General

DING Kuiling

Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

345 Lingling RD, Shanghai China

Tel: 021-54925201

E-mail: kding@sioc.ac.cn


Research Areas

Development of new strategies and catalysts for homogeneous & heterogeneous catalysis with organometallics, including asymmetric catalysis and CO2 transformation.


Education

1987.09-1990.10: Ph.D., Dept. of Chem., Nanjing University with Professor Yangjie Wu
1985.07-1987.09: Master course, Dept. of Chem., Zhengzhou University with Professor Yangjie Wu
1981.09-1985.07: B.Sc., Dept. of Chem., Zhengzhou University.


Experience

  • Professor, 1998.12-present, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China

  • Director, 2009.05-present, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China

  • Deputy Director, 2006.07-2009.04, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China

  • Invited Professor, 2010.05, Laboratoire de Chimie Inorganique Moléculaire et Catalyse, Université de Strasbourg, Institut de Chimie, UMR 7177 CNRS, F 67008 Strasbourg Cedex, France (hosted by Prof. Dominique MATT)

  • Visiting Professor, 2003.08-2003.11, Research Center of Material Science, Nagoya University, Japan (hosted by Prof. Masato Kitamura) 

  • Professor, 1995.12-1998.11, Department of Chemistry, Zhengzhou University, China

  • UNESCO research fellow, 1997.09-1998.09, Department of Applied Chemistry, Tokyo Institute of Technology, Japan (with Prof. Koichi Mikami)

  • Associate Professor, 1992.11-1995.11, Department of Chemistry, Zhengzhou University, China

  • Postdoctoral Fellow, 1993.09-1994.09, Department of Materials Chemistry, Faculty of Science and Technology, Ryukoku University, Japan (with Prof. Teruo Matsuura)

  • Assistant Professor, 1990.10-1992.10, Department of Chemistry, Zhengzhou University, China

Publications

   
Papers

Selected representative publications (among >160 publications)

 

  1. Tang, Wenjun*; Liu, Jiawang; Nie, Ming; Zhou, Qing-Hai; Gao, Shen; Jiang, Wenhao; Chung, Lung Wa*; Ding, Kuiling*, Enantioselective Palladium-Catalyzed Diboration of 1,1-Disubstituted Allenes, Chem. Sci. 2017, 8, 5161–5165.

  2. ​Jiawang Liu, Zhaobin Han, Xiaoming Wang, Fanyemeng, Zheng Wang*, and Kuiling Ding*, Pd-Catalyzed Asymmetric Construction of Vicinal Tertiary and All-Carbon Quaternary Stereocenters via Allylation of β-Ketocarbonyls with MBH Adducts, Angew. Chem. Int. Ed. 2017, 56, 5050-5054

  3. ​Xubin Wang, Xiaoming Wang, Zhaobin Han, Zheng Wang,* and Kuiling Ding,* Palladium-catalyzed Asymmetric Allylic Allylation of Racemic Morita-Baylis-Hillman Adducts, Angew. Chem. Int. Ed. 2017, 56, 1116-1119.

  4. Xinyi Ren, Zhiyao Zheng, Lei Zhang, Zheng Wang, Chungu Xia* and Kuiling Ding*, Rhodium Complex Catalyzed Hydroformylation of Olefins with CO2 and Hydrosilane, Angew. Chem. Int. Ed. 2017, 56, 310-313.    

  5. Jiawang Liu, Zhaobin Han, Xiaoming Wang, Zheng Wang* and Kuiling Ding*, Highly Regio- and Enantioselective Alkoxycarbonylative Amination of  Terminal Allenes Catalyzed by SKP/Pd(II) Complex, J. Am. Chem. Soc. 2015, 137, 15346–15349.

  6. Lei Zhang, Zhaobin Han, Xiaoyu Zhao, Zheng Wang and Kuiling Ding*, Highly Efficient Ruthenium-Catalyzed N-Formylation of Amines with H2 and CO2, Angew. Chem. Int. Ed. 2015, 54, 6186–6189.

  7. Xu Liu, Zhaobin Han, Zheng Wang, and Kuiling Ding*, SpinPhox/IrI-Catalyzed Asymmetric Hydrogenation of α-Alkylidene Cyclic Carbonyl Compounds, Angew. Chem. Int. Ed. 2014, 53, 1978-1982.

  8. Xiaoming Wang, Peihua Guo, Xubin Wang, Fanye Meng, Zheng Wang, Kuiling Ding*, Spiroketal-Based Diphosphine Ligands in Pd-catalyzed asymmetric allylic amination of MBH adducts: Exceptionally high efficiency and new mechanism, J. Am. Chem. Soc. 2014, 136, 405–411.

  9. Kaiwu Dong, Yang Li, Zheng Wang and Kuiling Ding*, Catalytic Asymmetric Hydrogenation of α- or β-CF3 Substituted Acrylic Acid Derivatives with Rh(I) Complexes of Chiral and Achiral Ligand Mixture, Angew. Chem. Int. Ed. 2013, 52, 14191–14195.

  10. Panke Zhang, Zhaobin Han, Zheng Wang, and Kuiling Ding*, Spiro[4,4]-1,6-nonadiene-Based Diphosphine Oxides in Lewis Base Catalyzed Asymmetric Double Aldol Reaction, Angew. Chem. Int. Ed. 2013, 52, 11054-11058.

  11. Yang Li, Kaiwu Dong, Zheng Wang and Kuiling Ding*, RhI-Catalyzed Enantioselective Hydrogenation of Substituted Acrylic Acids with Sterically Similar β,β-Diaryls, Angew. Chem. Int. Ed. 2013, 52, 6748-6752.

  12. Zhong-Yan Cao, Xiaoming Wang, Chen Tan, Xiao-Li Zhao, Jian Zhou* and Kuiling Ding, Highly Stereoselective Olefin Cyclopropanation of Diazooxindoles Catalyzed by a C2-Symmetric Spiroketal Biphosphine/Au(I) Complex, J. Am. Chem. Soc. 2013, 135, 8197–8200.

  13. Baoguo Zhao, Zhaobin Han, Kuiling Ding*, The N-H Functional Group in Organometallic Catalysis, Angew. Chem. Int. Ed. 2013, 52, 4744–4788.

  14. Zhaobin Han, Liangce Rong, Jiang Wu, Zheng Wang, Kuiling Ding*, Catalytic Hydrogenation of Cyclic Carbonates: A Practical Approach from CO2 and Epoxides to Methanol and Diols, Angew Chem. Int. Ed. 2012, 51, 13041–13045.(VIP)

  15. Xiaoming Wang, Fanye Meng, Yan Wang, Zhaobin Han, Yong-Jun Chen, Li Liu*, Zheng Wang* and Kuiling Ding*, Aromatic Spiroketal Bisphosphine Ligands: Palladium-Catalyzed Asymmetric Allylic Amination of Racemic Morita-Baylis-Hillman Adducts, Angew. Chem. Int. Ed. 2012, 51, 9276-9282.

  16. Kaiwu Dong, Zheng Wang, and Kuiling Ding*, Rh(I)-Catalyzed Enantioselective Hydrogenation of -Substituted Ethenylphosphonic Acids,  J. Am. Chem. Soc. 2012, 134, 12474−12477.

  17. Xiaoming Wang, Zhaobin Han, Zheng Wang*, and Kuiling Ding*, Catalytic Asymmetric Synthesis of Aromatic Spiroketals via SpinPhox/Iridium(I) Catalyzed Hydrogenation and Spiroketalization of α,α’-Bis(2-hydroxyarylidene)ketones, Angew. Chem. Int. Ed. 2012, 51, 936-940. (highlighted by Angew Chem)

  18. Jinzhu Zhang, Yang Li, Zheng Wang, and Kuiling Ding*, Asymmetric Hydrogenation - and -Enamido Phosphonates Catalyzed by RhI Complex of Monodentate Phosphoramidite, Angew. Chem. Int. Ed, 2011, 50, 11743-11747.

  19. Shao-Xu Huang, Kuiling Ding*, Catalytic Asymmetric Bromoamination of Chalcones with A Privileged N,N’-Dioxide/Sc(III) Catalyst, Angew. Chem. Int. Ed, 2011, 50, 7734–7736. (highlight)

  20. Zhipeng Zhang, Zheng Wang, Ruzhou Zhang, and Kuiling Ding*, Efficient Titanium Catalyst for Enantioselective Cyanation of Aldehydes: Cooperative Catalysis, Angew. Chem. Int. Ed, 2010, 49, 6746-6750. (VIP)

  21. Liting Yu, Zheng Wang, Jiang Wu, Shujiang Tu, and Kuiling Ding*, Directed Orthogonal Self-Assembly of Homochiral Coordination Polymers for Heterogeneous Enantioselective Hydrogenation, Angew. Chem. Int. Ed., 2010, 49, 3627-3630.

  22. Zhaobin Han, Zheng Wang, Xumu Zhang, and Kuiling Ding*, Spiro[4,4]-1,6-nonadiene-Based Phosphine-Oxazoline Ligands for Iridium-Catalyzed Enantioselective Hydrogenation of Ketimines, Angew Chem. Int. Ed. 2009, 48, 5345-5349.

  23. Zheng Wang, Gang Chen, and Kuiling Ding*, Self-Supported Catalysts, Chem. Rev. 2009, 109, 322-359.

  24. Hongli Bao, Jing Zhou, Zheng Wang,* Yinlong Guo, Tianpa You, and Kuiling Ding*, Insight into the Mechanism of the Asymmetric Ring-Opening Aminolysis of 4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane Catalyzed by Titanium-BINOLate-Water System: Evidence for the Ti(BINOLate)2-Bearing Active Catalyst Entities and the Role of Water, J. Am. Chem. Soc. 2008, 130, 10116-10127.

  25. Senmiao Xu, Zheng Wang, Xue Zhang, Xumu Zhang, Kuiling Ding*, Chiral Brönsted Acid Catalyzed Asymmetric Baeyer-Villiger Reaction of 3-Substituted Cyclobutanones Using Aqueous H2O2, Angew Chem.Int. Ed. 2008, 47, 2840-2843.

  26. Yan Liu, Christan A. Sandoval, Yoshiki Yamaguchi, Xue Zhang, Zheng Wang, Koichi Kato, Kuiling Ding*, Hydrogen-Bonding makes a difference in the rhodium-catalyzed enantioselective hydrogenation using monodentate phosphoramidites, J. Am. Chem. Soc. 2006, 128, 14212 - 14213.

  27. Lei Shi, Xingwang Wang, Christian A. Sandoval, Mingxing Li, Qiaoyun Qi, Zhanting Li, and Kuiling Ding*, Engineering a Polymeric Chiral Catalyst by Using Hydrogen Bonding and Coordination Interactions, Angew. Chem. Int. Ed. 2006, 45, 4108-4112.

  28. Xingwang Wang, Lei Shi, Mingxing Li and Kuiling Ding*, Heterogenization of Shibasaki’s Catalyst for Enantioselective Epoxidation of a,b-Unsaturated Ketones Using Multitopic BINOL Ligands: The Impact of Bridging Spacers, Angew. Chem. Int. Ed. 2005, 44, 6362-6366.

  29. Yan Liu and Kuiling Ding*, Modular Monodentate Phosphoramidite Ligands for Rhodium Catalyzed Enantioselective Hydrogenation, J. Am. Chem. Soc. 2005, 127, 10488-10489.

  30. Yuxue Liang, Qing Jing, Xin Li, Lei Shi, and Kuiling Ding*, Programmed Assembly of Two Different Ligands with Metallic Ions: Generation of Self-Supported Noyori-Type Catalysts for Heterogeneous Asymmetric Hydrogenation of Ketones, J. Am. Chem. Soc. 2005, 127, 7694-7695

  31. Xingwang Wang, Kuiling Ding*, Self-supported heterogeneous catalysts for enantioselective hydrogenation, J. Am. Chem. Soc. 2004, 126, 10524-10525.

  32. Yu Yuan, Xue Zhang, and Kuiling Ding*, Quasi Solvent-Free Enantioselective Carbonyl-Ene Reaction Using Extremely Low Catalyst Loading,Angew. Chem. Int. Ed. Engl., 2003, 42, 5478-5480.

  33. Yu Yuan, Xin Li, Jie Sun, and Kuiling Ding*, To Probe the Origin of Activation Effect of Carboxylic Acid and (+)-NLE in Tridentated Titanium Catalyst Systems, J. Am. Chem. Soc. 2002, 124, 14866-14867.

  34. J. Long, J. Hu, X. Shen, B. Ji, K. Ding*, Discovery of Exceptionally Efficient Catalysts for Solvent-free Enantioselective Hetero-Diels-Alder Reaction, J. Am. Chem. Soc. 2002, 124, 10-11.

  35. J. Long, K. Ding*, Engineering the catalysts for enantioselective addition of diethylzinc to aldehydes with racemic amino alcohols: nonlinear effect in asymmetric deactivation of racemic catalysts, Angew. Chem. Int. Ed. Engl., 2001, 40, 544-547.


Books and Book Chapters

1.       Organic Chemistry: Breakthroughs and Perspectives” Eds. Kuiling Ding and Li-Xin Dai, Wiley-VCH, Weinheim, 2012.

2.       Handbook of Asymmetric Heterogeneous Catalysis” Eds. Kuiling Ding and Yasuhiro Uozumi, Wiley-VCH, Weinheim, 2008.

3.       Asymmetric Catalysis: New Concepts & Methods” Eds. Kuiling Ding and Qinghua Fan, Chemical Industry Press: Beijing, 2008.

4.       Xingwang Wang, Zheng Wang, Kuiling Ding*, “Endeavors to Bridge the Gap between Homo- and Heterogeneous Asymmetric Catalysis with Organometallics” in Bridging Heterogeneous and Homogeneous Catalysis: Concepts, Strategies, and Applications, Eds. Can Li & Yan Liu, Wiley-VCH, Weinheim, 2014.

5.       Hongchao Guo, Kuiling Ding,Self-Supported Chiral Catalysts”, in Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques, and Applications, Eds. Michelangelo Gruttadauria & Francesco Giacalone, Wiley-VCH, Weinheim, 2011, pp.257-290.

6.       Hongchao Guo, Kuiling Ding,Indium Tribromide”, in Electronic Encyclopedia of Reagents for Organic Synthesis, DOI: 10.1002/047084289X.rn01294, Article Online Posting Date: March 15, 2011. Copyright © 2010 John Wiley & Sons, Ltd.

7.       Qinghua Fan, Kuiling Ding, “Enantioselective Catalysis with Structurally Tunable Immobilized Catalysts”, in Asymmetric Catalysis from a Chinese Perspective (Topics in Organometallic Chemistry, Vol 36), Ed. Shengming Ma, Springer: Berlin, 2011, pp 207-245.

8.       Haifeng Du, Kuiling Ding, “Asymmetric Catalysis of Diels–Alder Reaction” in Handbook of Cyclization Reactions, Ed. Shengming Ma, Wiley-VCH, Weinheim, 2009, pp.1-57.

9.       Zheng Wang, Kuiling Ding*, Yasuhiro Uozumi, “An Overview of Heterogeneous Asymmetric Catalysis”, in Handbook of Asymmetric Heterogeneous Catalysis, Eds. Kuiling Ding and Yasuhiro Uozumi, Wiley-VCH, Weinheim, 2008, pp.1-24.

10.   Kuiling Ding*, Zheng Wang, “Homochiral Metal-Organic Coordination Polymers for Heterogeneous Enantioselective Catalysis: Self-Supporting Strategy”, in Handbook of Asymmetric Heterogeneous Catalysis, Eds. Kuiling Ding and Yasuhiro Uozumi, Wiley-VCH, Weinheim, 2008, pp.323-352.

11.   Kuiling Ding*, Zheng Wang, “Synthesis of 5-, 6- and Larger Ring Oxa-3-cycloalkenes by Ring-Closure Reactions, Except Ring-Closing Metathesis”, in Science of Synthesis, Houben-Weyl Methods of Molecular Transformations, Vol. 37, Thieme: New York, 2008, pp.473-529.

12.   Yu Yuan, Kuiling Ding,* Gang Chen, “Titanium Lewis Acid”, in Acid Catalysis in Modern Organic Synthesis, Eds. H. Yamamoto and K. Ishihara, Wiley-VCH, Weinheim, 2008, pp.721-823.

13.   Christian A. Sandoval, Kuiling Ding*, “Covalently Anchored P-Ligands and Catalysts”, in Phosphorus Ligands in Asymmetric Catalysis, Ed. Armin Börner, Wiley-VCH, Weinheim, 2008, pp985-1029.

14.   Kuiling Ding*,(1R)-2’-(Diphenylphosphino)-N,N-dimethyl[1,1’-binaphthalen]-2-amine (MAP)” (first Update), in Electronic Encyclopedia of Reagents for Organic Synthesis, DOI: 10.1002/047084289X.rn00170.pub2, Article Online Posting Date: March 14, 2008. Copyright © 2008 John Wiley & Sons, Ltd.

15.  Zheng Wang, Kuiling Ding*, “Diphenylphosphine Oxide” (first Update), in Electronic Encyclopedia of Reagents for Organic Synthesis, Article Online Posting Date: September 17, 2007. Copyright © 2007 John Wiley & Sons, Ltd.


Students

已指导学生

肖友利  博士研究生  070303-有机化学  

荆庆  博士研究生  070303-有机化学  

刘龑  博士研究生  070303-有机化学  

赵东波  博士研究生  070303-有机化学  

赵宝国  博士研究生  070303-有机化学  

王细胜  博士研究生  070303-有机化学  

杜海峰  博士研究生  070303-有机化学  

王兴旺  博士研究生  070303-有机化学  

袁宇  博士研究生  070303-有机化学  

张雪  博士研究生  070303-有机化学  

陈刚  博士研究生  070303-有机化学  

韩召斌  博士研究生  070303-有机化学  

汪海明  博士研究生  070303-有机化学  

李洪基  博士研究生  070303-有机化学  

张志鹏  博士研究生  070303-有机化学  

张伟  博士研究生  070303-有机化学  

张金柱  博士研究生  070303-有机化学  

李跃辉  博士研究生  070303-有机化学  

商健  硕士研究生  070303-有机化学  

俞立挺  硕士研究生  070303-有机化学  

李杰  博士研究生  070303-有机化学  

张攀科  博士研究生  070303-有机化学  

董开武  博士研究生  070303-有机化学  

刘旭  博士研究生  070303-有机化学  

崔淇  硕士研究生  085204-材料工程  

郑治尧  博士研究生  070303-有机化学  

王晓明  博士研究生  070303-有机化学  

丁羽瑜  硕士研究生  085216-化学工程  

潘伟  博士研究生  070303-有机化学  

李洋  博士研究生  070303-有机化学  

刘家旺  博士研究生  070303-有机化学  

王旭斌  博士研究生  070303-有机化学  

任新意  博士研究生  070304-物理化学  

薛思经  硕士研究生  070303-有机化学  

孙守军  硕士研究生  070303-有机化学  

现指导学生

潘璠  博士研究生  070303-有机化学  

孟繁烨  博士研究生  070303-有机化学  

高申  硕士研究生  070303-有机化学  

李宇鹏  硕士研究生  070303-有机化学  

郭沛骅  博士研究生  070303-有机化学  

葛瑶  博士研究生  070303-有机化学  

汤易天  博士研究生  070303-有机化学  

张琳莉  博士研究生  070303-有机化学  

闫涛  硕士研究生  070303-有机化学  

孙牧言  硕士研究生  070303-有机化学  

李超鹏   硕士研究生  070303-有机化学  

邱佳  博士研究生  070303-有机化学  

魏长森  博士研究生  070303-有机化学  

刘传卓  硕士研究生  070303-有机化学  

Honors & Distinctions

Yoshida Prize, International Organic Chemistry Foundation (IOCF) Japan (2015)

Huang Yao-Zeng Organometallic Chemistry Award, Chinese Chemical Society (2014)

Chiral Chemistry Award, Chinese Chemical Society (2014)

Elected member of Chinese Academy of Sciences (2013)

8th Shanghai Peony Award for Natural Science Award (2011)

Shanghai Science and Technology Elite Award (2011)

Eli Lilly Scientific Excellence Award in Chemistry (2011)

3rd PKU-Eli Lilly Lectureships on Frontiers of Organic Chemistry (2010)

National Natural Science Award of China (2009)

Fellow of The Royal Society of Chemistry (FRSC) (2008)

Shanghai Natural Science Award (2008)

Shanghai Young Talents of Science and Technology (2006)

Chuang Chang-Kung Chemistry Award, Shanghai Society of Chemistry and Chemical Industry (2006)

Excellent Supervisor Award, Graduate School of Chinese Academy of Sciences (2006)

Synlett/Synthesis Journal Awardee (2005)

National Science Foundation for Distinguished Young Scholars of China (2002)

One-hundred talent program, Chinese Academy of Sciences (CAS)