090801-水产养殖

比较免疫学，微生物学

2009-09--2016-01   中国科学院水生生物研究所   博士学位
2005-09--2009-07   西南大学   学士学位

   

2024-01~现在, 中国科学院水生生物研究所, 研究员
2016-06~2023-12,中国科学院水生生物研究所, 助理研究员

   

（ 1 ） 柱状黄杆菌VI型分泌系统效应分子及其免疫蛋白及应用, 发明专利, 2022, 第 5 作者, 专利号: CN114540377A

（ 2 ） 一种柱状黄杆菌毒力蛋白在病原检测和弱毒株制备中的应用, 发明专利, 2022, 第 5 作者, 专利号: CN114149494A

（ 3 ） 鳜干扰素诱导蛋白启动子和应用, 发明专利, 2020, 第 3 作者, 专利号: CN110669765A

（ 4 ） 鳜鱼伽玛干扰素相关因子及其重组蛋白和应用, 专利授权, 2018, 第 3 作者, 专利号: CN108264548A

   

（1） Identification of type II interferons and receptors in an osteoglossiform fish, the arapaima Arapaima gigas, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2023, 第 2 作者
（2） Interaction of Nmi and IFP35 Promotes Mutual Protein Stabilization and IRF3 and IRF7 Degradation to Suppress Type I IFN Production in Teleost Fish, JOURNAL OF IMMUNOLOGY, 2023, 第 2 作者
（3） FTR33, a member of fish-specific TRIM (finTRIM) subfamily, regulates negatively type I IFN antiviral immunity in zebrafish, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2023, 第 7 作者  通讯作者
（4） Functional characterization of IL-18 receptor subunits, IL-18R�� and IL-18R��, and its natural inhibitor, IL-18 binding protein (IL-18BP) in rainbow trout Oncorhynchus mykiss, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2023, 第 2 作者
（5） Transcriptional regulation and signaling of type IV IFN with identification of the ISG repertoire in an amphibian model, Xenopus laevis, JOURNAL OF IMMUNOLOGY, 2023, 第 1 作者
（6） Molecular characterization and transcriptional conservation of N-myc-interactor, Nmi, by type I and type II IFNs in mandarin fish Siniperca chuatsi, DEVELOPMENTALANDCOMPARATIVEIMMUNOLOGY, 2022, 第 2 作者
（7） Molecular characterization and transcriptional conservation of N-myc-interactor, Nmi, by type I and type II IFNs in mandarin fish Siniperca chuatsi, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2022, 第 2 作者
（8） Presence of two RIG-I-like receptors, MDA5 and LGP2, and their dsRNA binding capacity in a perciform fish, the snakehead Channa argus, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2022, 第 4 作者  通讯作者
（9） Gene synteny, evolution and antiviral activity of type I IFNs in a reptile species, the Chinese soft-shelled turtle Pelodiscus sinensis, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2022, 第 1 作者
（10） Identification and establishment of type IV interferon and the characterization of interferon-�� including its class II cytokine receptors IFN-��R1 and IL-10R2, NATURE COMMUNICATIONS, 2022, 第 1 作者
（11） Tilapia dsRNA-activated protein kinase R (PKR): An interferon-induced antiviral effector with translation inhibition activity, FISH & SHELLFISH IMMUNOLOGY, 2021, 第 4 作者
（12） IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021, 第 2 作者
（13） Molecular and functional identification of a short-type peptidoglycan recognition protein, PGRP-S, in the Chinese soft-shelled turtle Pelodiscus sinensis, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021, 第 2 作者
（14） Transcriptional and subcellular characterization of interferon induced protein-35 (IFP35) in mandarin fish, Siniperca chuatsi, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021, 第 2 作者
（15） Retroposition of the long transcript from multiexon IFN-�� homologs in ancestry vertebrate gave rise to the proximal transcription elements of intronless IFN-�� promoter in humans, JOURNAL OF IMMUNOLOGY, 2021, 第 1 作者
（16） In Primitive Zebrafish, MHC Class II Expression Is Regulated by IFN-gamma, IRF1, and Two Forms of CIITA, JOURNAL OF IMMUNOLOGY, 2020, 第 2 作者
（17） Expression and antibacterial analysis of galectin-8 and -9 genes in mandarin fish, Siniperca chuatsi, FISH & SHELLFISH IMMUNOLOGY, 2020, 第 3 作者
（18） Myxovirus resistance (Mx) gene and its differential expression regulated by three type I and two type II IFNs in mandarin fish, Siniperca chuatsi, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2020, 第 2 作者
（19） Fish type I and type II interferons: composition, receptor usage, production and function, REVIEWS IN AQUACULTURE, 2020, 第 2 作者
（20） Identification of type I IFNs and their receptors in a cyprinid fish, the topmouth culter Culter alburnus, FISH & SHELLFISH IMMUNOLOGY, 2020, 第 2 作者
（21） Functional characterization of a group II interferon, IFNc in the perciform fish, Nile tilapia (Oreochromis niloticus), FISHSHELLFISHIMMUNOLOGY, 2020, 第 3 作者
（22） Identification and characterization of tilapia CRFB1, CRFB2 and CRFB5 reveals preferential receptor usage of three IFN subtypes in perciform fishes, FISH & SHELLFISH IMMUNOLOGY, 2020, 第 3 作者
（23） Molecular and functional characterization of a short-type peptidoglycan recognition protein, PGRP-S in the amphibian Xenopus laevis, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2019, 第 3 作者
（24） Receptor complex and signalling pathway of the two type II IFNs, IFN-gamma and IFN-gamma rel in mandarin fish or the so-called Chinese perch Siniperca chuatsi, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2019, 第 2 作者
（25） Functional characterization of interleukin (IL)-22 and its inhibitor, IL-22 binding protein (IL-22BP) in Mandarin fish, Siniperca chuatsi, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2019, 第 2 作者
（26） Identification and characterization of the interferon-gamma-inducible lysosomal thiol reductase gene in Chinese soft-shelled turtle, Pelodiscus sinensis, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2019, 第 2 作者
（27） Functional characterization of IL-10 and its receptor subunits in a perciform fish, the Mandarin fish, Siniperca chuatsi, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2019, 第 2 作者
（28） Unique Composition of Intronless and Intron-Containing Type I IFNs in the Tibetan Frog Nanorana parkeri Provides New Evidence To Support Independent Retroposition Hypothesis for Type I IFN Genes in Amphibians, JOURNAL OF IMMUNOLOGY, 2018, 第 3 作者
（29） Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2018, 第 2 作者
（30） Composition and transcription of all interferon regulatory factors (IRFs), IRF1-11 in a perciform fish, the mandarin fish, Siniperca chuatsi, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2018, 第 3 作者
（31） Intronless and intron-containing type I IFN genes coexist in amphibian Xenopus tropicalis: Insights into the origin and evolution of type I IFNs in vertebrates, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2017, 第 2 作者
（32） Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2017, 第 5 作者
（33） Two type II IFN members, IFN-gamma and IFN-gamma related (rel), regulate differentially IRF1 and IRF11 in zebrafish, FISH & SHELLFISH IMMUNOLOGY, 2017, 第 2 作者
（34） Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) in fish: current knowledge and future perspectives, IMMUNOLOGY, 2017, 第 1 作者
（35） Evolution of IFN-lambda in tetrapod vertebrates and its functional characterization in green anole lizard (Anolis carolinensis), DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2016, 第 1 作者
（36） Molecular and functional characterization of peptidoglycan-recognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae, FISH & SHELLFISH IMMUNOLOGY, 2016, 第 2 作者
（37） NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-kappa B, and also MDA5, RIG-I and MAVS, FISH & SHELLFISH IMMUNOLOGY, 2016, 第 6 作者
（38） Molecular cloning, expression analysis and functional characterization of interleukin-22 in So-iny mullet, Liza haematocheila, MOLECULAR IMMUNOLOGY, 2015, 第 5 作者
（39） Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish, FISH & SHELLFISH IMMUNOLOGY, 2015, 第 6 作者
（40） Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant, IMMUNOLOGY, 2014, 第 7 作者
（41） IFN-gamma in turtle: Conservation in sequence and signalling and role in inhibiting iridovirus replication in Chinese soft-shelled turtle Pelodiscus sinensis, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2014, 第 2 作者
（42） IFN-gamma and its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2013, 第 1 作者
（43） 斜带石斑鱼IFN-γ基因的克隆与表达分析, Molecular characterization and (IFN-y) in orange-spotted grouper expression of interferon gamma (Epinephelus coioides), 中国水产科学, 2013, 第 2 作者
（44） 斜带石斑鱼IgM、IgZ和IgD重链基因的克隆, Molecular characterization of IgM, IgZ and IgD heavy chain genes in orange-spotted grouper(Epinephelus coioides), 水产学报, 2012, 第 2 作者

   

（ 1 ） 水产生物免疫学, 负责人, 国家任务, 2024-01--2026-12
（ 2 ） 大宗水产动物重大病毒病害致病机理与高效防控技术, 参与, 中国科学院计划, 2023-12--2028-11
（ 3 ） 鲤新型干扰素介导的天然免疫调控机制, 负责人, 国家任务, 2022-12--2028-01
（ 4 ） 国家特色淡水鱼产业技术体系岗位科学家, 负责人, 国家任务, 2022-06--2025-12