微生物次级代谢与人体健康

微生物次级代谢产物是抗肿瘤药物、抗生素、免疫抑制剂等的重要来源之一。微生物次级代谢在多种疾病发生中发挥了重要作用。关于微生物次级代谢的研究对人类生活和健康状况的改善起了极大的推动作用。本实验室致力于运用分子遗传学、生物化学、化学和生物信息学的综合手段来研究微生物生产的具有实用价值的生物活性分子，筛选药物先导化合物，创新健康促进和疾病诊疗的先进手段。主要包括以下三个方面的研究内容：
（1） 挖掘人体致病菌、益生菌、食品等重要微生物中的次级代谢潜力，获取具有特定活性的化合物，解析其作用机制和生理功能，创新健康促进和疾病诊疗的先进手段。

（2）在对微生物药物分子和高活性化合物的生物合成机理充分了解的基础上，设计合理的策略，通过合成生物学和合成衍生等手段改造药物分子，创制新的先导药物。
（3） 利用次级代谢的多样性探索生命最基本的代谢和进化问题，理解生命形式的多样性。

   

100705-微生物与生化药学
071007-遗传学
071010-生物化学与分子生物学

微生物次级代谢
微生物药物的生物合成
天然产物的合成生物学

2001-09--2005-07   中国科学院微生物研究所   博士
1998-09--2001-06   南京农业大学   硕士
1994-09--1998-06   南京农业大学   本科

   

2011-04~现在, 中国科学院微生物研究所, 研究员
2006-07~2011-04,University of Wisconsin-Madison, Postdoc Research Associate

天然产物药物的生物合成及生物催化
微生物代谢工程
微生物学-II

   

   

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