Xiao Chen, Ph. D.

chenxiao@psych.ac.cn

Xiao is an assistant research fellow working with Prof. Chao-Gan Yan at the R-fMRI Lab. He completed his doctoral studies at Institute of Psychology after receiving a Master’s in 2016. Before graduate school, he received a Bachelor’s in Applied Psychology from Chongqing University. Xiao systematically evaluated the reproducibility of resting-state fMRI and gave recommendations on the strategy of multiple comparison correction (ESI top 1% of highly cited papers). He also developed a novel “rumination state” paradigm and uncovered the network mechanism of this psychological phenomenon. Xiao is now interested in exploring the psychological underpinnings of major depressive disorder (MDD) with state-of-the-art techniques including fMRI and SEEG.


Research Areas

Neural and cognitive underpinnings of mental disorders

Neuromodulation approaches for the treatment of mental disorders

Functional organization of human brain and its association with psychological processes


Education

Ph. D.

2016-2019

Institute of Psychology, Chinese Academy of Sciences, Beijing

M. Sc.

2013-2016

School of Psychology, Third Military Medical University, Chongqing

B. Sc.

2009-2013

Chongqing University, Chongqing


Publications

   
Papers

Chen, X., Blumberger, D. M., Downar, J., Middleton, V. J., Monira, N., Bowman, J., Kriske, J., Kriske, J., Donachie, N., & Kaster, T. S. (2024). Depressive symptom trajectories with prolonged rTMS treatment. Brain Stimul.

Jia, F. N.#, Chen, X.#, Du, X. D., Tang, Z., Ma, X. Y., Ning, T. T., Zou, S. Y., Zuo, S. F., Li, H. X., Cui, S. X., Deng, Z. Y., Fu, J. L., Fu, X. Q., Huang, Y. X., Li, X. Y., Lian, T., Liao, Y. F., Liu, L. L., Lu, B., . . . Liu, Y. S. (2023). Aberrant degree centrality profiles during rumination in major depressive disorder. Hum Brain Mapp, 44(17), 6245-6257.

Chen, X., Lu, B., Li, H. X., Li, X. Y., Wang, Y. W., Castellanos, F. X., … & Yan, C. G.* (2022). The DIRECT consortium and the REST-meta-MDD Project: towards neuroimaging biomarkers of major depressive disorder. Psychoradiology, 2(1), 32-42.

Li, H. X., Lu, B., Chen, X., Li, X. Y., Castellanos, F. X., & Yan, C. G. (2022). Exploring self-generated thoughts in a resting state with natural language processing. Behav Res Methods, 54(4), 1725-1743.

Li, H. X., Lu, B., Wang, Y. W., Li, X. Y., Chen, X., & Yan, C. G. (2022). Neural representations of self-generated thought during think-aloud fMRI. Neuroimage, 265, 119775.

Li, X. Y., Chen, X.*, Yan C.G.*. (2022). Altered cerebral activities and functional connectivity in depression: a systematic review of fMRI studies. Quantitative Biology, 10(4), 366‒380.

Lu, B., Li, H. X., Chang, Z. K., Li, L., Chen, N. X., ... Chen, X., Thompson, P. M., Castellanos, F. X., & Yan, C. G.* (2022). A practical Alzheimer’s disease classifier via brain imaging-based deep learning on 85,721 samples. Journal of Big Data, 9(1), 1-22.

Ding, Y. D., Chen, X., Chen, Z. B., Li, L., Li, X. Y., Castellanos, F. X., Bai, T. J., Bo, Q. J., Cao, J., Chang, Z. K., Chen, G. M., Chen, N. X., Chen, W., Cheng, C., Cheng, Y. Q., Cui, X. L., Duan, J., Fang, Y. R., Gong, Q. Y., . . . Guo, W. B.* (2022). Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder. Transl Psychiatry, 12(1), 236.

Chen, X. & Yan, C. G.* (2021) Hypostability in the default mode network and hyperstability in the frontoparietal control network of dynamic functional architecture during rumination. NeuroImage, 2021, 118427.

Yang, H.#, Chen, X.#, Chen, Z. B.#, Li, L., Li, X. Y., Castellanos, F. X., … & Yan, C. G.* (2021) Disrupted Intrinsic Functional Brain Topology in Patients with Major Depressive Disorder. Molecular Psychiatry. 26:7363-7371.

Deng, K., Yue, J. H., Xu, J., Ma, P. P., Chen, X., Li, L., ... & Cheng, Y. Q.* (2021). Impaired robust interhemispheric function integration of depressive brain from REST‐meta‐MDD database in China. Bipolar disorders.

Ding, Y. D., Yang, R., Yan, C. G., Chen, X., Bai, T. J., Bo, Q. J., ... & Guo, W. B.* (2021). Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project. Journal of Affective Disorders.

Liu, P. H., Li, Y., Zhang, A. X., Sun, N., Li, G. Z., Chen, X., ... & Zhang, K. R.* (2021). Brain structural alterations in MDD patients with gastrointestinal symptoms: Evidence from the REST-meta-MDD project. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 110386.

Chen, X., Chen, N. X., Shen, Y. Q., Li, H. X., Li, L., Lu, B., ... & Yan, C. G.* (2020). The subsystem mechanism of default mode network underlying rumination: A reproducible neuroimaging study. NeuroImage221, 117185. Most downloaded article

Zhou, H. X., Chen, X., Shen, Y. Q., Li, L., Chen, N. X., Zhu, Z. C., ... & Yan, C. G.* (2020). Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression. NeuroImage206, 116287.

Long, Y. C., Cao, H. Y., Yan, C. G., Chen, X., Li, L., Castellanos, F. X., ... & Liu, Z. N.* (2020). Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium. NeuroImage: Clinical26, 102163.

Shen, Y. Q., Zhou, H. X., Chen, X., Castellanos, F. X., & Yan, C. G.* (2020). Meditation effect in changing functional integrations across large-scale brain networks: Preliminary evidence from a meta-analysis of seed-based functional connectivity. Journal of Pacific Rim Psychology14.

Shi, J. Y., Wang, P., Wang, B. H., Xu, Y., Chen, X., & Li, H. J.* (2020). Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-ε4 Carriers. Neuroscience436, 74-81.

Fan, Z.#, Chen, X.#, Qi, Z. X., Li, L., Lu, B., Jiang, C. L., ... & Chen, L.* (2019). Physiological significance of R-fMRI indices: Can functional metrics differentiate structural lesions (brain tumors)?. NeuroImage: Clinical22, 101741.

Yan, C. G.*, Chen, X.#, Li, L.#, Castellanos, F. X., Bai, T. J., Bo, Q. J., ... & Zang, Y. F.* (2019). Reduced default mode network functional connectivity in patients with recurrent major depressive disorder. Proceedings of the National Academy of Sciences116(18), 9078-9083.

Chen, X., Lu, B., & Yan, C. G.* (2018). Reproducibility of R‐fMRI metrics on the impact of different strategies for multiple comparison correction and sample sizes. Human brain mapping39(1), 300-318. ESI Top 1% highly cited paper

Li, Q.#, Wang, L.#, Li, X. Y.#, Chen, X., Lu, B., Long, C., Yan, C. G.*, Xu, Y.* (2018) Total Salvianolic Acid Balances Brain Functional Network Topology in Rat Hippocampi Overexpressing miR-30e. Frontiers in Neuroscience, 12: 448.

Chen, X., Feng, Z. Z.*, Wang, T., Su, H., & Zhang, L. (2016). Internal switching and backward inhibition in depression and rumination. Psychiatry Research243, 342-348.

(*Corresponding author, #Equal contribution)


Research Interests

·          Neural and cognitive underpinnings of mental disorders

·          Neuromodulation approaches for the treatment of mental disorders

·          Functional organization of the human brain and its association with psychological processes