Structure and function of luminescent proteins

Genetically encoded optical indicators for monitoring neural activity

Fluorescent molecular sensors for detecting biomacromolecule activity

Biological signal monitoring and biosensing in living cells and in vivo

071006 - Neurobiology

071010 - Biochemistry and Molecular Biology

083100 - Biomedical Engineering

Biomedical Engineering (Academic Degree)

Biology and Medicine (Professional Degree)

Computer Science and Technology (Academic Degree)

Genetically encoded neural activity indicators; Calcium indicators

Genetically encoded fluorescent molecular sensors;

Protein structure and function; Protein engineering

   

Mengying Deng# ; Jing Yuan#; Haibin Yang; Xuli Wu; Xiaoyuan Wei; Yang Du; Garry Wong; Yuyong Tao; Gang Liu;

Zongwen Jin*; Jun Chu*; A Genetically Encoded BRET System for Fast and Highly Sensitive Detection of Antibodies

with a Bright Green Fluorescent Protein, ACS Nano, 2021, 15 : 17602-17612. 

Fangfang Yang#; Mengying Deng#; Xiaorong Pan; Jintao Wang; Pei Huang; Zirui Ou; Xiaoyu Zou; Muhammad Fahim;

Shiyi Gan; Qixing Yang; Cuihan Shi; Jingya Chen; Junfeng Li; Yong Juan Zhao; Pei- Gen Ren; Xin-an Liu; Yang Du; Tong

Wang; Zuxin Chen*; Jun Chu*; A sensitive green-red FRET sensorfor calpain-1 utilizing heterodimeric fluorescent

proteins from distinct evolutionary origins, ACS Sensors, 2026. 

Feng Liu# ; Huimin Hu# ; Mengying Deng# ; Zongqin Xiang ; Yuting Guo ; Xinmeng Guan ; Dong Li ; Qinxue Hu ;

Wenliang Lei; Hongjuan Peng#; Jun Chu#; A Bright Monomeric Near-Infrared Fluorescent Protein with an Excitation

Peak at 633 nm for Labeling Cellular Protein and Reporting Protein - Protein Interaction, ACS Sensors, 2022, 7:

1855-1866.

Wenfeng Liu # ; Mengying Deng # ; Chengming Yang # ; Feng Liu; Xinmeng Guan; Yichen Du; Liang Wang*; Jun Chu*. 

Genetically encoded circularly permuted fluorescent protein-based indicators, Journal of Physics D-Applied Physics, 

2020, 53: 113001.

Yongxian Xu # ; Mengying Deng # ; Shu Zhang # ; Junqi Yang # ; Luxin Peng; Jun Chu*; Peng Zou*. Imaging neuronal

activity with fast and sensitive red-shifted electrochromic FRET indicators, ACS Chemical Neuroscience, 2019, 10:

4768-4775. 

Mengying Deng; Yunhao Sun; Pai Li; Bei Fu; Dong Shen; Yongjun Lu*. The phytopathogenic virulent effector

protein RipI induces apoptosis in budding yeast Saccharomyces cerevisiae, Toxicon, 2016, 121: 109-118.

1. Jun Chu, Mengying Deng, Jing Yuan, Zongwen Jin. 05/2021. A green fluorescent protein Clover4 and a highly

sensitive antibody detection BRET system in serum. World Intellectual Property Organization, PCT/CN2021/091875

2. Jun Chu, Mengying Deng. 12/2025. Engineering and application of a red fluorescent protein mCrimsonX. China Patent, 

CN202511932649.1

3. Jun Chu, Mengying Deng. 12/2024. Engineering and application of A highly sensitive, low toxic red calcium indicator

based on cpFP. China Patent, CN202411939522.8

4. Jun Chu, Mengying Deng, Shu Zhang. 10/2025. A dark fluorescent protein, Nucleic acid sequences, vectors and

applications. China Patent, CN202211311868.4

5. Jun Chu, Mengying Deng, Jing Yuan, Zongwen Jin. 05/2021. Engineering and applications of a green fluorescent

protein Clover4 and highly sensitive sensors based on the BRET technique. China Patent, CN202110489938.4

6. Jun Chu, Mengying Deng, Chuqiu Zhang, Feng Liu. 12/2018. An orange fluorescent protein, nucleic acid molecules, 

vectors, fusion proteins, and applications. China Patent, ZL201811558957.2

7. Jun Chu, Feng Liu, Liang Wang, Mengying Deng, Wenfeng Liu, Xinmeng Guan. 12/2019. Near-infrared fluorescent

proteins, recombinant vectors, recombinant cells, and applications. China Patent, CN201911289599.4

8. Jun Chu, Chuqiu Zhang, Yuqi Guo, Mengying Deng. 12/2018. Fluorescent proteins, preparation methods, and

applications. China Patent, CN201811631279.8

Grant 32371149, National Natural Science Foundation of China. 

Grant 32000731, National Natural Science Foundation of China. 

Grant 2020A1515010675, Department of Science and Technology of Guangdong Province. 

Grant 2018M633180, China Postdoctoral Science Foundation. 

Grant JCYJ20250604183015020, Shenzhen Basic Research Special Fund (Natural Science Foundation) . 

Grant JCYJ20220531100802004, Shenzhen Basic Research Special Fund (Natural Science Foundation).