​陆瑶，研究员、博士生导师，国家高层次青年人才。长期从事微流控芯片、单细胞分析技术发展及其应用研究（微流控芯片、单细胞分析均是科技部《生物技术创新专项规划》重点部署的颠覆性技术），相关工作以第一、通讯作者发表于PNAS (3), Nature Communications, National Science Review, Science Signaling, Advanced Science, Biofabrication, Analytical Chemistry 等著名期刊，单篇最高他引500 余次；发展的喷蜡打印制造纸基质微流控芯片技术成为纸芯片最主要制备技术，大大推动相关领域发展；发展的单细胞分泌蛋白分析技术已被商业化，并被世界各地100 多家制药公司和医疗中心广泛使用，帮助肿瘤免疫治疗、细胞治疗药物开发和临床测试，被美国The Scientist 杂志评为2017 年度十大医疗技术发明首位；主持国家自然科学基金（3 项）等科研项目10 余项；共同主编中文（器官芯片，2019，科学出版社）、英文（Biosensors for Single-Cell Analysis, 2021, Elsevier 出版社）专著各一部；授权发明专利8 项（包括美国专利两件）。

 

热忱欢迎分析化学、生物医学工程、生物信息学、化学生物学等专业背景学生、博士后加入，近期主要研究方向包括：

1. 高通量单细胞多维、动态、互作分泌分析技术发展及其生物医学应用；

2. 微流控数字液滴中央处理器；

3. 面向中药现代化、细胞治疗的（单）细胞分析；

4. 基于微流控芯片的高通量、快速、高灵敏分析。

 

2003-09--2010-07   中科院大连化物所   硕博连读
1999-09--2003-07   安徽大学   学士

   

2015年10月—至今                 中国科学院大连化学物理研究所 

2014年10月—2015年9月       耶鲁大学生物医学工程系Associate Research Scientist       

2010年10月—2014年9月       耶鲁大学生物医学工程系Postdoctoral Associate

1.  国家高层次人才特殊支持计划青年拔尖人才 

2.  中国科学院青年创新促进会优秀会员 

3.  国际分析科学大会青年报告奖（2017 年，中国化学会） 

4.  中国科学院特聘研究岗位 

5.  中国科学院大连化学物理研究所“张大煜青年学者” 

6.  辽宁省百千万人才工程 

7.  大连市青年科技之星

2022

 1. Fengjiao Zhu, Yahui Ji, Jiu Deng, Linmei Li, Xue Bai, Xianming Liu, Bingcheng Lin, Yao Lu*. 

     Microfluidics-based technologies for the analysis of extracellular vesicles at the single-cell level and single-vesicle level. Chinese chemical letters, 2022, 33(6), 2893-2900.

2021

    1. Tahereh Khajvand, Peifeng Huang, Linmei Li, Mingxia Zhang, Fengjiao Zhu, Xing Xu, Mengjiao Huang, Chaoyong Yang, Yao Lu* and Zhi Zhu*. 

        Interfacing Droplet Microfluidics with Antibody Barcodes for Multiplexed Single-Cell Protein Secretion Profiling. Lab on a chip, 2021,21(24):4823-4830. 

    2. Fengjiao Zhu, Yahui Ji, Linmei Li, Xue Bai, Xianming Liu, Yong Luo, Tingjiao Liu, Bingcheng Lin, Yao Lu*. 

        High-throughput single-cell extracellular vesicle secretion analysis on the desktop scanner without cell counting. Analytical chemistry, 2021, 93(39): 13152–13160.

    3. Linmei Li, Weiwei Shi, Meimei Liu, Xue Bai, Yanting Sun, Xue Zhu, Haoran Su, Yahui Ji, Fengjiao Zhu, Xianming Liu, Yong Luo, Tingjiao Liu, Bingcheng Lin, Yao Lu*. 

       Single-cell Secretion Analysis in the Engineered Tumor Microenvironment Reveals Differential Modulation of Macrophage Immune Responses. Analytical Chemistry, 2021, 93(9):4198-4207.

    4.  Shiqiang Yan, Shuting Wang, Zhujing Hao, Meimei Liu, Chunyue Miao, Md Fazle Alam, Ruihan Bai, Linmei Li, Yong Luo, Tingjiao Liu, Bingcheng Lin, 

        Weijia Zhang*, Yao Lu*.  Rapid prototyping of PDMS microdevices via mu PLAT on nonplanar surfaces with flexible hollow-out mask. Biofabrication, 2021, 13(3):035003.

    5. Yaru Xing*, Yu Liu, Rifei Chen, Yuyan Li, Chengzhi Zhang, Youwei Jiang, Yao Lu, Bingcheng Lin, Peizhong Chen, Ruijun Tian, Xianming Liu* and Xing Cheng*. 

        A Robust and Scalable Active-Matrix Driven Digital Microfluidic Platform Based on Printed-Circuit Board Technology Dagger. Lab on a chip, 2021, 21(10):1886-1896.

2020

    1.  Meimei Liu, Meihua Jin,  Linmei Li, Yahui Ji,  Fengjiao Zhu,  Yong Luo,  Tingjiao Liu,  Bingcheng Lin,  Yao Lu* 

         PDMS Microwell Stencil Based Multiplexed Single‐Cell Secretion Analysis. Proteomics, 2020, 1900231.

2019

    1.  Yahui Ji, Dongyuan Qi, Linmei Li, Haoran Su, Xiaojie Li, Yong Luo, Bo Sun, Fuyin Zhang, Bingcheng Lin, Tingjiao  Liu*,  

         Yao Lu* Multiplexed Profiling of Single-cell Extracellular Vesicles Secretion. PNAS, 2019, 116 (13) 5979-5984.

    2.  Zhuo Chen#, Yao Lu#*, Kerou Zhang, Yang Xiao, Jun Lu, Rong Fan* Multiplexed, sequential secretion analysis of the  same 

         single cells reveals distinct effector response dynamics dependent on the initial basal state. Advanced Science, 2019,  6, 1801361 (Highlighted as Inside Cover).

    3.  Jun Ma#, Shiqiang Yan#, Chunyue Miao, Linmei Li, Weiwei Shi, Xianming Liu,  Yong Luo, Tingjiao Liu, Bingcheng Lin, 

         Wenming Wu,*, Yao Lu* Paper Microfluidics for Cell Analysis. Advanced Healthcare Materials, 2019, 8, 1801084.

2018

    1. Ruihan Bai, Linmei Li, Meimei Liu, Shiqiang Yan, Chunyue Miao, Ruijun Li, Yong Luo, Tingjiao Liu, Bingcheng  Lin, Yibing Ji*, and Yao Lu* 
        Paper Based 3D Scaffold for Multiplexed Single Cell Secretomic Analysis. Analytical Chemistry, 2018,  90 (9), pp 5825–5832.
    2. Linmei Li, Shiqiang Yan, Bingcheng Lin, Qihui Shi*, Yao Lu* 
        Single-Cell Proteomics for Cancer  Immunotherapy, Advances in Cancer Research, 2018.
    3. Yueyang Qu, Fan An, Yong Luo*, Yao Lu, Tingjiao Liu, Weijie Zhao, Bingcheng Lin. 
        A nephron model for study of    drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity. Biomaterials, 2018, 155, 41-53.

2017

1. Yao Lu, Liu Yang, Wei Wei*, Qihui Shi* Microchip-Based Single-Cell Functional Proteomics for BiomedicalApplications. Lab on a Chip, 2017, Mar 29;17(7):1250-1263. 

2. Shimeng Fang, Hongzhu Tian, Xiancheng Li, Dong Jin, Xiaojie Li, Jing Kong, Chun Yang, Xuesong Yang, Yao Lu, Yong Luo, Bingcheng Lin, Weidong Niu*, Tingjiao Liu* Clinical application of a microfluidic chip for immunocapture and quantification of circulating exosomes to assist breast cancer diagnosis and molecular classification. PLoS One. 2017 Apr 3;12(4):e0175050. doi: 10.1371/journal.pone.0175050. eCollection 2017.

3. 高志刚, 郑婷婷, 邓九, 李晓瑞, 曲玥阳, 陆瑶, 刘婷娇, 罗勇*, 赵伟杰, 林炳承 基于便携拉曼光谱仪和双层纸芯片的头发皮质醇超高灵敏检测 化学学报(Acta Chim. Sinica), 2017, 75, 355-359

 

2016

1. Kun Zou, Zhigang Gao, Quanfeng Deng, Yong Luo, Lijuan Zou, Yao Lu, Weijie Zhao and Bingcheng Lin Picomolar detection of carcinoembryonic antigen in whole blood using microfluidics and surface-enhanced Raman spectroscopy. Electrophoresis, 2016, 37(5-6):786-9.  

 

Before 2016 

1. Qiong Xue†, Yao Lu†, Markus R. Eisele, Endah S. Sulistijo, Nafeesa Khan, Rong Fan*, and Kathryn Miller-Jensen* Analysis of single cell secretion reveals a role for paracrine signaling in coordinating macrophage response to TLR4 stimulation. Science Signaling, 2015, 8(381), ra59.

2. Yao Lu†, Qiong Xue†, Markus Eisele, Endah Sulistijo, Kara Brower, Lin Han, El-ad David Amir, Dana Pe’er, Kathryn Miller-Jensen* & Rong Fan* Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands. PNAS, 2015, 112 (7), E607-E615.

3. Yao Lu†, Jonathan J. Chen†, Luye Mu, Qiong Xue, Yu Wu, Pei-Hsun Wu, Jie Li, Alexander O. Vortmeyer, Kathryn Miller-Jensen, Denis Wirtz, and Rong Fan* High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity. Analytical Chemistry 2013, 85 (4), 2548–2556

4. Yao Lu, Bingcheng Lin*, Jianhua Qin*. Patterned Paper as a Low-cost, Flexible Substrate for Rapid Prototyping PDMS Microdevices via “liquid molding” . Analytical Chemistry 2011, 83 (5), 1830–1835

5. Yao Lu, Weiwei Shi, Jianhua Qin*, Bingcheng Lin*. Fabrication And Characterization of Paper Based Microfluidics Prepared in Nitrocellulose Membrane By Wax Printing. Analytical Chemistry 2010, 82, 329–335 

6. Yao Lu, Weiwei Shi, Lei Jiang, Jianhua Qin*, Bingcheng Lin*. Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay . Electrophoresis 2009, 30, 1497–1500

7. Yao Lu, Weiwei Shi, Jianhua Qin*, Bingcheng Lin*. Low cost, portable detection of gold nanoparticle-labeled microfluidic immunoassay with camera cell phone. Electrophoresis 2009, 30, 579–582 (selected by editor as Fast Track)

8. Lei Jiang, Yao Lu, Zhongpeng Dai, Minhao Xie, Bingcheng Lin*.  Mini-electrochemical Detector for Microchip Electrophoresis. Lab Chip 2005, 5(9), 930-934

9. Lei Jiang, Xuening Jiang, Yao Lu, Zhongpeng Dai, Minhao Xie, Jianhua Qin*, Bingcheng Lin*. Development of a universal serial bus-powered mini-high-voltage power supply for microchip electrophoresis. Electrophoresis 2007, 28(8), 1259–1264.

10. Weiwei Shi, Hui Wen, Yao Lu, Yang Shi, Bingcheng Lin*，Jianhua Qin* Droplet Microfluidics for Characterizing the Neurotoxin-induced Responses in Individual Caenorhabditis elegans. Lab Chip, 2010, 10, 2855 – 2863

11. Wu Y, Lu Y, Chen WQ, Fu JP & Fan R*. In silico experimentation of glioma microenvironment development and anti-tumor therapy. PLoS Computational Biology, 8(2), 1002355 (2012).

12. Lee SK*, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, Han L, Hyung JH, Seol JK, Sander C, Gonzalez A, Li J, Fan R*. Nanowire Substrate-Based Laser Scanning Cytometry for Quantitation of Circulating Tumor Cells. Nano Letters, 12(6), 2697-2704(2012)

13. Minsuk Kwak, Luye Mu, Yao Lu, Jonathan Chen, Yu Wu, Kara Brower and Rong Fan*. Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction. Frontiers in Oncology, 2013; 3: 10

14. Meltem Elitas†, Kara Brower†, Yao Lu, Jonathan J. Chen and Rong Fan* A Microchip Platform for Interrogating Tumor-Immune Cell Communication at the Single-Cell Level. Lab on a Chip 14 (18), 3582-3588

15. Mao, Lin†; Shen, Li†; Chen, Jiahui; Wu, Yu; Kwak, Minsuk; Lu, Yao; Xue, Qiong; Pei, Jia; Zhang, Lei; Yuan, Guangyin; Fan, Rong; Ge, Junbo; Ding, Wen-Jiang Enhanced bioactivity of Mg-Nd-Zn-Zr alloy achieved with nanoscale MgF2 surface for vascular stent application ACS applied materials & interfaces, 7 (9), 5320–5330.