陈铎之，中国科学院昆明植物研究所研究员，主要研究方向为天然产物化学生物学与天然药物化学。已取得以1个候选药物 (新型抗白癜风候选药物)、2类先导化合物 (靶向N蛋白的抗新冠活性化合物、新型抗PEDV活性化合物)和3条新作用机制 (抗白癜风新型作用机制、靶向N蛋白的抗新冠病毒作用机制、抗PEDV新型作用机制)为代表的科研成果体系，在包括Nat. Chem. Biol.、Euro. J. Med. Chem.、J. Org. Chem.、Organ. Lett.等权威期刊发表论文45篇 (第一或通讯作者20篇，中科院1区4篇，2区8篇)，获国家发明专利十余项、美国专利1项。主持国家自然科学基金项目3项，省部级及其他科研项目10项；先后入选中科院“青年创新促进会”、云南省“万人计划-青年拔尖人才”和中组部-中科院“西部青年学者”等人才计划。

已指导博、硕士研究生十余人次，先后获得国家奖学金1人次，省部级三好学生2人次，校级奖学金8人次，欢迎药学、有机化学、药理学相关专业背景同学报考。

100701-药物化学
070303-有机化学

天然产物化学生物学
新型生物活性小分子研究与开发
天然药物化学

2010-09--2013-07   中国科学院昆明植物研究所   博士研究生/理学博士
2007-09--2009-12   昆明理工大学   硕士研究生/医学硕士
2003-09--2007-07   昆明理工大学   本科/工学学士

   

2022-01~现在, 中国科学院昆明植物研究所, 研究员
2016-01~2021-12,中国科学院昆明植物研究所, 副研究员
2013-12~2015-12,中国科学院昆明植物研究所, 助理研究员

   

[1] 周云夫, 李林, 郝小江, 陈铎之. 治疗或预防肥胖或其相关疾病的化合物及其应用. CN: CN109528717B, 2021-08-17.
[2] 郝小江, 陈铎之, 樊世瑞, 蔡洁云, 景晨旭, 王宜挺. 菲啶类衍生物及其制备方法和治疗白癜风药物. CN: CN112920164A, 2021-06-08.
[3] 周云夫, 李林, 陈铎之, 郝小江. Na/K-ATP酶抑制剂及其应用. CN: CN111939259A, 2020-11-17.
[4] 周云夫, 李林, 郝小江, 陈铎之. 治疗或预防肥胖或其相关疾病的化合物及其应用. CN: CN109528717A, 2019-03-29.
[5] 李林, 汪胜, 郝小江, 潘巍峻, 尹俊林, 聂芬, 陈铎之. 一种可用作Wnt信号途径激活剂的化合物及其制备与应用. CN: CN105343073A, 2016-02-24.
[6] 李林, 汪胜, 郝小江, 宋晓敏, 尹俊林, 陈铎之. 影响经典Wnt信号途径的药物的筛选方法及其应用. CN: CN104034856A, 2014-09-10.
[7] 李林, 汪胜, 郝小江, 潘巍峻, 尹俊林, 聂芬, 陈铎之. 一种可用作Wnt信号途径激活剂的化合物及其制备与应用. CN: CN104031055A, 2014-09-10.
[8] 郝小江, 陈铎之, 尹俊林, 彭宗根, 何红平, 蒋建东, 邸迎彤, 张于, 李顺林. 菲啶类衍生物及其药物组合物和其制备方法与应用. CN: CN103145617A, 2013-06-12.
[9] 郝小江, 陈铎之, 尹俊林, 李林, 汪胜. 三氮唑类化合物,其药物组合物和其制备方法与应用. CN: CN103113353A, 2013-05-22.

   

[1] ARCHIVES OF MICROBIOLOGY. 2023,   通讯作者  
[2] EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2022,   通讯作者  
[3] BIOORGANIC CHEMISTRY. 2022,   通讯作者  
[4] 陈铎之, 郝小江. 治疗丙型肝炎药物的研究进展. 云南民族大学学报:自然科学版[J]. 2021, 第 1 作者30(5): 419-435, http://lib.cqvip.com/Qikan/Article/Detail?id=7105623727.
[5] Chen, DuoZhi, Fan, ShiRui, Yang, BiJuan, Yao, HuoChun, Wang, YiTing, Cai, JieYun, Jing, ChenXu, Pan, ZiHao, Luo, Miao, Yuze, YanQiu, Liu, GuangJin, Hao, XiaoJiang. Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors. JOURNAL OF NATURAL PRODUCTS[J]. 2021, 第 1 作者84(4): 1175-1184, http://dx.doi.org/10.1021/acs.jnatprod.0c01252.
[6] Yuan, WenJuan, Gao, WenFen, Zhao, JiangYu, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Diterpenes with potential treatment of vitiligo from the aerials parts of Euphorbia antiquorum L. FITOTERAPIA[J]. 2020, 第 5 作者144(7): http://ir.kib.ac.cn/handle/151853/72049, http://www.irgrid.ac.cn/handle/1471x/6927915, http://ir.kib.ac.cn/handle/151853/72050, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000537596000004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[7] Fan, Shirui, Guo, Jingjing, Wang, Yiting, Yang, Bijuan, Chen, Duozhi, Hao, Xiaojiang. Two new bioactive lignans from leaves and twigs of Cleistanthus concinnus Croizat. NATURAL PRODUCT RESEARCH[J]. 2020, 第 5 作者  通讯作者  34(23): 3328-3334, https://www.webofscience.com/wos/woscc/full-record/WOS:000594432300004.
[8] Yang, BiJuan, Fan, ShiRui, Cai, JieYun, Wang, YiTing, Jing, Chenxu, Guo, JingJing, Chen, DuoZhi, Hao, XiaoJiang. Aphananoid A is an Anti-Inflammatory Limonoid with a New 5/6/5 Fused Ring Featuring a C-24 Carbon Skeleton from Aphanamixis polystachya. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 第 7 作者  通讯作者  85(13): 8597-8602, https://www.webofscience.com/wos/woscc/full-record/WOS:000547450900029.
[9] Jing, Chenxu, Guo, Jingjing, Yang, Bijuan, Fan, Shirui, Wang, Yiting, Chen, Duozhi, Hao, Xiaojiang. Stelleraguaianone B and C, two new sesquiterpenoids from Stellera chamaejasme L.. FITOTERAPIA[J]. 2019, 第 6 作者  通讯作者  134: 443-446, http://dx.doi.org/10.1016/j.fitote.2019.03.024.
[10] Zhang, Jiahui, Cao, Pei, Ma, Yuanliang, Fang, Xin, Yang, Jing, Zhang, Yu, Chen, Duozhi, Gu, Yucheng, Di, Yingtong, Hao, Xiaojiang. Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 第 7 作者82(3): 427-430, http://dx.doi.org/10.1021/acs.jnatprod.8b00232.
[11] Chen, Duozhi, Yang, Bijuan, He, Xiaoli, Fan, Shirui, Cai, Jieyun, Jing, Chenxu, Zhang, Heng, Zhang, Yu, Li, Lin, Hao, Xiaojiang. Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists. BIOORGANIC CHEMISTRY[J]. 2019, 第 1 作者84: 285-294, http://ir.kib.ac.cn/handle/151853/64207.
[12] Yi, Wenfang, Chen, Duozhi, Ding, Xiao, Li, Xiaonian, Li, Shunlin, Di, Yingtong, Zhang, Yu, Hao, Xiaojiang. Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus. FITOTERAPIA[J]. 2018, 第 2 作者128: 162-168, http://dx.doi.org/10.1016/j.fitote.2018.05.015.
[13] Duozhi Chen, Heng Zhang, Chenxu Jing, Xiaoli He, Bijuan Yang, Jieyun Cai, Yunfu Zhou, Xiaoming Song, Lin Li, Xiaojiang Hao, Xiaojiang Hao. Efficient synthesis of new phenanthridine Wnt/b-catenin signaling pathway agonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 第 1 作者157: 1491-1499, http://ir.kib.ac.cn/handle/151853/64656.
[14] Chen, Duozhi, Zhang, Heng, Jing, Chenxu, He, Xiaoli, Yang, Bijuan, Cai, Jieyun, Zhou, Yunfu, Song, Xiaoming, Li, Lin, Hao, Xiaojiang. Efficient synthesis of new phenanthridine Wnt/beta-catenin signaling pathway agonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 第 1 作者157: 1491-1499, http://202.127.25.143/handle/331003/3398.
[15] YuemaoShen, DuozhiChen. An Explorer of Chemical Biology of Plant Natural Products in Southwest China, Xiaojiang Hao. Natural Products and Bioprospecting[J]. 2018, 第 2 作者8(4): 217-226, http://npb.kib.ac.cn/EN/10.1007/s13659-018-0184-8.
[16] Zeng, YanRong, Yi, Ping, Gu, Wei, Xiao, ChunXia, Huang, LieJun, Tian, DongSong, Yan, Hui, Chen, DuoZhi, Yuan, ChunMao, Hao, XiaoJiang. Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 第 8 作者16(22): 4195-4198, http://ir.kib.ac.cn/handle/151853/64730.
[17] Yuan, Chun-Mao, Zeng, Yan-Rong, Yi, Ping, Gu, Wei, Xiao, Chun-Xia, Huang, Lie-Jun, Tian, Dong-Song, Yan, Hui, Chen, Duo-Zhi, Hao, Xiao-Jiang. Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum. PHYTOTAXA[J]. 2018, 第 9 作者356(1): 1-18, http://www.irgrid.ac.cn/handle/1471x/1781738.
[18] Guo, Jingjing, Yang, Bijuan, Jing, Chenxu, Chen, Duozhi, Hao, Xiaojiang. Rapid synthesis of ismine, a bioactive amaryllidaceae alkaloid. JOURNAL OF CHEMICAL RESEARCH[J]. 2017, 第 4 作者  通讯作者  41(4): 202-204, http://dx.doi.org/10.3184/174751917X14894997017496.
[19] Yuan, WenJuan, Gao, WenFen, Zhang, JiaHui, Cao, Pei, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. (+/-)-Perforison A, A Pair of New Chromone Enantiomers from Harrisonia perforata. NATURAL PRODUCT COMMUNICATIONS[J]. 2017, 第 6 作者12(1): 63-65, http://ir.kib.ac.cn/handle/151853/41892.
[20] Yuan, WenJuan, Ding, Xiao, Wang, Zhe, Yang, BiJuan, Li, XiaoNian, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Chen, Quan, Di, YingTong, Aisa, Haji Akber, Hao, XiaoJiang. Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A. SCIENTIFICREPORTS[J]. 2017, 第 7 作者7(1): https://doaj.org/article/e37a28dc25a9453b84cb871969fa2f32.
[21] Chen, DuoZhi, Jing, ChenXu, Cai, JieYun, Wu, JiBo, Wang, Sheng, Yin, Jun Lin, Li, XiaoNian, Li, Lin, Hao, XiaoJiang. Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/beta-Catenin Signaling Pathway Agonists. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 第 1 作者79(1): 180-188, http://ir.kib.ac.cn/handle/151853/25949.
[22] Yuan, WenJuan, Yang, GuoPing, Zhang, JiaHui, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata. PHYTOCHEMISTRY LETTERS[J]. 2016, 第 5 作者18(1): 176-179, http://dx.doi.org/10.1016/j.phytol.2016.10.008.
[23] Zhang, JiaHui, JingGuo, Jing, Yuan, Yu Xi, Fu, YanHui, Gu, YuCheng, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Four new tetracyclic alkaloids with cis-decahydroquinoline motif from Myrioneuron effusum. FITOTERAPIA[J]. 2016, 第 7 作者112: 217-221, http://dx.doi.org/10.1016/j.fitote.2016.06.006.
[24] Chen, Duozhi, Cai, Jieyun, Yin, Junlin, Jiang, Jiandong, Jing, Chenxu, Zhu, Yanping, Cheng, Junjun, Di, Yingtong, Zhang, Yu, Cao, Mingming, Li, Shunlin, Peng, Zonggen, Hao, Xiaojiang. Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors. FUTURE MEDICINAL CHEMISTRY[J]. 2015, 第 1 作者7(5): 561-570, http://www.irgrid.ac.cn/handle/1471x/963675.
[25] Zhang, Yu, Guo, Lingli, Yang, Guangmei, Guo, Feng, Di, Yingtong, Li, Shunlin, Chen, Duozhi, Hao, Xiaojiang. New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa. FITOTERAPIA[J]. 2015, 第 7 作者100: 150-155, http://ir.kib.ac.cn/handle/151853/20431.
[26] Yan, Ying, Zhang, JianXin, Huang, Tao, Mao, XinYing, Gu, Wei, He, HongPing, Di, YingTong, Li, ShunLin, Chen, DuoZhi, Zhang, Yu, Hao, XiaoJiang. Bioactive Limonoid Constituents of Munronia henryi. JOURNAL OF NATURAL PRODUCTS[J]. 2015, 第 9 作者78(4): 811-821, http://dx.doi.org/10.1021/np501057f.
[27] Jing, Chenxu, Cai, Jieyun, Zhang, Yu, Chen, Duozhi, Hao, Xiaojiang. Synthesis of 4-ethyl-5-methyl-5,6-dihydrophenanthridine-8,9-diol as the key intermediate of potent agonists of the Wnt signalling pathway. JOURNAL OF CHEMICAL RESEARCH[J]. 2015, 第 4 作者  通讯作者  247-250, http://www.irgrid.ac.cn/handle/1471x/1028939.
[28] Liu, WenXing, Chen, DuoZhi, Ding, JiaYin, Hao, XiaoJiang, Li, ShunLin. New Phragmalin-Type Limonoid Orthoesters from the Bark of Chukrasia tabularis var. velutina. HELVETICA CHIMICA ACTA[J]. 2015, 第 2 作者98(10): 1403-1410, http://www.irgrid.ac.cn/handle/1471x/1028985.
[29] Cao, MingMing, Zhang, Yu, Huang, ShengDian, Di, YingTong, Peng, ZongGen, Jiang, JianDong, Yuan, ChunMao, Chen, DuoZhi, Li, ShunLin, He, HongPing, Hao, XiaoJiang. Alkaloids with Different Carbon Units from Myrioneuron faberi. JOURNAL OF NATURAL PRODUCTS[J]. 2015, 第 8 作者78(11): 2609-2616, http://dx.doi.org/10.1021/acs.jnatprod.5b00543.
[30] Chen, Duozhi, Cai, Jieyun, Cheng, Junjun, Jing, Chenxu, Yin, Junlin, Jiang, Jiandong, Peng, Zonggen, Hao, Xiaojiang. Design, Synthesis and Structure-Activity Relationship Optimization of Lycorine Derivatives for HCV Inhibition. SCIENTIFIC REPORTS[J]. 2015, 第 1 作者5: http://www.irgrid.ac.cn/handle/1471x/1028970.
[31] Yan, Chen, Huang, Li, Liu, HongChun, Chen, DuoZhi, Liu, HaiYang, Li, XiaoHui, Zhang, Yu, Geng, MeiYu, Chen, Quan, Hao, XiaoJiang. Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2014, 第 4 作者24(8): 1884-1888, http://dx.doi.org/10.1016/j.bmcl.2014.03.019.
[32] Cai, JieYun, Chen, DuoZhi, Luo, ShiHong, Kong, NingChuan, Zhang, Yu, Di, YingTong, Zhang, Qiang, Hua, Juan, Jing, ShuXi, Li, ShunLin, Li, ShengHong, Hao, XiaoJiang, He, HongPing. Limonoids from Aphanamixis polystachya and Their Antifeedant Activity. Journal of Natural Products[J]. 2014, 第 2 作者77(3): 472-482, http://dx.doi.org/10.1021/np400678h.
[33] Cao, MingMing, Zhang, Yu, Li, XiaoHui, Peng, ZongGen, Jiang, JianDong, Gu, YuCheng, Di, YingTong, Li, XiaoNian, Chen, DuoZhi, Xia, ChengFeng, He, HongPing, Li, ShunLin, Hao, XiaoJiang. Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus. JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 第 9 作者79(17): 7945-7950, http://dx.doi.org/10.1021/jo501076x.
[34] Huang ShengDian, Zhang Yu, He HongPing, Li ShiFei, Tang GuiHua, Chen DuoZhi, Cao MingMing, Di YingTong, Hao XiaoJiang. A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2013, 第 6 作者11(4): 406-410, http://dx.doi.org/10.1016/S1875-5364(13)60060-6.
[35] Wang, Sheng, Yin, Junlin, Chen, Duozhi, Nie, Fen, Song, Xiaomin, Fei, Cong, Miao, Haofei, Jing, Changbin, Ma, Wenjing, Wang, Lei, Xie, Sichun, Li, Chen, Zeng, Rong, Pan, Weijun, Hao, Xiaojiang, Li, Lin. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. NATURE CHEMICAL BIOLOGY[J]. 2013, 第 3 作者9(9): 579-U82, http://dx.doi.org/10.1038/NCHEMBIO.1309.
[36] Li, YanPing, Dong, LiaoBin, Chen, DuoZhi, Li, HongMei, Zhong, JinDong, Li, Fei, Liu, Xing, Wang, Bei, Li, RongTao. Two new dihydrobenzofuran-type neolignans from Breynia fruticosa. PHYTOCHEMISTRY LETTERS[J]. 2013, 第 3 作者6(2): 281-285, http://dx.doi.org/10.1016/j.phytol.2013.03.009.
[37] 黄升殿, 张于, 何红平, 李石飞, 唐贵华, 陈铎之, 曹明明, 邸迎彤, 郝小江. 红花石蒜中的一个新石蒜生物碱（英文）. 中国天然药物[J]. 2013, 第 6 作者406-410, http://www.irgrid.ac.cn/handle/1471x/832399.
[38] Cai, JieYun, Zhang, Yu, Luo, ShiHong, Chen, DuoZhi, Tang, GuiHua, Yuan, ChunMao, Di, YingTong, Li, ShengHong, Hao, XiaoJiang, He, HongPing. Aphanamixoid A, a Potent Defensive Limonoid, with a New Carbon Skeleton from Aphanamixis polystachya. ORGANIC LETTERS[J]. 2012, 第 4 作者14(10): 2524-2527, http://dx.doi.org/10.1021/ol3008149.
[39] Cao, Mingming, Zhang, Yu, He, Hongping, Li, Shifei, Huang, Shendian, Chen, Duozhi, Tang, Guihua, Li, Shunlin, Di, Yingtong, Hao, Xiaojiang. Daphmacromines A-J, Alkaloids from Daphniphyllum macropodum. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 第 6 作者75(6): 1076-1082, http://www.irgrid.ac.cn/handle/1471x/522636.

   

（ 1 ） 菲啶类Wnt/β-catenin信号通路激动剂抗白癜风活性及其作用机制研究, 负责人, 国家任务, 2018-01--2021-12
（ 2 ） 中国“科学院青年创新促进会”人才计划, 负责人, 中国科学院计划, 2018-01--2021-12
（ 3 ） 新型菲啶类抗PEDV药物先导化合物的发现及其作用机制研究, 负责人, 国家任务, 2020-01--2023-12
（ 4 ） 云南省“万人计划，青年拔尖人才”人才计划, 负责人, 地方任务, 2020-01--2024-12
（ 5 ） 西部青年学者人才计划, 负责人, 中国科学院计划, 2022-01--2024-12

现指导学生

阮婷  硕士研究生  078001-药物化学