基本信息
陈义华 男 博导 中国科学院微生物研究所
电子邮件: chenyihua@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101
电子邮件: chenyihua@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101
研究领域
微生物次级代谢与人体健康
微生物次级代谢产物是抗肿瘤药物、抗生素、免疫抑制剂等的重要来源之一。微生物次级代谢在多种疾病发生中发挥了重要作用。关于微生物次级代谢的研究对人类生活和健康状况的改善起了极大的推动作用。本实验室致力于运用分子遗传学、生物化学、化学和生物信息学的综合手段来研究微生物生产的具有实用价值的生物活性分子,筛选药物先导化合物,创新健康促进和疾病诊疗的先进手段。主要包括以下三个方面的研究内容:
(1) 挖掘人体致病菌、益生菌、食品等重要微生物中的次级代谢潜力,获取具有特定活性的化合物,解析其作用机制和生理功能,创新健康促进和疾病诊疗的先进手段。
(2)在对微生物药物分子和高活性化合物的生物合成机理充分了解的基础上,设计合理的策略,通过合成生物学和合成衍生等手段改造药物分子,创制新的先导药物。
(3) 利用次级代谢的多样性探索生命最基本的代谢和进化问题,理解生命形式的多样性。
招生信息
招生专业
100705-微生物与生化药学071007-遗传学071010-生物化学与分子生物学
招生方向
微生物次级代谢与人体健康微生物药物的生物合成合成生物学
教育背景
2001-09--2005-07 中国科学院微生物研究所 博士1998-09--2001-06 南京农业大学 硕士1994-09--1998-06 南京农业大学 本科
工作经历
工作简历
2011-04~现在, 中国科学院微生物研究所, 研究员2006-07~2011-04,University of Wisconsin-Madison, Postdoc Research Associate
教授课程
微生物代谢工程与合成生物学天然产物药物的生物合成及生物催化微生物代谢工程微生物学-II
专利与奖励
出版信息
发表论文
[1] Chen, Meng, Guo, Zhengyan, Sun, Jinyuan, Tang, Wei, Wang, Min, Tang, Yue, Li, Pengwei, Wu, Bian, Chen, Yihua. Insights into the biosynthesis of septacidin L-heptosamine moiety unveils a VOC family sugar epimerase. ACTA PHARMACEUTICA SINICA B[J]. 2023, 第 9 作者 通讯作者 13(2): 765-774, http://dx.doi.org/10.1016/j.apsb.2022.05.031.[2] 刘俐璐, 王文昭, 陈萌, 张雨薇, 毛会金, 王大成, 李鹏伟. Characterization of three succinyl-CoA acyltransferases involved in polyketide chain assembly.. Appl Microbiol Biotechnol[J]. 2023, [3] Xinli Li, Yue Tang, Yong Ding, Pengwei Li, Yihua Chen. Engineering the C3N Pathway as a Short Detour for De Novo NAD + Biosynthesis in Saccharomyces cerevisiae. FERMENTATION[J]. 2023, 第 5 作者9(10): https://doaj.org/article/f6fc1319ce4a47fc8bf9d35ce3b74441.[4] Zhang, Yuwei, Liao, Ge, Wang, Min, Zhang, Zhao, Liu, Liwei, Song, Yuqin, Wang, Dacheng, Hao, Tingting, Feng, Jie, Xia, Bin, Wang, Yixiang, Tang, Xiaoyu, Chen, Yihua. Human-associated bacteria adopt an unusual route for synthesizing 3-acetylated tetramates for environmental adaptation. MICROBIOME[J]. 2023, 第 13 作者 通讯作者 11(1): http://dx.doi.org/10.1186/s40168-023-01548-4.[5] Zhang, Yuwei, Li, Pengwei, Ma, Yue, Wang, Jun, Chen, Yihua. Artificial intelligence accelerates the mining of bioactive small molecules from human microbiome. CLINICAL AND TRANSLATIONAL MEDICINE[J]. 2022, 第 5 作者 通讯作者 12(8): http://dx.doi.org/10.1002/ctm2.1011.[6] 魏维佳等, 陈义华. Construction and heterologous expression of the di-AFN A1 biosynthetic gene cluster in Streptomyces model strains.. Chinese Journal of Natural Medicines[J]. 2022, 第 2 作者 通讯作者 22: 60197-3, [7] 陈萌, 曹贞菊等, 陈义华. Discovery of novel septacidin congeners from a high yield heterologous expression strain Streptomyces albus 1597.. Journal of Antitiotics[J]. 2022, 第 3 作者 通讯作者 [8] Tang, Yue, Tang, Wei, Wang, Min, Zhang, Zhilong, Chen, Yihua. A conservative distribution of tridomain NDP-heptose synthetases in actinobacteria. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 第 5 作者 通讯作者 65(5): 1014-1023, http://dx.doi.org/10.1007/s11427-021-2000-2.[9] Sun, Zhi, Wei, Weijia, Zhang, Mingyue, Shi, Wenjia, Zong, Yeqing, Chen, Yihua, Yang, Xiaojing, Yu, Bo, Tang, Chao, Lou, Chunbo. Synthetic robust perfect adaptation achieved by negative feedback coupling with linear weak positive feedback. NUCLEIC ACIDS RESEARCH[J]. 2022, 第 6 作者50(4): 2377-2386, http://dx.doi.org/10.1093/nar/gkac066.[10] Ma, Yue, Guo, Zhengyan, Xia, Binbin, Zhang, Yuwei, Liu, Xiaolin, Yu, Ying, Tang, Na, Tong, Xiaomei, Wang, Min, Ye, Xin, Feng, Jie, Chen, Yihua, Wang, Jun. Identification of antimicrobial peptides from the human gut microbiome using deep learning. NATURE BIOTECHNOLOGY. 2022, 第 12 作者 通讯作者 40(6): 921-931, http://dx.doi.org/10.1038/s41587-022-01226-0.[11] 张志龙, 李鹏伟, 王敏, 张雁, 吴边, 陶勇, 潘国辉, 陈义华. (S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine.. mLife[J]. 2022, 第 8 作者 通讯作者 [12] 张雨薇, 李鹏伟, 陈义华. Artificial intelligence accelerates the mining of bioactive small molecules from human microbiome.. Clin. Transl. Med.[J]. 2022, 第 3 作者 通讯作者 [13] Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang. Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius. ACS SYNTHETIC BIOLOGY[J]. 2022, 第 11 作者 通讯作者 11(6): 2163-2174, http://dx.doi.org/10.1021/acssynbio.2c00087.[14] Wang, Dacheng, Li, Pengwei, Yan, JiaLei, Mao, Huijin, Liu, Lilu, Wang, Min, Chen, Meng, Ye, Tao, Chen, Yihua. Assigning the stereochemical structures of aurantinin A and B with the assistance of biosynthetic investigations. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 9 作者 通讯作者 9(21): 5949-5954, http://dx.doi.org/10.1039/d2qo01251k.[15] Li, Chao, Bao, Wuyundalai, Zhang, Haoyue, Lyu, Zhitang, Chen, Yihua, Guo, Zhengyan. Discovery of Brominated Alboflavusins With Anti-MRSA Activities. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 5 作者12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920986/.[16] 张昊月, 郭正彦, 吕志堂, 陈义华. 应用响应面法优化发酵培养基提高达托霉素产量. 微生物学通报[J]. 2021, 第 4 作者48(1): 113-122, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb21010113?st=article_issue.[17] Guo, Zhengyan, Tang, Yue, Tang, Wei, Chen, Yihua. Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses. NATURAL PRODUCT REPORTS. 2021, 第 4 作者 通讯作者 38(10): 1887-1909, http://dx.doi.org/10.1039/d0np00075b.[18] Ding, Yong, Wang, Min, Li, Jine, Li, Pengwei, Guo, Zhenyan, Chen, Yihua. Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 第 6 作者 通讯作者 543: 8-14, http://dx.doi.org/10.1016/j.bbrc.2021.01.042.[19] Chen, Ying, Dou, Guili, Wang, Dandan, Yang, Jingyi, Zhang, Yixin, Garnett, James A, Chen, Yihua, Wang, Yixiang, Xia, Bin. Comparative Microbial Profiles of Caries and Black Extrinsic Tooth Stain in Primary Dentition. CARIES RESEARCH[J]. 2021, 第 7 作者 通讯作者 55(4): 310-321, http://dx.doi.org/10.1159/000517006.[20] Ding, Yong, Li, Xinli, Horsman, Geoff P, Li, Pengwei, Wang, Min, Li, Jine, Zhang, Zhilong, Liu, Weifeng, Wu, Bian, Tao, Yong, Chen, Yihua. Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway. ADVANCED SCIENCE[J]. 2021, 第 11 作者 通讯作者 8(9): https://doaj.org/article/7c65560618944b09848626d4f5994e7e.[21] Pengwei Li, Meng Chen, Wei Tang, Zhengyan Guo, Yuwei Zhang, Min Wang, Geoff P Horsman, Jin Zhong, Zhaoxin Lu, Yihua Chen. Initiating polyketide biosynthesis by on-line methyl esterification. NATURE COMMUNICATIONS[J]. 2021, 第 10 作者 通讯作者 12(1): http://dx.doi.org/10.1038/s41467-021-24846-7.[22] Xueyan Yao, Zhenying Zhang, Jun Huang, Shiping Wei, Xianyun Sun, Yihua Chen, Hongwei Liu, Shaojie Li. Candicidin Isomer Production Is Essential for Biocontrol of Cucumber Rhizoctonia Rot by Streptomyces albidoflavus W68. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2021, 第 6 作者87(9): e03078-20-., http://dx.doi.org/10.1128/AEM.03078-20.[23] 陈义华. Deciphering the Biosynthesis of TDP-β‑L‑oleandrose in Avermectin. Journal of Natural Products. 2020, 第 1 作者 通讯作者 [24] Qiao, Shanshan, Bao, Li, Wang, Kai, Sun, Shanshan, Liao, Mingfang, Liu, Chang, Zhou, Nan, Ma, Ke, Zhang, Yuwei, Chen, Yihua, Liu, ShuangJiang, Liu, Hongwei. Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalcoholic Hepatic Steatosis. CELL REPORTS[J]. 2020, 第 10 作者32(6): https://doaj.org/article/3c0c6df27461447caf7c341d1077a6ea.[25] Zhang, Qian, Ren, JinWei, Wang, Weishan, Zhai, Jian, Yang, Jing, Liu, Ning, Huang, Ying, Chen, Yihua, Pan, Guohui, Fan, Keqiang. A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters. ACS CHEMICAL BIOLOGY[J]. 2020, 第 8 作者15(9): 2551-2557, https://www.webofscience.com/wos/woscc/full-record/WOS:000574920900024.[26] Feng, Jing, Li, Ruifeng, Zhang, Shasha, Bu, Yifan, Chen, Yanchun, Cui, Yinglu, Lin, Baixue, Chen, Yihua, Tao, Yong, Wu, Bian. Bioretrosynthesis of FunctionalizedN-Heterocycles from Glucose via One-Pot Tandem Collaborations of Designed Microbes. ADVANCED SCIENCE[J]. 2020, 第 8 作者7(17): https://doaj.org/article/9c2328f94707485287af5a2f1cbca236.[27] Pei Du, Huiwei Zhao, Haoqian Zhang, Ruisha Wang, Jianyi Huang, Ye Tian, Xudong Luo, Xunxun Luo, Min Wang, Yanhui Xiang, Long Qian, Yihua Chen, Yong Tao, Chunbo Lou. De novo design of an intercellular signaling toolbox for multi-channel cell-cell communication and biological computation. NATURE COMMUNICATIONS[J]. 2020, 第 12 作者11(1): http://dx.doi.org/10.1038/s41467-020-17993-w.[28] Zhang, Yuwei, Wang, Min, Tian, Jun, Liu, Jia, Guo, Zhengyan, Tang, Wei, Chen, Yihua. Activation of paulomycin production by exogenous gamma-butyrolactone signaling molecules in Streptomyces albidoflavus J1074. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2020, 第 7 作者 通讯作者 104(4): 1695-1705, https://www.webofscience.com/wos/woscc/full-record/WOS:000519153800025.[29] Tang, Yue, Wang, Min, Qin, Hua, An, Xiangxiang, Guo, Zhengyan, Zhu, Guoliang, Zhang, Lixin, Chen, Yihua. Deciphering the Biosynthesis of TDP-beta-L-oleandrose in Avermectin. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 第 8 作者 通讯作者 83(10): 3199-3206, http://dx.doi.org/10.1021/acs.jnatprod.0c00902.[30] Tang, Wei, Li, Pengwei, Chen, Meng, Guo, Zhengyan, Chen, Yihua. Characterization of SepE and SepF for the N-6-Glycosylated Adenine Structure Formation in Septacidin Biosynthesis. ORGANIC LETTERS[J]. 2020, 第 5 作者 通讯作者 22(13): 5251-5254, http://dx.doi.org/10.1021/acs.orglett.0c01918.[31] 陈义华. Activation of paulomycin production by exogenous γ-butyrolactone signaling molecules in Streptomyces albidoflavus J1074.. Applied Microbiology and Biotechnology. 2020, 第 1 作者 通讯作者 [32] Wang, Min, Xie, Zhoujie, Tang, Shoubin, Chang, Ee Ling, Tang, Yue, Guo, Zhengyan, Cui, Yinglu, Wu, Bian, Ye, Tao, Chen, Yihua. Reductase of Mutanobactin Synthetase Triggers Sequential C-C Macrocyclization, C-S Bond Formation, and C-C Bond Cleavage. ORGANIC LETTERS[J]. 2020, 第 10 作者 通讯作者 22(3): 960-964, http://dx.doi.org/10.1021/acs.orglett.9b04501.[33] Gong, Luyao, Li, Ming, Cheng, Feiyue, Zhao, Dahe, Chen, Yihua, Xiang, Hua. Primed adaptation tolerates extensive structural and size variations of the CRISPR RNA guide in Haloarcula hispanica. NUCLEIC ACIDS RESEARCH[J]. 2019, 第 5 作者47(11): 5880-5891, https://www.webofscience.com/wos/woscc/full-record/WOS:000475702000039.[34] Wang, Junyang, Wang, Weishan, Wang, Huizhuan, Yuan, Fang, Xu, Zhen, Yang, Keqian, Li, Zilong, Chen, Yihua, Fan, Keqiang. Improvement of stress tolerance and riboflavin production of Bacillus subtilis by introduction of heat shock proteins from thermophilic bacillus strains. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 第 8 作者 通讯作者 103(11): 4455-4465, https://www.webofscience.com/wos/woscc/full-record/WOS:000467209500016.[35] Tingting Hao, Zhoujie Xie, Min Wang, Liwei Liu, Yuwei Zhang, Weicang Wang, Zhao Zhang, Xuejin Zhao, Pengwei Li, Zhengyan Guo, Shushan Gao, Chunbo Lou, Guodong Zhang, Justin Merritt, Geoff P. Horsman, Yihua Chen. An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters. NATURE COMMUNICATIONS[J]. 2019, 第 16 作者 通讯作者 10(1): 1-13, [36] 陈萌, 唐伟, 郭正彦, 陈义华. L-六碳糖形成机制的研究进展. 微生物学通报[J]. 2019, 第 4 作者46(7): 1678-1694, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb19071678?st=article_issue.[37] Wei Chen, Jun Yao, Jie Meng, Wenjing Han, Yong Tao, Yihua Chen, Yixin Guo, Guizhi Shi, Yang He, JianMing Jin, ShuangYan Tang. Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis. NATURE COMMUNICATIONS[J]. 2019, 第 6 作者10(1): 1-12, https://doaj.org/article/50f81279cb524a48a1d4752c99adf030.[38] Urs, Ankanahalli N Nanjaraj, Hu, Yiling, Li, Pengwei, Yuchi, Zhiguang, Chen, Yihua, Zhang, Yan. Cloning and Expression of a Nonribosomal Peptide Synthetase to Generate Blue Rose. ACS SYNTHETIC BIOLOGY[J]. 2019, 第 5 作者 通讯作者 8(8): 1698-1704, [39] Yang, Tongjian, Yang, Keqian, Chen, Yihua, Fan, Keqiang. Characterization of a Bi-directional Promoter OtrRp Involved in Oxytetracycline Biosynthesis. CURRENT MICROBIOLOGY[J]. 2019, 第 3 作者 通讯作者 76(11): 1264-1269, http://dx.doi.org/10.1007/s00284-019-01753-1.[40] Tang, Wei, Guo, Zhengyan, Cao, Zhenju, Wang, Min, Li, Pengwei, Meng, Xiangxi, Zhao, Xuejin, Xie, Zhoujie, Wang, Wenzhao, Zhou, Aihua, Lou, Chunbo, Chen, Yihua. D-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 第 12 作者 通讯作者 115(11): 2818-2823, http://dx.doi.org/10.1073/pnas.1711665115.[41] Li, Pengwei, Guo, Zhengyan, Tang, Wei, Chen, Yihua. Activation of three natural product biosynthetic gene clusters from Streptomyces lavendulae CGMCC 4.1386 by a reporter-guided strategy. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2018, 第 4 作者 通讯作者 3(4): 254-260, http://lib.cqvip.com/Qikan/Article/Detail?id=7103845359.[42] Luo, Xuming, Cao, Jidong, Huang, Junkai, Wang, Zongyi, Guo, Zhengyan, Chen, Yihua, Ma, Shumei, Liu, Jun. Genome sequencing and comparative genomics reveal the potential pathogenic mechanism of Cercospora sojina Hara on soybean. DNA RESEARCH[J]. 2018, 第 6 作者25(1): 25-37, http://dx.doi.org/10.1093/dnares/dsx035.[43] Guo, Zhengyan, Li, Pengwei, Chen, Guozhu, Li, Chao, Cao, Zhenju, Zhang, Yuwei, Ren, Jinwei, Xiang, Hua, Lin, Shuangjun, Ju, Jianhua, Chen, Yihua. Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 第 11 作者 通讯作者 140(51): 18009-18015, http://dx.doi.org/10.1021/jacs.8b10136.[44] Song, Fangying, Liu, Ning, Liu, Minghao, Chen, Yihua, Huang, Ying. Identification and Characterization of Mycemycin Biosynthetic Gene Clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp FXJ1.235. MARINE DRUGS[J]. 2018, 第 4 作者16(3): https://doaj.org/article/9d3da177d7d046829ae78463a8304478.[45] Zhao, Tianhu, Zhang, Yuhuan, Wu, Huijun, Wang, Di, Chen, Yihua, Zhu, MeiJun, Ma, Luyan Z. Extracellular aminopeptidase modulates biofilm development of Pseudomonas aeruginosa by affecting matrix exopolysaccharide and bacterial cell death. ENVIRONMENTAL MICROBIOLOGY REPORTS[J]. 2018, 第 5 作者10(5): 583-593, https://www.webofscience.com/wos/woscc/full-record/WOS:000446986500009.[46] 向华. Guo Z, Li P, Chen G, Li C, Cao Z, Zhang Y, Ren J, Xiang H, Lin S, Ju J, Chen Y*. Design and biosynthesis of dimeric alboflavusins with biaryl linkages via regiospecific C-C bond coupling.. JOURNALOFTHEAMERICANCHEMICALSOCIETY140511800918015. 2018, [47] Tang, Yue, Wang, Min, Ding, Yong, Li, Jine, Chen, Yihua. Improvement of Paulomycin Stability by Addition of Paulic Acid. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 第 5 作者 通讯作者 38(9): 2420-2426, http://dx.doi.org/10.6023/cjoc201805045.[48] 陈义华. 通过保罗酸的加成提高保罗霉素的稳定性. 有机化学. 2018, 第 1 作者 通讯作者 [49] Gao, Chunzhi, Guo, Zhengyan, Lu, Xingzhong, Chen, Haiyan, Liu, Liwei, Yu, Zhiguo, Chen, Yihua. Hexaricins, Pradimicin-like Polyketides from a Marine Sediment-Derived Streptosporangium sp and Their Antioxidant Effects. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 第 7 作者 通讯作者 81(9): 2069-2074, http://dx.doi.org/10.1021/acs.jnatprod.8b00397.[50] Xue, Dingrong, Tian, Fang, Yang, Fenghuan, Chen, Huamin, Yuan, Xiaochen, Yang, ChingHong, Chen, Yihua, Wang, Qi, He, Chenyang. Phosphodiesterase EdpX1 Promotes Xanthomonas oryzae pv. oryzae Virulence, Exopolysaccharide Production, and Biofilm Formation. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2018, 第 7 作者84(22): https://www.webofscience.com/wos/woscc/full-record/WOS:000448811300012.[51] 谢周杰, 张昭, 刘力伟, 柳孝晨, 陈义华, , , , , , . 变形链球菌中的次级代谢产物及其在口腔生物被膜中的生态功能. 生物工程学报[J]. 2017, 第 5 作者33(9): 1547-1554, https://cjb.ijournals.cn/cjbcn/article/abstract/gc17091547?st=article_issue.[52] Meng Xiangxi, Wang Wenzhao, Xie Zhoujie, Li Pengwei, Li Yue, Guo Zhengyan, Lu Yingjian, Yang Jie, Guan Kaile, Lu Zhaoxin, Tan Huarong, Chen Yihua. Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387. SCIENCE CHINA LIFE SCIENCES[J]. 2017, 第 0 作者[53] 张志国, 唐越, 王敏, 陈义华. 新结构硫脲类化合物的合成、鉴定及抑菌活性评价. 微生物学通报[J]. 2017, 第 4 作者44(6): 1437-1443, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb17061437?st=article_issue.[54] Pan, Guohui, Gao, Xiaoqin, Fan, Keqiang, Liu, Junlin, Meng, Bing, Gao, Jinmin, Wang, Bin, Zhang, Chaobo, Han, Hui, Ai, Guomin, Chen, Yihua, Wu, Dong, Liu, ZhiJie, Yang, Keqian. Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis. ACS CHEMICAL BIOLOGY[J]. 2017, 第 11 作者12(1): 142-152, http://dx.doi.org/10.1021/acschembio.6b00621.[55] Meng, Xiangxi, Wang, Wenzhao, Xie, Zhoujie, Li, Pengwei, Li, Yue, Guo, Zhengyan, Lu, Yingjian, Yang, Jie, Guan, Kaile, Lu, Zhaoxin, Tan, Huarong, Chen, Yihua. Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387. SCIENCE CHINA-LIFE SCIENCES[J]. 2017, 第 12 作者 通讯作者 60(9): 980-991, http://dx.doi.org/10.1007/s11427-017-9120-8.[56] Xie, Zhoujie, Zhang, Zhao, Cao, Zhenju, Chen, Meng, Li, Pengwei, Liu, Weifeng, Qin, Hua, Zhao, Xuejin, Tao, Yong, Chen, Yihua. An external substrate-free blue/white screening system in Escherichia coli. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2017, 第 10 作者 通讯作者 101(9): 3811-3820, http://dx.doi.org/10.1007/s00253-017-8252-2.[57] Liu, Liwei, Hao, Tingting, Xie, Zhoujie, Horsman, Geoff P, Chen, Yihua. Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans. SCIENTIFIC REPORTS[J]. 2016, 第 5 作者 通讯作者 6: http://dx.doi.org/10.1038/srep37479.[58] Tian, Jun, Chen, Haiyan, Guo, Zhengyan, Liu, Ning, Li, Jine, Huang, Ying, Xiang, Wensheng, Chen, Yihua. Discovery of pentangular polyphenols hexaricins A-C from marine Streptosporangium sp CGMCC 4.7309 by genome mining. 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