丁楠  男  硕导  中国科学院近代物理研究所
电子邮件: dn@impcas.ac.cn
通信地址: 甘肃省兰州市南昌路509号
邮政编码: 730000


1. 辐射旁效应及其机理研究

2. 空间辐射的生物学效应研究;

3. 重离子辐射的肿瘤杀伤效应研究




2009-09--2013-12   兰州大学   理学博士
2004-09--2007-06   兰州大学   理学硕士
1999-09--2003-06   兰州大学   理学学士


2017-08~2018-10,俄亥俄州立大学,哥伦布,美国, 访问学者
2011-10~2012-04,国立放射医学研究所,千叶,日本, 访问学者
2007-07~现在, 中国科学院近代物理研究所, 科研


( 1 ) miR-197在作为肝癌检测标志物中的应用, 发明专利, 2016, 第 1 作者, 专利号: CN105238863A

( 2 ) 循环血miR-34a作为辐射生物标志物在辐射监控中的应用, 发明专利, 2015, 第 4 作者, 专利号: CN104977398A

( 3 ) CD73作为肾透明细胞癌干细胞表面标志物的应用, 发明专利, 2013, 第 7 作者, 专利号: CN103278634A

( 4 ) hsa-miR-185的新用途, 发明专利, 2011, 第 5 作者, 专利号: CN102102102A


(1) Immunoregulatory liposomes hitchhiking on neutrophils for enhanced carbon ion radiotherapy-assisted immunotherapy of glioblastoma, NANO TODAY, 2023, 第 10 作者
(2) Identification of the Kupffer cell-derived circulating IGFBP-3 as a universal radiation biomarker for heavy ion, proton, and X-ray exposure, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 第 10 作者
(3) Radiation-Induced Bystander Effect on the Genome of Bone Marrow Mesenchymal Stem Cells in Lung Cancer, ANTIOXIDANTS & REDOX SIGNALING, 2022, 第 13 作者
(4) MiR-663a Inhibits Radiation-Induced Epithelium-to-Mesenchymal Transition by Targeting TGF-?1, BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2022, 通讯作者
(5) Chk1 Inhibition Hinders the Restoration of H3.1K56 and H3.3K56 Acetylation and Reprograms Gene Transcription After DNA Damage Repair, FRONTIERS IN ONCOLOGY, 2022, 通讯作者
(6) Ionizing radiation downregulates estradiol synthesis via endoplasmic reticulum stress and inhibits the proliferation of estrogen receptor-positive breast cancer cells, CELL DEATH & DISEASE, 2021, 第 9 作者
(7) LsrB, the hub of ABC transporters involved in the membrane damage mechanisms of heavy ion irradiation in Escherichia coli, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2021, 第 8 作者
(8) Ionizing Radiation Upregulates Glutamine Metabolism and Induces Cell Death via Accumulation of Reactive Oxygen Species, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 第 8 作者
(9) 黄芪不同有效成分对电离辐射致BMSCs DNA损伤防护作用的比较研究, Comparative Study on the Protective Effects of Different Effective Components of Astragali Radix against Ionizing Radiation-induced BMSCs DNA Damage, 中国药房, 2020, 第 6 作者
(10) The Role of MiR-5094 as a Proliferation Suppressor during Cellular Radiation Response via Downregulating STAT5b, JOURNAL OF CANCER, 2020, 第 1 作者
(11) Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 第 8 作者
(12) USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage, CELL CYCLE, 2020, 第 2 作者
(13) Serum Proteins as New Biomarkers for Whole-Body Exposure to High- andLow-LET Ionizing Radiation, DOSE-RESPONSE, 2020, 第 8 作者
(14) DNA—PKcs在细胞辐射超敏感性中的作用研究, DNA-PKcs functions in cellular hyper-radiosensitivity, 中华放射医学与防护杂志, 2018, 第 3 作者
(15) Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4, TRANSLATIONAL CANCER RESEARCH, 2018, 第 1 作者
(16) 黄芪多糖对重离子辐射BMSCs防护作用及与NF-κB相关机制研究, Protective effect of Astragalus Polysaccharide on heavy ionizing radiation on BMSCs and its mechanism related with NF-κB, 中华中医药杂志, 2018, 第 6 作者
(17) Radiation-induced miR-5094 expression inhibits cell proliferation by targeting STAT5b, CANCER RESEARCH, 2018, 第 1 作者
(18) Ecto-5′-nucleotidase (CD73) is a biomarker for clear cell renal carcinoma stem-like cells, ONCOTARGET, 2017, 第 6 作者
(19) Comparisons between bio-radiation effects of X-rays and carbon-ion irradiation on glioma stem cells, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 第 8 作者
(20) GANRA纳米药对淋巴母细胞的辐射防护作用及辐射敏感microRNA的影响, Assessment of the protective effects of GANRA nanoparticles against X-ray radiation-induced cellular damage and microRNA alterations, 辐射研究与辐射工艺学报, 2017, 第 2 作者
(21) miR-300 regulates cellular radiosensitivity through targeting p53 and apaf1 in human lung cancer cells, CELL CYCLE, 2017, 第 10 作者
(22) Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia, SCIENTIFIC REPORTS, 2017, 第 7 作者
(23) RAC2-P38 MAPK-dependent NADPH oxidase activity is associated with the resistance of quiescent cells to ionizing radiation, CELL CYCLE, 2017, 第 4 作者
(24) Serum microRNAs as Early Indicators for Estimation of Exposure Degree in Response to Ionizing Irradiation, RADIATION RESEARCH, 2017, 第 4 作者
(25) 黄芪多糖对电离辐射骨髓间充质干细胞向神经分化潜能的影响, Effects of Astragalus polysaccharide on neuronal differentiation potential of mesenchymal stem cell induced by ionizing radiation, 中国药理学通报, 2017, 第 5 作者
(26) 当归多糖防护X线辐射对大鼠肝脏损伤的研究, Research on protection of Angelica sinensis polysaccharides on liver injury of rats induced by X-ray radiation, 中草药, 2017, 第 6 作者
(27) 当归及当归多糖对辐射所致大鼠肝肾损伤的防护作用, Protective effects of Angelica sinensis and Angelica sinensis polysaccharides against liver and kidney injury induced by irradiation in rats, 解放军医学杂志, 2017, 第 6 作者
(28) 黄芪多糖对X线辐射骨髓间充质干细胞向成骨方向分化的影响, Effects of Astragalus Polysaccharide on Osteoblastic Differentiation of Bone Mesenchymal Stem Cells Induced by X-ray Radiation, 中国中医药信息杂志, 2017, 第 9 作者
(29) p53-p21通路抑制组蛋白甲基转移酶NSD2的表达, p53-p21 Pathway Inhibits Expression of the Histone Methyltransferase NSD2, 激光生物学报, 2016, 第 4 作者
(30) 从中医阴阳平衡探讨辐射诱发细胞基因组不稳定性及益气滋阴法防护机制, Study on cellular genomic instability induced by radiation and corresponding protection mechanism as benefiting Qi and nourishing Yin method based on theory of equilibrium between Yin and Yang, 中华中医药杂志, 2016, 第 6 作者
(31) 不同X线剂量照射对骨髓间充质干细胞的增殖及DNA损伤的影响, Effects of different doses of X-ray irradiation on the proliferation and DNA damage of bone marrow mesen- chymal stem cell, 医学研究生学报, 2016, 第 5 作者
(32) Exosome-mediated microRNA transfer plays a role in radiation-induced bystander effect, RNA BIOLOGY, 2015, 第 3 作者
(33) 未照射条件培养基通过影响活性氧水平引起细胞DNA损伤, 激光生物学报, 2015, 第 2 作者
(34) Cadmium delays non-homologous end joining (NHEJ) repair via inhibition of DNA-PKcs phosphorylation and downregulation of XRCC4 and Ligase IV, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2015, 第 5 作者
(35) 电离辐射改变长链非编码RNA的表达谱, Expression Profile of Long Non-coding RNAs in Response to Ionizing Radiation, 原子核物理评论, 2015, 第 4 作者
(36) Identification and application of radiation-related microRNAs, RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI, 2014, 第 3 作者
(37) Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells, RADIATION ONCOLOGY, 2014, 第 2 作者
(38) MiR-21 is involved in radiation-induced bystander effects, RNA BIOLOGY, 2014, 第 2 作者
(39) Cancer risk of high-charge and -energy ions and the biological effects of the induced secondary particles in space, RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI, 2014, 第 1 作者
(40) Modulation of microRNAs by ionizing radiation in human gastric cancer, ONCOLOGY REPORTS, 2014, 第 3 作者
(41) MicroRNA-19b通过下调BTG1增加重离子辐射诱导的基因组不稳定性, MicroRNA-19b Enhances Heavy Ion Induced Genomic Instability by Down-regulation of BTG1, 原子核物理评论, 2014, 第 3 作者
(42) MiR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode, RNA BIOLOGY, 2014, 第 8 作者
(43) Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells, RADIATION ONCOLOGY (LONDON, ENGLAND), 2014, 第 2 作者
(44) Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures, JOURNAL OF RADIATION RESEARCH, 2014, 第 4 作者
(45) Simulated studies on the biological effects of space radiation on quiescent human fibroblasts, ADVANCES IN SPACE RESEARCH, 2013, 第 1 作者
(46) Quantitative proteomic analysis for radiation-induced cell cycle suspension in 92-1 melanoma cell line, JOURNAL OF RADIATION RESEARCH, 2013, 第 8 作者
(47) Corrosion resistance of E6-glass fibre in simulated oilfield environments, JOURNAL OF REINFORCED PLASTICS AND COMPOSITES, 2012, 第 4 作者
(48) GANRA类药物的抗辐射效应研究, Study on Radioprotective Effects of GANRA-Iike Medicine, 原子核物理评论, 2012, 第 5 作者
(49) miR-3928 activates ATR pathway by targeting Dicer, RNA BIOLOGY, 2012, 第 7 作者
(50) Detection of Novel Human MiRNAs Responding to X-ray Irradiation, JOURNAL OF RADIATION RESEARCH, 2011, 第 1 作者
(51) Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity, RADIATION ONCOLOGY, 2011, 第 6 作者
(52) Study on DNA Damage Induced by Neon Beam Irradiation in Saccharomyces Cerevisiae, PLASMA SCIENCE & TECHNOLOGY, 2010, 第 9 作者
(53) DNA-PKcs基因组不稳定性和辐射超敏感性, Study on the relationship between DNA-PKcs and genomic instability & hyper-radiosensitivity, 辐射研究与辐射工艺学报, 2010, 第 4 作者
(54) X射线辐照后人肝细胞、肝癌细胞存活与端粒酶活性关系的研究, The relationship between cell survival rate and telomerase activity of the human hepatocellular cells and carcinoma cells irradiated by X-rays, 辐射研究与辐射工艺学报, 2010, 第 7 作者
(55) Study on DNA Damage Induced by Neon Beam Irradiation in Saccharomyces Cerevisiae, Study on DNA Damage Induced by Neon Beam Irradiation in Saccharomyces Cerevisiae, 等离子体科学和技术:英文版, 2010, 第 9 作者
(56) MicroRNA发现的研究现状及重离子辐照相关应用前景, Progress on Finding Novel MicroRNAs and Expectation of Heavy Ion Irradiation Application in This Field, 原子核物理评论, 2009, 第 1 作者
(57) ATM与BRCA1的双杂合性通过影响若干通路增加肿瘤发生风险, 生物物理学报, 2009, 第 6 作者


( 1 ) 海藻酸钠/咪喹莫特微球在肿瘤重离子免疫联合治疗中应用基础研究, 负责人, 国家任务, 2020-01--2023-12
( 2 ) 数字诊疗辐射生物效应及其评估新技术研究, 参与, 国家任务, 2017-06--2019-12
( 3 ) 辐射诱导表达上调的miR-5094通过下调STAT5b影响T细胞增殖, 负责人, 国家任务, 2015-01--2017-12
( 4 ) miR-181b、miR-197作为血清标志物用于甲状腺癌早期诊断和预后的研究, 负责人, 中国科学院计划, 2015-01--2016-12
( 5 ) 空间重离子辐照生物效应研究系统项目, 参与, 国家任务, 2015-04--2015-12
( 6 ) 空间辐射与微重力复合作用所诱发的上皮细胞间质转换及其在肿瘤发生中的作用, 参与, 国家任务, 2014-01--2018-12
( 7 ) 细胞初级纤毛在空间重离子辐射诱导的辐射旁效应中的功能研究, 负责人, 地方任务, 2022-01--2023-12
( 8 ) 基于“细胞初级纤毛-TGF-β信号途径”的空间重离子辐射旁效应机制研究, 负责人, 国家任务, 2023-01--2026-12
( 9 ) 细胞初级纤毛调控的空间重离子辐射旁效应研究, 负责人, 中国科学院计划, 2023-01--2025-12



王园  硕士研究生  071011-生物物理学