基本信息

陈畅  女  博导  中国科学院生物物理研究所
电子邮件: changchen@moon.ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

研究领域

细胞氧化还原调控机制;衰老及衰老相关疾病;中医药机制。

教育背景

1993-09--1996-06   北京大学   理学博士
1990-09--1993-06   北京师范大学   理学硕士
1986-09--1990-06   南开大学   理学学士
学历
北京大学 -- 研究生
学位
北京大学 -- 博士

教授课程

生物活性小分子
本科生毕业设计(生物科学)
发现生命奥秘
科研实践II
巯基修饰与细胞氧化还原调控
生物物理学系列讲座

出版信息

   
发表论文
(1) S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKC�� S-nitrosation, REDOX BIOLOGY, 2024, 第 10 作者  通讯作者
(2) Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation, CELL METABOLISM, 2024, 第 14 作者  通讯作者
(3) Lycium barbarum polysaccharide increases thermogenesis and energy metabolism through modulation of the gut microbiota to confer resistance to cold temperatures., FASEB JOURNAL, 2024, 第 5 作者  通讯作者
(4) The Aging Biomarker Consortium represents a new era for aging research in China, NATURE MEDICINE, 2023, 第 8 作者
(5) Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023, 第 8 作者  通讯作者
(6) Biomarkers of aging, Biomarkers of aging, SCIENCE CHINA-LIFE SCIENCES, 2023, 第 64 作者  通讯作者
(7) Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis, Cell Reports, 2023, 第 11 作者  通讯作者
(8) LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1, ISCIENCE, 2023, 第 7 作者  通讯作者
(9) Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells, SCIENCE CHINA Life Sciences, 2023, 第 6 作者  通讯作者
(10) 枸杞子多糖提取物LBP1C通过激活TFEB延缓衰老, LBP1C Extracted From Lycium barbarum Delays Aging by Activating TFEB, 生物化学与生物物理进展, 2023, 第 9 作者
(11) Multi-Omics Approach Reveals Redox Homeostasis Reprogramming in Early-Stage Clear Cell Renal Cell Carcinoma, ANTIOXIDANTS, 2023, 第 6 作者  通讯作者
(12) LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRIA/BMPRII/Noggin, CARBOHYDRATE POLYMERS, 2023, 第 6 作者  通讯作者
(13) Exploring the precision redox map during fasting-refeeding and satiation in C. elegans, STRESS BIOLOGY, 2023, 第 10 作者  通讯作者
(14) Identification of the redox-stress signaling threshold (RST): Increased RST helps to delay aging in C. elegans, FREE RADICAL BIOLOGY AND MEDICINE, 2022, 第 4 作者  通讯作者
(15) 锻炼缓解内质网还原应激从而促进健康衰老, Exercise Alleviates ER Reductive Stress and Promotes Healthy Aging, 生物化学与生物物理进展, 2022, 第 7 作者
(16) Exercise Alleviates ER Reductive Stress and Promotes Healthy Aging, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2022, 第 7 作者  通讯作者
(17) GAPDH S-nitrosation contributes to age-related sarcopenia through mediating apoptosis, NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2022, 第 6 作者  通讯作者
(18) A Lycium barbarum extract inhibits beta-amyloid toxicity by activating the antioxidant system and mtUPR in a Caenorhabditis elegans model of Alzheimer's disease, FASEB JOURNAL, 2022, 第 8 作者  通讯作者
(19) ER reductive stress caused by Ero1 alpha S-nitrosation accelerates senescence, FREE RADICAL BIOLOGY & MEDICINE, 2022, 第 16 作者  通讯作者
(20) Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8, REDOX BIOLOGY, 2022, 第 14 作者  通讯作者
(21) Nitric oxide inhibits alginate biosynthesis in Pseudomonas aeruginosa and increases its sensitivity to tobramycin by downregulating algU gene expression, NITRIC OXIDE, 2022, 第 6 作者  通讯作者
(22) 精准氧化还原调控, Precision redox regulation, 药学学报, 2022, 第 1 作者
(23) SLC-30A9 is required for Zn 2+ homeostasis, Zn 2+ mobilization, and mitochondrial health, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 第 12 作者
(24) Precision Redox: The Key for Antioxidant Pharmacology, ANTIOXIDANTS & REDOX SIGNALING, 2021, 第 15 作者  通讯作者
(25) Redox-stress response capacity decline and ER reductive stress in aging, FREE RADICAL BIOLOGY AND MEDICINE, 2021, 第 1 作者
(26) Redox environment metabolomic evaluation (REME) of the heart after myocardial ischemia/reperfusion injury, FREE RADICAL BIOLOGY AND MEDICINE, 2021, 第 10 作者  通讯作者
(27) GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation, REDOX BIOLOGY, 2021, 第 10 作者  通讯作者
(28) Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration, CELLREPORTS, 2021, 第 14 作者  通讯作者
(29) Elevated serum 4HNE plus decreased serum thioredoxin: Unique feature and implications for acute exacerbation of chronic obstructive pulmonary disease, PLOS ONE, 2021, 第 4 作者
(30) Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020, 第 7 作者  通讯作者
(31) An extract of Lycium barbarum mimics exercise to improve muscle endurance through increasing type IIa oxidative muscle fibers by activating ERR��., FASEB J., 2020, 第 1 作者  通讯作者
(32) Phase Separation and Cytotoxicity of Tau are Modulated by Protein Disulfide Isomerase and S-nitrosylation of this Molecular Chaperone, JOURNAL OF MOLECULAR BIOLOGY, 2020, 第 15 作者
(33) Preparative Separation of Flavonoids from Goji Berries by Mixed-Mode Macroporous Adsorption Resins and Effect on A beta-Expressing and Anti-Aging Genes, MOLECULES, 2020, 第 7 作者  通讯作者
(34) In memoriam Steven Yue Qian (1960���2019), REDOX BIOLOGY, 2020, 第 5 作者
(35) S -Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal ��-helical lid, JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 第 10 作者  通讯作者
(36) 川陈皮素通过调控RORα改善自然衰老小鼠骨流失(英文), 生物化学与生物物理进展, 2020, 第 3 作者
(37) S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal ��-helical lid, JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 第 10 作者
(38) In memoriam Steven Yue Qian (1960-2019), FREE RADICAL BIOLOGY AND MEDICINE, 2020, 第 5 作者
(39) Preparative separation of flavonoids from Goji berries by Mixed-Mode Macroporous Adsorption Resins and Effect on A��-expressing and anti-aging genes, MOLECULES, 2020, 第 7 作者
(40) Improvement of the CRISPR-Cas9 mediated gene disruption and large DNA fragment deletion based on a chimeric promoter in Acremonium chrysogenum, FUNGAL GENETICS AND BIOLOGY, 2020, 第 1 作者
(41) 川陈皮素通过调控RORα改善自然衰老小鼠骨流失, Nobiletin Improves Bone Loss due to Natural Aging by Regulating ROR��, 生物化学与生物物理进展, 2020, 第 3 作者
(42) Nobiletin Improves Bone Loss due to Natural Aging by Regulating ROR alpha, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2020, 第 3 作者  通讯作者
(43) An extract ofLycium barbarummimics exercise to improve muscle endurance through increasing type IIa oxidative muscle fibers by activating ERR gamma, FASEB JOURNAL, 2020, 第 5 作者  通讯作者
(44) 枸杞对秀丽隐杆线虫寿命和产卵的影响及其抗氧化作用, Effect of Goji Berries(Lycium barbarum)on Lifespan and Spawning of Caenorhabditis elegans and Its Antioxidant Capacity, 食品科学, 2019, 第 4 作者
(45) 川陈皮素改善衰老认知功能损伤的作用与机制, Nobiletin Rescues Cognitive Impairment in Naturally Aging Mice, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2019, 第 5 作者  通讯作者
(46) S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension, REDOX BIOLOGY, 2019, 第 9 作者  通讯作者
(47) Nobiletin rescues congnitive impairment in naturally aging mice, Progress in Biochemistry and Biophysics, 2019, 第 1 作者  通讯作者
(48) 川陈皮素改善衰老认知功能损伤的作用与机制(英文), Nobiletin Rescues Cognitive Impairment*in Naturally Aging Mice, 生物化学与生物物理进展, 2019, 第 5 作者
(49) ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells., CELL DISCOVERY, 2018, 第 13 作者
(50) PI4KIIα regulates insulin secretion and glucose homeostasis via a PKD-dependent pathway, PI4KII�� regulates insulin secretion and glucose homeostasis via a PKD-dependent pathway, 生物物理学报:英文版, 2018, 第 7 作者
(51) GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation, REDOX BIOLOGY, 2018, 第 15 作者  通讯作者
(52) PI4KIIα regulates insulin secretion and glucose homeostasis via a PKD-dependent pathway, PI4KII�� regulates insulin secretion and glucose homeostasis via a PKD-dependent pathway, 生物物理学报:英文版, 2018, 第 7 作者
(53) 枸杞多糖药理作用研究进展, Advances in the pharmacologic of Lycium barbarum polysaccharide, 时珍国医国药, 2018, 第 4 作者
(54) Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome., PROTEIN & CELL, 2018, 第 11 作者
(55) Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKII alpha, JOURNAL OF NEUROSCIENCE, 2017, 第 13 作者  通讯作者
(56) Increased GSNOR expression during aging impairs cognitive function and decreases S-nitrosation of CaMKII��, JOURNAL OF NEUROSCIENCE, 2017, 
(57) PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KII alpha, Inhibits the Growth of Breast Cancer Cells, CANCER RESEARCH, 2017, 第 13 作者  通讯作者
(58) The decay of Redox-stress Adaptive Capacity is a substantive characteristic of aging: revising the redox theory of aging, Redox Biology, 2017, 第 1 作者  通讯作者
(59) The decay of Redox-stress Response Capacity is a substantive characteristic of aging: Revising the redox theory of aging, REDOX BIOLOGY, 2017, 第 7 作者  通讯作者
(60) Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia, AUTOPHAGY, 2017, 第 12 作者  通讯作者
(61) Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia���reperfusion injury, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2017, 第 12 作者  通讯作者
(62) 162 - GSNOR Impaired Cognitive Function in Aging Through De-Nitrosation of CamKIIalpha, FREE RADICAL BIOLOGY AND MEDICINE, 2016, 第 2 作者
(63) GSNOR Impaired Cognitive Function in Aging Through De-Nitrosation of CamKIIalpha, FREE RADICAL BIOLOGY AND MEDICINE, 2016, 第 2 作者
(64) Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa, REDOX BIOLOGY, 2016, 第 6 作者  通讯作者
(65) Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 5 作者  通讯作者
(66) 173 - Decay of Redox Adaptive Capacity Is a Substantive Characteristic of Aging: Retrospecting the Redox Theory of Aging, FREE RADICAL BIOLOGY AND MEDICINE, 2016, 第 2 作者
(67) Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response *, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 
(68) Decay of Redox Adaptive Capacity Is a Substantive Characteristic of Aging: Retrospecting the Redox Theory of Aging, FREE RADICAL BIOLOGY AND MEDICINE, 2016, 第 2 作者
(69) 160 - The Homeostasis of Nitric Oxide and S-Nitrosothiols in Neurite Growth and Neurogenesis, FREE RADICAL BIOLOGY AND MEDICINE, 2015, 第 1 作者
(70) Pro-inflammatory Macrophages suppress PPAR�� activity in Adipocytes via S-nitrosylation, FREE RADICAL BIOLOGY AND MEDICINE, 2015, 第 8 作者
(71) Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa. Redox Biology, Redox Biology, 2015, 第 1 作者  通讯作者
(72) Cellular redox regulation and thiol modification, Chinese Bulletin of Life Sciences, 2015, 第 1 作者  通讯作者
(73) S-nitrosylation of PPAR��: a potential link between inflammation and insulin resistance, Free Radic Biol Med, 2015, 第 1 作者  通讯作者
(74) A Werner Syndrome Stem Cell Model Unveils Heterochromatin Alterations as a Driver of Human Aging, SCIENCE, 2015, 第 23 作者
(75) Pro-inflammatory Macrophages suppress PPAR gamma activity in Adipocytes via S-nitrosylation, FREE RADICAL BIOLOGY AND MEDICINE, 2015, 第 8 作者  通讯作者
(76) 未折叠蛋白响应:2014年拉斯克基础医学研究奖解读, @@, 科学通报, 2014, 第 3 作者
(77) Activation of GSNOR transcription by NF-kappa B negatively regulates NGF-induced PC12 differentiation, FREERADICALRESEARCH, 2014, 
(78) A potential tool for future antioxidant therapy, FREE RADICAL RESEARCH, 2014, 第 3 作者
(79) Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIla as anti-tumor strategy, Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIla as anti-tumor strategy, 蛋白质与细胞:英文版, 2014, 第 7 作者
(80) Cellular Redox Regulation and Aging, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2014, 第 3 作者  通讯作者
(81) Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha, NATURE COMMUNICATIONS, 2014, 第 11 作者
(82) 衰老: 老问题,新挑战, 生物化学与生物物理进展, 2014, 第 1 作者
(83) Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KII�� as anti-tumor strategy, 蛋白质与细胞, 2014, 第 7 作者
(84) A Novel Suppressive Effect of Alcohol Dehydrogenase 5 in Neuronal Differentiation, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 第 13 作者
(85) Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II��, NATURE COMMUNICATIONS, 2014, 第 11 作者
(86) 细胞氧化还原调控与衰老, Cellular Redox Regulation and Aging, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2014, 第 3 作者  通讯作者
(87) Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KII alpha as anti-tumor strategy, PROTEIN & CELL, 2014, 第 7 作者  通讯作者
(88) Puzzle out the regulation mechanism of PI4K����� activity, SCIENCE CHINA. LIFE SCIENCES, 2014, 第 3 作者
(89) Puzzle out the regulation mechanism of PI4KII alpha activity, SCIENCE CHINA-LIFE SCIENCES, 2014, 第 3 作者  通讯作者
(90) 小脑颗粒神经元谷氨酸兴奋性毒性模型的优化, Optimization of a Glutamate Excitotoxicity Model in Cultured Cerebellar Granule Neurons, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2013, 第 3 作者  通讯作者
(91) Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock, CELL RESEARCH, 2013, 第 15 作者
(92) 亚硝基化谷胱甘肽还原酶: 一个调控炎症反应的新分子, GSNOR:a Novel Regulator of Inflammation, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2013, 第 4 作者  通讯作者
(93) 亚硝基化谷胱甘肽还原酶: 一个调控炎症反应的新分子, GSNOR:a Novel Regulator of Inflammation, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2013, 第 4 作者  通讯作者
(94) 一氧化氮的功能及其作用机制(II)——蛋白质巯基亚硝基化修饰, Function and Mechanism of Nitric Oxide (11)- Mechanism and Protein S-Nitrosation, 生物物理学报, 2012, 第 2 作者
(95) SNO spectral counting (SNOSC), a label-free proteomic method for quantification of changes in levels of protein S-nitrosation, FREE RADICAL RESEARCH, 2012, 第 3 作者  通讯作者
(96) SNO spectral counting (SNOSC), a label-free proteomic method for quantification of changes in levels of protein S-nitrosation, FREE RADICAL RESEARCH, 2012, 第 3 作者  通讯作者
(97) SNObase, a database for S-nitrosation modification, PROTEIN & CELL, 2012, 第 8 作者  通讯作者
(98) 一氧化氮的功能及其作用机制(Ⅰ)——性质与功能, Function and Mechanism of Nitric Oxide(���)������Characteristics and Function, 生物物理学报, 2012, 第 2 作者
(99) 一氧化氮的功能及其作用机制(Ⅱ)——蛋白质巯基亚硝基化修饰, Function and Mechanism of Nitric Oxide (���) ��������� Mechanism and Protein S-Nitrosation, 生物物理学报, 2012, 第 2 作者
(100) 一氧化氮的功能及其作用机制(I)——性质与功能, Function and Mechanism of Nitric Oxide (I) --Characteristics and Function, 生物物理学报, 2012, 第 2 作者
(101) Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila, NITRIC OXIDE, 2011, 第 14 作者
(102) Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila, NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2011, 第 14 作者
(103) 硒代硫酸钠诱导HL60细胞凋亡——还原态硒的细胞毒性(英文), Induction of Apoptosis in HL60 Cells by Selenosulfate������Cytotoxicity of Selenium Anion, 生物物理学报, 2010, 第 3 作者
(104) Quantitative proteomic analysis of S-nitrosated proteins in diabetic mouse liver with ICAT switch method, Quantitative proteomic analysis of S -nitrosated proteins in diabetic mouse liver with ICAT switch method, PROTEIN & CELL, 2010, 第 4 作者  通讯作者
(105) Specific Quantitative High-throughput Methods to Detect Snitrosation, FREE RADICAL BIOLOGY AND MEDICINE, 2010, 第 6 作者
(106) Repression of classical nuclear export by S-nitrosylation of CRM 1, NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2010, 第 1 作者
(107) ESNOQ, Proteomic Quantification of Endogenous S-Nitrosation, PLOS ONE, 2010, 第 7 作者
(108) Detection of Protein S-Nitrosation using Irreversible Biotinylation Procedures (IBP), FREE RADICAL BIOLOGY AND MEDICINE, 2010, 第 2 作者  通讯作者
(109) Lipin proteins form homo- and hetero-oligomers, BIOCHEMICAL JOURNAL, 2010, 第 5 作者
(110) NADPH oxidase 4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction, FREE RADICAL BIOLOGY AND MEDICINE, 2010, 第 8 作者
(111) PI4KII�� is a novel regulator of tumor growth via its action on angiogenesis and HIF-1�� regulation, oncogene, 2009, 第 1 作者  通讯作者
(112) Repression of classical nuclear export by S-nitrosylation of CRM1, JOURNAL OF CELL SCIENCE, 2009, 第 9 作者
(113) Repression of Classical Nuclear Export by S-Nitrosylation of CRM1, FREE RADICAL BIOLOGY AND MEDICINE, 2009, 第 3 作者
(114) Nonlinear cooperation of p53-ING1-induced bax expression and protein S-nitrosylation in GSNO-induced thymocyte apoptosis: a quantitative approach with cross-platform validation, APOPTOSIS, 2009, 第 6 作者
(115) Detergent-free biotin switch combined with liquid chromatography/tandem mass spectrometry in the analysis of S-nitrosylated proteins, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2008, 第 2 作者  通讯作者
(116) On-gel fluorescent visualization and the site identification of S-nitrosylated proteins, ANALYTICAL BIOCHEMISTRY, 2008, 第 5 作者  通讯作者
(117) Nitric oxide controls nuclear export of ape1/ref-1 through s-nitrosation of cysteines 93 and 310, NUCLEIC ACIDS RESEARCH, 2007, 第 4 作者  通讯作者
(118) Nitric oxide destabilizes Pias3 and regulates sumoylation, FREE RADICAL BIOLOGY AND MEDICINE, 2007, 第 8 作者
(119) An ascorbate-dependent artifact that interferes with the interpretation of the biotin switch assay, FREE RADICAL BIOLOGY AND MEDICINE, 2006, 第 2 作者  通讯作者
(120) 蛋白质巯基亚硝基化——一种典型氧化还原依赖的蛋白质翻译后修饰, S-nitrosation:The Prototypic Redox-based Post-translational Modification of Proteins, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2006, 第 1 作者  通讯作者
(121) 蛋白质巯基亚硝基化——一种典型氧化还原依赖的蛋白质翻译后修饰, S-nitrosation:The Prototypic Redox-based Post-translational Modification of Proteins, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2006, 第 1 作者  通讯作者
(122) 活性氧参与一氧化氮诱导的神经细胞凋亡, 生物化学与生物物理进展, 2001, 第 7 作者
(123) EPC-K1防止ONOO~-诱导的小脑颗粒神经元凋亡, 生物化学与生物物理学报, 1999, 第 3 作者
(124) 一氧化氮损伤神经细胞线粒体并诱导细胞凋亡, 科学通报, 1999, 第 4 作者
(125) Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation, CELL METABOLISM, 第 14 作者
(126) LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1, ISCIENCE, 第 7 作者
发表著作
(1) 磁共振食品科学, Magnetic Resonance in Food Science , The Royal Society of Chemistry, 2001-03, 第 1 作者
(2) 自由基生物医学, 艺轩图书出版社, 2013-05, 第 5 作者

科研活动

   
科研项目
( 1 ) 生命过程大分子精准氧化还原稳态维持及胁迫干预, 负责人, 国家任务, 2022-12--2027-11
( 2 ) 衰老过程中细胞氧化还原响应抵抗的发现和机制研究, 负责人, 中国科学院计划, 2020-01--2024-12
( 3 ) 枸杞功效的重大基础研究及功能产品研发, 负责人, 中国科学院计划, 2020-01--2021-12
( 4 ) 衰老相关肥胖和代谢下降的新调控分子GSNOR的发现及机制研究, 负责人, 国家任务, 2019-01--2022-12
( 5 ) 枸杞功效的重大基础研究及功能产品研发, 负责人, 地方任务, 2017-08--2020-12
( 6 ) 蛋白质稳态的氧化还原调控, 负责人, 国家任务, 2017-07--2022-06
( 7 ) 基于组学特征谱的H 型高血压首发脑卒中分子分型研, 参与, 国家任务, 2016-08--2018-07
( 8 ) 还原应激对内质网功能的调控及机制研究, 负责人, 国家任务, 2016-01--2019-12
( 9 ) 个性化药物——基于疾病分子分型的普惠新药研发, 负责人, 中国科学院计划, 2016-01--2017-12
( 10 ) 蛋白质的生成、修饰与质量控制, 参与, 国家任务, 2012-01--2017-12
( 11 ) NO蛋白质巯基亚硝基化修饰及代谢调控(生理学与整合生物学), 负责人, 国家任务, 2012-01--2016-12
( 12 ) 亚细胞代谢调控及其相关老年痴呆症等疾病机理, 负责人, 国家任务, 2011-01--2015-12
( 13 ) 调控蛋白质亚硝基化的关键分子GSNOR在神经系统中的功能研究, 负责人, 国家任务, 2011-01--2014-12
参与会议
(1)Analysis of scientific connotation of anti-aging effect of Lycium barbarum   2024-12-06
(2)Carry forward the cause and forge ahead into the future -Memory of past 20 years SFRR-Asia biennial meetings   2024-10-21
(3)精准氧化还原调控与衰老   香山科学会议 “衰老的机制和干预”   2024-08-28
(4)枸杞子抗衰老功效科学内涵解析   2024 中国衰老科学大会   2024-04-26
(5)氧化还原调控与衰老及干预策略   《海南西部医学论坛-衰老与再生医学》学术论坛   2024-03-22
(6)Say NO to Aging   2023-11-24
(7)衰老相关肥胖的亚硝基化调控机制   第九届LipidALL脂代谢会议   2023-09-20
(8)精准氧化还原调控新时代   中国生理学会肾脏生理专业委员会空中论坛第4期   2023-08-28
(9)氧化还原生物学与医学研究主要问题与挑战思考   2023中国氧化还原生物学与医学大会   2023-08-13
(10)中年发福的亚硝基化修饰调控机制   第六届中国生物物理学会代谢生物学分会学术研讨会   2023-07-28
(11)Precision redox: The key for antioxidant pharmacology   2023-06-21
(12)枸杞子“久服坚筋骨,轻身不老”功效的科学内涵   北京中医药大学第四届整合医学前沿国际会议   2023-06-09
(13)The Underlying Mechanism of Lycium Barbarum in Strengthening Muscle and Bones and Anti-aging   2023-05-09
(14)基于RRC-RRR-RST主动抗氧化延缓衰老   2023中国衰老科学大会   2023-04-22
(15)Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells   第五届中国生物物理学会代谢生物学分会学术研讨会   2022-12-16
(16)衰老标志物:氧化还原应激反应能力RRC及氧化还原状态检测指标RSI   首届中国衰老标志物大会   2022-11-27
(17)Improving RST-RRC as active health strategy and precision redox regulation in anti-aging   2022-11-04
(18)精准氧化还原调控与衰老   第八届中国衰老与抗衰老学术大会   2021-12-18
(19)慢性高原低氧损伤的精准氧化还原应激机制   国家自然科学基金委“慢性高原低氧应激损伤机制与干预”研讨会   2021-12-15
(20)心血管疾病中的精准氧化还原调控   2021 年浙江省医学会心血管病学学术大会   2021-11-23
(21)Cellular Precision Redox Regulation   2021-10-09
(22)Thoughts on the biological study of redox stress   2021-06-25
(23)Precision Redox and Aging   2021-04-25
(24)Precision Redox and its application in cardiovascular disease research   2021-04-23
(25)Technical and methodological needs and challenges in free basic biology research   2021-04-20
(26)Women in Science Round Table   2021-03-15
(27)Redox-stress response capacity decline and ER reductive stress in aging   2021-03-15
(28)Say NO to Aging   2020-10-27
(29)The role of protein redox modification in the regulation of cardiovascular function   2020-10-19
(30)Precision Redox   2020-06-13
(31)Revising the redox theory of aging,   2020-01-06
(32) Function and Mechanism of Nitric Oxide   2019-11-03
(33)Redox response resistance and aging   2019-08-04
(34) Redox response resistance and ER Reductive Stress in Aging   2019-07-24
(35)S-nitros(yl)ation in cardiovascular disea   2019-04-19
(36)The effect and mechanism of Endoplasmic Reticulum reductive stress on aging   2019-04-18
(37)Increased GSNOR causes age-related cognitive impairment via denitrosation of CaMKIIα   2019-04-04
(38) Redox-stress Response Capacity and Aging   2019-01-13
(39)Redox-stress Response Capacity And Aging   2018-11-26
(40)Increased GSNOR causes age-related cognitive impairment via denitrosylation of CaMKIIα   2018第一届中国主动健康大会暨心脑联防共管高峰论坛   2018-10-28
(41)Increased GSNOR causes age-related cognitive impairment via denitrosylation of CaMKIIα   2018-10-19
(42) Revising Redox and Aging and the Mechanism of Traditional Chinese Medicine Biography   第四届世界华人暨第八届海峡两岸暨港澳地区 自由基生物学与自由基医学学术大会   2018-09-21
(43)氧化还原调控与衰老及中医药抗衰老机制   2018 衰老科学前沿论坛 (Frontiers in Geroscience, 2018) 暨衰老细胞生物学分会成立大会   2018-09-12
(44)氧化还原应激反应能力(RRC)与衰老    2018-08-24
(45)蛋白质巯基氧化还原修饰的检测与挑战   第二届全国自由基化学学术研讨会   2017-11-27
(46)神奇的一氧化氮   女科学家走基层广西行   2017-11-13
(47)氧化还原活性小分子与生物大分子作用   暨南大学中医学院“杏林大讲坛”   2017-11-11
(48)Say NO to aging related cognitive impairment and metabolic disorder   2017-11-03
(49)Say NO to aging related congnitive impairment   2017整合生理学学术研讨会   2017-10-23
(50)The decay of Redox-stress Response Capacity (RRC) is a substantive characteristic of aging: revising the redox theory of aging   2017-09-08
(51)The decay of Redox-stress Adaptive Capacity is a substantive characteristic of aging: revising the redox theory of aging   2017-07-15
(52) Reductive stress of ER and its function in aging   2016-11-16
(53)Abnormal metabolism of nitric oxide in aging and cognitive dysfunction   2016-10-21
(54)Abnormal metabolism of nitric oxide in aging and cognitive dysfunction   2016-10-20
(55)The homeostasis of nitric oxide and S-nitrosothiols in neurite growth and neurogenesis   chen chang   2015-11-29
(56)The homeostasis of nitric oxide and S-nitrosothiols in neurite growth and neurogenesis   chen chang   2015-11-18
(57)Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα   chen chang   2014-09-03
(58)Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-tumor strategy   chen chang   2014-07-07
(59)A novel suppressive effect of nitrosoglutathione reductase (GSNOR) in neurogenesis   chen chang   2014-03-22
(60)Say NO to SUMOylation: Crosstalk between S-nitrosation, ubiquitination and sumoylation   Jing Qu, Chang Chen   2012-02-05
(61)PI4KIIα, a new regulator of tumor growth   Jiangmei Li, Chang Chen   2011-10-30
(62)Functionnal study and method developing of S-nitrosation   Bo Huang,Chang Chen   2011-08-31
(63)Quantitative proteomic research and integrative analysis of S-nitrosated proteins in diabetic mouse liver with ICAT switch method.   Xu Zhang,Chang Chen   2011-04-28
(64)Specific quantitative high-throughput methods to detect S-nitrosation.   Bo Huang, Chang Chen   2010-11-07
(65)Nitric Oxide Metabolism Plays a Crucial Role in Visual Pattern Memory in Drosophila   Qinlong Hou, Chang Chen   2010-10-24
(66)New function of phosphatidylinositol 4-kinase type IIα (PI4KIIα)   Jiangmei Li, Chang Chen   2010-09-01
(67)Protein S-nitros(yl)ation in nuclear protein export regulation   Chang Chen   2010-08-23

指导学生

已指导学生

何杰  博士研究生  071011-生物物理学  

韩佩韦  博士研究生  071011-生物物理学  

李琳  硕士研究生  071011-生物物理学  

曲静  博士研究生  071011-生物物理学  

王铁鹏  博士研究生  071011-生物物理学  

周晞晞  博士研究生  071011-生物物理学  

侯勤龙  博士研究生  071011-生物物理学  

王鹏  博士研究生  071009-细胞生物学  

李江美  博士研究生  071009-细胞生物学  

吴凯源  博士研究生  071009-细胞生物学  

黄波  博士研究生  071009-细胞生物学  

张栩  博士研究生  071009-细胞生物学  

胡明曦  博士研究生  071009-细胞生物学  

李亚子  博士研究生  071009-细胞生物学  

赵莹莹  硕士研究生  071010-生物化学与分子生物学  

张伦峰  博士研究生  071009-细胞生物学  

张玉英  博士研究生  071009-细胞生物学  

高振  博士研究生  071009-细胞生物学  

乔新华  博士研究生  071009-细胞生物学  

李晓鹏  博士研究生  071009-细胞生物学  

吕振宇  硕士研究生  085238-生物工程  

张英敏  博士研究生  071009-细胞生物学  

郭苗苗  博士研究生  071009-细胞生物学  

陈于哲  硕士研究生  071010-生物化学与分子生物学  

吕振宇  博士研究生  071009-细胞生物学  

王圆圆  博士研究生  071009-细胞生物学  

时畅  硕士研究生  085238-生物工程  

叶傲君  博士研究生  071009-细胞生物学  

韩文生  博士研究生  071009-细胞生物学  

王家瑞  硕士研究生  071009-细胞生物学  

现指导学生

谢婷  博士研究生  071009-细胞生物学  

褚博煜  博士研究生  071009-细胞生物学  

李世龙  硕士研究生  071009-细胞生物学  

时浩洋  硕士研究生  071009-细胞生物学  

时畅  博士研究生  071009-细胞生物学  

朱乔丽  博士研究生  071009-细胞生物学  

邓明昊  博士研究生  071009-细胞生物学  

黄雨云飞  博士研究生  071009-细胞生物学  

刘哲文  硕士研究生  071006-神经生物学  

武暄淏  硕士研究生  071010-生物化学与分子生物学  

何雨珂  硕士研究生  071009-细胞生物学  

杨濛瑶  硕士研究生  071010-生物化学与分子生物学