基本信息
崔颖璐 女 硕导 中国科学院微生物研究所
电子邮件： cuiyinglu@im.ac.cn
通信地址： 北京市朝阳区北辰西路1号院3号
邮政编码：
电子邮件： cuiyinglu@im.ac.cn
通信地址： 北京市朝阳区北辰西路1号院3号
邮政编码：
招生信息
招生专业
100705-微生物与生化药学
招生方向
计算机蛋白质设计与微生物催化
教育背景
2010-09--2015-07 吉林大学 博士学位
2006-09--2010-07 吉林大学 学士学位
2006-09--2010-07 吉林大学 学士学位
工作经历
工作简历
2021-11~现在, 中国科学院微生物研究所, 副研究员
2017-05~2021-11,中国科学院微生物研究所, 助理研究员
2015-07~2017-05,北京林业大学, 博士后
2017-05~2021-11,中国科学院微生物研究所, 助理研究员
2015-07~2017-05,北京林业大学, 博士后
专利与奖励
奖励信息
（1） 人工智能设计β丙氨酸合成酶及产业化应用, 一等奖, 省级, 2022
出版信息
发表论文
[1] 刘欣悦, 崔颖璐. PET塑料废弃物及微塑料生物降解与转化的研究现状与展望. 生物加工过程[J]. 2022, 第 2 作者20(2): 226-234, http://lib.cqvip.com/Qikan/Article/Detail?id=7106927324.
[2] Cui, Yinglu, Sun, Jinyuan, Wu, Bian. Computational enzyme redesign: large jumps in function. TRENDS IN CHEMISTRY. 2022, 第 1 作者4(5): 409-419, http://dx.doi.org/10.1016/j.trechm.2022.03.001.
[3] Zhu, Tong, Cui, Yinglu, Geng, Wenchao, Liu, Guoxia, Jiang, Huifeng, Li, Ruifeng, Wu, Bian. Creating an Unusual Glycine-Rich Motif in a Peptide Amidase Leads to Versatile Protein C-Terminal Traceless Functionalization. ACS CATALYSIS. 2022, 第 2 作者8019-8026, http://dx.doi.org/10.1021/acscatal.2c01456.
[4] Li, Ruifeng, Schmidt, Marcel, Zhu, Tong, Yang, Xinyu, Feng, Jing, Tian, Yue, Cui, Yinglu, Nuijens, Timo, Wu, Bian. Traceless enzymatic protein synthesis without ligation sites constraint. NATIONAL SCIENCE REVIEW[J]. 2022, 第 7 作者9(5): 104-114, http://dx.doi.org/10.1093/nsr/nwab158.
[5] Cui, Yinglu, Chen, Yanchun, Liu, Xinyue, Dong, Saijun, Tian, Yue, Qiao, Yuxin, Mitra, Ruchira, Han, Jing, Li, Chunli, Han, Xu, Liu, Weidong, Chen, Quan, Wei, Wangqing, Wang, Xin, Du, Wenbin, Tang, Shuangyan, Xiang, Hua, Liu, Haiyan, Liang, Yong, Houk, Kendall N, Wu, Bian. Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy. ACS CATALYSIS[J]. 2021, 第 1 作者11(3): 1340-1350, http://dx.doi.org/10.1021/acscatal.0c05126.
[6] Cui, Yinglu, Wang, Yinghui, Tian, Wenya, Bu, Yifan, Li, Tao, Cui, Xuexian, Zhu, Tong, Li, Ruifeng, Wu, Bian. Development of a versatile and efficient C-N lyase platform for asymmetric hydroamination via computational enzyme redesign. NATURE CATALYSIS[J]. 2021, 第 1 作者4(5): 364-373, http://dx.doi.org/10.1038/s41929-021-00604-2.
[7] Wang, Min, Xie, Zhoujie, Tang, Shoubin, Chang, Ee Ling, Tang, Yue, Guo, Zhengyan, Cui, Yinglu, Wu, Bian, Ye, Tao, Chen, Yihua. Reductase of Mutanobactin Synthetase Triggers Sequential C-C Macrocyclization, C-S Bond Formation, and C-C Bond Cleavage. ORGANIC LETTERS[J]. 2020, 第 7 作者22(3): 960-964, http://dx.doi.org/10.1021/acs.orglett.9b04501.
[8] Li, Tao, Cui, Xuexian, Cui, Yinglu, Sun, Jinyuan, Chen, Yanchun, Zhu, Tong, Li, Chuijian, Li, Ruifeng, Wu, Bian. Exploration of Transaminase Diversity for the Oxidative Conversion of Natural Amino Acids into 2-Ketoacids and High-Value Chemicals. ACS CATALYSIS[J]. 2020, 第 3 作者10(14): 7950-7957, http://dx.doi.org/10.1021/acscatal.0c01895.
[9] Zhu, Tong, Li, Ruifeng, Sun, Jinyuan, Cui, Yinglu, Wu, Bian. Characterization and efficient production of a thermostable, halostable and organic solvent-stable cellulase from an oil reservoir. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2020, 第 4 作者159: 622-629, http://dx.doi.org/10.1016/j.ijbiomac.2020.05.021.
[10] Feng, Jing, Li, Ruifeng, Zhang, Shasha, Bu, Yifan, Chen, Yanchun, Cui, Yinglu, Lin, Baixue, Chen, Yihua, Tao, Yong, Wu, Bian. Bioretrosynthesis of FunctionalizedN-Heterocycles from Glucose via One-Pot Tandem Collaborations of Designed Microbes. ADVANCED SCIENCE[J]. 2020, 第 6 作者7(17): https://doaj.org/article/9c2328f94707485287af5a2f1cbca236.
[11] Li, Tao, Li, Ruifeng, Zhu, Tong, Cui, Xuexian, Li, Chuijian, Cui, Yinglu, Wu, Bian. Improving the System Performance of the Asymmetric Biosynthesis of D-Pantoic Acid by Using Artificially Self-Assembled Enzymes in Escherichia coli. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2020, 第 6 作者6(1): 219-+, http://dx.doi.org/10.1021/acsbiomaterials.9b01754.
[12] Mu, Qingxuan, Cui, Yinglu, Tian, Yue, Hu, Meirong, Tao, Yong, Wu, Bian. Thermostability improvement of the glucose oxidase from Aspergillus niger for efficient gluconic acid production via computational design. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 第 2 作者136: 1060-1068, http://dx.doi.org/10.1016/j.ijbiomac.2019.06.094.
[13] Li, Tao, Cui, Yinglu, Wu, Bian. Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2019, 第 2 作者37(10): 2527-2537,
[14] Li, Xiaoxiao, Bai, Yuxiang, Ji, Hangyan, Wang, Jinpeng, Cui, Yinglu, Jin, Zhengyu. Functional characterization of tryptophan437 at subsite+2 in pullulanase from Bacillus subtilis str. 168. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 第 5 作者133: 920-928, http://dx.doi.org/10.1016/j.ijbiomac.2019.04.103.
[15] Zheng, Xinxin, Cui, Yinglu, Li, Tao, Li, Ruifeng, Guo, Lu, Li, Defeng, Wu, Bian. Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 第 2 作者103(19): 8051-8062, http://dx.doi.org/10.1007/s00253-019-10105-9.
[16] Li, Tao, Cui, Yinglu, Wu, Bian. Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2019, 第 2 作者37(10): 2527-2537,
[17] 崔颖璐, 吴边. 符合工程化需求的生物元件设计. 中国科学院院刊[J]. 2018, 第 1 作者33(11): 1150-1157, http://lib.cqvip.com/Qikan/Article/Detail?id=676797241.
[18] Tian, Xiuyun, He, GuangJun, Hu, Pengjie, Chen, Lei, Tao, Changyu, Cui, YingLu, Shen, Lan, Ke, Weixin, Xu, Haijiao, Zhao, Youbao, Xu, Qijiang, Bai, Fengyan, Wu, Bian, Yang, Ence, Lin, Xiaorong, Wang, Linqi. Cryptococcus neoformans sexual reproduction is controlled by a quorum sensing peptide. NATUREMICROBIOLOGY[J]. 2018, 第 6 作者3(6): 698-707, https://www.webofscience.com/wos/woscc/full-record/WOS:000433302800012.
[19] Bu, Yifan, Cui, Yinglu, Peng, Ying, Hu, Meirong, Tian, Yue, Tao, Yong, Wu, Bian. Engineering improved thermostability of the GH11 xylanase from Neocallimastix patriciarum via computational library design. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 第 2 作者102(8): 3675-3685, https://www.webofscience.com/wos/woscc/full-record/WOS:000428316700018.
[20] Li, Ruifeng, Wijma, Hein J, Song, Lu, Cui, Yinglu, Otzen, Marleen, Tian, Yue, Du, Jiawei, Li, Tao, Niu, Dingding, Chen, Yanchun, Feng, Jing, Han, Jian, Chen, Hao, Tao, Yong, Janssen, Dick B, Wu, Bian. Computational redesign of enzymes for regio- and enantioselective hydroamination. NATURE CHEMICAL BIOLOGY[J]. 2018, 第 4 作者14(7): 664-+,
[21] Gao, Pan, Cui, YingLu, Wu, RongLing. Molecular dynamic modeling of CYP51B in complex with azole inhibitors. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2018, 第 2 作者 通讯作者 36(6): 1511-1519,
[22] 崔颖璐, 吴边. 计算机辅助蛋白结构预测及酶的计算设计研究进展. 广西科学[J]. 2017, 第 1 作者24(1): 1-6, http://lib.cqvip.com/Qikan/Article/Detail?id=671521007.
[23] Feng, Jin, Zhang, Peng, Cui, Yinglu, Li, Kai, Qiao, Xue, Zhang, YingTao, Li, ShuMing, Cox, Russell J, Wu, Bian, Ye, Min, Yin, WenBing. Regio- and Stereospecific O-Glycosylation of Phenolic Compounds Catalyzed by a Fungal Glycosyltransferase from Mucor hiemalis. ADVANCED SYNTHESIS & CATALYSIS[J]. 2017, 第 3 作者359(6): 995-1006, https://www.doi.org/10.1002/adsc.201601317.
[24] Cui, YingLu, Wu, RongLing. Molecular dynamics investigations of membrane-bound CYP2C19 polymorphisms reveal distinct mechanisms for peripheral variants by long-range effects on the enzymatic activity. MOLECULAR BIOSYSTEMS[J]. 2017, 第 1 作者13(6): 1070-1079, http://dx.doi.org/10.1039/c6mb00827e.
[25] Xue, Qiao, Cui, YingLu, Zheng, QingChuan, Zhang, HongXing. Molecular dynamics investigations of BioH protein substrate specificity for biotin synthesis. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2016, 第 2 作者34(5): 1052-1060, http://dx.doi.org/10.1080/07391102.2015.1068223.
[26] Cui, YingLu, Xu, Fang, Wu, Rongling. Molecular dynamics investigations of regioselectivity of anionic/aromatic substrates by a family of enzymes: a case study of diclofenac binding in CYP2C isoforms. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2016, 第 1 作者18(26): 17428-17439, https://www.webofscience.com/wos/woscc/full-record/WOS:000379482100038.
[27] Fan, JingRong, Zheng, QingChuan, Cui, YingLu, Li, WeiKang, Zhang, HongXing. Investigation of ligand selectivity in CYP3A7 by molecular dynamics simulations. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2015, 第 3 作者33(11): 2360-2367, https://www.webofscience.com/wos/woscc/full-record/WOS:000361981800005.
[28] Cui, YingLu, Xue, Qiao, Zheng, QingChuan, Zhang, JiLong, Kong, ChuiPeng, Fan, JingRong, Zhang, HongXing. Structural features and dynamic investigations of the membrane-bound cytochrome P450 17A1. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES[J]. 2015, 第 1 作者1848(10): 2013-2021, https://www.webofscience.com/wos/woscc/full-record/WOS:000362153400008.
[29] Cui, YingLu, Zheng, QingChuan, Zhang, JiLong, Zhang, HongXing. Molecular Basis of the Recognition of Arachidonic Acid by Cytochrome P450 2E1 Along Major Access Tunnel. BIOPOLYMERS[J]. 2015, 第 1 作者103(1): 53-66, https://www.webofscience.com/wos/woscc/full-record/WOS:000344466700006.
[30] Xue, Qiao, Zheng, QingChuan, Zhang, JiLong, Cui, YingLu, Chu, WenTing, Zhang, HongXing. Mutation and low pH effect on the stability as well as unfolding kinetics of transthyretin dimer. BIOPHYSICAL CHEMISTRY[J]. 2014, 第 4 作者189: 8-15, http://dx.doi.org/10.1016/j.bpc.2014.02.002.
[31] Kong, ChuiPeng, Cui, YingLu, Zhang, JiLong, Zheng, QingChuan, Zhang, HongXing. Mechanism of A pH-induced Peptide Inserting into a POPC Bilayer: A Molecular Dynamic Study. CURRENT PHARMACEUTICAL BIOTECHNOLOGY[J]. 2014, 第 2 作者15(9): 814-822, https://www.webofscience.com/wos/woscc/full-record/WOS:000345277100006.
[32] 吴云剑, 崔颖璐, 郑清川, 张红星. CYP2 C9酶与Warfarin结合模型的立体选择性理论研究. 高等学校化学学报[J]. 2014, 第 2 作者35(12): 2605-2611, http://lib.cqvip.com/Qikan/Article/Detail?id=663144606.
[33] Xue, Qiao, Zheng, QingChuan, Zhang, JiLong, Cui, YingLu, Zhang, HongXing. Exploring the Mechanism How Marburg Virus VP35 Recognizes and Binds dsRNA by Molecular Dynamics Simulations and Free Energy Calculations. BIOPOLYMERS[J]. 2014, 第 4 作者101(8): 849-860, https://www.doi.org/10.1002/bip.22463.
[34] Wu Yunjian, Zheng Qingchuan, Xu Yu, Chu Wenting, Cui Yinglu, Wang Yan, Zhang Hongxing. Insight into the Urea Binding and K166R Mutation Stabilizing Mechanism of TlpB: Molecular Dynamics and Principal Component Analysis Study. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES[J]. 2014, 第 5 作者30(6): 1011-1017, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5301756&detailType=1.
[35] Wu, YunJian, Zheng, QingChuan, Zhang, JiLong, Chu, WenTing, Cui, YingLu, Wang, Yan, Zhang, HongXing. Fosfomycin Induced Structural Change in Fosfomycin Resistance Kinases FomA: Molecular Dynamics and Molecular Docking Studies. JOURNAL OF MOLECULAR MODELING[J]. 2014, 第 5 作者20(5): 2236-1-2236-11, http://dx.doi.org/10.1007/s00894-014-2236-2.
[36] 徐钰, 崔颖璐, 郑清川, 张红星, 孙家锺. 人类谷胱甘肽硫转移酶家族等位基因蛋白B与抑制剂作用模型的理论研究. 高等学校化学学报[J]. 2013, 第 2 作者34(5): 1226-1232, http://lib.cqvip.com/Qikan/Article/Detail?id=45652081.
[37] Cui, YingLu, Zhang, JiLong, Zheng, QingChuan, Niu, RuiJuan, Xu, Yu, Zhang, HongXing, Sun, ChiaChung. Structural and Dynamic Basis of Human Cytochrome P4507B1: A Survey of Substrate Selectivity and Major Active Site Access Channels. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2013, 第 1 作者19(2): 548-556, http://dx.doi.org/10.1002/chem.201202627.
[38] Li, XiaoXi, Zhang, JiLong, Zheng, QingChuan, Cui, YingLu, Niu, RuiJuan, Zhang, HongXing, Sun, ChiaChung. CATALYTIC MECHANISM OF ALL-TRANS-RETINOIC ACID 4-HYDROXYLATION MEDIATED BY CYTOCHROME P450 2C8: HOW DOES ARGININE 241 AFFECT THE C-H BOND ACTIVATION?. JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY[J]. 2013, 第 4 作者12(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000328359500009.
[39] 崔颖璐, 郑清川, 张红星. 细胞色素P450对底物的选择性及催化机制. 分子科学学报[J]. 2013, 第 1 作者29(6): 461-468, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5027614&detailType=1.
[40] Cui, YingLu, Zheng, QingChuan, Zhang, JiLong, Xue, Qiao, Wang, Yan, Zhang, HongXing. Molecular Dynamic Investigations of the Mutational Effects on Structural Characteristics and Tunnel Geometry in CYP17A1. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2013, 第 1 作者53(12): 3308-3317, http://dx.doi.org/10.1021/ci400553w.
[41] Xue, Qiao, Zhang, JiLong, Zheng, QingChuan, Cui, YingLu, Chen, Lin, Chu, WenTing, Zhang, HongXing. Exploring the Molecular Basis of dsRNA Recognition by Mss116p Using Molecular Dynamics Simulations and Free-Energy Calculations. LANGMUIR[J]. 2013, 第 4 作者29(35): 11135-11144, https://www.webofscience.com/wos/woscc/full-record/WOS:000326128900021.
[42] Wang, Yan, Zheng, QingChuan, Zhang, JiLong, Cui, YingLu, Xue, Qiao, Zhang, HongXing. Highlighting a pi-pi interaction: a protein modeling and molecular dynamics simulation study on Anopheles gambiae glutathione S-transferase 1-2. JOURNAL OF MOLECULAR MODELING[J]. 2013, 第 4 作者19(12): 5213-5223, http://dx.doi.org/10.1007/s00894-013-2009-3.
[2] Cui, Yinglu, Sun, Jinyuan, Wu, Bian. Computational enzyme redesign: large jumps in function. TRENDS IN CHEMISTRY. 2022, 第 1 作者4(5): 409-419, http://dx.doi.org/10.1016/j.trechm.2022.03.001.
[3] Zhu, Tong, Cui, Yinglu, Geng, Wenchao, Liu, Guoxia, Jiang, Huifeng, Li, Ruifeng, Wu, Bian. Creating an Unusual Glycine-Rich Motif in a Peptide Amidase Leads to Versatile Protein C-Terminal Traceless Functionalization. ACS CATALYSIS. 2022, 第 2 作者8019-8026, http://dx.doi.org/10.1021/acscatal.2c01456.
[4] Li, Ruifeng, Schmidt, Marcel, Zhu, Tong, Yang, Xinyu, Feng, Jing, Tian, Yue, Cui, Yinglu, Nuijens, Timo, Wu, Bian. Traceless enzymatic protein synthesis without ligation sites constraint. NATIONAL SCIENCE REVIEW[J]. 2022, 第 7 作者9(5): 104-114, http://dx.doi.org/10.1093/nsr/nwab158.
[5] Cui, Yinglu, Chen, Yanchun, Liu, Xinyue, Dong, Saijun, Tian, Yue, Qiao, Yuxin, Mitra, Ruchira, Han, Jing, Li, Chunli, Han, Xu, Liu, Weidong, Chen, Quan, Wei, Wangqing, Wang, Xin, Du, Wenbin, Tang, Shuangyan, Xiang, Hua, Liu, Haiyan, Liang, Yong, Houk, Kendall N, Wu, Bian. Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy. ACS CATALYSIS[J]. 2021, 第 1 作者11(3): 1340-1350, http://dx.doi.org/10.1021/acscatal.0c05126.
[6] Cui, Yinglu, Wang, Yinghui, Tian, Wenya, Bu, Yifan, Li, Tao, Cui, Xuexian, Zhu, Tong, Li, Ruifeng, Wu, Bian. Development of a versatile and efficient C-N lyase platform for asymmetric hydroamination via computational enzyme redesign. NATURE CATALYSIS[J]. 2021, 第 1 作者4(5): 364-373, http://dx.doi.org/10.1038/s41929-021-00604-2.
[7] Wang, Min, Xie, Zhoujie, Tang, Shoubin, Chang, Ee Ling, Tang, Yue, Guo, Zhengyan, Cui, Yinglu, Wu, Bian, Ye, Tao, Chen, Yihua. Reductase of Mutanobactin Synthetase Triggers Sequential C-C Macrocyclization, C-S Bond Formation, and C-C Bond Cleavage. ORGANIC LETTERS[J]. 2020, 第 7 作者22(3): 960-964, http://dx.doi.org/10.1021/acs.orglett.9b04501.
[8] Li, Tao, Cui, Xuexian, Cui, Yinglu, Sun, Jinyuan, Chen, Yanchun, Zhu, Tong, Li, Chuijian, Li, Ruifeng, Wu, Bian. Exploration of Transaminase Diversity for the Oxidative Conversion of Natural Amino Acids into 2-Ketoacids and High-Value Chemicals. ACS CATALYSIS[J]. 2020, 第 3 作者10(14): 7950-7957, http://dx.doi.org/10.1021/acscatal.0c01895.
[9] Zhu, Tong, Li, Ruifeng, Sun, Jinyuan, Cui, Yinglu, Wu, Bian. Characterization and efficient production of a thermostable, halostable and organic solvent-stable cellulase from an oil reservoir. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2020, 第 4 作者159: 622-629, http://dx.doi.org/10.1016/j.ijbiomac.2020.05.021.
[10] Feng, Jing, Li, Ruifeng, Zhang, Shasha, Bu, Yifan, Chen, Yanchun, Cui, Yinglu, Lin, Baixue, Chen, Yihua, Tao, Yong, Wu, Bian. Bioretrosynthesis of FunctionalizedN-Heterocycles from Glucose via One-Pot Tandem Collaborations of Designed Microbes. ADVANCED SCIENCE[J]. 2020, 第 6 作者7(17): https://doaj.org/article/9c2328f94707485287af5a2f1cbca236.
[11] Li, Tao, Li, Ruifeng, Zhu, Tong, Cui, Xuexian, Li, Chuijian, Cui, Yinglu, Wu, Bian. Improving the System Performance of the Asymmetric Biosynthesis of D-Pantoic Acid by Using Artificially Self-Assembled Enzymes in Escherichia coli. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2020, 第 6 作者6(1): 219-+, http://dx.doi.org/10.1021/acsbiomaterials.9b01754.
[12] Mu, Qingxuan, Cui, Yinglu, Tian, Yue, Hu, Meirong, Tao, Yong, Wu, Bian. Thermostability improvement of the glucose oxidase from Aspergillus niger for efficient gluconic acid production via computational design. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 第 2 作者136: 1060-1068, http://dx.doi.org/10.1016/j.ijbiomac.2019.06.094.
[13] Li, Tao, Cui, Yinglu, Wu, Bian. Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2019, 第 2 作者37(10): 2527-2537,
[14] Li, Xiaoxiao, Bai, Yuxiang, Ji, Hangyan, Wang, Jinpeng, Cui, Yinglu, Jin, Zhengyu. Functional characterization of tryptophan437 at subsite+2 in pullulanase from Bacillus subtilis str. 168. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 第 5 作者133: 920-928, http://dx.doi.org/10.1016/j.ijbiomac.2019.04.103.
[15] Zheng, Xinxin, Cui, Yinglu, Li, Tao, Li, Ruifeng, Guo, Lu, Li, Defeng, Wu, Bian. Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 第 2 作者103(19): 8051-8062, http://dx.doi.org/10.1007/s00253-019-10105-9.
[16] Li, Tao, Cui, Yinglu, Wu, Bian. Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2019, 第 2 作者37(10): 2527-2537,
[17] 崔颖璐, 吴边. 符合工程化需求的生物元件设计. 中国科学院院刊[J]. 2018, 第 1 作者33(11): 1150-1157, http://lib.cqvip.com/Qikan/Article/Detail?id=676797241.
[18] Tian, Xiuyun, He, GuangJun, Hu, Pengjie, Chen, Lei, Tao, Changyu, Cui, YingLu, Shen, Lan, Ke, Weixin, Xu, Haijiao, Zhao, Youbao, Xu, Qijiang, Bai, Fengyan, Wu, Bian, Yang, Ence, Lin, Xiaorong, Wang, Linqi. Cryptococcus neoformans sexual reproduction is controlled by a quorum sensing peptide. NATUREMICROBIOLOGY[J]. 2018, 第 6 作者3(6): 698-707, https://www.webofscience.com/wos/woscc/full-record/WOS:000433302800012.
[19] Bu, Yifan, Cui, Yinglu, Peng, Ying, Hu, Meirong, Tian, Yue, Tao, Yong, Wu, Bian. Engineering improved thermostability of the GH11 xylanase from Neocallimastix patriciarum via computational library design. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 第 2 作者102(8): 3675-3685, https://www.webofscience.com/wos/woscc/full-record/WOS:000428316700018.
[20] Li, Ruifeng, Wijma, Hein J, Song, Lu, Cui, Yinglu, Otzen, Marleen, Tian, Yue, Du, Jiawei, Li, Tao, Niu, Dingding, Chen, Yanchun, Feng, Jing, Han, Jian, Chen, Hao, Tao, Yong, Janssen, Dick B, Wu, Bian. Computational redesign of enzymes for regio- and enantioselective hydroamination. NATURE CHEMICAL BIOLOGY[J]. 2018, 第 4 作者14(7): 664-+,
[21] Gao, Pan, Cui, YingLu, Wu, RongLing. Molecular dynamic modeling of CYP51B in complex with azole inhibitors. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2018, 第 2 作者 通讯作者 36(6): 1511-1519,
[22] 崔颖璐, 吴边. 计算机辅助蛋白结构预测及酶的计算设计研究进展. 广西科学[J]. 2017, 第 1 作者24(1): 1-6, http://lib.cqvip.com/Qikan/Article/Detail?id=671521007.
[23] Feng, Jin, Zhang, Peng, Cui, Yinglu, Li, Kai, Qiao, Xue, Zhang, YingTao, Li, ShuMing, Cox, Russell J, Wu, Bian, Ye, Min, Yin, WenBing. Regio- and Stereospecific O-Glycosylation of Phenolic Compounds Catalyzed by a Fungal Glycosyltransferase from Mucor hiemalis. ADVANCED SYNTHESIS & CATALYSIS[J]. 2017, 第 3 作者359(6): 995-1006, https://www.doi.org/10.1002/adsc.201601317.
[24] Cui, YingLu, Wu, RongLing. Molecular dynamics investigations of membrane-bound CYP2C19 polymorphisms reveal distinct mechanisms for peripheral variants by long-range effects on the enzymatic activity. MOLECULAR BIOSYSTEMS[J]. 2017, 第 1 作者13(6): 1070-1079, http://dx.doi.org/10.1039/c6mb00827e.
[25] Xue, Qiao, Cui, YingLu, Zheng, QingChuan, Zhang, HongXing. Molecular dynamics investigations of BioH protein substrate specificity for biotin synthesis. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2016, 第 2 作者34(5): 1052-1060, http://dx.doi.org/10.1080/07391102.2015.1068223.
[26] Cui, YingLu, Xu, Fang, Wu, Rongling. Molecular dynamics investigations of regioselectivity of anionic/aromatic substrates by a family of enzymes: a case study of diclofenac binding in CYP2C isoforms. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2016, 第 1 作者18(26): 17428-17439, https://www.webofscience.com/wos/woscc/full-record/WOS:000379482100038.
[27] Fan, JingRong, Zheng, QingChuan, Cui, YingLu, Li, WeiKang, Zhang, HongXing. Investigation of ligand selectivity in CYP3A7 by molecular dynamics simulations. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS[J]. 2015, 第 3 作者33(11): 2360-2367, https://www.webofscience.com/wos/woscc/full-record/WOS:000361981800005.
[28] Cui, YingLu, Xue, Qiao, Zheng, QingChuan, Zhang, JiLong, Kong, ChuiPeng, Fan, JingRong, Zhang, HongXing. Structural features and dynamic investigations of the membrane-bound cytochrome P450 17A1. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES[J]. 2015, 第 1 作者1848(10): 2013-2021, https://www.webofscience.com/wos/woscc/full-record/WOS:000362153400008.
[29] Cui, YingLu, Zheng, QingChuan, Zhang, JiLong, Zhang, HongXing. Molecular Basis of the Recognition of Arachidonic Acid by Cytochrome P450 2E1 Along Major Access Tunnel. BIOPOLYMERS[J]. 2015, 第 1 作者103(1): 53-66, https://www.webofscience.com/wos/woscc/full-record/WOS:000344466700006.
[30] Xue, Qiao, Zheng, QingChuan, Zhang, JiLong, Cui, YingLu, Chu, WenTing, Zhang, HongXing. Mutation and low pH effect on the stability as well as unfolding kinetics of transthyretin dimer. BIOPHYSICAL CHEMISTRY[J]. 2014, 第 4 作者189: 8-15, http://dx.doi.org/10.1016/j.bpc.2014.02.002.
[31] Kong, ChuiPeng, Cui, YingLu, Zhang, JiLong, Zheng, QingChuan, Zhang, HongXing. Mechanism of A pH-induced Peptide Inserting into a POPC Bilayer: A Molecular Dynamic Study. CURRENT PHARMACEUTICAL BIOTECHNOLOGY[J]. 2014, 第 2 作者15(9): 814-822, https://www.webofscience.com/wos/woscc/full-record/WOS:000345277100006.
[32] 吴云剑, 崔颖璐, 郑清川, 张红星. CYP2 C9酶与Warfarin结合模型的立体选择性理论研究. 高等学校化学学报[J]. 2014, 第 2 作者35(12): 2605-2611, http://lib.cqvip.com/Qikan/Article/Detail?id=663144606.
[33] Xue, Qiao, Zheng, QingChuan, Zhang, JiLong, Cui, YingLu, Zhang, HongXing. Exploring the Mechanism How Marburg Virus VP35 Recognizes and Binds dsRNA by Molecular Dynamics Simulations and Free Energy Calculations. BIOPOLYMERS[J]. 2014, 第 4 作者101(8): 849-860, https://www.doi.org/10.1002/bip.22463.
[34] Wu Yunjian, Zheng Qingchuan, Xu Yu, Chu Wenting, Cui Yinglu, Wang Yan, Zhang Hongxing. Insight into the Urea Binding and K166R Mutation Stabilizing Mechanism of TlpB: Molecular Dynamics and Principal Component Analysis Study. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES[J]. 2014, 第 5 作者30(6): 1011-1017, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5301756&detailType=1.
[35] Wu, YunJian, Zheng, QingChuan, Zhang, JiLong, Chu, WenTing, Cui, YingLu, Wang, Yan, Zhang, HongXing. Fosfomycin Induced Structural Change in Fosfomycin Resistance Kinases FomA: Molecular Dynamics and Molecular Docking Studies. JOURNAL OF MOLECULAR MODELING[J]. 2014, 第 5 作者20(5): 2236-1-2236-11, http://dx.doi.org/10.1007/s00894-014-2236-2.
[36] 徐钰, 崔颖璐, 郑清川, 张红星, 孙家锺. 人类谷胱甘肽硫转移酶家族等位基因蛋白B与抑制剂作用模型的理论研究. 高等学校化学学报[J]. 2013, 第 2 作者34(5): 1226-1232, http://lib.cqvip.com/Qikan/Article/Detail?id=45652081.
[37] Cui, YingLu, Zhang, JiLong, Zheng, QingChuan, Niu, RuiJuan, Xu, Yu, Zhang, HongXing, Sun, ChiaChung. Structural and Dynamic Basis of Human Cytochrome P4507B1: A Survey of Substrate Selectivity and Major Active Site Access Channels. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2013, 第 1 作者19(2): 548-556, http://dx.doi.org/10.1002/chem.201202627.
[38] Li, XiaoXi, Zhang, JiLong, Zheng, QingChuan, Cui, YingLu, Niu, RuiJuan, Zhang, HongXing, Sun, ChiaChung. CATALYTIC MECHANISM OF ALL-TRANS-RETINOIC ACID 4-HYDROXYLATION MEDIATED BY CYTOCHROME P450 2C8: HOW DOES ARGININE 241 AFFECT THE C-H BOND ACTIVATION?. JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY[J]. 2013, 第 4 作者12(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000328359500009.
[39] 崔颖璐, 郑清川, 张红星. 细胞色素P450对底物的选择性及催化机制. 分子科学学报[J]. 2013, 第 1 作者29(6): 461-468, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5027614&detailType=1.
[40] Cui, YingLu, Zheng, QingChuan, Zhang, JiLong, Xue, Qiao, Wang, Yan, Zhang, HongXing. Molecular Dynamic Investigations of the Mutational Effects on Structural Characteristics and Tunnel Geometry in CYP17A1. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2013, 第 1 作者53(12): 3308-3317, http://dx.doi.org/10.1021/ci400553w.
[41] Xue, Qiao, Zhang, JiLong, Zheng, QingChuan, Cui, YingLu, Chen, Lin, Chu, WenTing, Zhang, HongXing. Exploring the Molecular Basis of dsRNA Recognition by Mss116p Using Molecular Dynamics Simulations and Free-Energy Calculations. LANGMUIR[J]. 2013, 第 4 作者29(35): 11135-11144, https://www.webofscience.com/wos/woscc/full-record/WOS:000326128900021.
[42] Wang, Yan, Zheng, QingChuan, Zhang, JiLong, Cui, YingLu, Xue, Qiao, Zhang, HongXing. Highlighting a pi-pi interaction: a protein modeling and molecular dynamics simulation study on Anopheles gambiae glutathione S-transferase 1-2. JOURNAL OF MOLECULAR MODELING[J]. 2013, 第 4 作者19(12): 5213-5223, http://dx.doi.org/10.1007/s00894-013-2009-3.
科研活动
科研项目
（ 1 ） 聚对苯二甲酸乙二酯(PET)塑料降解互补酶MHETase的机制解析及改造应用, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） 塑料降解酶智能化新酶构建及荧光纳米探针高通量筛选研究, 负责人, 地方任务, 2019-01--2020-12
（ 3 ） 新分子生化反应设计与核心生命途径重构, 参与, 国家任务, 2019-01--2024-12
（ 4 ） 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2022-01--2026-01
（ 2 ） 塑料降解酶智能化新酶构建及荧光纳米探针高通量筛选研究, 负责人, 地方任务, 2019-01--2020-12
（ 3 ） 新分子生化反应设计与核心生命途径重构, 参与, 国家任务, 2019-01--2024-12
（ 4 ） 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2022-01--2026-01