Xiao Chen, Ph. D.
chenxiao@psych.ac.cn
Xiao is a research assistant professor working with Prof. Xun Liu at the Institute of Psychology, Chinese Academy of Sciences. He was a visiting postdoctoral fellow at The Centre for Addiction and Mental Health (CAMH). He completed his doctoral studies at the Institute of Psychology after receiving a Master’s in 2016. Before graduate school, he received a Bachelor’s in Applied Psychology from Chongqing University. Xiao’s research interests are the neural mechanism of rumination and potential neuromodulation therapy for it. He developed a novel “rumination state” paradigm and investigated the network mechanism of this psychological process. Xiao’s current work includes developing next-generation neuromodulation therapy targeting rumination using the transcranial magnetic stimulation (TMS) and understanding the neural mechanism underlying rumination with functional MRI and intracranial Electroencephalogram (iEEG).
Research Areas
Neural and cognitive underpinnings of mental disorders
Neuromodulation approaches for the treatment of mental disorders
Functional organization of human brain and its association with psychological processes
Education
Ph. D. | 2016-2019 | Institute of Psychology, Chinese Academy of Sciences, Beijing |
M. Sc. | 2013-2016 | School of Psychology, Third Military Medical University, Chongqing |
B. Sc. | 2009-2013 | Chongqing University, Chongqing |
Publications
Papers
Dan, X. J., Wang, Y. W., Sun, J. Y., Gao, L. L., Chen, X., Yang, X. Y., Xu, E. H., Ma, J. H., Yan, C. G., Wu, T., & Chan, P. (2024). Reorganization of intrinsic functional connectivity in early-stage Parkinson's disease patients with probable REM sleep behavior disorder. NPJ Parkinsons Dis, 10(1), 5.
Shao, K.#, Chen, X.#, Yu, X., Yang, J., Wei, M., Zhang, M., Li, R., Wang, X., Wei, Y., Yan, C. G.*, & Han, Y.* (2024). Functional connectivity changes in two cortico-hippocampal networks of Alzheimer's disease continuum and their correlations with cognition: A SILCODE study. J Alzheimers Dis, 13872877241291236.
Chen, X.#, Fan, Z.#, Chen, D.#, Wang, L.*, Chen, L.*, & Yan, C. G.* (2024). Intracranial neurophysiological correlates of rumination: A cross-sectional observational study. Medicine Plus, 1(3), 100048.
Chen, X., Blumberger, D. M., Downar, J., Middleton, V. J., Monira, N., Bowman, J., Kriske, J., Kriske, J., Donachie, N., & Kaster, T. S.* (2024). Depressive symptom trajectories with prolonged rTMS treatment. Brain Stimul, 17(3), 525-532.
Li, H. X., Chen, X., Wang, Z. H., Lu, B., Liao, Y. F., Li, X. Y., Wang, Y. W., Liu, Y. S., Castellanos, F. X., & Yan, C. G. (2024). Characterizing human spontaneous thoughts and its application in major depressive disorder. J Affect Disord.
Zhu, J., Chen, X., Lu, B., Li, X. Y., Wang, Z. H., Cao, L. P., Chen, G. M., Chen, J. S., Chen, T., Chen, T. L., Cheng, Y. Q., Chu, Z. S., Cui, S. X., Cui, X. L., Deng, Z. Y., Gong, Q. Y., Guo, W. B., He, C. C., Hu, Z. J.,…Yu, Y. (2024). Transcriptomic decoding of regional cortical vulnerability to major depressive disorder. Commun Biol, 7(1), 960.
Jia, F. N.#, Chen, X.#, Du, X. D., Tang, Z., Ma, X. Y., Ning, T. T., Zou, S. Y., Zuo, S. F., Li, H. X., Cui, S. X., Deng, Z. Y., Fu, J. L., Fu, X. Q., Huang, Y. X., Li, X. Y., Lian, T., Liao, Y. F., Liu, L. L., Lu, B., . . . Liu, Y. S. (2023). Aberrant degree centrality profiles during rumination in major depressive disorder. Hum Brain Mapp, 44(17), 6245-6257.
Chen, X., Lu, B., Li, H. X., Li, X. Y., Wang, Y. W., Castellanos, F. X., … & Yan, C. G.* (2022). The DIRECT consortium and the REST-meta-MDD Project: towards neuroimaging biomarkers of major depressive disorder. Psychoradiology, 2(1), 32-42.
Li, H. X., Lu, B., Chen, X., Li, X. Y., Castellanos, F. X., & Yan, C. G. (2022). Exploring self-generated thoughts in a resting state with natural language processing. Behav Res Methods, 54(4), 1725-1743.
Li, H. X., Lu, B., Wang, Y. W., Li, X. Y., Chen, X., & Yan, C. G. (2022). Neural representations of self-generated thought during think-aloud fMRI. Neuroimage, 265, 119775.
Li, X. Y., Chen, X.*, Yan C.G.*. (2022). Altered cerebral activities and functional connectivity in depression: a systematic review of fMRI studies. Quantitative Biology, 10(4), 366‒380.
Lu, B., Li, H. X., Chang, Z. K., Li, L., Chen, N. X., ... Chen, X., Thompson, P. M., Castellanos, F. X., & Yan, C. G.* (2022). A practical Alzheimer’s disease classifier via brain imaging-based deep learning on 85,721 samples. Journal of Big Data, 9(1), 1-22.
Ding, Y. D., Chen, X., Chen, Z. B., Li, L., Li, X. Y., Castellanos, F. X., Bai, T. J., Bo, Q. J., Cao, J., Chang, Z. K., Chen, G. M., Chen, N. X., Chen, W., Cheng, C., Cheng, Y. Q., Cui, X. L., Duan, J., Fang, Y. R., Gong, Q. Y., . . . Guo, W. B.* (2022). Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder. Transl Psychiatry, 12(1), 236.
Chen, X. & Yan, C. G.* (2021) Hypostability in the default mode network and hyperstability in the frontoparietal control network of dynamic functional architecture during rumination. NeuroImage, 2021, 118427.
Yang, H.#, Chen, X.#, Chen, Z. B.#, Li, L., Li, X. Y., Castellanos, F. X., … & Yan, C. G.* (2021) Disrupted Intrinsic Functional Brain Topology in Patients with Major Depressive Disorder. Molecular Psychiatry. 26:7363-7371.
Deng, K., Yue, J. H., Xu, J., Ma, P. P., Chen, X., Li, L., ... & Cheng, Y. Q.* (2021). Impaired robust interhemispheric function integration of depressive brain from REST‐meta‐MDD database in China. Bipolar disorders.
Ding, Y. D., Yang, R., Yan, C. G., Chen, X., Bai, T. J., Bo, Q. J., ... & Guo, W. B.* (2021). Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project. Journal of Affective Disorders.
Liu, P. H., Li, Y., Zhang, A. X., Sun, N., Li, G. Z., Chen, X., ... & Zhang, K. R.* (2021). Brain structural alterations in MDD patients with gastrointestinal symptoms: Evidence from the REST-meta-MDD project. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 110386.
Chen, X., Chen, N. X., Shen, Y. Q., Li, H. X., Li, L., Lu, B., ... & Yan, C. G.* (2020). The subsystem mechanism of default mode network underlying rumination: A reproducible neuroimaging study. NeuroImage, 221, 117185. Most downloaded article
Zhou, H. X., Chen, X., Shen, Y. Q., Li, L., Chen, N. X., Zhu, Z. C., ... & Yan, C. G.* (2020). Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression. NeuroImage, 206, 116287.
Long, Y. C., Cao, H. Y., Yan, C. G., Chen, X., Li, L., Castellanos, F. X., ... & Liu, Z. N.* (2020). Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium. NeuroImage: Clinical, 26, 102163.
Shen, Y. Q., Zhou, H. X., Chen, X., Castellanos, F. X., & Yan, C. G.* (2020). Meditation effect in changing functional integrations across large-scale brain networks: Preliminary evidence from a meta-analysis of seed-based functional connectivity. Journal of Pacific Rim Psychology, 14.
Shi, J. Y., Wang, P., Wang, B. H., Xu, Y., Chen, X., & Li, H. J.* (2020). Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-ε4 Carriers. Neuroscience, 436, 74-81.
Fan, Z.#, Chen, X.#, Qi, Z. X., Li, L., Lu, B., Jiang, C. L., ... & Chen, L.* (2019). Physiological significance of R-fMRI indices: Can functional metrics differentiate structural lesions (brain tumors)?. NeuroImage: Clinical, 22, 101741.
Yan, C. G.*, Chen, X.#, Li, L.#, Castellanos, F. X., Bai, T. J., Bo, Q. J., ... & Zang, Y. F.* (2019). Reduced default mode network functional connectivity in patients with recurrent major depressive disorder. Proceedings of the National Academy of Sciences, 116(18), 9078-9083.
Chen, X., Lu, B., & Yan, C. G.* (2018). Reproducibility of R‐fMRI metrics on the impact of different strategies for multiple comparison correction and sample sizes. Human brain mapping, 39(1), 300-318. ESI Top 1% highly cited paper
Li, Q.#, Wang, L.#, Li, X. Y.#, Chen, X., Lu, B., Long, C., Yan, C. G.*, Xu, Y.* (2018) Total Salvianolic Acid Balances Brain Functional Network Topology in Rat Hippocampi Overexpressing miR-30e. Frontiers in Neuroscience, 12: 448.
Chen, X., Feng, Z. Z.*, Wang, T., Su, H., & Zhang, L. (2016). Internal switching and backward inhibition in depression and rumination. Psychiatry Research, 243, 342-348.
(*Corresponding author, #Equal contribution)Dan, X. J., Wang, Y. W., Sun, J. Y., Gao, L. L., Chen, X., Yang, X. Y., Xu, E. H., Ma, J. H., Yan, C. G., Wu, T., & Chan, P. (2024). Reorganization of intrinsic functional connectivity in early-stage Parkinson's disease patients with probable REM sleep behavior disorder. NPJ Parkinsons Dis, 10(1), 5.
Shao, K.#, Chen, X.#, Yu, X., Yang, J., Wei, M., Zhang, M., Li, R., Wang, X., Wei, Y., Yan, C. G.*, & Han, Y.* (2024). Functional connectivity changes in two cortico-hippocampal networks of Alzheimer's disease continuum and their correlations with cognition: A SILCODE study. J Alzheimers Dis, 13872877241291236.
Chen, X.#, Fan, Z.#, Chen, D.#, Wang, L.*, Chen, L.*, & Yan, C. G.* (2024). Intracranial neurophysiological correlates of rumination: A cross-sectional observational study. Medicine Plus, 1(3), 100048.
Chen, X., Blumberger, D. M., Downar, J., Middleton, V. J., Monira, N., Bowman, J., Kriske, J., Kriske, J., Donachie, N., & Kaster, T. S.* (2024). Depressive symptom trajectories with prolonged rTMS treatment. Brain Stimul, 17(3), 525-532.
Li, H. X., Chen, X., Wang, Z. H., Lu, B., Liao, Y. F., Li, X. Y., Wang, Y. W., Liu, Y. S., Castellanos, F. X., & Yan, C. G. (2024). Characterizing human spontaneous thoughts and its application in major depressive disorder. J Affect Disord.
Zhu, J., Chen, X., Lu, B., Li, X. Y., Wang, Z. H., Cao, L. P., Chen, G. M., Chen, J. S., Chen, T., Chen, T. L., Cheng, Y. Q., Chu, Z. S., Cui, S. X., Cui, X. L., Deng, Z. Y., Gong, Q. Y., Guo, W. B., He, C. C., Hu, Z. J.,…Yu, Y. (2024). Transcriptomic decoding of regional cortical vulnerability to major depressive disorder. Commun Biol, 7(1), 960.
Jia, F. N.#, Chen, X.#, Du, X. D., Tang, Z., Ma, X. Y., Ning, T. T., Zou, S. Y., Zuo, S. F., Li, H. X., Cui, S. X., Deng, Z. Y., Fu, J. L., Fu, X. Q., Huang, Y. X., Li, X. Y., Lian, T., Liao, Y. F., Liu, L. L., Lu, B., . . . Liu, Y. S. (2023). Aberrant degree centrality profiles during rumination in major depressive disorder. Hum Brain Mapp, 44(17), 6245-6257.
Chen, X., Lu, B., Li, H. X., Li, X. Y., Wang, Y. W., Castellanos, F. X., … & Yan, C. G.* (2022). The DIRECT consortium and the REST-meta-MDD Project: towards neuroimaging biomarkers of major depressive disorder. Psychoradiology, 2(1), 32-42.
Li, H. X., Lu, B., Chen, X., Li, X. Y., Castellanos, F. X., & Yan, C. G. (2022). Exploring self-generated thoughts in a resting state with natural language processing. Behav Res Methods, 54(4), 1725-1743.
Li, H. X., Lu, B., Wang, Y. W., Li, X. Y., Chen, X., & Yan, C. G. (2022). Neural representations of self-generated thought during think-aloud fMRI. Neuroimage, 265, 119775.
Li, X. Y., Chen, X.*, Yan C.G.*. (2022). Altered cerebral activities and functional connectivity in depression: a systematic review of fMRI studies. Quantitative Biology, 10(4), 366‒380.
Lu, B., Li, H. X., Chang, Z. K., Li, L., Chen, N. X., ... Chen, X., Thompson, P. M., Castellanos, F. X., & Yan, C. G.* (2022). A practical Alzheimer’s disease classifier via brain imaging-based deep learning on 85,721 samples. Journal of Big Data, 9(1), 1-22.
Ding, Y. D., Chen, X., Chen, Z. B., Li, L., Li, X. Y., Castellanos, F. X., Bai, T. J., Bo, Q. J., Cao, J., Chang, Z. K., Chen, G. M., Chen, N. X., Chen, W., Cheng, C., Cheng, Y. Q., Cui, X. L., Duan, J., Fang, Y. R., Gong, Q. Y., . . . Guo, W. B.* (2022). Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder. Transl Psychiatry, 12(1), 236.
Chen, X. & Yan, C. G.* (2021) Hypostability in the default mode network and hyperstability in the frontoparietal control network of dynamic functional architecture during rumination. NeuroImage, 2021, 118427.
Yang, H.#, Chen, X.#, Chen, Z. B.#, Li, L., Li, X. Y., Castellanos, F. X., … & Yan, C. G.* (2021) Disrupted Intrinsic Functional Brain Topology in Patients with Major Depressive Disorder. Molecular Psychiatry. 26:7363-7371.
Deng, K., Yue, J. H., Xu, J., Ma, P. P., Chen, X., Li, L., ... & Cheng, Y. Q.* (2021). Impaired robust interhemispheric function integration of depressive brain from REST‐meta‐MDD database in China. Bipolar disorders.
Ding, Y. D., Yang, R., Yan, C. G., Chen, X., Bai, T. J., Bo, Q. J., ... & Guo, W. B.* (2021). Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project. Journal of Affective Disorders.
Liu, P. H., Li, Y., Zhang, A. X., Sun, N., Li, G. Z., Chen, X., ... & Zhang, K. R.* (2021). Brain structural alterations in MDD patients with gastrointestinal symptoms: Evidence from the REST-meta-MDD project. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 110386.
Chen, X., Chen, N. X., Shen, Y. Q., Li, H. X., Li, L., Lu, B., ... & Yan, C. G.* (2020). The subsystem mechanism of default mode network underlying rumination: A reproducible neuroimaging study. NeuroImage, 221, 117185. Most downloaded article
Zhou, H. X., Chen, X., Shen, Y. Q., Li, L., Chen, N. X., Zhu, Z. C., ... & Yan, C. G.* (2020). Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression. NeuroImage, 206, 116287.
Long, Y. C., Cao, H. Y., Yan, C. G., Chen, X., Li, L., Castellanos, F. X., ... & Liu, Z. N.* (2020). Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium. NeuroImage: Clinical, 26, 102163.
Shen, Y. Q., Zhou, H. X., Chen, X., Castellanos, F. X., & Yan, C. G.* (2020). Meditation effect in changing functional integrations across large-scale brain networks: Preliminary evidence from a meta-analysis of seed-based functional connectivity. Journal of Pacific Rim Psychology, 14.
Shi, J. Y., Wang, P., Wang, B. H., Xu, Y., Chen, X., & Li, H. J.* (2020). Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-ε4 Carriers. Neuroscience, 436, 74-81.
Fan, Z.#, Chen, X.#, Qi, Z. X., Li, L., Lu, B., Jiang, C. L., ... & Chen, L.* (2019). Physiological significance of R-fMRI indices: Can functional metrics differentiate structural lesions (brain tumors)?. NeuroImage: Clinical, 22, 101741.
Yan, C. G.*, Chen, X.#, Li, L.#, Castellanos, F. X., Bai, T. J., Bo, Q. J., ... & Zang, Y. F.* (2019). Reduced default mode network functional connectivity in patients with recurrent major depressive disorder. Proceedings of the National Academy of Sciences, 116(18), 9078-9083.
Chen, X., Lu, B., & Yan, C. G.* (2018). Reproducibility of R‐fMRI metrics on the impact of different strategies for multiple comparison correction and sample sizes. Human brain mapping, 39(1), 300-318. ESI Top 1% highly cited paper
Li, Q.#, Wang, L.#, Li, X. Y.#, Chen, X., Lu, B., Long, C., Yan, C. G.*, Xu, Y.* (2018) Total Salvianolic Acid Balances Brain Functional Network Topology in Rat Hippocampi Overexpressing miR-30e. Frontiers in Neuroscience, 12: 448.
Chen, X., Feng, Z. Z.*, Wang, T., Su, H., & Zhang, L. (2016). Internal switching and backward inhibition in depression and rumination. Psychiatry Research, 243, 342-348.
(*Corresponding author, #Equal contribution)
Conferences
2024 Jun 27. Presenter. Intracranial neurophysiological mechanisms underlying rumination. The 2024 OHBM Annual Meeting. Seoul, Korea. Presenter(s): Xiao Chen, Zhen Fan, Dong Chen, Liang Wang, Liang Chen, Chao-Gan Yan. (Oral Presentation).
Honors & Distinctions
Beijing Municipal Science & Technology Commission, Second Prize of the Beijing Science and Technology Award, Second Principal Contributor (2022)
Chinese Academy of Sciences, Excellent Ph. D. dissertations (2020)
Chongqing University, Outstanding Graduates (2013)
Chongqing University, National Scholarship (2009)