基本信息

韩大力  男  博导  中国科学院北京基因组研究所
电子邮件: handl@big.ac.cn
通信地址: 北京市朝阳区北辰西路1号院104号楼
邮政编码:

研究领域

RNA modification

Bioinformatics

Anti-tumor therapies

Stem cells and tissue regeneration

招生信息

   
招生专业
0710J3-生物信息学
0710Z1-基因组学
071007-遗传学
招生方向
表观基因组
DNA,RNA 新型核酸修饰
精准基因组医学

教育背景

2007-09--2012-07   中国科学院,遗传与发育生物学研究所   博士
2003-09--2007-07   中国科学技术大学   学士

工作经历

   
工作简历
2012-12~2017-09,美国芝加哥大学, 博士后学者

教授课程

组学当代话题
omics brush up
基因组科学前沿

出版信息

   
发表论文
[1] Xiao-Yang Jin, Zu-Rui Huang, Li-Jun Xie, Li Liu, Da-Li Han, Liang Cheng. Photo-Facilitated Detection and Sequencing of 5-Formylcytidine RNA. Angewandte Chemie International Edition[J]. 2022, 61: e202210652-, [2] Dong, Lihui, Chen, Chuanyuan, Zhang, Yawei, Guo, Peijin, Wang, Zhenghang, Li, Jian, Liu, Yi, Liu, Jun, Chang, Renbao, Li, Yilin, Liang, Guanghao, Lai, Weiyi, Sun, Mengxue, Dougherty, Urszula, Bissonnette, Marc B, Wang, Hailin, Shen, Lin, Xu, Meng Michelle, Han, Dali. The loss of RNA N-6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8(+) T cell dysfunction and tumor growth. CANCER CELL[J]. 2021, 39(7): 945-+, http://dx.doi.org/10.1016/j.ccell.2021.04.016.
[3] Liu, Yi, Liang, Guanghao, Xu, Hongjiao, Dong, Wenxin, Dong, Ze, Qiu, Zhiwei, Zhang, Zihao, Li, Fangle, Huang, Yue, Li, Yilin, Wu, Jun, Yin, Shenyi, Zhang, Yawei, Guo, Peijin, Liu, Jun, Xi, Jianzhong Jeff, Jiang, Peng, Han, Dali, Yang, CaiGuang, Xu, Meng Michelle. Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. CELL METABOLISM[J]. 2021, 33(6): 1221-+, http://dx.doi.org/10.1016/j.cmet.2021.04.001.
[4] Jun Liu, Xiaoyang Dou, Chuanyuan Chen, Chuan Chen, Chang Liu, Meng Michelle Xu, Siqi Zhao, Bin Shen, Yawei Gao, Dali Han, Chuan He. N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription. SCIENCE (NEW YORK, N.Y.). 2020, 367(6477): 580-586, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213019/.
[5] Han, Dali, Liu, Jun, Chen, Chuanyuan, Dong, Lihui, Liu, Yi, Chang, Renbao, Huang, Xiaona, Liu, Yuanyuan, Wang, Jianying, Dougherty, Urszula, Bissonnette, Marc B, Shen, Bin, Weichselbaum, Ralph R, Xu, Meng Michelle, He, Chuan. Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells (vol 566, pg 270, 2019). NATUREnull. 2019, 568(7751): E3-E3, [6] Gu, Tongnian, Zhao, Siqi, Pi, Yishuang, Chen, Weizhong, Chen, Chuanyuan, Liu, Qian, Li, Min, Han, Dali, Ji, Quanjiang. Highly efficient base editing in Staphylococcus aureus using an engineered CRISPR RNA-guided cytidine deaminase. CHEMICAL SCIENCE[J]. 2018, 9(12): 3248-3253, https://www.webofscience.com/wos/woscc/full-record/WOS:000428987200020.
[7] Tian, Xin, Sun, Baofa, Chen, Chuanyuan, Gao, Chunchun, Zhang, Ji, Lu, Xingyu, Wang, Linchen, Li, Xiangnan, Xing, Yurong, Liu, Ruijuan, Han, Xiao, Qi, Zheng, Zhang, Xiaojian, He, Chuan, Han, Dali, Yang, YunGui, Kan, Quancheng. Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer. CELL RESEARCHnull. 2018, 28(5): 597-600, http://lib.cqvip.com/Qikan/Article/Detail?id=675657276.
[8] Qing Dai, Sharon MoshitchMoshkovitz, Dali Han, Nitzan Kol, Ninette Amariglio, Gideon Rechavi, Dan Dominissini, Chuan He. Nm-seq maps 2′- O- methylation sites in human mRNA with base precision. NATURE METHODS. 2017, 14(7): 695-698, [9] Han, Dali, Lu, Xingyu, Shih, Alan H, Nie, Ji, You, Qiancheng, Xu, Meng Michelle, Melnick, Ari M, Levine, Ross L, He, Chuan. A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations. MOLECULAR CELL[J]. 2016, 63(4): 711-719, http://dx.doi.org/10.1016/j.molcel.2016.06.028.
[10] Lu, Xingyu, Han, Dali, Zhao, Boxuan Simen, Song, ChunXiao, Zhang, LiSheng, Dore, Louis C, He, Chuan. Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics. CELL RESEARCH[J]. 2015, 25(3): 386-389, https://www.webofscience.com/wos/woscc/full-record/WOS:000350568800012.
[11] Bo Xia, Dali Han, Xingyu Lu, Zhaozhu Sun, Ankun Zhou, Qiangzong Yin, Hu Zeng, Menghao Liu, Xiang Jiang, Wei Xie, Chuan He, Chengqi Yi. Bisulfite-free and Base-resolution Analysis of 5-formylcytosine at Whole-genome Scale. NATURE METHODS. 2015, 12(11): 1047-1050, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626315/.
[12] Su, Ming, Han, Dali, BoydKirkup, Jerome, Yu, Xiaoming, Han, JingDong J. Evolution of Alu Elements toward Enhancers. CELL REPORTS[J]. 2014, 7(2): 376-385, http://dx.doi.org/10.1016/j.celrep.2014.03.011.
[13] Yixing HanDali HanZheng YanJerome D Boydx2010KirkupChristopher D GreenPhilipp KhaitovichJingx2010Dong J Han. Stress‐associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain. AGING CELL[J]. 2012, 11(6): http://gooa.las.ac.cn/external/index?type=-1&pid=1076521.
[14] Liu, Yi, Han, Dali, Han, Yixing, Yan, Zheng, Xie, Bin, Li, Jing, Qiao, Nan, Hu, Haiyang, Khaitovich, Philipp, Gao, Yuan, Han, JingDong J. Ab initio identification of transcription start sites in the Rhesus macaque genome by histone modification and RNA-Seq. NUCLEIC ACIDS RESEARCH[J]. 2011, 39(4): 1408-1418, http://dx.doi.org/10.1093/nar/gkq956.

科研活动

   
科研项目
( 1 ) RNA新型修饰调控多能性干细胞初始态和始发态转变机制研究, 主持, 国家级, 2018-07--2022-12
( 2 ) DNA 5hmC和5fC调控胚胎发育机制研究, 主持, 国家级, 2018-01--2018-12
( 3 ) 核酸新型修饰调控器官再生机制研究, 主持, 部委级, 2017-12--2022-11
( 4 ) 急性髓系白血病的RNA 5-甲基胞嘧啶修饰异常改变及调控机制研究, 主持, 国家级, 2019-01--2021-12
( 5 ) RNA修饰, 主持, 国家级, 2020-01--2022-12