基本信息
丁秋蓉  女  博导  中国科学院上海营养与健康研究院
电子邮件: qrding@sibs.ac.cn
通信地址: 上海市岳阳路320号新生命大楼A2104室
邮政编码: 200031

研究领域

1. 基于人多能干细胞的疾病研究和靶向治疗

利用患者来源的诱导性多能干细胞(iPSC)或者体外建立的疾病胚胎干细胞(ESC),结合基因编辑和定向分化平台,在功能基因组水平研究人类肝脏疾病的分子机理,发现新型靶标;发展基于干细胞疾病模型的药物筛选和毒理评价体系;进行药物化合物筛选,研发针对特定靶标的药物先导化合物;优化体外多能干细胞肝向分化平台,建立肝脏异种嵌合动物模型,探索基于人多能干细胞来源的肝脏细胞作为肝移植潜在肝源的可行性。

2. 肝脏脂代谢紊乱的遗传及表观遗传基础

结合干细胞疾病模型、基因编辑在体大规模筛选和人群疾病遗传学分析,研究肝脏脂代谢紊乱及其导致的肝再生能力下降的遗传和表观遗传基础,探索预防和治疗包括脂肪肝、肝纤维化等肝病的方法和手段。

3. 代谢疾病的基因治疗研究
针对高甘油三酯血症、高胆固醇血症、肿瘤恶病质等代谢疾病,以CRISPR/Cas9在体靶向技术为基础,筛选新型靶标,优化基因治疗方案,开展临床前研究。


招生信息

   
招生专业
071003-生理学
100104-病理学与病理生理学
招生方向
肝脏脂质代谢
多能干细胞与转化医学
代谢疾病基因治疗

教育背景

2004-09--2010-08   中科院上海生科院营养科学研究所   博士研究生/获得博士学位
2000-09--2004-08   南京大学   本科生/获得学士学位

工作经历

   
工作简历
2014-09~现在, 中科院上海生命科学研究院营养科学研究所, 研究员,博士生导师
2010-09~2014-08,哈佛干细胞研究所,哈佛大学干细胞与转化生物学系, 博士后研究
社会兼职
2017-06-01-2020-06-01,Nutrition&Metabolism副主编,
2017-02-01-2020-02-01,Gene Therapy 副主编,

教授课程

营养学

专利与奖励

   
奖励信息
(1) 国家青年****, 国家级, 2016
(2) 中科院****, 部委级, 2015
(3) 上海浦江人才计划, 省级, 2015
专利成果
( 1 ) 通过基因编辑特异靶向肌肉组织MSTN治疗恶病质, 发明, 2016, 第 1 作者, 专利号: 201610965140.1
( 2 ) 一种高特异性的CRISPR基因组编辑体系, 发明, 2016, 第 1 作者, 专利号: 201610805040.2
( 3 ) 罗丹宁衍生物在治疗代谢性疾病中的应用, 发明, 2019, 第 1 作者, 专利号: 201910032899.8
( 4 ) 吲哚满酮衍生物在治疗肥胖及其相关疾病中的应用, 发明, 2018, 第 1 作者, 专利号: 201811135612.6

出版信息

   
发表论文
[1] Trends in Molecular Medicine. 2024,   通讯作者  
[2] Molecular Cell. 2023,   通讯作者  
[3] Nature Communications. 2023,   通讯作者  
[4] Cell Regeneration. 2023,   通讯作者  
[5] Bao, Hainan, Cao, Jiani, Chen, Mengting, Chen, Min, Chen, Wei, Chen, Xiao, Chen, Yanhao, Chen, Yu, Chen, Yutian, Chen, Zhiyang, Chhetri, Jagadish K, Ding, Yingjie, Feng, Junlin, Guo, Jun, Guo, Mengmeng, He, Chuting, Jia, Yujuan, Jiang, Haiping, Jing, Ying, Li, Dingfeng, Li, Jiaming, Li, Jingyi, Liang, Qinhao, Liang, Rui, Liu, Feng, Liu, Xiaoqian, Liu, Zuojun, Luo, Oscar Junhong, Lv, Jianwei, Ma, Jingyi, Mao, Kehang, Nie, Jiawei, Qiao, Xinhua, Sun, Xinpei, Tang, Xiaoqiang, Wang, Jianfang, Wang, Qiaoran, Wang, Siyuan, Wang, Xuan, Wang, Yaning, Wang, Yuhan, Wu, Rimo, Xia, Kai, Xiao, FuHui, Xu, Lingyan, Xu, Yingying, Yan, Haoteng, Yang, Liang, Yang, Ruici, Yang, Yuanxin, Ying, Yilin, Zhang, Le, Zhang, Weiwei, Zhang, Wenwan, Zhang, Xing, Zhang, Zhuo, Zhou, Min, Zhou, Rui, Zhu, Qingchen, Zhu, Zhengmao, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, HouZao, Chen, Jun, Ci, Weimin, Ding, BiSen, Ding, Qiurong, Gao, Feng, Han, JingDong J, Huang, Kai, Ju, Zhenyu, Kong, QingPeng, Li, Ji, Li, Jian, Li, Xin, Liu, Baohua, Liu, Feng, Liu, Lin, Liu, Qiang, Liu, Qiang, Liu, Xingguo, Liu, Yong, Luo, Xianghang, Ma, Shuai, Ma, Xinran, Mao, Zhiyong, Nie, Jing, Peng, Yaojin, Qu, Jing, Ren, Jie, Ren, Ruibao, Song, Moshi, Zhou Songyang, Sun, Yi Eve, Sun, Yu, Tian, Mei, Wang, Shusen, Wang, Si, Wang, Xia, Wang, Xiaoning, Wang, YanJiang, Wang, Yunfang, Wong, Catherine C L, Xiang, Andy Peng, Xiao, Yichuan, Xie, Zhengwei, Xu, Daichao, Ye, Jing, Yue, Rui, Zhang, Cuntai, Zhang, Hongbo, Zhang, Liang, Zhang, Weiqi, Zhang, Yong, Zhang, YunWu, Zhang, Zhuohua, Zhao, Tongbiao, Zhao, Yuzheng, Zhu, Dahai, Zou, Weiguo, Pei, Gang, Liu, GuangHui, Aging Biomarker Consortium. Biomarkers of aging. SCIENCE CHINA-LIFE SCIENCES[J]. 2023, 第 70 作者  通讯作者  66(5): 893-1066, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7491049&detailType=1.
[6] Journal of Hepatology. 2022,   通讯作者  
[7] Cell Discovery. 2022,   通讯作者  
[8] Liu, Xiaojian, Yang, Yuanyuan, Qiu, Yan, ReyadUlFerdous, Md, Ding, Qiurong, Wang, Yi. SeqCor: correct the effect of guide RNA sequences in clustered regularly interspaced short palindromic repeats/Cas9 screening by machine learning algorithm. JOURNAL OF GENETICS AND GENOMICS[J]. 2021, 第 5 作者  通讯作者  47(11): 672-680, http://dx.doi.org/10.1016/j.jgg.2020.10.007.
[9] Luo, XiaoLing, Zhang, Peng, Liu, Xiangyuan, Huang, Shiqian, Rao, SenLe, Ding, Qiurong, Yang, HuangTian. Myosin light chain 2 marks differentiating ventricular cardiomyocytes derived from human embryonic stem cells. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY[J]. 2021, 第 6 作者473(7): 991-1007, http://dx.doi.org/10.1007/s00424-021-02578-3.
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[14] Yang, Yuanyuan, Liu, Xiaojian, Li, Shuang, Chen, Yanhao, Zhao, Yongxu, Wei, Yuda, Qiu, Yan, Liu, Yan, Zhou, Zhihua, Han, Jun, Wu, Guohao, Ding, Qiurong. Genome-scale CRISPR screening for potential targets of ginsenoside compound K. CELL DEATH & DISEASE[J]. 2020, 第 12 作者  通讯作者  11(1): https://doaj.org/article/920f27a1b94f412a9d02ecb0ee8809cc.
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[19] Zhao, Yongxu, Feng, Zhuanghui, Ding, Qiurong. Type 2 Diabetes Variants in the SLC16A11 Coding Region Are Not Loss-of-Function Mutations. CELL REPORTS[J]. 2019, 第 3 作者  通讯作者  29(3): 781-784, http://dx.doi.org/10.1016/j.celrep.2019.09.022.
[20] Ding, Luyang, Liang, Lizong, Zhao, Yongxu, Yang, Yanan, Liu, Feng, Ding, Qiurong, Luo, Lijun. Porphyromonas gingivalis-derived lipopolysaccharide causes excessive hepatic lipid accumulation via activating NF-kappa B and JNK signaling pathways. ORAL DISEASES[J]. 2019, 第 6 作者  通讯作者  25(7): 1789-1797, http://dx.doi.org/10.1111/odi.13153.
[21] Zhao, Yongxu, Feng, Zhuanghui, Zhang, Yongxian, Sun, Yingmin, Chen, Yanhao, Liu, Xiaojian, Li, Shuang, Zhou, Tingting, Chen, Lanlan, Wei, Yuda, Ma, Danjun, Lui, Kathy O, Ying, Hao, Chen, Yan, Ding, Qiurong. Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes. CELL REPORTS[J]. 2019, 第 15 作者  通讯作者  26(4): 884-+, http://dx.doi.org/10.1016/j.celrep.2018.12.100.
[22] Xixi Zhang, Haiwei Zhang, Chengxian Xu, Xiaoming Li, Ming Li, Xiaoxia Wu, Wenjuan Pu, Bin Zhou, Haikun Wang, Dali Li, Qiurong Ding, Hao Ying, Hui Wang, Haibing Zhang. Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. NATURE COMMUNICATIONS[J]. 2019, 第 11 作者10(1): 1-15, http://dx.doi.org/10.1038/s41467-019-11839-w.
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[24] Li, Shuang, Huang, ShiQian, Zhao, YongXu, Ding, YuJie, Ma, DanJun, Ding, QiuRong. Derivation and applications of human hepatocyte-like cells. WORLD JOURNAL OF STEM CELLS[J]. 2019, 第 6 作者  通讯作者  11(8): 535-547, http://lib.cqvip.com/Qikan/Article/Detail?id=7002847915.
[25] Yuan, Juanjuan, Ma, Yunqing, Huang, Tao, Chen, Yanhao, Peng, Yuanzheng, Li, Bing, Li, Jia, Zhang, Yuchen, Song, Bing, Sun, Xiaofang, Ding, Qiurong, Song, Yan, Chang, Xing. Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase. MOLECULAR CELL[J]. 2018, 第 11 作者72(2): 380-+, http://dx.doi.org/10.1016/j.molcel.2018.09.002.
[26] Li, Shuang, Li, Mushan, Liu, Xiaojian, Yang, Yuanyuan, Wei, Yuda, Chen, Yanhao, Qiu, Yan, Zhou, Tingting, Feng, Zhuanghui, Ma, Danjun, Fang, Jing, Ying, Hao, Wang, Hui, Musunuru, Kiran, Shao, Zhen, Zhao, Yongxu, Ding, Qiurong. Genetic and Chemical Screenings Identify HDAC3 as a Key Regulator in Hepatic Differentiation of Human Pluripotent Stem Cells. STEM CELL REPORTS[J]. 2018, 第 17 作者  通讯作者  11(1): 22-31, http://dx.doi.org/10.1016/j.stemcr.2018.05.001.
[27] Shao, Yanjiao, Wang, Liren, Guo, Nana, Wang, Shengfei, Yang, Lei, Li, Yajing, Wang, Mingsong, Yin, Shuming, Han, Honghui, Zeng, Li, Zhang, Ludi, Hui, Lijian, Ding, Qiurong, Zhang, Jiqin, Geng, Hongquan, Liu, Mingyao, Li, Dali. Cas9-nickase-mediated genome editing corrects hereditary tyrosinemia in rats. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 第 13 作者293(18): 6883-6892, http://dx.doi.org/10.1074/jbc.RA117.000347.
[28] Yuan Juanjuan, Ma Yunqing, Huang Tao, Chen Yanhao, Peng Yuanzheng, Li Bing, Li Jia, Zhang Yuchen, Song Bing, Sun Xiaofang, Ding Qiurong, Song Yan, Chang Xing. Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase. MOLECULAR CELL[J]. 2018, 第 11 作者72(2): 380-+, 
[29] Qiu, Yan, Sun, Yingmin, Xu, Danqing, Yang, Yuanyuan, Liu, Xiaojian, Wei, Yuda, Chen, Yanhao, Feng, Zhuanghui, Li, Shuang, Reyadul Ferdous, Md, Zhao, Yongxu, Xu, Hongxi, Lao, Yuanzhi, Ding, Qiurong. Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue. EBIOMEDICINE[J]. 2018, 第 14 作者  通讯作者  37(-): 344-355, http://dx.doi.org/10.1016/j.ebiom.2018.10.019.
[30] Sun, Yingmin, Ding, Qiurong. Genome engineering of stem cell organoids for disease modeling. PROTEIN & CELL[J]. 2017, 第 2 作者  通讯作者  8(5): 315-327, http://lib.cqvip.com/Qikan/Article/Detail?id=672366139.
[31] Yingmin Sun, Qiurong Ding. Genome engineering of stem cell organoids for disease modeling. 蛋白质与细胞:英文版[J]. 2017, 第 2 作者8(5): 315-327, http://lib.cqvip.com/Qikan/Article/Detail?id=672366139.
[32] Liu, Yongbo, Fan, Cunxian, Zhang, Yifan, Yu, Xianjun, Wu, Xiaoxia, Zhang, Xixi, Zhao, Qun, Zhang, Haiwei, Xie, Qun, Li, Ming, Li, Xiaoming, Ding, Qiurong, Ying, Hao, Li, Dali, Zhang, Haibing. RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice. CELL DEATH AND DIFFERENTIATION[J]. 2017, 第 12 作者24(8): 1459-1469, 
[33] 丁秋蓉. CRISPR/Cas9 with single guide RNA expression driven by small tRNA promoters showed reduced editing efficiency compared to U6 promoter.. RNA. 2017, 第 1 作者  通讯作者  
[34] Zhang, YuYao, Li, Chao, Yao, GaoFeng, Du, LinJuan, Liu, Yuan, Zheng, XiaoJun, Yan, Shuai, Sun, JianYong, Liu, Yan, Liu, MingZhu, Zhang, Xiaoran, Wei, Gang, Tong, Wenxin, Chen, Xiaobei, Wu, Yong, Sun, Shuyang, Liu, Suling, Ding, Qiurong, Yu, Ying, Yin, Huiyong, Duan, ShengZhong. Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ER/HGF/Met Pathway. DIABETES[J]. 2017, 第 18 作者66(6): 1535-1547, http://dx.doi.org/10.2337/db16-1354.
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[38] Chen, Yanhao, Liu, Xiaojian, Zhang, Yongxian, Wang, Hui, Ying, Hao, Liu, Mingyao, Li, Dali, Lui, Kathy O, Ding, Qiurong. A Self-restricted CRISPR System to Reduce Off-target Effects. MOLECULAR THERAPY. 2016, 第 9 作者  通讯作者  24(9): 1508-1510, http://dx.doi.org/10.1038/mt.2016.172.
[39] 丁秋蓉. CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo.. Arterioscler Thromb Vasc Biol.. 2016, 第 1 作者  通讯作者  
[40] 刘改改, 李爽, 张永贤, 丁秋蓉. 基因组编辑技术在干细胞疾病模型和疾病治疗中的应用. 生命科学[J]. 2015, 第 4 作者27(1): 083-092, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5355227&detailType=1.
[41] Ding, Qiurong, Strong, Alanna, Patel, Kevin M, Ng, SzeLing, Gosis, Bridget S, Regan, Stephanie N, Cowan, Chad A, Rader, Daniel J, Musunuru, Kiran. Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing. CIRCULATION RESEARCH[J]. 2014, 第 1 作者115(5): 488-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000341164500007.
[42] Ding, Qiurong, Lee, YounKyoung, Schaefer, Esperance A K, Peters, Derek T, Veres, Adrian, Kim, Kevin, Kuperwasser, Nicolas, Motola, Daniel L, Meissner, Torsten B, Hendriks, William T, Trevisan, Marta, Gupta, Rajat M, Moisan, Annie, Banks, Eric, Friesen, Max, Schinzel, Robert T, Xia, Fang, Tang, Alexander, Xia, Yulei, Figueroa, Emmanuel, Wann, Amy, Ahfeldt, Tim, Daheron, Laurence, Zhang, Feng, Rubin, Lee L, Peng, Lee F, Chung, Raymond T, Musunuru, Kiran, Cowan, Chad A. A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models. CELL STEM CELL[J]. 2013, 第 1 作者12(2): 238-251, http://dx.doi.org/10.1016/j.stem.2012.11.011.
[43] Ding, Qiurong, Regan, Stephanie N, Xia, Yulei, Oostrom, Leonie A, Cowan, Chad A, Musunuru, Kiran. Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs. CELL STEM CELL. 2013, 第 1 作者12(4): 393-394, http://dx.doi.org/10.1016/j.stem.2013.03.006.
[44] Jin, Ting, Xu, Daqian, Ding, Qiurong, Zhang, Yixuan, Mao, Chenqian, Pan, Yi, Wang, Zhenzhen, Chen, Yan. Identification of the topology and functional domains of PAQR10. BIOCHEMICAL JOURNAL[J]. 2012, 第 3 作者443: 643-653, http://dx.doi.org/10.1042/BJ20112105.
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[46] Lu Zhu, Lingdi Wang, Xiaolin Luo, Yongxian Zhang, Qiurong Ding, Xiaomeng Jiang, Xiao Wang, Yi Pan, Yan Chen. Tollip, an Intracellular Trafficking Protein, Is a Novel Modulator of the Transforming Growth Factor-β Signaling Pathway*. JOURNAL OF BIOLOGICAL CHEMISTRY. 2012, 第 5 作者287(47): 39653-39663, http://dx.doi.org/10.1074/jbc.M112.388009.
[47] Ting Jin, Qiurong Ding, Heng Huang, Daqian Xu, Yuhui Jiang, Ben Zhou, Zhenghu Li, Xiaomeng Jiang, Jing He, Weizhong Liu, Yixuan Zhang, Yi Pan, Zhenzhen Wang, Walter G Thomas, Yan Chen. PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. 细胞研究:英文版[J]. 2012, 第 2 作者22(4): 661-676, http://lib.cqvip.com/Qikan/Article/Detail?id=41470958.
[48] 丁秋蓉. In vivo disruption of TGF-β signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis.. PLOS ONE. 2010, 第 1 作者
[49] Qiu, Yifu, Mao, Ting, Zhang, Yongliang, Shao, Mengle, You, Jia, Ding, Qiurong, Chen, Yan, Wu, Dongmei, Xie, Dong, Lin, Xu, Gao, Xiang, Kaufman, Randal J, Li, Wenjun, Liu, Yong. A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1 alpha Activation in Pancreatic beta Cells. SCIENCE SIGNALING[J]. 2010, 第 6 作者3(106): 
[50] Ding, Qiurong, Wang, Zhenzhen, Chen, Yan. Endocytosis of adiponectin receptor 1 through a clathrin- and Rab5-dependent pathway. CELL RESEARCH[J]. 2009, 第 1 作者19(3): 317-327, http://dx.doi.org/10.1038/cr.2008.299.
[51] Ding, Qiurong, Jin, Ting, Wang, Zhenzhen, Chen, Yan. Catalase potentiates retinoic acid-induced THP-1 monocyte differentiation into macrophage through inhibition of peroxisome proliferator-activated receptor gamma. JOURNAL OF LEUKOCYTE BIOLOGY[J]. 2007, 第 1 作者81(6): 1568-1576, https://www.webofscience.com/wos/woscc/full-record/WOS:000246988600024.
[52] Xiaojian Liu, Yuanyuan Yang, Yan Qiu, Md Reyadulferdous, Qiurong Ding, Yi Wang. SeqCor: correct the effect of gRNA sequences in CRISPR/Cas9 screenings by machine learning algorithm. JOURNAL OF GENETICS AND GENOMICS. 第 5 作者http://dx.doi.org/10.1016/j.jgg.2020.10.007.
[53] Xiaojian Liu, Yuanyuan Yang, Yan Qiu, Md Reyadulferdous, Qiurong Ding, Yi Wang. SeqCor: correct the effect of gRNA sequences in clustered regularly interspaced short palindromic repeats/Cas9 screenings by machine learning algorithm. JOURNAL OF GENETICS AND GENOMICS. 第 5 作者http://dx.doi.org/10.1016/j.jgg.2020.10.007.

科研活动

   
科研项目
( 1 ) 探索利用CRISPR技术进行基因治疗心血管疾病的基础研究, 主持, 省级, 2015-07--2017-06
( 2 ) 利用干细胞疾病模型探索ALS 病人中C9ORF72基因组区域突变的致病机理研究, 主持, 国家级, 2015-01--2016-12
( 3 ) LincRNA通过编码蛋白小肽调节脂肪细胞代谢的分子机制研究, 主持, 国家级, 2017-01--2020-12
( 4 ) 多能干细胞自我更新和分化的表观遗传调控研究, 主持, 国家级, 2017-07--2021-12
( 5 ) 人类多能干细胞定向心肌分化的阶段性调控机制、分 子标记和功能特征, 参与, 国家级, 2017-07--2021-12
( 6 ) 用于异种移植的肝细胞的体外获得与扩增技术, 主持, 部委级, 2017-12--2022-11

指导学生

现指导学生

李爽  博士研究生  071010-生物化学与分子生物学  

韦余达  博士研究生  071010-生物化学与分子生物学  

杨圆圆  硕士研究生  085238-生物工程  

邱艳  博士研究生  071010-生物化学与分子生物学  

陈兰兰  硕士研究生  071010-生物化学与分子生物学  

田程  硕士研究生  071010-生物化学与分子生物学  

窦唯  硕士研究生  071010-生物化学与分子生物学  

陈彦好  博士研究生  071003-生理学  

吴晓珊  博士研究生  071010-生物化学与分子生物学  

刘小健  博士研究生  071010-生物化学与分子生物学  

冯庄慧  博士研究生  071010-生物化学与分子生物学  

周婷婷  硕士研究生  071009-细胞生物学