可吸收生物医用高分子材料的合成和应用

   

070305-高分子化学与物理

生物医用高分子材料及应用
高分子合成

1993-09--1996-07   云南大学   理学硕士
1985-09--1989-06   四川师范大学化学系   学士

云南大学 --研究生

云南大学 -- 硕士

   

1996-07~现在, 中国科学院成都有机化学研究所, 研实员、助研、副研究员、研究员、硕导、博导
1989-06~1993-08,绵阳市212#中学, 中教二级

生物医用高分子材料

申请和授权专利：
1. 陈栋梁，李庆，邓先模，熊成东， 制膜装置，中国专利：ZL 2006 1 0167511.8（授权中国发明专利）
2. 陈栋梁，李庆，熊成东，一种可吸收医用膜，中国专利，CN1857235A
3. 陈栋梁，李庆，熊成东，张胜蓝，张志萍，一种制备１．４－二噁烷酮的方法，中国专利， CN101367789A
4. 陈栋梁，李庆，熊成东，制膜装置，中国专利，CN201046596Y（中国授权专利）
5. 熊成东，杨德娟，陈栋梁，李庆，可吸收生物医用膜，中国专利，CN1803204A
6.瞿美臻; 于作龙; 刘宝春; 刘多敏; 周固民; 陈栋梁; 张伯兰. 移动床催化裂解法连续制备碳纳米管. 中国发明专利， 授权公告号：CN1168656C, 授权公告日：2004.09.29

7.瞿美臻; 于作龙; 周德蓉; 陈栋梁; 李庆; 周固民; 张伯兰，回转型移动床反应器连续制备碳纳米管，中国发明专利， 授权公告号：CN1224573C, 授权公告日：2005.10.26

8.瞿美臻; 于作龙; 江奇; 周固民; 陈栋梁，碳纳米管用于超级电容器电极材料，中国发明专利，申请号：CN00132073.4，公开号：CN1357899A

9.瞿美臻; 王先忠; 陶家林; 李庆; 康星武; 林世浒; 陈栋梁; 于作龙，一种天然气旋焰乙炔炉余热喷油产混合气的使用方法，中国发明专利，申请号：CN99117433.X

10.陈和春;张大宏;熊成东;庞秀炳;陈栋梁，一种用于可降解输尿管支架管的复合材料及可降解输尿管支架管，中国发明专利，授权公告号：CN103041454B

11.熊成东; 陈和春;陈栋梁;王昕;陈龙;肖建平;包一红，一种可降解输尿管支架，授权公告号：CN112516390B

12.李庆; 曹烽;王琦;马驰;陈和春;熊成东;庞秀炳;陈栋梁，一种骨水泥灌装球囊装置，中国发明专利，授权公告号：CN102835995B

13.包一红;庞秀炳;曹烽;金国首;熊成东;陈栋梁;陈东源;张平，一种用于向弹夹内装载止血夹的包装盒，中国发明专利，授权公告号：CN104490445B

14.张志萍; 熊成东; 陈东源; 伍春林; 刘如意; 曹烽; 庞秀炳; 陈栋梁， 一种防脱落的止血夹，中国发明专利，申请号：CN201410084114.9

15.马驰; 熊左春; 熊成东; 蒋国华; 刘如意; 陈栋梁; 庞秀炳，可降解的防粘连复合膜及其制备方法，中国发明专利，申请号：CN201210557020.X，公开号：CN103007363A

16.曹烽; 熊成东; 包一红; 徐秀忠; 李宝春; 陈和春; 曹美刚; 曹湘湘; 陈栋梁; 张志萍; 包一良; 吴永良，非肾盂内固定的可降解输尿管支架，发明专利，申请号CN202210430712.1，公开号：CN114712031A

17.曹烽; 熊成东; 包一红; 陈和春; 包一良; 曹湘湘; 徐秀忠; 李宝春; 陈栋梁; 张志萍，一种可降解输尿管支架，发明专利，申请号CN202210302180.3，公开号：CN114587703A

18.李庆; 张轲; 陈东源; 熊成东; 陈栋梁; 石春霞; 张立静， 一种可吸收骨折内固定捆扎带材料及其制造方法，发明专利，申请号：CN202010271448.2，公开号（公开）CN111184919A

19.陈和春; 张丽芳; 熊成东; 陈栋梁; 李会玲; 彭丽君用于输尿管支架管的复合材料及改性可降解输尿管支架管，中国发明专利，申请号：CN201910689685.8，公开号：CN110330774A

20.陈栋梁; 鲁越; 曹剑飞; 熊成东; 陈和春; 熊左春，改性无机纳米粒子、改性无机纳米粒子/生物可降解聚酯类复合材料及其制备方法，中国发明专利，申请号：CN201810283580.8，公开号：CN110343372A

[1] 熊成东, 陈和春, 陈栋梁, 王昕, 陈龙, 肖建平, 包一红. 一种可降解输尿管支架. CN: CN112516390A, 2021-03-19.
[2] 李庆, 张轲, 陈东源, 熊成东, 陈栋梁, 石春霞, 张立静. 一种可吸收医用组合式捆绑带. CN: CN212699093U, 2021-03-16.
[3] 李庆, 张轲, 陈东源, 熊成东, 陈栋梁, 石春霞, 张立静. 一种可吸收骨折内固定捆扎带材料及其制造方法. CN: CN111184919A, 2020-05-22.
[4] 陈栋梁, 鲁越, 曹剑飞, 熊成东, 陈和春, 熊左春. 改性无机纳米粒子、改性无机纳米粒子/生物可降解聚酯类复合材料及其制备方法. CN: CN110343372A, 2019-10-18.
[5] 陈和春, 张丽芳, 熊成东, 陈栋梁, 李会玲, 彭丽君. 用于输尿管支架管的复合材料及改性可降解输尿管支架管. CN: CN110330774A, 2019-10-15.
[6] 包一红, 庞秀炳, 曹烽, 金国首, 熊成东, 陈栋梁, 陈东源, 张平. 一种用于向弹夹内装载止血夹的包装盒. CN: CN104490445B, 2016-10-05.
[7] 李庆, 曹烽, 王琦, 马驰, 陈和春, 熊成东, 庞秀炳, 陈栋梁. 一种骨水泥灌装球囊装置. CN: CN102835995B, 2015-07-29.
[8] 陈和春, 齐雪飞, 刘如意, 熊成东, 陈栋梁, 曹烽, 张平, 庞秀炳. 一种可止逆释放的止血夹施夹钳. CN: CN204336988U, 2015-05-20.
[9] 包一红, 庞秀炳, 曹烽, 金国首, 熊成东, 陈栋梁, 陈东源, 张平. 一种用于向弹夹内装载止血夹的包装盒. CN: CN204336990U, 2015-05-20.
[10] 陈东源, 华菲, 蒋国华, 熊成东, 陈栋梁, 曹烽, 张平, 庞秀炳. 一种便于补充止血夹的施夹钳. CN: CN204336985U, 2015-05-20.
[11] 包一红, 庞秀炳, 曹烽, 金国首, 熊成东, 陈栋梁, 陈东源, 张平. 一种用于向弹夹内装载止血夹的包装盒. CN: CN104490445A, 2015-04-08.
[12] 陈和春, 张大宏, 熊成东, 庞秀炳, 陈栋梁. 一种用于可降解输尿管支架管的复合材料及可降解输尿管支架管. CN: CN103041454B, 2014-11-05.
[13] 蒋柳云, 徐莉娟, 熊成东, 陈栋梁, 熊左春, 庞秀炳. 用于引导骨组织再生的复合膜及其制备方法. CN: CN104014003A, 2014-09-03.
[14] 张志萍, 熊成东, 陈东源, 伍春林, 刘如意, 曹烽, 庞秀炳, 陈栋梁. 一种防脱落的止血夹. CN: CN103919589A, 2014-07-16.
[15] 李庆, 曹烽, 王琦, 马驰, 陈和春, 熊成东, 庞秀炳, 陈栋梁. 一种骨水泥灌装球囊装置. CN: CN202875454U, 2013-04-17.
[16] 马驰, 熊左春, 熊成东, 蒋国华, 刘如意, 陈栋梁, 庞秀炳. 可降解的防粘连复合膜及其制备方法. CN: CN103007363A, 2013-04-03.
[17] 李庆, 曹烽, 王琦, 马驰, 陈和春, 熊成东, 庞秀炳, 陈栋梁. 一种骨水泥灌装球囊装置. CN: CN102835995A, 2012-12-26.
[18] 陈栋梁, 李庆, 邓先模, 熊成东. 制膜装置. CN: CN100540258C, 2009-09-16.
[19] 陈栋梁, 李庆, 熊成东, 张盛蓝, 张志萍. 一种制备1,4－二噁烷酮的方法. CN: CN101367789A, 2009-02-18.
[20] 陈栋梁, 李庆, 邓先模, 熊成东. 制膜装置. CN: CN201046596Y, 2008-04-16.
[21] 陈栋梁, 李庆, 熊成东. 一种可吸收医用膜. CN: CN1857235A, 2006-11-08.
[22] 熊成东, 杨德娟, 陈栋梁, 李庆. 可吸收生物医用膜. CN: CN1803204A, 2006-07-19.
[23] 瞿美臻, 于作龙, 周德蓉, 陈栋梁, 李庆, 周固民, 张伯兰. 回转型移动床反应器连续制备碳纳米管. CN: CN1224573C, 2005-10-26.
[24] 瞿美臻, 于作龙, 刘宝春, 刘多敏, 周固民, 陈栋梁, 张伯兰. 移动床催化裂解法连续制备碳纳米管. CN: CN1168656C, 2004-09-29.
[25] 瞿美臻, 于作龙, 周德蓉, 陈栋梁, 李庆, 周固民, 张伯兰. 回转型移动床反应器连续制备碳纳米管. CN: CN1406864A, 2003-04-02.
[26] 瞿美臻, 于作龙, 江奇, 周固民, 陈栋梁. 碳纳米管用于超级电容器电极材料. CN: CN1357899A, 2002-07-10.
[27] 瞿美臻, 于作龙, 刘宝春, 刘多敏, 周固民, 陈栋梁, 张伯兰. 移动床催化裂解法连续制备碳纳米管. CN: CN1317446A, 2001-10-17.
[28] 瞿美臻, 王先忠, 陶家林, 李庆, 康星武, 林世浒, 陈栋梁, 于作龙. 一种天然气旋焰乙炔炉余热喷油产混合气的使用方法. CN: CN1298859A, 2001-06-13.

   

[1] Li, Kaiqi, Liu, Xiliang, Fan, Youkun, Feng, Shaomin, Chen, Dongliang. Preventive effect of surface charge on encrustation of biodegradable ureteral stents. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION[J]. 2023, 34(2): 258-275, [2] 高分子通报null. 2023, [3] 肖冰玉, 熊左春, 冯少敏, 黄冬玲, 丁佳强, 吴锦秋, 陈栋梁. P（CL-TMC）的合成与性能研究. 塑料工业. 2022, 50(7): 32-36, https://d.wanfangdata.com.cn/periodical/slgy202207006.
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[6] He, Jianming, Liu, Shaoying, Chen, Dongliang, Wang, Gongying, Wang, Qingyin, Bai, Yuansheng. Preparation and characterization of high-performance fibers copolymerized by melamine formaldehyde with 1,4-cyclohexanedimethanol. JOURNAL OF APPLIED POLYMER SCIENCE[J]. 2022, 139(17): http://dx.doi.org/10.1002/app.52031.
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[9] 杜雨寒, 侯培杰, 邢璐瑶, 刘锡亮, 陈栋梁, 熊成东, 张丽芳. 生物3D打印PLCL/PPDO基骨修复支架. 合成化学. 2022, 30(10): 797-802, http://lib.cqvip.com/Qikan/Article/Detail?id=7108228541.
[10] Li Kaiqi, Chen Dongliang, Xiong, ZuoChun. Synthesis of new aliphatic poly(ester-carbonate)s bearing amino groups based on photolabile protecting group and evaluation of antibacterial property. POLYMERS FOR ADVANCED TECHNOLOGIES[J]. 2022, 33(4): 1100-1108, http://dx.doi.org/10.1002/pat.5583.
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[20] Jian He, Xulin Hu, Jianfei Cao, Yu Zhang, Jianping Xiao, liJun Peng, Dongliang Chen, Chengdong Xiong, Lifang Zhang. Chitosan-coated hydroxyapatite and drug-loaded polytrimethylene carbonate/polylactic acid scaffold for enhancing bone regeneration. CARBOHYDRATE POLYMERS. 2021, 253: [21] Liu, Xiliang, Liu, Song, Fan, Youkun, Qi, Jin, Wang, Xin, Bai, Wei, Chen, Dongliang, Xiong, Chengdong, Zhang, Lifang. Biodegradable cross-linked poly(L-lactide-co-epsilon-caprolactone) networks for ureteral stent formed by gamma irradiation under vacuum. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY[J]. 2021, 104: 73-84, http://dx.doi.org/10.1016/j.jiec.2021.08.014.
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[25] 袁明伟, 曹剑飞, 鲁越, 陈栋梁, 熊成东. 纳米ZnO-PLLA／聚乳酸复合薄膜的性能研究. 塑料工业[J]. 2018, 46(3): 124-127, http://lib.cqvip.com/Qikan/Article/Detail?id=674839357.
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[42] Chen Dongliang. Miscibility and isothermal crystallization behavior of poly(L-lactide-co –glycolide)/poly(para-dioxanone) composites. POLYMPOLYMCOMPOS. 2014, [43] 陈栋梁. PPDO/PLLA共混物相容性研究. 合成化学. 2014, [44] Wang, Bing, Dong, Jun, Li, Qijie, Xiong, Zuochun, Xiong, Chengdong, Chen, Dongliang. Mechanism of inhibition on L929 rat fibroblasts proliferation induced by potential adhesion barrier material poly(p-dioxanone-co-L-phenylalanine) electrospun membranes. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A[J]. 2014, 102(11): 4062-4070, [45] Wang, Bing, Ma, Chi, Xiong, ZuoChun, Bai, Wei, Xiong, ChengDong, Chen, DongLiang. Amino acid endcapped poly(p-dioxanone): synthesis and crystallization. JOURNAL OF POLYMER RESEARCH[J]. 2013, 20(4): [46] Wang, Bing, Ma, Chi, Xiong, ZuoChun, Xiong, ChengDong, Zhou, QuanHua, Chen, DongLiang. Synthesis of novel copolymer: Poly(p-dioxanone-co-L-phenylalanine). CHINESE CHEMICAL LETTERS[J]. 2013, 24(5): 392-396, http://dx.doi.org/10.1016/j.cclet.2013.03.017.
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[48] Jiang Liuyun, Xiong Chengdong, Jiang Lixin, Chen Dongliang, Li Qing. Effect of n-HA content on the isothermal crystallization, morphology and mechanical property of n-HA/PLGA composites. MATERIALS RESEARCH BULLETIN[J]. 2013, 48(3): 1233-1238, http://dx.doi.org/10.1016/j.materresbull.2012.11.113.
[49] 黄冬玲, 董军, 陈龙, 陈栋梁, 熊成东, 熊左春. 聚右旋丙交酯和聚左旋丙交酯乙交酯的制备及其共混物的结晶行为. 合成化学[J]. 2013, 21(4): 406-409,419, http://lib.cqvip.com/Qikan/Article/Detail?id=46759035.
[50] Wang, Bing, Ma, Chi, Xiong, ZuoChun, Xiong, ChengDong, Zhou, HongWei, Zhou, Quanhua, Chen, DongLiang. Regulating the physical and biological performances of poly(p-dioxanone) by copolymerization with L-phenylalanine. JOURNAL OF APPLIED POLYMER SCIENCE[J]. 2013, 130(4): 2311-2319, [51] Ma, Chi, Wang, Bing, Xiong, ChengDong, Chen, DongLiang, Xiong, ZuoChun. Dimensional stability of electrospun membranes of poly(L-lactide-co-glycolide)/poly(L-lactide-co-glycolide)-b-polyethylene glycol blends under stretch. JOURNAL OF POLYMER RESEARCH[J]. 2012, 19(12): [52] 陈栋梁. 粒子尺寸与表面改性对聚二氧环己酮（PPDO）/CaCO3复合物结晶性能的影响. 四川大学学报（工程科学版）. 2012, [53] Ma, Chi, Huang, DongLing, Chen, HeChun, Chen, DongLiang, Xiong, ZuoChun. Preparation and characterization of electrospun poly (lactide-co-glycolide) membrane with different L-lactide and D-lactide ratios. JOURNAL OF POLYMER RESEARCH[J]. 2012, 19(2): [54] Chen Dongliang. Preparation and characterization of electrospun poly(lactide-co-glycolide) membrane with different L-lactide and D-lactide reatios.. J. Polym. Res.. 2012, [55] Chen Dongliang. Effect of n-HA with different surface-modi?ed on the properties of n-HA/PLGA composite. Applied Surface Science 259 (2012) 72– 78. 2012, [56] Jiang Liuyun, Xiong Chengdong, Chen Dongliang, Jiang Lixin, Pang Xiubing. Effect of n-HA with different surface-modified on the properties of n-HA/PLGA composite. APPLIED SURFACE SCIENCE[J]. 2012, 259: 72-78, http://dx.doi.org/10.1016/j.apsusc.2012.06.091.
[57] Wang, Liansong, Chen, Hechun, Zhang, Lifang, Chen, Dongliang, Pang, Xiubing, Xiong, Chengdong. Biodegradable thermoplastic elastomer comprising PLLCA and CaCO3 whiskers: mechanical properties, thermal stability and shape memory properties. JOURNAL OF POLYMER RESEARCH[J]. 2011, 18(3): 329-336, [58] 吴航, 张丽芳, 熊左春, 马驰, 陈栋梁, 熊成东. 酯交换反应条件对聚（L-丙交酯-co-ε-己内酯）力学性能的影响. 合成化学[J]. 2011, 19(5): 590-594, http://lib.cqvip.com/Qikan/Article/Detail?id=39240119.
[59] Bai, Wei, Zhang, LiFang, Li, Qing, Chen, DongLiang, Xiong, ChengDong. In vitro hydrolytic degradation of poly(para-dioxanone)/poly(D,L-lactide) blends. MATERIALS CHEMISTRY AND PHYSICS[J]. 2010, 122(1): 79-86, http://dx.doi.org/10.1016/j.matchemphys.2010.02.064.
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[61] 庞迪, 叶京兵, 陈栋梁, 李箭, 熊成东, 李庆. PLLA和PLGA体内早期降解的对比研究. 生物医学工程学杂志[J]. 2010, 1298-1302, http://lib.cqvip.com/Qikan/Article/Detail?id=36457909.
[62] 鲁越, 熊左春, 张胜蓝, 熊成东, 陈栋梁. L-丙交酯与ε-己内酯共聚物微观结构与热力学性能研究. 中国塑料[J]. 2010, 29-33, http://lib.cqvip.com/Qikan/Article/Detail?id=33854515.
[63] 李广, 陈栋梁, 熊成东. 微波辐射下开环共聚合成聚乙交酯-丙交酯. 合成化学[J]. 2010, 18(3): 297-300, http://lib.cqvip.com/Qikan/Article/Detail?id=34198750.
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（ 1 ） ＂骨组织损伤固定修复材料及其临床应用研究＂, 参与, 中国科学院计划, 2007-04--2011-03
（ 2 ） “可吸收弹性输尿管支架管的研制及应用”, 参与, 中国科学院计划, 2009-01--2011-12
（ 3 ） “可吸收止血夹”, 参与, 地方任务, 2009-01--2011-12
（ 4 ） “可吸收生物夹材料合成”, 负责人, 其他任务, 2010-01--2011-01
（ 5 ） “可吸收扎带材料合成”, 负责人, 其他任务, 2010-01--2011-01
（ 6 ） 用于冠脉支架可吸收医用材料的制备研究, 负责人, 中国科学院计划, 2012-01--2014-12
（ 7 ） 可吸收医用辅料制备和应用研究, 负责人, 其他任务, 2015-01--2017-12
（ 8 ） 可吸收骨折内固定捆扎带, 负责人, 企业委托, 2017-03--2021-03
（ 9 ） 微动金属锁定接骨板系统, 负责人, 企业委托, 2017-03--2021-03
（ 10 ） 丙烯酸酯共聚物小试制备工艺研究, 负责人, 企业委托, 2018-07--2020-07
（ 11 ） 可降解皮下填充粉剂的研发, 负责人, 企业委托, 2018-11--2023-11
（ 12 ） 可降解输尿管支架的研发, 负责人, 企业委托, 2020-03--2025-03

已指导学生

鲁越  硕士研究生  070305-高分子化学与物理  

吴艾  硕士研究生  070305-高分子化学与物理  

王冰  博士研究生  070305-高分子化学与物理  

李丽楠  博士研究生  070305-高分子化学与物理  

鲁越  博士研究生  070305-高分子化学与物理  

李凯祺  博士研究生  070305-高分子化学与物理  

现指导学生

樊佑坤  博士研究生  070305-高分子化学与物理  

何建明  博士研究生  070305-高分子化学与物理