基本信息
陈岳文  男  硕导  中国科学院深圳先进技术研究院
电子邮件: yw.chen1@siat.ac.cn
通信地址: 广东省深圳市南山区学苑大道1068号深圳先进技术研究院脑所206室
邮政编码:

研究领域

神经发育的分子细胞基础

神经发育障碍性疾病的病变机制


招生信息

   
招生专业
071006-神经生物学
071010-生物化学与分子生物学
招生方向
神经发育的分子基础
神经退行性疾病致病机制

教育背景

2009-09--2012-06   暨南大学   博士学位
2005-09--2008-12   北京协和医学院   硕士学位
2001-09--2005-07   兰州大学   学士学位
学历
博士

学位
博士

工作经历

   
工作简历
2017-03~现在, 中国科学院深圳先进技术研究院, 副研究员
2014-12~2017-02,香港科技大学深圳研究院, 研究与项目开发经理
2012-07~2014-11,暨南大学, 博士后
2009-01~2009-08,北京协和医学院, 研究助理

专利与奖励

   
专利成果
[1] 陈宇, 陈岳文, 许进英, 陈艺菁. 一种神经退行性疾病标志物Chromogranin B及其应用. CN: CN112858684A, 2021-05-28.
[2] 陈宇, 陈岳文, 许进英, 陈艺菁. 一种神经退行性疾病标志物β-spectrin及其应用. CN: CN112858685A, 2021-05-28.
[3] 李伟丽, 陈宇, 陈岳文. 一种可调式双孔插芯针夹持器. CN: CN211560186U, 2020-09-25.

出版信息

   
发表论文
[1] Cao, Han, Zhou, Xiaopu, Chen, Yu, Ip, Fanny C F, Chen, Yuewen, Lai, Nicole C H, Lo, Ronnie M N, Tong, Estella P S, Mok, Vincent C T, Kwok, Timothy C Y, Fu, Amy K Y, Ip, Nancy Y, Alzheimers Dis Neuroimaging Initi. Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk. JOURNAL OF ALZHEIMERS DISEASE[J]. 2022, 86(4): 1861-1873, [2] Tao Ye, Yangyang Duan, Hayley W S Tsang, He Xu, Yuewen Chen, Han Cao, Yu Chen, Amy K Y Fu, Nancy Y Ip. Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases. COMMUNICATIONS BIOLOGY[J]. 2021, 4(1): https://doaj.org/article/70fb7c21e42e47428a1ea40e2a8b140e.
[3] Chen, Yuewen, Xu, Jinying, Zhang, Yulin, Ma, Shuangshuang, Yi, Wanying, Liu, Saijuan, Yu, Xiaojun, Wang, Jiali, Chen, Yu. Coronin 2B regulates dendrite outgrowth by modulating actin dynamics. FEBS LETTERS[J]. 2020, 594(18): 2975-2987, http://dx.doi.org/10.1002/1873-3468.13886.
[4] Ouyang, Li, Chen, Yu, Wang, Ye, Chen, Yuewen, Fu, Amy K Y, Fu, WingYu, Ip, Nancy Y. p39-associated Cdk5 activity regulates dendritic morphogenesis. SCIENTIFIC REPORTS[J]. 2020, 10(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603351/.
[5] Chen, Yijing, Fang, Lihua, Chen, Shuo, Zhou, Haokui, Fan, Yingying, Lin, Li, Li, Jing, Xu, Jinying, Chen, Yuewen, Ma, Yingfei, Chen, Yu. Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer's Disease. BIOMED RESEARCH INTERNATIONAL[J]. 2020, 2020: https://doaj.org/article/fb16f83bda19424aae44eb69492030ed.
[6] Xu, Zhenyan, Chen, Yuewen, Chen, Yu. Spatiotemporal Regulation of Rho GTPases in Neuronal Migration. CELLSnull. 2019, 8(6): https://doaj.org/article/53c7970349284bc3a1f3690f09e4230b.
[7] Chen, Yuewen, Xu, Jinying, Zhou, Xiaopu, Liu, Saijuan, Zhang, Yulin, Ma, Shuangshuang, Fu, Amy K Y, Ip, Nancy Y, Chen, Yu. Changes of Protein Phosphorylation Are Associated with Synaptic Functions during the Early Stage of Alzheimer's Disease. ACS CHEMICAL NEUROSCIENCE[J]. 2019, 10(9): 3986-3996, https://www.webofscience.com/wos/woscc/full-record/WOS:000487179600009.
[8] Xiaopu Zhou, Yu Chen, Kin Y Mok, Timothy C Y Kwok, Vincent C T Mok, Qihao Guo, Fanny C Ip, Yuewen Chen, Nandita Mullapudi, Alzheimers Disease Neuroimaging Initiative, Paola GiustiRodrguez, Patrick F Sullivan, John Hardy, Amy K Y Fu, Yun Li, Nancy Y Ip. Non-coding variability at the APOE locus contributes to the Alzheimer's risk. NATURE COMMUNICATIONS[J]. 2019, 10(1): http://dx.doi.org/10.1038/s41467-019-10945-z.
[9] Zhou, Xiaopu, Chen, Yu, Mok, Kin Y, Zhao, Qianhua, Chen, Keliang, Chen, Yuewen, Hardy, John, Li, Yun, Fu, Amy K Y, Guo, Qihao, Ip, Nancy Y, Alzheimers Dis Neuroimagi. Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(8): 1697-1706, http://ir.siat.ac.cn:8080/handle/172644/13859.
[10] Chen, Yu, Liang, Zhuoyi, Fei, Erkang, Chen, Yuewen, Zhou, Xiaopu, Fang, Weiqun, Fu, WingYu, Fu, Amy K Y, Ip, Nancy Y. Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. PLOS ONE[J]. 2015, 10(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000358621000018.
[11] Chen, Yuewen, Ip, Fanny C F, Shi, Lei, Zhang, Zhe, Tang, Huibin, Ng, Yu Pong, Ye, WenCai, Fu, Amy K Y, Ip, Nancy Y. Coronin 6 Regulates Acetylcholine Receptor Clustering through Modulating Receptor Anchorage to Actin Cytoskeleton. JOURNAL OF NEUROSCIENCE[J]. 2014, 34(7): 2413-2421, https://www.webofscience.com/wos/woscc/full-record/WOS:000331614700003.
[12] Ng, Yu Pong, Chen, Yuewen, Hu, Yueqing, Ip, Fanny C F, Ip, Nancy Y. Olean-12-Eno2,3-c 1,2,5Oxadiazol-28-Oic Acid (OEOA) Induces G(1) Cell Cycle Arrest and Differentiation in Human Leukemia Cell Lines. PLOS ONE[J]. 2013, 8(5): https://doaj.org/article/d2a3fce1d6d14454846a87c34b33b214.
[13] Xiao Yangui, Peng Yinghui, Wan Jun, Tang Genyun, Chen Yuewen, Tang Jing, Ye Wen-Cai, Ip Nancy Y., Shi Lei. The Atypical Guanine Nucleotide Exchange Factor Dock4 Regulates Neurite Differentiation through Modulation of Rac1 GTPase and Actin Dynamics *. The Journal of Biological Chemistry. 288(27): 20034-20045, http://dx.doi.org/10.1074/jbc.M113.458612.

科研活动

   
科研项目
( 1 ) Coronin 2B介导的肌动蛋白动态变化调控神经元极性分化的分子机制研究, 主持, 国家级, 2015-01--2017-12
( 2 ) 阿尔茨海默症的环路机制和干预措施研究, 参与, 省级, 2015-12--2018-12
( 3 ) 阿尔茨海默症的诊治方法研究, 参与, 省级, 2018-12--2022-12
( 4 ) Coronin 2B调控核糖体RNA转录机制及其在神经树突发育中的功能, 主持, 省级, 2019-10--2022-09
( 5 ) 中国人群阿尔茨海默症多维度生物标志物综合研究, 参与, 国家级, 2019-08--2022-07

指导学生

现指导学生

陈静  硕士研究生  071008-发育生物学