhibits cell proliferation by targeting STAT5b. CANCER RESEARCHnull. 2018, 78(13): https://www.webofscience.com/wos/woscc/full-record/WOS:000468819503078.
[12] Song, Lei, Ye, Wenling, Cui, Yong, Lu, Jianzhong, Zhang, Yanan, Ding, Nan, Hu, Wentao, Pei, Hailong, Yue, Zhongjin, Zhou, Guangming. Ecto-5'-nucleotidase (CD73) is a biomarker for clear cell renal carcinoma stem-like cells. ONCOTARGET[J]. 2017, 8(19): 31977-31992, https://www.webofscience.com/wos/woscc/full-record/WOS:000401003200109.
[13] Sun, Fang, Zhang, Xurui, Zhou, Xia, Hua, Junrui, Zhang, Yanan, Wang, Bing, Hu, Wentao, Ding, Nan, He, Jinpeng, Li, He, Pei, Hailong, Zhao, Xudong, Zhou, Guangming, Wang, Jufang. Comparisons between bio-radiation effects of X-rays and carbon-ion irradiation on glioma stem cells. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE[J]. 2017, 10(3): 4639-4648, https://www.webofscience.com/wos/woscc/full-record/WOS:000400552900042.
[14] 林素兰, 丁楠, 危文俊, 何进鹏, 王菊芳. GANRA纳米药对淋巴母细胞的辐射防护作用及辐射敏感microRNA的影响. 辐射研究与辐射工艺学报[J]. 2017, 35(3): 030201-1, [15] He, Jinpeng, Feng, Xiu, Hua, Junrui, Wei, Li, Lu, Zhiwei, Wei, Wenjun, Cai, Hui, Wang, Bing, Shi, Wengui, Ding, Nan, Li, He, Zhang, Yanan, Wang, Jufang. miR-300 regulates cellular radiosensitivity through targeting p53 and apaf1 in human lung cancer cells. CELL CYCLE[J]. 2017, 16(20): 1943-1953, https://www.webofscience.com/wos/woscc/full-record/WOS:000414094300015.
[16] Wengui Shi, Yanfang Xie, Jinpeng He, Jian Zhou, Yuhai Gao, Wenjun Wei, Nan Ding, Huiping Ma, Cory J Xian, Keming Chen, Jufang Wang. Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/a0be59ecfd824f6e9e318cb14dc4d29a.
[17] Pei, Hailong, Zhang, Jian, Nie, Jing, Ding, Nan, Hu, Wentao, Hua, Junrui, Hirayama, Ryoichi, Furusawa, Yoshiya, Liu, Cuihua, Li, Bingyan, Hei, Tom K, Zhou, Guangming. RAC2-P38 MAPK-dependent NADPH oxidase activity is associated with the resistance of quiescent cells to ionizing radiation. CELL CYCLE[J]. 2017, 16(1): 113-122, https://www.webofscience.com/wos/woscc/full-record/WOS:000392737300021.
[18] Wei, Wenjun, He, Jinpeng, Wang, Jufang, Ding, Nan, Wang, Bing, Lin, Sulan, Zhang, Xurui, Hua, Junrui, Li, He, Hu, Burong. Serum microRNAs as Early Indicators for Estimation of Exposure Degree in Response to Ionizing Irradiation. RADIATION RESEARCH[J]. 2017, 188(3): 342-354, https://www.webofscience.com/wos/woscc/full-record/WOS:000408424300009.
[19] 卢志伟, 王磊, 张利英, 何进鹏, 丁楠, 任春贞, 李玲, 王凤梅, 刘永琦. 黄芪多糖对电离辐射骨髓间充质干细胞向神经分化潜能的影响. 中国药理学通报[J]. 2017, 33(7): 950-955, http://lib.cqvip.com/Qikan/Article/Detail?id=672605403.
[20] 王磊, 许小敏, 卢志伟, 刘永琦, 张利英, 丁楠, 何进鹏, 张艳辉, 李程豪. 当归多糖防护X线辐射对大鼠肝脏损伤的研究. 中草药[J]. 2017, 48(20): 4284-4288, [21] 王磊, 卢志伟, 许小敏, 刘永琦, 张利英, 张苡铭, 张丽昕, 何进鹏, 丁楠. 黄芪多糖对X线辐射骨髓间充质干细胞向成骨方向分化的影响. 中国中医药信息杂志[J]. 2017, 24(12): 47-51, http://lib.cqvip.com/Qikan/Article/Detail?id=7000353792.
[22] 卢志伟, 许小敏, 王磊, 张利英, 何进鹏, 丁楠, 李程豪, 苏韫, 刘永琦. 当归及当归多糖对辐射所致大鼠肝肾损伤的防护作用. 解放军医学杂志[J]. 2017, 42(9): 815-819, https://doaj.org/article/4154bbb133f34755a0c6fe551965619b.
[23] 刘涌爱, 胡文涛, 张栩锐, 丁楠, 周妮娜, 王菊芳. p53-p21通路抑制组蛋白甲基转移酶NSD2的表达. 激光生物学报. 2016, 25(3): 257-262, http://lib.cqvip.com/Qikan/Article/Detail?id=669290803.
[24] 周妮娜, 张利英, 刘永琦, 卢志伟, 丁楠, 刘涌爱, 华君瑞, 武有明. 不同X线剂量照射对骨髓间充质干细胞的增殖及DNA损伤的影响. 医学研究生学报[J]. 2016, 29(9): 923-927, http://lib.cqvip.com/Qikan/Article/Detail?id=670089605.
[25] 周妮娜, 刘永琦, 张利英, 卢志伟, 武有明, 丁楠, 张栩锐, 刘涌爱. 从中医阴阳平衡探讨辐射诱发细胞基因组不稳定性及益气滋阴法防护机制. 中华中医药杂志[J]. 2016, 31(11): 4711-4713, [26] Xu, Shuai, Wang, Jufang, Ding, Nan, Hu, Wentao, Zhang, Xurui, Wang, Bing, Hua, Junrui, Wei, Wenjun, Zhu, Qiyun. Exosome-mediated microRNA transfer plays a role in radiation-induced bystander effect. RNA BIOLOGY[J]. 2015, 12(12): 1355-1363, https://www.webofscience.com/wos/woscc/full-record/WOS:000368027500008.
[27] 徐帅, 丁楠, 华君瑞, 王兵, 王菊芳. 未照射条件培养基通过影响活性氧水平引起细胞DNA损伤. 激光生物学报. 2015, 24(5): 436-440, http://lib.cqvip.com/Qikan/Article/Detail?id=666500357.
[28] Li, Weiwei, Gu, Xueyan, Zhang, Xiaoning, Kong, Jinxin, Ding, Nan, Qi, Yongmei, Zhang, Yingmei, Wang, Jufang, Huang, Dejun. Cadmium delays non-homologous end joining (NHEJ) repair via inhibition of DNA-PKcs phosphorylation and downregulation of XRCC4 and Ligase IV. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS[J]. 2015, 779: 112-123, http://dx.doi.org/10.1016/j.mrfmmm.2015.07.002.
[29] 李朋飞, 胡文涛, 裴海龙, 丁楠, 周光明. 电离辐射改变长链非编码RNA的表达谱. 原子核物理评论[J]. 2015, 32(4): 484-489, [30] Wang, Jufang, Wu, Xin, Ding, Nan, Chang, Lei, He, Jinpeng, Su, Fengtao, Zhou, Guangming. Identification and application of radiation-related microRNAs. RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI[J]. 2014, 25: S49-S52, https://www.webofscience.com/wos/woscc/full-record/WOS:000332688700010.
[31] Wu, Xin, Ding, Nan, Hu, Wentao, He, Jinpeng, Xu, Shuai, Pei, Hailong, Hua, Junrui, Zhou, Guangming, Wang, Jufang. Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells. RADIATION ONCOLOGY[J]. 2014, 9(1): http://dx.doi.org/10.1186/1748-717X-9-179.
[32] Xu, Shuai, Ding, Nan, Pei, Hailong, Hu, Wentao, Wei, Wenjun, Zhang, Xurui, Zhou, Guangming, Wang, Jufang. MiR-21 is involved in radiation-induced bystander effects. RNA BIOLOGY[J]. 2014, 11(9): 1161-1170, https://www.webofscience.com/wos/woscc/full-record/WOS:000348463500008.
[33] 吴鑫, 华君瑞, 丁楠, 胡文涛, 何进鹏, 徐帅, 裴海龙, 周光明, 王菊芳. MicroRNA-19b通过下调BTG1增加重离子辐射诱导的基因组不稳定性. 原子核物理评论[J]. 2014, 533-537, http://lib.cqvip.com/Qikan/Article/Detail?id=72876884504849524852484955.
[34] Ding, Nan, Pei, Hailong, Hu, Wentao, He, Jinpeng, Li, He, Wang, Jufang, Wang, Tieshan, Zhou, Guangming. Cancer risk of high-charge and -energy ions and the biological effects of the induced secondary particles in space. RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI[J]. 2014, 25: S59-S63, https://www.webofscience.com/wos/woscc/full-record/WOS:000332688700012.
[35] He, Jinpeng, Hua, Junrui, Ding, Nan, Xu, Shuai, Sun, Rui, Zhou, Guangming, Xie, Xiaodong, Wang, Jufang. Modulation of microRNAs by ionizing radiation in human gastric cancer. ONCOLOGY REPORTS[J]. 2014, 32(2): 787-793, https://www.webofscience.com/wos/woscc/full-record/WOS:000338908700043.
[36] Hu, Wentao, Xu, Shuai, Yao, Bin, Hong, Mei, Wu, Xin, Pei, Hailong, Chang, Lei, Ding, Nan, Gao, Xiaofei, Ye, Caiyong, Wang, Jufang, Hei, Tom K, Zhou, Guangming. MiR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode. RNA BIOLOGY[J]. 2014, 11(9): 1189-1198, https://www.webofscience.com/wos/woscc/full-record/WOS:000348463500011.
[37] Xin Wu, Nan Ding, Wentao Hu, Jinpeng He, Shuai Xu, Hailong Pei, Junrui Hua, Guangming Zhou, Jufang Wang. Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells. Radiation Oncology (London, England). 2014, 9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252025/.
[38] Hu, Wentao, Pei, Hailong, Li, He, Ding, Nan, He, Jinpeng, Wang, Jufang, Furusawa, Yoshiya, Hirayama, Ryoichi, Matsumoto, Yoshitaka, Liu, Cuihua, Li, Yinghui, Kawata, Tetsuya, Zhou, Guangming. Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures. JOURNAL OF RADIATION RESEARCH[J]. 2014, 55(1): 10-16, https://www.webofscience.com/wos/woscc/full-record/WOS:000329861800003.
[39] Ding, Nan, Pei, Hailong, He, Jinpeng, Furusawa, Yoshiya, Hirayama, Ryoichi, Liu, Cuihua, Matsumoto, Yoshitaka, Li, He, Hu, Wentao, Li, Yinghui, Wang, Jufang, Wang, Tieshan, Zhou, Guangming. Simulated studies on the biological effects of space radiation on quiescent human fibroblasts. ADVANCES IN SPACE RESEARCH[J]. 2013, 52(7): 1314-1319, https://www.webofscience.com/wos/woscc/full-record/WOS:000325045800012.
[40] Wang, Fengling, Bing, Zhitong, Zhang, Yanan, Ao, Bin, Zhang, Sheng, Ye, Caiyong, He, Jinpeng, Ding, Nan, Ye, Wenling, Xiong, Jie, Sun, Jintu, Furusawa, Yoshiya, Zhou, Guangming, Yang, Lei. Quantitative proteomic analysis for radiation-induced cell cycle suspension in 92-1 melanoma cell line. JOURNAL OF RADIATION RESEARCH[J]. 2013, 54(4): 649-662, https://www.webofscience.com/wos/woscc/full-record/WOS:000321769500007.
[41] Li, Houbu, Zhang, Xuemin, Qi, Dongtao, Ding, Nan, Cai, Xuehua. Corrosion resistance of E6-glass fibre in simulated oilfield environments. JOURNAL OF REINFORCED PLASTICS AND COMPOSITES[J]. 2012, 31(8): 563-572, https://www.webofscience.com/wos/woscc/full-record/WOS:000302180900004.
[42] 朱明月, 裴海龙, 叶文凌, 张亚楠, 丁楠, 王菊芳, 李文建, 周光明. GANRA类药物的抗辐射效应研究. 原子核物理评论[J]. 2012, 29(1): 109-113, http://lib.cqvip.com/Qikan/Article/Detail?id=41249437.
[43] Chang, Lei, Hu, Wentao, Ye, Caiyong, Yao, Bin, Song, Lei, Wu, Xin, Ding, Nan, Wang, Jufang, Zhou, Guangming. miR-3928 activates ATR pathway by targeting Dicer. RNA BIOLOGY[J]. 2012, 9(10): 1247-1254, https://www.webofscience.com/wos/woscc/full-record/WOS:000310575700006.
[44] Ding, Nan, Wu, Xin, He, Jinpeng, Chang, Lei, Hu, Wentao, Li, Wenjian, Wang, Jufang, Wang, Tieshan, Zhou, Guangming. Detection of Novel Human MiRNAs Responding to X-ray Irradiation. JOURNAL OF RADIATION RESEARCH[J]. 2011, 52(4): 425-432, http://dx.doi.org/10.1269/jrr.10158.
[45] Wang, Jufang, Su, Fengtao, Smilenov, Lubomir B, Zhou, Libin, Hu, Wentao, Ding, Nan, Zhou, Guangming. Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity. RADIATION ONCOLOGY[J]. 2011, 6(1): http://dx.doi.org/10.1186/1748-717X-6-96.
[46] Lu Dong, Li Wenjian, Wu Xin, Wang Jufang, Ma Shuang, Liu Qingfang, He Jinyu, Jing Xigang, Ding Nan, Dai Zhongying, Zhou Jianping. Study on DNA Damage Induced by Neon Beam Irradiation in Saccharomyces Cerevisiae. PLASMA SCIENCE & TECHNOLOGY[J]. 2010, 12(6): 753-756, http://lib.cqvip.com/Qikan/Article/Detail?id=36468107.
[47] 杨康, 朱佳赟, 李君红, 丁楠, 胡文涛, 何进鹏, 苏锋涛, 李莎. DNA-PKcs基因组不稳定性和辐射超敏感性. 辐射研究与辐射工艺学报. 2010, 28(2): 114-118, http://lib.cqvip.com/Qikan/Article/Detail?id=33559175.
[48] 刘金婷, 党秉荣, 李文建, 荆西刚, 魏巍, 王转子, 丁楠, 高清祥. X射线辐照后人肝细胞、肝癌细胞存活与端粒酶活性关系的研究. 辐射研究与辐射工艺学报. 2010, 28(2): 119-123, http://lib.cqvip.com/Qikan/Article/Detail?id=33559176.
[49] LU Dong, LI Wenjian, WU Xin, WANG Jufang, MA Shuang, LIU Qingfang, HE Jinyu, JING Xigang, DING Nan, DAI Zhongying, ZHOU Jianping. Study on DNA Damage Induced by Neon Beam Irradiation in Saccharomyces Cerevisiae. 等离子体科学和技术:英文版. 2010, 753-756, http://lib.cqvip.com/Qikan/Article/Detail?id=36468107.
[50] 丁楠, 周光明. MicroRNA发现的研究现状及重离子辐照相关应用前景. 原子核物理评论. 2009, 172-176, http://lib.cqvip.com/Qikan/Article/Detail?id=30813681.
[51] 胡文涛, 苏锋涛, Lubomir BSmilenov, 周利斌, 朱佳赟, 丁楠, 刘苑辛, 高清祥, Tom KHei, Eric JHall, 周光明. ATM与BRCA1的双杂合性通过影响若干通路增加肿瘤发生风险. 生物物理学报[J]. 2009, 2009(S1): 154-155, http://ir.impcas.ac.cn/handle/113462/2093.

科研活动

   
科研项目
( 1 ) 海藻酸钠/咪喹莫特微球在肿瘤重离子免疫联合治疗中应用基础研究, 负责人, 国家任务, 2020-01--2023-12
( 2 ) 数字诊疗辐射生物效应及其评估新技术研究, 参与, 国家任务, 2017-06--2019-12
( 3 ) 辐射诱导表达上调的miR-5094通过下调STAT5b影响T细胞增殖, 负责人, 国家任务, 2015-01--2017-12
( 4 ) miR-181b、miR-197作为血清标志物用于甲状腺癌早期诊断和预后的研究, 负责人, 中国科学院计划, 2015-01--2016-12
( 5 ) 空间重离子辐照生物效应研究系统项目, 参与, 国家任务, 2015-04--2015-12
( 6 ) 空间辐射与微重力复合作用所诱发的上皮细胞间质转换及其在肿瘤发生中的作用, 参与, 国家任务, 2014-01--2018-12
( 7 ) 细胞初级纤毛在空间重离子辐射诱导的辐射旁效应中的功能研究, 负责人, 地方任务, 2022-01--2023-12