主要研究方向

1.肺癌多核磁共振分子影像研究领域

       瞄准肺癌早期诊断的重大需求，构建了高灵敏度、高特异性、环境响应型的分子探针，利用¹²⁹Xe/¹⁹F/¹H多核磁共振技术，对肿瘤微环境和实体瘤进行多分子成像，更全面、精准、无创地探测早期肺癌；通过对肺癌分子功能、细胞行为，活体病变到病人肺功能的多尺度研究，为超灵敏129Xe磁共振分子影像在肿瘤基础研究向临床转化提供理论依据。

2.活体多核(¹H/¹⁹F/¹²⁹Xe)磁共振分子影像

       相对于传统的单核1H磁共振造影剂，多核¹H/¹⁹F/¹²⁹Xe的磁共振分子影像具有无背景信号干扰、可原位活体对肺癌实现多分子精准探测等优点。其中19F对目标部位环境变化比较敏感，可产生较大的化学位移变化（>350ppm），结合超灵敏的¹²⁹Xe，可获得更为丰富、独特的信息，从而揭示更多肿瘤演进中微环境的改变。

3.利用多核磁共振成像技术，全面获取肺癌从人体到动物到分子水平的多角度、多层面信息。

       从分子，组织，活体到病人多个层面“精读”肺癌，全面获取肺癌从人体到动物到分子水平的多层面信息。从而能进行肺癌癌前病变及早期癌发生、发展的分子机理研究，这对指导肺部重大疾病的早期发现、诊断以及治疗，提高患者生存率具有重大学术和临床实践意义。

招收博士研究生、硕士研究生

招生专业：070302-分析化学、086001-生物技术与工程

招生方向：多模态分子影像、磁共振分子影像、生物传感

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2018-10~现在, 中国科学院武汉物理与数学研究所, 研究员
2013-10~2018-09,中国科学院武汉物理与数学研究所, 副研究员
2011-07~2013-09,中国科学院武汉物理与数学研究所, 博士后

2024-03-10-今,磁共振波谱与成像（全国）重点实验室, 副主任
2023-11-01-今,中国医药生物技术协会生物医学成像技术分会第二届委员会, 常务委员
2019-10-01-今,中国科学院磁共振联盟, 副秘书长

发表论文

1.    Lei Zhang^#, Maosong Qiu^#, Ruifang Wang, Sha Li, Xiaoxun Liu, Qiuyi Xu, Long Xiao, Zhong-Xing Jiang, Xin Zhou*, Shizhen Chen*, Monitoring ROS Responsive Fe3O4-based Nanoparticle Mediated Ferroptosis&Immunotherapy via 129Xe MRI Angewandte Chemie International Edition, 2024

2.    Long Xiao^#, Lei Zhang^#, Sha Li, Yue Zhu, Qiao Yu, Zhaoqing Liu, Maosong Qiu, Yu Li, Shizhen Chen*, Xin Zhou*. Visualization and Quantification of Drug Release by GSH-Responsive Multimodal Integrated Micelles. JACS Au. (2024).

3.    Yujie Zheng^#, Yu Li^#, Changsheng Ke^#, Mojie Duan, Lijun Zhu, Xin Zhou, Minghui Yang, Zhongxing Jiang*, Shizhen Chen*. Jellyfish-inspired Smart Tetraphenylethene Lipids with Unique AIE Fluorescence, Thermal Response, and Cell Membrane Interaction. Journal of Materials Chemistry B, Vol 12(9), 2373-2383. (2024)

4.     Maosong Qiu, Lei Zhang, Yu Li, Ruifang Wang, Long Xiao, Shizhen Chen*, Xin Zhou*. An Acid Microenvironment-driven Theranostics Platform for Lung Cancer ¹⁹F MR/PA/FL Multimodal Imaging-guided Photothermal Therapy. Materials Research Bulletin, Vol 174, 112731. (2024).

5.     Lan Yang^#, Yu Li^#, Mou Jiang^#, Rui Zhou, Hengjiang Cong, Minghui Yang, Lei Zhang, Shenhui Li, Yunhuang Yang, Maili Liu, Xin Zhou, Zhongxing Jiang*, Shizhen Chen*. Fluorinated [2]Rotaxanes as Sensitive¹⁹F MRI Agents: Threading for Higher Sensitivity. Chinese Chemical Letters. (2024).

6.    Xin Guo, Lei Zhang, Jiesheng Hu, Balázs Szilágyi, Meng Yu*, Shizhen Chen*, Gyula Tircsó, Xin Zhou, Jun Tao*. Improving the Potential of ParaCEST through Magnetic-coupling Induced Line Sharpening. Chemical Science, Vol 14(48), 14157-14165. (2023)

7.    Qiao Yu^#, Lei Zhang^#, Mou Jiang, Long Xiao, Yunhui Xiang, Ruifang Wang, Zhaoqing Liu, Rui Zhou, Minghui Yang, Conggang Li, Maili Liu, Xin Zhou, Shizhen Chen*. An NIR Fluorescence Turn-on and MRI Bimodal Probe for Concurrent Real-time in Vivo Sensing and Labeling of β-Galactosidase. Angewandte Chemie International Edition, Vol 62(46), e202313137. (2023).

8.     Ruifang Wang^#, Maosong Qiu^#, Lei Zhang^#, Meiju Sui, Long Xiao, Qiao Yu, Chaohui Ye, Shizhen Chen*, Xin Zhou*. Augmenting Immunotherapy via Bioinspired MOF-based Ros Homeostasis Disruptor with Nanozyme-Cascade Reaction. Advanced Materials, Vol 35(49), 2306748. (2023)

9.    Yu Li^#, Jing Zhang^#, Lijun Zhu, Mou Jiang, Changsheng Ke, Hanxiong Long, Ruoyun Lin, Chaohui Ye, Xin Zhou, Zhongxing Jiang*, Shizhen Chen*. All-in-One Heptamethine Cyanine Amphiphiles for Dual Imaging-Guided Chemo-Photodynamic-Photothermal Therapy of Breast Cancer. Advanced Healthcare Materials, Vol 12(27), 2300941. (2023).

10. Lijun Zhu, Yu Li, Mou Jiang, Changsheng Ke, Hanxiong Long, Maosong Qiu, Lei Zhang, Chaohui Ye, Xin Zhou, Zhongxing Jiang*, Shizhen Chen*. Self-Assembly of Precisely Fluorinated Albumin for Dual Imaging-Guided Synergistic Chemo-Photothermal-Photodynamic Cancer Therapy. ACS Applied Materials & Interfaces, Vol 15(2), 2665-2678. (2023).

11. Shizhen Chen^#, Mou Jiang^#, Yaping Yuan, Baolong Wang, Yu Li, Lei Zhang, Zhongxing Jiang, Chaohui Ye, Xin Zhou*. Using Endogenous Glycogen as Relaxation Agent for Imaging Liver Metabolism by MRI. Fundamental Research, Vol 3(4), 481-487. (2023).

12. Ting Tang^#, Qiang Zhu^#, Shuang Liu, Hailong Dai, Yu Li, Caihong Tang, Kexin Chen, Mou Jiang, Lijun Zhu, Xin Zhou, Shizhen Chen*, Zitong Zheng*, Zhongxing Jiang*. ¹⁹F MRI-Fluorescence Imaging Dual-Modal Cell Tracking with Partially Fluorinated Nanoemulsions. Frontiers in Bioengineering and Biotechnology, Vol 10, 1049750. (2022)

13.  李海东^#，陈世桢^#，娄昕，张定宇，周欣*. 多核磁共振成像助力新冠肺炎疫情防控. 中国科学基金，Vol 36(4), 644-653. (2022)

14.  Shizhen Chen^#, Long Xiao^#, Yu Li, Maosong Qiu, Yaping Yuan, Rui Zhou, Conggang Li, Lei Zhang, Zhongxing Jiang, Maili Liu, Xin Zhou*. In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent ¹⁹F NMR. Angewandte Chemie International Edition, Vol 61(50), e202213495. (2022).

15.  Shizhen Chen^#, Maosong Qiu^#, Ruifang Wang, Lei Zhang, Conggang Li, Chaohui Ye, Xin Zhou*. Photoactivated Nanohybrid for Dual-Nuclei MR/US/PA Multimodal-Guided Photothermal Therapy. Bioconjugate Chemistry, Vol 33(9), 1729-1740. (2022).

16.  Shizhen Chen, Yina Lan, Haidong Li, Liming Xia, Chaohui Ye, Xin Lou*, Xin Zhou*. Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized ¹²⁹Xe-MRI-based 8-Month Follow-Up. Biomedicines, Vol 10(4), 781-789. (2022)

17.  Sha Li, Weiping Jiang, Yaping Yuan, Meiju Sui, Yuqi Yang, Liqun Huang, Ling Jiang, Maili Liu, Shizhen Chen*, Xin Zhou*. Delicately Designed Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted¹⁹F MR/PA/FL Imaging-Guided Photothermal Therapy. ACS Applied Materials & Interfaces, Vol 12(51), 57290-57301. (2020)

18. Lili Ren^#, Shizhen Chen^#*, Weiping Jiang, Qingbin Zeng, Xu Zhang, Long Xiao, Michael T. McMahon, Lou Xin, Xin Zhou*. Efficient Temperature-feedback Liposome for ¹⁹F MRI Signal Enhancement. Chemical Communications, Vol 56(92), 14427-14430. (2020).

19. Huaibin Zhang, Shaowei Bo, Kai Zeng, Jie Wang, Yu Li, Zhigang Yang, Xin Zhou*, Shizhen Chen*, Zhongxing Jiang*. Fluorinated Porphyrin-Based Theranostics for Dual Imaging and Chemo-Photodynamic Therapy. Journal of Materials Chemistry B, Vol 8(20), 4469-4474. (2020).

20. Huaibin Zhang, Qiao Yu, Yu Li, Zhigang Yang, Xin Zhou, Shizhen Chen*, Zhongxing Jiang*. Fluorinated Cryptophane-A and Porphyrin-based Theranostics for Multimodal Imaging-guided Photodynamic Therapy. Chemical Communications, Vol 56(25), 3617-3620. (2020).

21. Lianhua Liu, Yaping Yuan, Yuqi Yang, Michael McMahon, Shizhen Chen*, Xin Zhou*. A Fluorinated Aza-BODIPY Derivative for NIR fluorescence/PA/¹⁹F MR Tri-modality In Vivo Imaging. Chemical Communications, Vol 55(42), 5851-5854. (2019)

22. Huaibin Zhang^#, Shizhen Chen^#, Yaping Yuan, Yu Li, Zhongxing Jiang*, Xin Zhou*. ¹²⁹Xe Hyper-CEST/¹⁹F MRI Multimodal Imaging System for Sensitive and Selective Tumor Cells Detection. ACS Applied Bio Materials, Vol 2(1), 27-32. ((2019)

23. Yuqi Yang^#, Shizhen Chen^#, Haidong Li, Yaping Yuan, Zhiying Zhang, Junshuai Xie, Dennis.W Hwang, Aidong Zhang, Maili Liu, Xin Zhou*. Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging. Nano Letters, Vol 19(1), 441-448. (2019)

24. Sha Li, Yaping Yuan, Yuqi Yang, Conggang Li, Michael McMahon, Maili Liu, Shizhen Chen*, Xin Zhou*. Potential Detection of Cancer with Fluorinated Silicon Nanoparticles in ¹⁹F MR and Fluorescence Imaging. Journal of Materials Chemistry B, Vol 6,4293-4300. (2018)

25. Xi Huang, Yaping Yuan, Weiwei Ruan, Lianhua Liu, Maili Liu, Shizhen Chen*, Xin Zhou*. pH-responsive Theranostic Nanocomposites as Synergistically Enhancing Positive and Negative Magnetic Resonance Imaging Contrast Agents. Journal of Nanobiotechnology, Vol 16(30). (2018)

26. Xin Liu, Yaping Yuan, Shaowei Bo, Zhigang Yang, Xin Zhou, Shizhen Chen*, Zhongxing Jiang*. Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with ¹⁹F Magnetic Resonance. European Journal of Organic Chemistry, Vol 2017(30), 4461-4468. (2017)

27. Yuqi Yang^#, Shizhen Chen^#, Lianhua Liu, Sha Li, Qingbin Zeng, Xiuchao Zhao, Haidong Li, Zhiying Zhang, Louis-S. Bouchard, Maili Liu, Xin Zhou*. Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation. ACS Applied Materials & Interfaces, Vol 9(28), 23400-23408. (2017).

28.  Lili Ren^#, Shizhen Chen^#, Haidong Li, Zhiying Zhang, Jianping Zhong, Maili Liu, Xin Zhou*. MRI-Guided Liposomes for Targeted Tandem Chemotherapy and Therapeutic Response Prediction. Acta Biomaterialia, Vol 35, 260-268. (2016).

29. Shizhen Chen, Yuqi Yang, Haidong Li, Xin Zhou*, Maili Liu. pH-Triggered Au-Fluorescent Mesoporous Silica Nanoparticles for ¹⁹F MR/Fluorescent Multimodal Cancer Cellular Imaging. Chemical Communications, Vol 50(3), 283-285. (2014). 

（ 1 ） 用于识别癌细胞A549 的磁共振和荧光双功能探针的研究, 负责人, 国家任务, 2014-01--2016-12
（ 2 ） MicroRNA响应的19F MRI/近红外分子探针对肺癌的靶向诊断和治疗, 负责人, 国家任务, 2016-01--2019-12
（ 3 ） 多功能探针对肺癌的诊疗一体化研究, 负责人, 地方任务, 2015-01--2016-12
（ 4 ） 金纳米棒@全氟化碳微泡用于肺癌的超灵敏129Xe/19F双核 MRI 及光声成像研究, 负责人, 国家任务, 2019-01--2022-12
（ 5 ） 活体肺部超灵敏磁共振研究, 负责人, 中国科学院计划, 2016-01--2020-12
（ 6 ） 多通道微流控的超极化磁共振分析系统, 负责人, 中国科学院计划, 2020-01--2021-12
（ 7 ） 超灵敏多核磁共振分子影像, 负责人, 地方任务, 2021-09--2024-10
（ 8 ） 肺部气体MRI对新冠恢复患者的肺部结构和功能的定量可视化研究, 负责人, 国家任务, 2022-01--2025-12
（ 9 ） 磁共振分子影像, 负责人, 中国科学院计划, 2018-01--2021-12
（ 10 ） 早期慢性阻塞性肺炎或肺癌的活体定量分析, 负责人, 中国科学院计划, 2017-01--2021-12

武汉大学

华中科技大学

武汉金银潭医院

博士后及研究生

在读

已毕业

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