丁宝全  男  博导  国家纳米科学中心
电子邮件: dingbq@nanoctr.cn
通信地址: 国家纳米科学中心
邮政编码: 100190

研究领域

生物纳米材料与器件

招生信息

   
招生专业
070304-物理化学(含:化学物理)
071011-生物物理学
0703J1-纳米科学与技术
招生方向
生物纳米材料
自组装与微纳加工结合技术
纳米电子光子学

教育背景

2000-09--2006-08   纽约大学   博士学位
1996-09--2000-07   吉林大学   学士学位

工作经历

2009-10--2010-10 亚利桑那州立大学 研究助理教授
2006-09--2009-09 劳伦斯伯克利国家实验室 博士后

教授课程

纳米功能材料

专利与奖励

   
专利成果
( 1 ) Polygonal nanostructures of polynucleic acid multi-crossover molecules and assembly of lattices based on double crossover cohesion, 发明, 2006, 第 2 作者, 专利号: U.S. Pat. Appl. Publ. (2006), 55 pp
( 2 ) 一种用于运载抗肿瘤药物的核酸纳米结构及其制备方法和应用, 发明, 2013, 第 1 作者, 专利号: 201310351835.7
( 3 ) 一种金钯双金属卫星结构组装体及其制备方法和应用, 发明, 2013, 第 1 作者, 专利号: 201310351835.7
( 4 ) 一种海参状核壳结构金银纳米复合材料, 发明, 2015, 第 1 作者, 专利号: 201510172371.2
( 5 ) 一种用于活体光声成像的核酸纳米结构-贵金属光敏造影剂复合物探针及其制备方法和应用, 发明, 2014, 第 1 作者, 专利号: 201410426106.8
( 6 ) 装载凝血酶的DNA自组装纳米结构、其制备方法及应用, 发明, 2014, 第 3 作者, 专利号: 201410207351.X

出版信息

   
通讯作者发表论文
[1] Wu, Tiantian, Cao, Yuanwei, Liu, Qing, Wu, Xiaohui, Shang, Yingxu, Piao, Jiafang, Li, Yujie, Dong, Yuanchen, Liu, Dongsheng, Wang, Haoyi, Liu, Jianbing, Ding, Baoquan. Genetically Encoded Double-Stranded DNA-Based Nanostructure Folded by a Covalently Bivalent CRISPR/dCas System. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 144(14): 6575-6582, [2] Wu, Tiantian, Cao, Yuanwei, Liu, Qing, Wu, Xiaohui, Shang, Yingxu, Piao, Jiafang, Li, Yujie, Dong, Yuanchen, Liu, Dongsheng, Wang, Haoyi, Liu, Jianbing, Ding, Baoquan. Genetically Encoded Double-Stranded DNA-Based Nanostructure Folded by a Covalently Bivalent CRISPR/dCas System br. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 144(14): 6575-6582, [3] Li, Runze, Wu, Xiaohui, Li, Jing, Lu, Xuehe, Zhao, Robert Chunhua, Liu, Jianbing, Ding, Baoquan. A covalently conjugated branched DNA aptamer cluster-based nanoplatform for efficiently targeted drug delivery. NANOSCALE[J]. 2022, 14: 9369-9378, [4] Zhu, Jinjin, Wu, Fan, Han, Zihong, Shang, Yingxu, Liu, Fengsong, Yu, Haiyin, Yu, Li, Li, Na, Ding, Baoquan. Strong Light-Matter Interactions in Chiral Plasmonic-Excitonic Systems Assembled on DNA Origami. NANO LETTERS[J]. 2021, 21(8): 3573-3580, http://dx.doi.org/10.1021/acs.nanolett.1c00596.
[5] Wang, Zhaoran, Song, Linlin, Liu, Qing, Tian, Run, Shang, Yingxu, Liu, Fengsong, Liu, Shaoli, Zhao, Shuai, Han, Zihong, Sun, Jiashu, Jiang, Qiao, Ding, Baoquan. A Tubular DNA Nanodevice as a siRNA/Chemo-Drug Co-delivery Vehicle for Combined Cancer Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(5): 2594-2598, https://www.webofscience.com/wos/woscc/full-record/WOS:000594468400001.
[6] HAN Lin, WANG Yuang, TANG Wantao, LIU Jianbing, DING Baoquan. Bioimaging Based on Nucleic Acid Nanostructures. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES[J]. 2021, 37(4): 823-828, [7] Liu, Jianbing, Lu, Xuehe, Wu, Tiantian, Wu, Xiaohui, Han, Lin, Ding, Baoquan. Branched Antisense and siRNA Co-Assembled Nanoplatform for Combined Gene Silencing and Tumor Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(4): 1853-1860, [8] 丁宝全. Nucleic acid–based aggregates and their biomedical applications. Aggregate. 2021, [9] Xu, Xuehui, Shang, Yingxu, Liu, Fengsong, Jiang, Qiao, Ding, Baoquan. Logic devices based on nucleic acid self-assembly. INFOMATnull. 2021, 3(10): 1070-1082, http://dx.doi.org/10.1002/inf2.12240.
[10] Li, Yan, Pei, Jin, Lu, Xuehe, Jiao, Yunfei, Liu, Fengsong, Wu, Xiaohui, Liu, Jianbing, Ding, Baoquan. Hierarchical Assembly of Super-DNA Origami Based on a Flexible and Covalent-Bound Branched DNA Structure. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 143(47): 19893-19900, [11] Liu, Qing, Wan, Kaiwei, Shang, Yingxu, Wang, ZhenGang, Zhang, Yiyang, Dai, Luru, Wang, Chen, Wang, Hui, Shi, Xinghua, Liu, Dongsheng, Ding, Baoquan. Cofactor-free oxidase-mimetic nanomaterials from self-assembled histidine-rich peptides. NATURE MATERIALS[J]. 2021, 20(3): 395-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000594824700001.
[12] Shuai Zhao, Run Tian, Jun Wu, Shaoli Liu, Yuanning Wang, Meng Wen, Yingxu Shang, Qing Liu, Yan Li, Ying Guo, Zhaoran Wang, Ting Wang, Yujing Zhao, Huiru Zhao, Hui Cao, Yu Su, Jiashu Sun, Qiao Jiang, Baoquan Ding. A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807036/.
[13] Fei Tian, Shaohua Zhang, Chao Liu, Ziwei Han, Yuan Liu, Jinqi Deng, Yike Li, Xia Wu, Lili Cai, Lili Qin, Qinghua Chen, Yang Yuan, Yi Liu, Yulong Cong, Baoquan Ding, Zefei Jiang, Jiashu Sun. Protein analysis of extracellular vesicles to monitor and predict therapeutic response in metastatic breast cancer. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/ad4f67eb76a945bbab6cae162e3f55be.
[14] Han, Ziwei, Wan, Fangning, Deng, Jinqi, Zhao, Junxiang, Li, Yike, Yang, Yunjie, Jiang, Qiao, Ding, Baoquan, Liu, Chao, Dai, Bo, Sun, Jiashu. Ultrasensitive detection of mRNA in extracellular vesicles using DNA tetrahedron-based thermophoretic assay. NANO TODAY[J]. 2021, 38: http://dx.doi.org/10.1016/j.nantod.2021.101203.
[15] Liu, Shaoli, Jiang, Qiao, Zhao, Xiao, Zhao, Ruifang, Wang, Yuanning, Wang, Yiming, Liu, Jianbing, Shang, Yingxu, Zhao, Shuai, Wu, Tiantian, Zhang, Yinlong, Nie, Guangjun, Ding, Baoquan. A DNA nanodevice-based vaccine for cancer immunotherapy. NATURE MATERIALS[J]. 2021, 20(3): 421-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000566892000002.
[16] Tang, Wantao, Han, Lin, Lu, Xuehe, Wang, Zhaoran, Liu, Fengsong, Li, Yan, Liu, Shengbo, Liu, Shaoli, Tian, Run, Liu, Jianbing, Ding, Baoquan. A Nucleic Acid/Gold Nanorod-Based Nanoplatform for Targeted Gene Editing and Combined Tumor Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 13(18): 20974-20981, [17] Tang, Wantao, Han, Lin, Duan, Su, Lu, Xuehe, Wang, Yuang, Wu, Xiaohui, Liu, Jianbing, Ding, Baoquan. An Aptamer-Modified DNA Tetrahedron-Based Nanogel for Combined Chemo/Gene Therapy of Multidrug-Resistant Tumors. ACS APPLIED BIO MATERIALS[J]. 2021, 4(10): 7701-7707, [18] Wu, Xiaohui, Liu, Qing, Liu, Fengsong, Wu, Tiantian, Shang, Yingxu, Liu, Jianbing, Ding, Baoquan. An RNA/DNA hybrid origami-based nanoplatform for efficient gene therapy. NANOSCALE[J]. 2021, 13(30): 12848-12853, [19] Song, Linlin, Wang, Zhaoran, Liu, Jianbing, Wang, Ting, Jiang, Qiao, Ding, Baoquan. Tumor-Targeted DNA Bipyramid for in Vivo Dual -Modality Imaging. ACS APPLIED BIO MATERIALS[J]. 2020, 3(5): 2854-2860, http://dx.doi.org/10.1021/acsabm.9b01096.
[20] Lu, Xuehe, Wu, Xiaohui, Wu, Tiantian, Han, Lin, Liu, Jianbing, Ding, Baoquan. Efficient construction of a stable linear gene based on a TNA loop modified primer pair for gene delivery. CHEMICAL COMMUNICATIONS[J]. 2020, 56(68): 9894-9897, [21] Shang, Yingxu, Liu, Fengsong, Wang, Yuanning, Li, Na, Ding, Baoquan. Enzyme Mimic Nanomaterials and Their Biomedical Applications. CHEMBIOCHEM[J]. 2020, 21(17): 2408-2418, https://www.webofscience.com/wos/woscc/full-record/WOS:000527372300001.
[22] Wu, Xiaohui, Wu, Tiantian, Liu, Jianbing, Ding, Baoquan. Gene Therapy Based on Nucleic Acid Nanostructure. ADVANCED HEALTHCARE MATERIALS[J]. 2020, 9(19): [23] Shang, Yingxu, Li, Na, Liu, Shengbo, Wang, Ling, Wang, ZhenGang, Zhang, Zhong, Ding, Baoquan. Site-Specific Synthesis of Silica Nanostructures on DNA Origami Templates. ADVANCED MATERIALS[J]. 2020, 32(21): https://www.webofscience.com/wos/woscc/full-record/WOS:000526806300001.
[24] Liu, Fengsong, Shang, Yingxu, Wang, Zhaoran, Jiao, Yunfei, Li, Na, Ding, Baoquan. DNA origami directed fabrication of shape-controllable nanomaterials. APL MATERIALS[J]. 2020, 8(11): https://doaj.org/article/1a237e9ea71344f59be0e7cf584b0ce3.
[25] 丁宝全. Cofactor-freeoxidase-mimeticnanomaterials fromself-assembled histidine-rich peptides. Nature Materials. 2020, [26] Zhu Jinjin, Shang Yingxu, Yu Haiyin, Li Na, Ding Baoquan. Shape-controllable Synthesis of Functional Nanomaterials on DNA Templates. CHEMICAL RESEARCH IN CHINESE UNIVERSITIESnull. 2020, 36(2): 171-176, http://lib.cqvip.com/Qikan/Article/Detail?id=7101349529.
[27] 丁宝全. Logic gated plasmonic nanodevices based on DNA-templated assembly. CCS Chemistry. 2020, [28] 丁宝全. Strong Plasmon-Exciton Coupling in Bimetallic Nanoring and Nanocuboids. Journal of Materials Chemistry C. 2020, [29] Li, Na, Wu, Fan, Han, Zihong, Wang, Xiaofeng, Liu, Yi, Yi, Chenglin, Ye, Shunsheng, Lu, Guowei, Yu, Li, Nie, Zhihong, Ding, Baoquan. Shape Complementarity Modulated Self-Assembly of Nanoring and Nanosphere Hetero-nanostructures. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(27): 11680-11684, https://www.webofscience.com/wos/woscc/full-record/WOS:000550639000010.
[30] 丁宝全. A Multifunctional Double Bundle DNA Tetrahedron for Efficient Regulation of Gene Expression. ACS Applied Materials & Interfaces. 2020, [31] Li, Na, Han, Zihong, Huang, Yuming, Liang, Kun, Wang, Xiaofeng, Wu, Fan, Qi, Xiaoying, Shang, Yingxu, Yu, Li, Ding, Baoquan. Strong plasmon-exciton coupling in bimetallic nanorings and nanocuboids. JOURNAL OF MATERIALS CHEMISTRY C[J]. 2020, 8(23): 7672-7678, https://www.webofscience.com/wos/woscc/full-record/WOS:000544086800005.
[32] Li, Na, Shang, Yingxu, Han, Zihong, Wang, Ting, Wang, ZhenGang, Ding, Baoquan. Fabrication of Metal Nanostructures on DNA Templates. ACS APPLIED MATERIALS & INTERFACESnull. 2019, 11(15): 13835-13852, https://www.webofscience.com/wos/woscc/full-record/WOS:000465189000002.
[33] Liu, Shaoli, Jiang, Qiao, Wang, Yuanning, Ding, Baoquan. Biomedical Applications of DNA-Based Molecular Devices. ADVANCED HEALTHCARE MATERIALSnull. 2019, 8(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000468803300012.
[34] Lu, Xuehe, Liu, Jianbing, Wu, Xiaohui, Ding, Baoquan. Multifunctional DNA Origami Nanoplatforms for Drug Delivery. CHEMISTRY-AN ASIAN JOURNAL[J]. 2019, 14(13): 2193-2202, [35] Liu, Chao, Zhao, Junxiang, Tian, Fei, Cai, Lili, Zhang, Wei, Feng, Qiang, Chang, Jianqiao, Wan, Fangning, Yang, Yunjie, Dai, Bo, Cong, Yulong, Ding, Baoquan, Sun, Jiashu, Tan, Weihon. Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers. NATURE BIOMEDICAL ENGINEERING[J]. 2019, 3(3): 183-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000460576800009.
[36] 聂广军, 蒋乔, 李素萍, 丁宝全, 赵宇亮. DNA纳米机器人:第一次在活体内高效完成定点药物输运. 前沿科学. 2019, 13(1): 22-24, http://lib.cqvip.com/Qikan/Article/Detail?id=7001829940.
[37] Jiang, Qiao, Zhao, Shuai, Liu, Jianbing, Song, Linlin, Wang, ZhenGang, Ding, Baoquan. Rationally designed DNA-based nanocarriers. ADVANCED DRUG DELIVERY REVIEWSnull. 2019, 147: 2-21, http://dx.doi.org/10.1016/j.addr.2019.02.003.
[38] Jiang, Qiao, Liu, Shaoli, Liu, Jianbing, Wang, ZhenGang, Ding, Baoquan. Rationally Designed DNA-Origami Nanomaterials for Drug Delivery In Vivo. ADVANCED MATERIALS[J]. 2019, 31(45): [39] Wu, Tiantian, Liu, Jianbing, Liu, Manman, Liu, Shaoli, Zhao, Shuai, Tian, Run, Wei, Dengshuai, Liu, Yangzhong, Zhao, Yao, Xiao, Haihua, Ding, Baoquan. A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(40): 14224-14228, [40] Li, Na, Shang, Yingxu, Xu, Rui, Jiang, Qiao, Liu, Jianbing, Wang, Ling, Cheng, Zhihai, Ding, Baoquan. Precise Organization of Metal and Metal Oxide Nanoclusters into Arbitrary Patterns on DNA Origami. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(45): 17968-17972, https://www.webofscience.com/wos/woscc/full-record/WOS:000498281600003.
[41] Jiang, Qiao, Xu, Xuehui, Yin, PingAn, Ma, Kai, Zhen, Yonggang, Duan, Pengfei, Peng, Qian, Chen, WeiQiang, Ding, Baoquan. Circularly Polarized Luminescence of Achiral Cyanine Molecules Assembled on DNA Templates. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(24): 9490-9494, https://www.webofscience.com/wos/woscc/full-record/WOS:000471835600011.
[42] Liu, Jianbing, Wu, Tiantian, Lu, Xuehe, Wu, Xiaohui, Liu, Shaoli, Zhao, Shuai, Xu, Xuehui, Ding, Baoquan. A Self-Assembled Platform Based on Branched DNA for sgRNA/Cas9/Antisense Delivery. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(48): 19032-19037, [43] Li, Suping, Jiang, Qiao, Ding, Baoquan, Nie, Guangjun. Anticancer Activities of Tumor-killing Nanorobots. TRENDS IN BIOTECHNOLOGYnull. 2019, 37(6): 573-577, http://dx.doi.org/10.1016/j.tibtech.2019.01.010.
[44] Wang, ZhenGang, Li, Yunzhe, Wang, Hui, Wan, Kaiwei, Liu, Qing, Shi, Xinghua, Ding, Baoquan. Enzyme Mimic Based on a Self-Assembled Chitosan/DNA Hybrid Exhibits Superior Activity and Tolerance. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2019, 25(54): 12576-12582, https://www.webofscience.com/wos/woscc/full-record/WOS:000484830600001.
[45] Zhao, Shuai, Duan, Fangyuan, Liu, Shaoli, Wu, Tiantian, Shang, Yingxu, Tian, Run, Liu, Jianbing, Wang, ZhenGang, Jiang, Qiao, Ding, Baoquan. Efficient Intracellular Delivery of RNase A Using DNA Origami Carriers. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(12): 11112-11118, [46] Wei, Yu, Xu, Xuehui, Shang, Yingxu, Jiang, Qiao, Li, Can, Ding, Baoquan. Visualization of the intracellular location and stability of DNA flowers with a label-free fluorescent probe. RSC ADVANCES[J]. 2019, 9(27): 15205-15209, [47] Liu, Jianbing, Song, Linlin, Liu, Shaoli, Jiang, Qiao, Liu, Qing, Li, Na, Wang, ZhenGang, Ding, Baoquan. A DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy. NANO LETTERS[J]. 2018, 18(6): 3328-3334, [48] Jiashu Sun, Yike Li, Fusheng Yan, Chao Liu, Yutao Sang, Fei Tian, Qiang Feng, Pengfei Duan, Li Zhang, Xinghua Shi, Baoquan Ding, Minghua Liu. Control over the emerging chirality in supramolecular gels and solutions by chiral microvortices in milliseconds. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/b6310ce7abdf4680bde9fd4f08db883a.
[49] Huabing Chen, Zhanjun Gu, Hongwei An, Chunying Chen, Jie Chen, Ran Cui, Siqin Chen, Weihai Chen, Xuesi Chen, Xiaoyuan Chen, Zhuo Chen, Baoquan Ding, Qian Dong, Qin Fan, Ting Fu, Dayong Hou, Qiao Jiang, Hengte Ke, Xiqun Jiang, Gang Liu, Suping Li, Tianyu Li, Zhuang Liu, Guangjun Nie, Muhammad Ovais, Daiwen Pang, Nasha Qiu, Youqing Shen, Huayu Tian, Chao Wang, Hao Wang, Ziqi Wang, Huaping Xu, JiangFei Xu, Xiangliang Yang, Shuang Zhu, Xianchuang Zheng, Xianzheng Zhang, Yanbing Zhao, Weihong Tan, Xi Zhang, Yuliang Zhao. Precise nanomedicine for intelligent therapy of cancer. 中国科学:化学英文版null. 2018, 61(12): 1503-1552, http://lib.cqvip.com/Qikan/Article/Detail?id=6100154608.
[50] Li, Suping, Jiang, Qiao, Liu, Shaoli, Zhang, Yinlong, Tian, Yanhua, Song, Chen, Wang, Jing, Zou, Yiguo, Anderson, Gregory J, Han, JingYan, Chang, Yung, Liu, Yan, Zhang, Chen, Chen, Liang, Zhou, Guangbiao, Nie, Guangjun, Yan, Hao, Ding, Baoquan, Zhao, Yuliang. A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo. NATURE BIOTECHNOLOGY[J]. 2018, 36(3): 258-+, http://www.corc.org.cn/handle/1471x/2178140.
[51] Jianbing Liu, Zhengang Wang, Shuai Zhao, Baoquan Ding. Multifunctional nucleic acid nanostructures for gene therapies. 纳米研究:英文版. 2018, 11(10): 5017-5027, http://lib.cqvip.com/Qikan/Article/Detail?id=676513399.
[52] Li, Yunzhe, Wang, ZhenGang, Li, Huanrong, Ding, Baoquan. NAD(+) Cofactor Regeneration by TMB-Mediated Horseradish-Peroxidase-Catalyzed Reactions. CHEMISTRYSELECT[J]. 2018, 3(39): 10900-10904, https://www.webofscience.com/wos/woscc/full-record/WOS:000449032600012.
[53] Wang, ZhenGang, Wang, Hui, Liu, Qing, Duan, Fangyuan, Shi, Xinghua, Ding, Baoquan. Designed Self-Assembly of Peptides with G-Quadruplex/Hemin DNAzyme into Nanofibrils Possessing Enzyme-Mimicking Active Sites and Catalytic Functions. ACS CATALYSIS[J]. 2018, 8(8): 7016-7024, https://www.webofscience.com/wos/woscc/full-record/WOS:000441112400025.
[54] Wang, ZhenGang, Li, Na, Wang, Ting, Ding, Baoquan. Surface-Guided Chemical Processes on Self-Assembled DNA Nanostructures. LANGMUIR[J]. 2018, 34(49): 14954-14962, https://www.webofscience.com/wos/woscc/full-record/WOS:000453489200032.
[55] Zhan, Pengfei, Wen, Te, Wang, Zhengang, He, Yingbo, Shi, Jia, Wang, Ting, Liu, Xinfeng, Lu, Guowei, Ding, Baoquan. DNA Origami Directed Assembly of Gold Bowtie Nanoantennas for Single-Molecule Surface-Enhanced Raman Scattering. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(11): 2846-2850, https://www.webofscience.com/wos/woscc/full-record/WOS:000426490700013.
[56] Liu, Jianbing, Wang, Zhengang, Zhao, Shuai, Ding, Baoquan. Multifunctional nucleic acid nanostructures for gene therapies. NANO RESEARCH[J]. 2018, 11(10): 5017-5027, [57] Yang, Juanjuan, Jiang, Qiao, He, Lin, Zhan, Pengfei, Liu, Qing, Liu, Shaoli, Fu, Meifang, Liu, Jianbing, Li, Can, Ding, Baoquan. Self-Assembled Double-Bundle DNA Tetrahedron for Efficient Antisense Delivery. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(28): 23693-23699, [58] Shang, Yingxu, Shi, Jia, Liu, Huan, Liu, Xinfeng, Wang, ZhenGang, Ding, Baoquan. A bumpy gold nanostructure exhibiting DNA-engineered stimuli-responsive SERS signals. NANOSCALE[J]. 2018, 10(20): 9455-9459, https://www.webofscience.com/wos/woscc/full-record/WOS:000433260300004.
[59] []. A tailored DNA nanoplatform for synergistic RNAi-/chemotherapy of multidrug-resistant tumors. 中国科学基金:英文版. 2018, 26(4): 8-8, http://lib.cqvip.com/Qikan/Article/Detail?id=6100153837.
[60] Xiaodong Qi, Fei Zhang, Zhaoming Su, Shuoxing Jiang, Dongran Han, Baoquan Ding, Yan Liu, Wah Chiu, Peng Yin, Hao Yan. Programming molecular topologies from single-stranded nucleic acids. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/39a636c817ce4fed8648e1011f0317b4.
[61] Chen, Huabing, Gu, Zhanjun, An, Hongwei, Chen, Chunying, Chen, Jie, Cui, Ran, Chen, Siqin, Chen, Weihai, Chen, Xuesi, Chen, Xiaoyuan, Chen, Zhuo, Ding, Baoquan, Dong, Qian, Fan, Qin, Fu, Ting, Hou, Dayong, Jiang, Qiao, Ke, Hengte, Jiang, Xiqun, Liu, Gang, Li, Suping, Li, Tianyu, Liu, Zhuang, Nie, Guangjun, Ovais, Muhammad, Pang, Daiwen, Qiu, Nasha, Shen, Youqing, Tian, Huayu, Wang, Chao, Wang, Hao, Wang, Ziqi, Xu, Huaping, Xu, JiangFei, Yang, Xiangliang, Zhu, Shuang, Zheng, Xianchuang, Zhang, Xianzheng, Zhao, Yanbing, Tan, Weihong, Zhang, Xi, Zhao, Yuliang. Precise nanomedicine for intelligent therapy of cancer. SCIENCE CHINA-CHEMISTRYnull. 2018, 61(12): 1503-1552, http://lib.cqvip.com/Qikan/Article/Detail?id=6100154608.
[62] Song, Linlin, Jiang, Qiao, Wang, ZhenGang, Ding, Baoquan. Self-Assembled DNA Nanostructures for Biomedical Applications. CHEMNANOMATnull. 2017, 3(10): 713-724, [63] Zhan, Pengfei, Dutta, Palash K, Wang, Pengfei, Song, Gang, Dai, Mingjie, Zhao, ShuXia, Wang, ZhenGang, Yin, Peng, Zhang, Wei, Ding, Baoquan, Ke, Yonggang. Reconfigurable Three-Dimensional Gold Nanorod Plasmonic Nanostructures Organized on DNA Origami Tripod. ACS NANO[J]. 2017, 11(2): 1172-1179, https://www.webofscience.com/wos/woscc/full-record/WOS:000395357300006.
[64] Jiang, Qiao, Liu, Qing, Shi, Yuefeng, Wang, ZhenGang, Zhan, Pengfei, Liu, Jianbing, Liu, Chao, Wang, Hui, Shi, Xinghua, Zhang, Li, Sun, Jiashu, Ding, Baoquan, Liu, Minghua. Stimulus-Responsive Plasmonic Chiral Signals of Gold Nanorods Organized on DNA Origami. NANO LETTERS[J]. 2017, 17(11): 7125-7130, https://www.webofscience.com/wos/woscc/full-record/WOS:000415029000092.
[65] Qu, Yijiao, Yang, Juanjuan, Zhan, Pengfei, Liu, Shaoli, Zhang, Kun, Jiang, Qiao, Li, Can, Ding, Baoquan. Self-Assembled DNA Dendrimer Nanoparticle for Efficient Delivery of Immunostimulatory CpG Motifs. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(24): 20324-20329, https://www.webofscience.com/wos/woscc/full-record/WOS:000404090000008.
[66] Liu, Qing, Wang, Hui, Shi, Xinghua, Wang, ZhenGang, Ding, Baoquan. Self-Assembled DNA/Peptide-Based Nanoparticle Exhibiting Synergistic Enzymatic Activity. ACS NANO[J]. 2017, 11(7): 7251-7258, https://www.webofscience.com/wos/woscc/full-record/WOS:000406649700074.
[67] Zhan, Pengfei, Dutta, Palash K, Wang, Pengfei, Song, Gang, Dai, Mingjie, Zhao, ShuXia, Wang, ZhenGang, Yin, Peng, Zhang, Wei, Ding, Baoquan, Ke, Yonggang. Reconfigurable Three-Dimensional Gold Nanorod Plasmonic Nanostructures Organized on DNA Origami Tripod. ACS NANO[J]. 2017, 11(2): 1172-1179, https://www.webofscience.com/wos/woscc/full-record/WOS:000395357300006.
[68] Song, Linlin, Jiang, Qiao, Liu, Jianbing, Li, Na, Liu, Qing, Dai, Luru, Gao, Yuan, Liu, Weili, Liu, Dongsheng, Ding, Baoquan. DNA origami/gold nanorod hybrid nanostructures for the circumvention of drug resistance. NANOSCALE[J]. 2017, 9(23): 7750-7754, https://www.webofscience.com/wos/woscc/full-record/WOS:000403427300009.
[69] Liu, Qing, Liu, Guocheng, Wang, Ting, Fu, Jing, Li, Rujiao, Song, Linlin, Wang, ZhenGang, Ding, Baoquan, Chen, Fei. Enhanced Stability of DNA Nanostructures by Incorporation of Unnatural Base Pairs. CHEMPHYSCHEM[J]. 2017, 18(21): 2977-2980, https://www.webofscience.com/wos/woscc/full-record/WOS:000414406400003.
[70] Feng, Qiang, Liu, Jianping, Li, Xuanyu, Chen, Qinghua, Sun, Jiashu, Shi, Xinghua, Ding, Baoquan, Yu, Haijun, Li, Yaping, Jiang, Xingyu. One-Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid-Switchable Surface Charge for Overcoming Drug Resistance. SMALL[J]. 2017, 13(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000397606100013.
[71] Fu, Meifang, Dai, Luru, Jiang, Qiao, Tang, Yunqing, Zhang, Xiaoming, Ding, Baoquan, Li, Junbai. Observation of intracellular interactions between DNA origami and lysosomes by the fluorescence localization method. CHEMICAL COMMUNICATIONS[J]. 2016, 52(59): 9240-9242, http://ir.iccas.ac.cn/handle/121111/35188.
[72] Liu, Chao, Ding, Baoquan, Xue, Chundong, Tian, Yu, Hu, Guoqing, Su, Jiashu. Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning. ANALYTICAL CHEMISTRY[J]. 2016, 88(24): 12547-12553, http://www.irgrid.ac.cn/handle/1471x/1147637.
[73] Du, Yang, Jiang, Qiao, Beziere, Nicolas, Song, Linlin, Zhang, Qian, Peng, Dong, Chi, Chongwei, Yang, Xin, Guo, Hongbo, Diot, Gael, Ntziachristos, Vasilis, Ding, Baoquan, Tian, Jie. DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy. ADVANCED MATERIALS[J]. 2016, 28(45): 10000-10007, http://ir.iccas.ac.cn/handle/121111/36533.
[74] Urban, Maximilian J, Dutta, Palash K, Wang, Pengfei, Duan, Xiaoyang, Shen, Xibo, Ding, Baoquan, Ke, Yonggang, Liu, Na. Plasmonic Toroidal Metamolecules Assembled by DNA Origami. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 138(17): 5495-5498, https://www.webofscience.com/wos/woscc/full-record/WOS:000375521100006.
[75] 丁宝全. DNA-Based Nanotemplate Directed In Situ Synthesis of Silver Nanoclusters with Specific Fluorescent Emission: Surface-Guided Chemical Reactions. Chem. Mater. 2016, [76] Jia, Ruokun, Wang, Ting, Jiang, Qiao, Wang, Zhengang, Song, Chen, Ding, Baoquan. Self-Assembled DNA Nanostructures for Drug Delivery. CHINESE JOURNAL OF CHEMISTRYnull. 2016, 34(3): 265-272, http://lib.cqvip.com/Qikan/Article/Detail?id=668562506.
[77] Zhuang, Xiaoxi, Ma, Xiaowei, Xue, Xiangdong, Jiang, Qiao, Song, Linlin, Dai, Luru, Zhang, Chunqiu, Jin, Shubin, Yang, Keni, Ding, Baoquan, Wang, Paul C, Liang, XingJie. A Photosensitizer-Loaded DNA Origami Nanosystem for Photodynamic Therapy. ACS NANO[J]. 2016, 10(3): 3486-3495, http://www.corc.org.cn/handle/1471x/2176516.
[78] Zhan, Pengfei, Wang, ZhenGang, Li, Na, Ding, Baoquan. Engineering Gold Nanoparticles with DNA Ligands for Selective Catalytic Oxidation of Chiral Substrates. ACS CATALYSIS[J]. 2015, 5(3): 1489-1498, https://www.webofscience.com/wos/woscc/full-record/WOS:000350843500011.
[79] Jiang, Qiao, Shi, Yuefeng, Zhang, Qian, Li, Na, Zhan, Pengfei, Song, Linlin, Dai, Luru, Tian, Jie, Du, Yang, Cheng, Zhen, Ding, Baoquan. A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics. SMALL[J]. 2015, 11(38): 5134-5141, http://ir.ia.ac.cn/handle/173211/10334.
[80] Rao, Chengcheng, Wang, ZhenGang, Li, Na, Zhang, Wei, Xu, Xuecheng, Ding, Baoquan. Tunable optical activity of plasmonic dimers assembled by DNA origami. NANOSCALE[J]. 2015, 7(20): 9147-9152, https://www.webofscience.com/wos/woscc/full-record/WOS:000354456800005.
[81] Liu, Qing, Song, Chen, Wang, ZhenGang, Li, Na, Ding, Baoquan. Precise organization of metal nanoparticles on DNA origami template. METHODS[J]. 2014, 67(2): 205-214, http://dx.doi.org/10.1016/j.ymeth.2013.10.006.
[82] Shen, Xibo, Zhan, Pengfei, Kuzyk, Anton, Liu, Qing, AsenjoGarcia, Ana, Zhang, Hui, Javier Garcia de Abajo, F, Govorov, Alexander, Ding, Baoquan, Liu, Na. 3D plasmonic chiral colloids. NANOSCALE[J]. 2014, 6(4): 2077-2081, https://www.webofscience.com/wos/woscc/full-record/WOS:000330796700012.
[83] Li, Na, Tittl, Andreas, Yue, Song, Giessen, Harald, Song, Chen, Ding, Baoquan, Liu, Na. DNA-assembled bimetallic plasmonic nanosensors. LIGHT-SCIENCE & APPLICATIONS[J]. 2014, 3: https://www.webofscience.com/wos/woscc/full-record/WOS:000346707900002.
[84] Wang, ZhenGang, Liu, Qing, Ding, Baoquan. Shape-Controlled Nanofabrication of Conducting Polymer on Planar DNA Templates. CHEMISTRY OF MATERIALS[J]. 2014, 26(11): 3364-3367, https://www.webofscience.com/wos/woscc/full-record/WOS:000337199400006.
[85] Wang, ZhenGang, Ding, Baoquan. Engineering DNA Self-Assemblies as Templates for Functional Nanostructures. ACCOUNTS OF CHEMICAL RESEARCHnull. 2014, 47(6): 1654-1662, https://www.webofscience.com/wos/woscc/full-record/WOS:000337645100003.
[86] Liu, Huan, Shen, Xibo, Wang, ZhenGang, Kuzyk, Anton, Ding, Baoquan. Helical nanostructures based on DNA self-assembly. NANOSCALEnull. 2014, 6(16): 9331-9338, https://www.webofscience.com/wos/woscc/full-record/WOS:000340217900001.
[87] Zhan, Pengfei, Wang, Jinye, Wang, ZhenGang, Ding, Baoquan. Engineering the pH-Responsive Catalytic Behavior of AuNPs by DNA. SMALL[J]. 2014, 10(2): 399-406, https://www.webofscience.com/wos/woscc/full-record/WOS:000331112100023.
[88] Zhang, Qian, Jiang, Qiao, Li, Na, Dai, Luru, Liu, Qing, Song, Linlin, Wang, Jinye, Li, Yaqian, Tian, Jie, Ding, Baoquan, Du, Yang. DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy. ACS NANO[J]. 2014, 8(7): 6633-6643, https://www.webofscience.com/wos/woscc/full-record/WOS:000339463100017.
[89] Zhan, Pengfei, Jiang, Qiao, Wang, Zhengang, Li, Na, Yu, Haiyin, Ding, Baoquan. DNA Nanostructure-Based Imaging Probes and Drug Carriers. CHEMMEDCHEMnull. 2014, 9(9): 2013-2020, https://www.webofscience.com/wos/woscc/full-record/WOS:000341623300006.
[90] Wang, ZhenGang, Song, Chen, Ding, Baoquan. Functional DNA Nanostructures for Photonic and Biomedical Applications. SMALLnull. 2013, 9(13): 2210-2222, https://www.webofscience.com/wos/woscc/full-record/WOS:000322566700001.
[91] 丁宝全. 3D Plasmonic Chiral Tetramers Assembled by DNA Origami. Nano Letters. 2013, [92] Wang, ZhenGang, Ding, Baoquan. DNA-Based Self-Assembly for Functional Nanomaterials. ADVANCED MATERIALS[J]. 2013, 25(28): 3905-3914, https://www.webofscience.com/wos/woscc/full-record/WOS:000327749400013.
[93] Shi, Dangwei, Song, Chen, Jiang, Qiao, Wang, ZhenGang, Ding, Baoquan. A facile and efficient method to modify gold nanorods with thiolated DNA at a low pH value. CHEMICAL COMMUNICATIONS[J]. 2013, 49(25): 2533-2535, https://www.webofscience.com/wos/woscc/full-record/WOS:000315465000016.
[94] Wang, ZhenGang, Zhan, Pengfei, Ding, Baoquan. Self-Assembled Catalytic DNA Nanostructures for Synthesis of Para-directed Polyaniline. ACS NANO[J]. 2013, 7(2): 1591-1598, https://www.webofscience.com/wos/woscc/full-record/WOS:000315618700080.
[95] Song, Chen, Wang, ZhenGang, Ding, Baoquan. Smart Nanomachines Based on DNA Self-Assembly. SMALLnull. 2013, 9(14): 2382-2392, https://www.webofscience.com/wos/woscc/full-record/WOS:000327697500004.
[96] Jiang, Qiao, Wang, ZhenGang, Ding, Baoquan. Programmed Colorimetric Logic Devices Based on DNAGold Nanoparticle Interactions. SMALL[J]. 2013, 9(7): 1016-1020, https://www.webofscience.com/wos/woscc/full-record/WOS:000317019800008.
[97] Shen, Xibo, Jiang, Qiao, Wang, Jinye, Dai, Luru, Zou, Guozhang, Wang, ZhenGang, Chen, WeiQiang, Jiang, Wei, Ding, Baoquan. Visualization of the intracellular location and stability of DNA origami with a label-free fluorescent probe. CHEMICAL COMMUNICATIONS[J]. 2012, 48(92): 11301-11303, https://www.webofscience.com/wos/woscc/full-record/WOS:000310283000006.
[98] Shen, Xibo, Song, Chen, Wang, Jinye, Shi, Dangwei, Wang, Zhengang, Liu, Na, Ding, Baoquan. Rolling Up Gold Nanoparticle-Dressed DNA Origami into Three-Dimensional Plasmonic Chiral Nanostructures. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 134(1): 146-149, https://www.webofscience.com/wos/woscc/full-record/WOS:000301084200038.
[99] Jiang, Qiao, Song, Chen, Nangreave, Jeanette, Liu, Xiaowei, Lin, Lin, Qiu, Dengli, Wang, ZhenGang, Zou, Guozhang, Liang, Xingjie, Yan, Hao, Ding, Baoquan. DNA Origami as a Carrier for Circumvention of Drug Resistance. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 134(32): 13396-13403, https://www.webofscience.com/wos/woscc/full-record/WOS:000307487200044.
[100] Alloyeau, Damien, Ding, Baoquan, Ramasse, Quentin, Kisielowski, Christian, Lee, Zonghoon, Jeon, KiJoon. Direct imaging and chemical analysis of unstained DNA origami performed with a transmission electron microscope. CHEMICAL COMMUNICATIONS[J]. 2011, 47(33): 9375-9377, https://www.webofscience.com/wos/woscc/full-record/WOS:000293648200025.
[101] Pal, Suchetan, Deng, Zhengtao, Ding, Baoquan, Yan, Hao, Liu, Yan. DNA-Origami-Directed Self-Assembly of Discrete Silver-Nanoparticle Architectures. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2010, 49(15): 2700-2704, https://www.webofscience.com/wos/woscc/full-record/WOS:000276780500008.
[102] Ding, Baoquan, Wu, Hao, Xu, Wei, Zhao, Zhao, Liu, Yan, Yu, Hongbin, Yan, Hao. Interconnecting Gold Islands with DNA Origami Nanotubes. NANO LETTERS[J]. 2010, 10(12): 5065-5069, https://www.webofscience.com/wos/woscc/full-record/WOS:000284990900049.
[103] 丁宝全. Gold Nanoparticles Self-similar Chain Structure Organized by DNA Origami. J. Am. Chem. Soc.. 2010, [104] Deng, Zhengtao, Schulz, Olaf, Lin, Su, Ding, Baoquan, Liu, Xiaowei, Wei, XiXi, Ros, Robert, Yan, Hao, Liu, Yan. Aqueous Synthesis of Zinc Blende CdTe/CdS Magic-Core/Thick-Shell Tetrahedral-Shaped Nanocrystals with Emission Tunable to Near-Infrared. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2010, 132(16): 5592-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000276991700029.
[105] 丁宝全. DNA Directed Assembly of Nanoparticles Linear Structure for Nanophotonics. Journal of Vacuum Science and Technology B. 2009, [106] Ding, Baoquan, Seeman, Nadrian C. Operation of a DNA robot arm inserted into a 2D DNA crystalline substrate. SCIENCE[J]. 2006, 314(5805): 1583-1585, https://www.webofscience.com/wos/woscc/full-record/WOS:000242624600037.
[107] Ding, BQ, Sha, RJ, Seeman, NC. Pseudohexagonal 2D DNA crystals from double crossover cohesion. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2004, 126(33): 10230-10231, https://www.webofscience.com/wos/woscc/full-record/WOS:000223433700019.

科研活动

   
科研项目
( 1 ) 中国科学院****,结构DNA 纳米技术的研究, 主持, 部委级, 2011-01--2013-12
( 2 ) DNA 折纸结构模板引导的金属和半导体纳米粒子精确自组装结构及其在等离子体器件与灵敏检测中的应用, 主持, 国家级, 2012-01--2015-12
( 3 ) DNA 折纸结构模板引导的金属纳米粒子手性螺旋链的自组装, 主持, 国家级, 2012-01--2014-12
( 4 ) 科技部纳米重大研究计划项目,基于肿瘤微环境调控的抗肿瘤纳米材料设计和机制研究, 参与, 国家级, 2012-01--2016-12
( 5 ) 生物纳米材料, 主持, 国家级, 2013-01--2015-12
( 6 ) 万人计划青年拔尖人才, 主持, 国家级, 2016-01--2019-12
( 7 ) 肿瘤微环境调控型智能纳米材料, 主持, 部委级, 2016-01--2018-12
( 8 ) DNA纳米模板引导的抗体蛋白精确自组装结构及其作为肿瘤治疗平台的研究, 主持, 国家级, 2016-01--2019-12
( 9 ) 核酸纳米结构作为高效抗肿瘤光热转换材料运输载体的研究, 主持, 省级, 2014-01--2016-12
( 10 ) DNA折纸纳米结构作为肿瘤药物靶向性输送载体的设计与制造, 主持, 省级, 2012-01--2014-12

指导学生

已指导学生

刘清  02  63228  

蒋乔  01  20652  

邹翊国  02  20652  

刘欢  02  63222  

现指导学生

宋琳琳  01  20652  

李彤彤  02  19217  

湛鹏飞  01  20652  

刘清  01  20652  

徐雪卉  02  19184  

段方圆  02  67922  

赵帅  02  67921  

韩梓弘   02  20652  

尚颖旭  01  20652  

课题组介绍

课题组在2010年成立,目前实验室有副研究员1名,助理研究员两名,纳米中心在校学生8名,联合培养学生3名,博士后学生一名。本课题组在丁宝全研究员带领下,致力于DNA折纸术的合理设计与制备,及自组装的生物纳米材料与电子束光刻等方法向结合制备的纳米器件的研究,并且取得了一系列创新性成果,已在JACS,Nano Letters,ACS Nano等重要期刊发表论文,并与多个实验室建立了良好的合作关系。我们课题组有着对知识的渴求,对科研的追求,以及踏实认真的学习态度,欢迎对纳米材料等前沿研究领域感兴趣并热爱科研的本科生、研究生、博士生加入本课题组, 我们也热忱欢迎海内外企业、科研机构及专家、学者来课题组访问、交流、合作。
2014年与毕业生合影留念
 
                                         刘清师兄与蒋乔师姐毕业合影留念
2015年与毕业生合影留念

                                               
                                                邹翊国师兄毕业合影
与Nadrian C. Seeman 教授相聚


                             课题组部分成员与Nadrian C. Seeman 教授
课题组成员


                                                              课题组成员