基本信息
曹玉锦  男  硕导  中国科学院青岛生物能源与过程研究所
电子邮件: caoyj@qibebt.ac.cn
通信地址: 青岛市崂山区松岭路189号
邮政编码:

招生信息

   
招生专业
081703-生物化工
招生方向
生物催化,生物合成,发酵工程

教育背景

2008-09--2011-07   中科院青岛生物能源与过程研究所   博士
2005-09--2008-07   中科院新疆理化技术研究所   硕士
1999-09--2003-07   北京大学   学士

工作经历

   
工作简历
2011-07~现在, 中科院青岛生物能源与过程研究所, 职工

专利与奖励

   
奖励信息
(1) 青岛市自然科学奖, 三等奖, 市地级, 2015
(2) 中国石油和化学工业联合会科学技术奖, 三等奖, 部委级, 2011
专利成果
[1] 张汝兵, 咸漠, 曹玉锦, 孙超. 一种高间苯三酚合成能力的基因工程菌及构建方法和应用. CN: CN106929527B, 2020-03-06.

[2] 咸漠, 刘炜, 袁珊, 张汝兵, 曹玉锦. 一种可提高间苯三酚生物合成产量并降低生产成本的基因工程菌及其构建方法与应用. CN: CN109943513A, 2019-06-28.

[3] 咸漠, 刘会洲, 郭静, 曹玉锦. 联产异戊二烯和1,3-丙二醇的基因工程菌及构建方法和应用. CN: CN106350476B, 2019-06-04.

[4] 咸漠, 孙超, 张汝兵, 曹玉锦, 刘辉. 一种用于大规模连续发酵的发酵与分离耦合系统. CN: CN106916726B, 2019-03-15.

[5] 张汝兵, 咸漠, 孙超, 刘炜, 曹玉锦. 一种高产2,4-二乙酰基间苯三酚的重组菌及其构建方法与应用. CN: CN109456927A, 2019-03-12.

[6] 咸漠, 蒋昱东, 刘炜, 曹玉锦. 一种体外酶反应生成1,2,4‑丁三醇的方法及应用. 中国: CN104450798B, 2018.02.02.

[7] 咸漠, 赵广, 刘敏, 曹玉锦, 刘长水. 一种高产间苯三酚的基因工程菌及其构建方法与应用. 中国: CN104388371B, 2018-05-04.

[8] 咸漠, 孙伟之, 张汝兵, 曹玉锦. 一种三硝基间苯三酚的绿色合成方法及应用. 中国: CN104926660A, 2015-09-23.

[9] 咸漠, 徐鑫, 曹玉锦, 张汝兵. 一种以乙酸为原料合成间苯三酚的基因工程菌及其构建方法与应用. 中国: CN104371966A, 2015-02-25.

[10] 咸漠, 刘炜, 曹玉锦, 孙超. 一种提高细胞间苯三酚合成产量的方法及应用. 中国: CN104357495A, 2015-02-18.

[11] 咸漠, 曹玉锦, 刘炜. 一种生物法合成木糖酸的方法. 中国: CN103865959A, 2014-06-18.

[12] 咸漠, 曹玉锦, 刘炜, 王纪明. 一种2-甲基赤藓糖醇4-磷酸胞苷酰转移酶突变体及其应用. 中国: CN103642767A, 2014-03-19.

[13] 咸漠, 程涛, 曹玉锦, 邹慧斌. 一种高效利用脂肪酸生产甲羟戊酸的方法及构建得到的基因工程菌. 中国: CN103571785A, 2014-02-12.

[14] 咸漠, 曹玉锦, 张汝兵, 曹志峰. 一种以甘油三酯为碳源的大肠杆菌及其在生物基化学品合成中的应用. 中国: CN103571786A, 2014-02-12.

[15] 咸漠, 曹玉锦, 赵国明, 张海波. 一种提高工程大肠杆菌间苯三酚合成能力的方法. 中国: CN102787135A, 2012-11-21.

出版信息

   
发表论文
[1] Liu, Hui, Cao, Yujin, Guo, Jing, Xu, Xin, Long, Qi, Song, Lili, Xian, Mo. Study on the isoprene-producing co-culture system of Synechococcus elongates-Escherichia coli through omics analysis. MICROBIAL CELL FACTORIES[J]. 2021, 20(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000608249600002.
[2] Feng, Xinming, Guo, Jing, Zhang, Rubing, Liu, Wei, Cao, Yujin, Xian, Mo, Liu, Huizhou. An Aminotransferase from Enhydrobacter aerosaccus to Obtain Optically Pure beta-Phenylalanine. ACS OMEGA[J]. 2020, 5(14): 7745-7750, [3] Cao, Yujin, Mu, Hui, Guo, Jing, Liu, Hui, Zhang, Rubing, Liu, Wei, Xian, Mo, Liu, Huizhou. Metabolic engineering of Escherichia coli for the utilization of ethanol. JOURNAL OF BIOLOGICAL RESEARCH-THESSALONIKI[J]. 2020, 27(1): http://dx.doi.org/10.1186/s40709-020-0111-0.
[4] Liu, Wen, Zhang, Rubing, Wei, Manman, Cao, Yujin, Xian, Mo. Increasing the pyruvate pool by overexpressing phosphoenolpyruvate carboxykinase or triosephosphate isomerase enhances phloroglucinol production in Escherichia coli. Biotechnology Letters[J]. 2020, 42(4): 633-640, https://www.webofscience.com/wos/woscc/full-record/WOS:000519159800013.
[5] Yuan Shan, Zhang Rubing, Cao Yujin, Guo Jing, Xian Mo, Liu Wei. New expression system to increase the yield of phloroglucinol. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT[J]. 2020, 34(1): 405-412, https://doaj.org/article/8434c3c3685a4d6b89d2214cc1ee3917.
[6] Mu, Hui, Zhao, Chunhui, Zhao, Yuxiao, Hua, Dongliang, Li, Yan, Zhang, Xiaodong, Cao, Yujin. Optimizing Methane Production from Anaerobic Batch Co-Digestion of Apple Pomace and Vegetable Waste. JOURNAL OF BIOBASED MATERIALS AND BIOENERGY[J]. 2019, 13(4): 508-516, https://www.webofscience.com/wos/woscc/full-record/WOS:000473061100010.
[7] Guo, Jing, Cao, Yujin, Liu, Hui, Zhang, Rubing, Xian, Mo, Liu, Huizhou. Improving the production of isoprene and 1,3-propanediol by metabolically engineered Escherichia coli through recycling redox cofactor between the dual pathways. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 103(6): 2597-2608, https://www.webofscience.com/wos/woscc/full-record/WOS:000463023900011.
[8] Cao, Yujin, Zhang, Rubing, Liu, Wei, Zhao, Guang, Niu, Wei, Guo, Jiantao, Xian, Mo, Liu, Huizhou. Manipulation of the precursor supply for high-level production of longifolene by metabolically engineered Escherichia coli. SCIENTIFIC REPORTS[J]. 2019, 9(1): https://doaj.org/article/42f5a2254dae4515900e791e9c31ba18.
[9] Cao, Yujin, Mu, Hui, Liu, Wei, Zhang, Rubing, Guo, Jing, Xian, Mo, Liu, Huizhou. Electricigens in the anode of microbial fuel cells: pure cultures versus mixed communities. MICROBIAL CELL FACTORIESnull. 2019, 18(1): https://doaj.org/article/bb3f7264f2b240b49f3e6b7b0599b9ba.
[10] Cao, Yujin, Zhang, Haibo, Liu, Hui, Liu, Wei, Zhang, Rubing, Xian, Mo, Liu, Huizhou. Biosynthesis and production of sabinene: current state and perspectives. APPLIED MICROBIOLOGY AND BIOTECHNOLOGYnull. 2018, 102(4): 1535-1544, [11] Cao, Yujin, Zhang, Rubing, Cheng, Tao, Guo, Jing, Xian, Mo, Liu, Huizhou. Imidazolium-based ionic liquids for cellulose pretreatment: recent progresses and future perspectives. APPLIED MICROBIOLOGY AND BIOTECHNOLOGYnull. 2017, 101(2): 521-532, http://ir.qibebt.ac.cn/handle/337004/9174.
[12] Zhang, Rubing, Liu, Wei, Cao, Yujin, Xu, Xin, Xian, Mo, Liu, Huizhou. An in vitro synthetic biosystem based on acetate for production of phloroglucinol. BMC Biotechnology[J]. 2017, 17(1): http://www.irgrid.ac.cn/handle/1471x/1755637.
[13] Huizhou Liu, Rubing Zhang, Yujin Cao, Wei Liu, Mo Xian. Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression. Microbial Cell Factories,. Microbial Cell Factories[J]. 2017, 227-237, http://www.irgrid.ac.cn/handle/1471x/1755936.
[14] Zhang, Rubing, Cao, Yujin, Liu, Wei, Xian, Mo, Liu, Huizhou. Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression. Microbial Cell Factories[J]. 2017, 16(1): http://www.irgrid.ac.cn/handle/1471x/1755376.
[15] Liu, Wei, Xu, Xin, Zhang, Rubing, Cheng, Tao, Cao, Yujin, Li, Xiaoxiao, Guo, Jiantao, Liu, Huizhou, Xian, Mo. Engineering Escherichia coli for high-yield geraniol production with biotransformation of geranyl acetate to geraniol under fed-batch culture. BIOTECHNOLOGY FOR BIOFUELS[J]. 2016, 9(JUN): http://ir.qibebt.ac.cn/handle/337004/8058.
[16] Cao, Yujin, Cheng, Tao, Zhao, Guang, Niu, Wei, Guo, Jiantao, Xian, Mo, Liu, Huizhou. Metabolic engineering of Escherichia coli for the production of hydroxy fatty acids from glucose. BMC BIOTECHNOLOGY[J]. 2016, 16(16): http://ir.qibebt.ac.cn/handle/337004/8054.
[17] Huizhou Liu, Yujin Cao, Rubing Zhang, Tao Cheng, Jing Guo, Mo Xian. Imidazolium-based ionic liquids for cellulose pretreatment: recentprogresses and future perspectives.. Appl Microbiol Biotechnol[J]. 2016, 101: 521-532, http://ir.qibebt.ac.cn/handle/337004/9890.
[18] 郭静, 曹玉锦, 咸漠, 刘会洲. 大肠杆菌生产异戊二烯的代谢工程研究进展. 生物工程学报[J]. 2016, 32(8): 1026-1037, [19] Liu, Wei, Xu, Xin, Zhang, Rubing, Cheng, Tao, Cao, Yujin, Li, Xiaoxiao, Guo, Jiantao, Liu, Huizhou, Xian, Mo. Engineering Escherichia coli for high-yield geraniol production with biotransformation of geranyl acetate to geraniol under fed-batch culture (vol 9, 58, 2016). BIOTECHNOLOGY FOR BIOFUELSnull. 2016, 9(JUN): http://ir.ipe.ac.cn/handle/122111/21171.
[20] 杨洁, 曹玉锦. 新一代基因组编辑技术-NgAgo-gDNA. 生物学教学. 2016, 41(11): 75-75, http://lib.cqvip.com/Qikan/Article/Detail?id=670415707.
[21] Zheng, Yanning, Li, Lingling, Liu, Qiang, Zhang, Haibo, Cao, Yujin, Xian, Mo, Liu, Huizhou. High-specificity synthesis of novel monomers by remodeled alcohol hydroxylase. BMC BIOTECHNOLOGY[J]. 2016, 16(1): http://ir.qibebt.ac.cn/handle/337004/8498.
[22] Zhang, Haibo, Zhou, Fengli, Jiang, Xinglin, Cao, Mingle, Wang, Shilu, Zou, Huibin, Cao, Yujin, Xian, Mo, Liu, Huizhou. Microbial production of amino acid-modified spider dragline silk protein with intensively improved mechanical properties. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2016, 46(6): 552-558, http://www.irgrid.ac.cn/handle/1471x/1110004.
[23] Cao, Yujin, Niu, Wei, Guo, Jiantao, Xian, Mo, Liu, Huizhou. Biotechnological production of 1,2,4-butanetriol: An efficient process to synthesize energetic material precursor from renewable biomass. SCIENTIFIC REPORTS[J]. 2015, 5: http://ir.qibebt.ac.cn/handle/337004/6842.
[24] 曹玉锦, 咸漠, 刘会洲. 大宗化学品可持续化工—生物融合转化探析. 中国科学. 化学[J]. 2015, 45(5): 501-509, [25] Jiang, Yudong, Liu, Wei, Cheng, Tao, Cao, Yujin, Zhang, Rubing, Xian, Mo. Characterization of D-xylonate dehydratase YjhG from Escherichia coli. BIOENGINEERED[J]. 2015, 6(4): 227-232, http://ir.qibebt.ac.cn/handle/337004/6521.
[26] 咸漠, 曹玉锦. 从生物质到火炸药:含能材料的生物合成. 火炸药学报[J]. 2015, 38(2): 1-, http://ir.qibebt.ac.cn/handle/337004/8678.
[27] Zhang, Haibo, Liu, Qiang, Cao, Yujin, Feng, Xinjun, Zheng, Yanning, Zou, Huibin, Liu, Hui, Yang, Jianming, Xian, Mo. Microbial production of sabinene-a new terpene-based precursor of advanced biofuel. MICROBIAL CELL FACTORIES[J]. 2014, 13(1): 20-20, http://ir.qibebt.ac.cn/handle/337004/12577.
[28] Liu, Hui, Cheng, Tao, Xian, Mo, Cao, Yujin, Fang, Fang, Zou, Huibin. Fatty acid from the renewable sources: A promising feedstock for the production of biofuels and biobased chemicals. BIOTECHNOLOGY ADVANCESnull. 2014, 32(2): 382-389, http://dx.doi.org/10.1016/j.biotechadv.2013.12.003.
[29] Cao, Yujin, Liu, Wei, Xu, Xin, Zhang, Haibo, Wang, Jiming, Xian, Mo. Production of free monounsaturated fatty acids by metabolically engineered Escherichia coli. BIOTECHNOLOGY FOR BIOFUELS[J]. 2014, 7(1): http://ir.qibebt.ac.cn/handle/337004/6298.
[30] Cao, Yujin, Zhang, Rubing, Sun, Chao, Cheng, Tao, Liu, Yuhua, Xian, Mo. Fermentative Succinate Production: An Emerging Technology to Replace the Traditional Petrochemical Processes. BIOMED RESEARCH INTERNATIONALnull. 2013, 2013: http://www.irgrid.ac.cn/handle/1471x/830126.
[31] Cao, Yujin, Xian, Mo, Zou, Huibin, Zhang, Haibo. Metabolic Engineering of Escherichia coli for the Production of Xylonate. PLOS ONE[J]. 2013, 8(7): http://www.irgrid.ac.cn/handle/1471x/830128.
[32] Jiang, Xinglin, Zhang, Haibo, Yang, Jianming, Zheng, Yanning, Feng, Dexin, Liu, Wei, Xu, Xin, Cao, Yujin, Zou, Huibin, Zhang, Rubin, Cheng, Tao, Jiao, Fengjiao, Xian, Mo. Biodegradation-inspired bioproduction of methylacetoin and 2-methyl-2,3-butanediol (vol 3, 2445, 2013). SCIENTIFIC REPORTSnull. 2013, 3(1): http://www.irgrid.ac.cn/handle/1471x/1001140.
[33] Jiang, Xinglin, Zhang, Haibo, Yang, Jianming, Liu, Min, Feng, Hongru, Liu, Xiaobin, Cao, Yujin, Feng, Dexin, Xian, Mo. Induction of gene expression in bacteria at optimal growth temperatures. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2013, 97(12): 5423-5431, http://www.irgrid.ac.cn/handle/1471x/830130.
[34] Zou, Huibin, Wu, Zaiqiang, Xian, Mo, Liu, Hui, Cheng, Tao, Cao, Yujin. Not only osmoprotectant: Betaine increased lactate dehydrogenase activity and L-lactate production in lactobacilli. BIORESOURCE TECHNOLOGY[J]. 2013, 148(148c): 591-595, http://dx.doi.org/10.1016/j.biortech.2013.08.105.
[35] 刘敏, 刘建忠, 冯红茹, 杨建明, 苏思正, 曹玉锦. 异戊二烯焦磷酸异构酶的表达及其催化功能验证. 武汉科技大学学报:自然科学版. 2013, 36(3): 214-218, http://lib.cqvip.com/Qikan/Article/Detail?id=46004844.
[36] Jiang, Xinglin, Zhang, Haibo, Yang, Jianming, Zheng, Yanning, Feng, Dexin, Liu, Wei, Xu, Xin, Cao, Yujin, Zou, Huibin, Zhang, Rubin, Cheng, Tao, Jiao, Fengjiao, Xian, Mo. Biodegradation-inspired bioproduction of methylacetoin and 2-methyl-2,3-butanediol. SCIENTIFIC REPORTS[J]. 2013, 3(3): http://www.irgrid.ac.cn/handle/1471x/830138.
[37] Wang, Qi, Yang, Peng, Xian, Mo, Liu, Hui, Cao, Yujin, Yang, Ying, Zhao, Guang. Production of Block Copolymer Poly(3-hydroxybutyrate)-block-poly(3-hydroxypropionate) with Adjustable Structure from an Inexpensive Carbon Source. ACS MACRO LETTERS[J]. 2013, 2(11): 996-1000, http://ir.qibebt.ac.cn/handle/337004/6033.
[38] Wang, Xiangwei, Li, Lingling, Zheng, Yanning, Zou, Huibin, Cao, Yujin, Liu, Hui, Liu, Wei, Xian, Mo. Biosynthesis of long chain hydroxyfatty acids from glucose by engineered Escherichia coli. BIORESOURCE TECHNOLOGY[J]. 2012, 114(114): 561-566, http://dx.doi.org/10.1016/j.biortech.2012.02.119.
[39] Zheng, Yanning, Li, Lingling, Liu, Qiang, Qin, Wen, Yang, Jianming, Cao, Yujin, Jiang, Xinglin, Zhao, Guang, Xian, Mo. Boosting the free fatty acid synthesis of Escherichia coli by expression of a cytosolic Acinetobacter baylyi thioesterase. BIOTECHNOLOGY FOR BIOFUELS[J]. 2012, 5(1): 76-76, http://www.irgrid.ac.cn/handle/1471x/834372.
[40] Meng, Xin, Yang, Jianming, Cao, Yujin, Li, Liangzhi, Jiang, Xinglin, Xu, Xin, Liu, Wei, Xian, Mo, Zhang, Yingwei. Increasing fatty acid production in E. coli by simulating the lipid accumulation of oleaginous microorganisms. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2011, 38(8): 919-925, http://www.irgrid.ac.cn/handle/1471x/265158.
[41] Wang, Xiangwei, Zhao, Guoming, Zou, Huibin, Cao, Yujin, Zhang, Yongguang, Zhang, Rubing, Zhang, Fan, Xian, Mo. The base-free and selective oxidative transformation of 1,3-propanediol into methyl esters by different Au/CeO2 catalysts. GREEN CHEMISTRY[J]. 2011, 13(10): 2690-2695, http://www.irgrid.ac.cn/handle/1471x/515901.
[42] Cao, Yujin, Xian, Mo. Production of phloroglucinol by Escherichia coli using a stationary-phase promoter. BIOTECHNOLOGY LETTERS[J]. 2011, 33(9): 1853-1858, http://www.irgrid.ac.cn/handle/1471x/515899.
[43] Cao, Yujin, Jiang, Xinglin, Zhang, Rubing, Xian, Mo. Improved phloroglucinol production by metabolically engineered Escherichia coli. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2011, 91(6): 1545-1552, http://www.irgrid.ac.cn/handle/1471x/265157.
[44] Yu, Chao, Cao, Yujin, Zou, Huibin, Xian, Mo. Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols. APPLIED MICROBIOLOGY AND BIOTECHNOLOGYnull. 2011, 89(3): 573-583, http://www.irgrid.ac.cn/handle/1471x/265159.
[45] Cao, Yujin, Yang, Jianming, Xian, Mo, Xu, Xin, Liu, Wei. Increasing unsaturated fatty acid contents in Escherichia coli by coexpression of three different genes. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2010, 87(1): 271-280, http://www.irgrid.ac.cn/handle/1471x/265148.
[46] Cao, Yujin, Xian, Mo, Yang, Jianming, Xu, Xin, Liu, Wei, Li, Liangzhi. Heterologous expression of stearoyl-acyl carrier protein desaturase (S-ACP-DES) from Arabidopsis thaliana in Escherichia coli. PROTEIN EXPRESSION AND PURIFICATION[J]. 2010, 69(2): 209-214, http://dx.doi.org/10.1016/j.pep.2009.08.011.
[47] 孟鑫, 曹玉锦, 杨建明, 咸漠.. 工程大肠杆菌制备燃料脂肪酸. 中国新能源及可再生能源科技发展论坛null. 2009, http://ir.qibebt.ac.cn/handle/337004/1128.

科研活动

   
科研项目
( 1 ) 脂肪酸ω-羟化酶催化特异性研究, 主持, 国家级, 2013-01--2015-12
( 2 ) XXX的稳定生产技术, 主持, 国家级, 2016-11--2018-11
( 3 ) XXX的生物合成, 主持, 国家级, 2016-11--2018-11
( 4 ) XXX工程化技术, 主持, 国家级, 2017-01--2020-12