生物信息学，人工智能与机器学习，健康信息学，健康大数据

   

081203-计算机应用技术
083100-生物医学工程

生物医学大数据与人工智能
健康信息学
生物信息学

2001-09--2007-01   清华大学   博士学位
1997-09--2001-07   清华大学   工学学士学位

   

2011-06~现在, 中国科学院深圳先进技术研究院, 副研究员,研究员
2007-10~2011-04,美国佛罗里达大学, 博士后

   

（1） Bridging the interpretability gap for medical artificial intelligence models using class-association manifold learning, Nature Biomedical Engineering, 2026, 第 11 作者  通讯作者
（2） Weakly Supervised Lesion Localization and Attribution for OCT Images with a Guided Counterfactual Explainer Model, Expert Systems with Applications, 2025, 第 7 作者  通讯作者
（3） ProtChat: An AI Multi-Agent for Automated Protein Analysis Leveraging GPT-4 and Protein Language Model, Journal of Chemical Information and Modeling, 2024, 第 5 作者  通讯作者
（4） Accurate Explanation Model for Image Classifiers using Class Association Embedding, 2024 IEEE 40th International Conference on Data Engineering (ICDE), 2024, 第 6 作者  通讯作者
（5） DPN: Dynamics Priori Networks for Radiology Report Generation, Tsinghua Science and Technology, 2024, 第 5 作者  通讯作者
（6） Graph Polish: A Novel Graph Generation Paradigm for Molecular Optimization, IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS, 2023, 第 4 作者  通讯作者
（7） Classification of Medical Image Notes for Image Labeling by Using MinBERT, Classification of Medical Image Notes for Image Labeling by Using MinBERT, TSINGHUA SCIENCE AND TECHNOLOGY, 2023, 第 7 作者  通讯作者
（8） Smoothness Sensor: Adaptive Smoothness-Transition Graph Convolutions for Attributed Graph Clustering, IEEE TRANSACTIONS ON CYBERNETICS, 2022, 第 4 作者  通讯作者
（9） Heterogeneous Graph Convolutional Networks and Matrix Completion for miRNA-Disease Association Prediction, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 第 4 作者  通讯作者
（10） A novel hybrid network of fusing rhythmic and morphological features for atrial fibrillation detection on mobile ECG signals, NEURAL COMPUTING & APPLICATIONS, 2020, 第 6 作者  通讯作者
（11） Risk stratification of cutaneous melanoma reveals carcinogen metabolism enrichment and immune inhibition in high-risk patients, AGING-US, 2020, 第 2 作者  通讯作者
（12） Accurate Prediction of Coronary Heart Disease for Patients With Hypertension From Electronic Health Records With Big Data and Machine-Learning Methods: Model Development and Performance Evaluation, JMIR MEDICAL INFORMATICS, 2020, 第 10 作者  通讯作者
（13） A System Analysis of the Relationships between Anemia and Ischemic Stroke Rehabilitation based on RNA-Seq data, Frontiers in Genetics, 2019, 第 1 作者  通讯作者
（14） Better prognostic determination and feature characterization of cutaneous melanoma through integrative genomic analysis, AGING (ALBANY NY), 2019, 第 2 作者
（15） A benchmark study of sequence alignment methods for protein clustering, BMC BIOINFORMATICS, 2018, 第 3 作者  通讯作者
（16） Mobile GPU-based implementation of automatic analysis method for long-term ECG., BIOMEDICAL ENGINEERING ONLINE, 2018, 第 5 作者  通讯作者
（17） ESPRIT-FOREST:parallel clustering of massive amplicon sequence data in subquadratic time, PLOS COMPUTATIONAL BIOLOGY, 2017, 第 1 作者  通讯作者
（18） Multi-label Learning for Predicting the Activities of Antimicrobial Peptides, SCIENTIFIC REPORTS, 2017, 第 6 作者  通讯作者
（19） A survey on database resources for microRNA–disease relationships, BRIEFINGS IN FUNCTIONAL GENOMICS, 2017, 第 2 作者  通讯作者
（20） Obtaining Human Ischemic Stroke Gene Expression Biomarkers from Animal Models: A Cross-species Validation Study, SCIENTIFIC REPORTS, 2016, 第 2 作者  通讯作者
（21） Evolving-Pattern Analysis of Transient and Long-Term Biomarkers for Cancers: Hepatocellular Carcinoma as a Case, INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2015, 第 2 作者  通讯作者
（22） Risk Prediction of One-Year Mortality in Patients with Cardiac Arrhythmias Using Random Survival Forest, COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2015, 第 2 作者
（23） OVERSAMPLING METHOD FOR IMBALANCED CLASSIFICATION, COMPUTING AND INFORMATICS, 2015, 第 2 作者
（24） Differential impacts of juvenile hormone, soldier head extract and alternatecaste phenotypes on host and symbiont transcriptome composition in the gut ofthe termite Reticulitermes flavipes, BMCGENOMICS, 2013, 第 3 作者
（25） The hindgut lumen prokaryotic microbiota of the termite Reticulitermes flavipes and its responses to dietary lignocellulose composition, MOLECULAR ECOLOGY, 2013, 第 2 作者
（26） Comparative metatranscriptomic signatures of wood and paper feeding in the gut of the termite Reticulitermes flavipes (Isoptera: Rhinotermitidae), INSECT MOLECULAR BIOLOGY, 2013, 
（27） A Candidate Molecular Biomarker Panel for the Detection of Bladder Cancer, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2012, 第 3 作者
（28） Secondary structure information does not improve OTU assignment for partial 16s rRNA sequences, ISME JOURNAL, 2012, 第 2 作者
（29） A large-scale benchmark study of existing algorithms for taxonomy-independent microbial community analysis, BRIEFINGS IN BIOINFORMATICS, 2012, 第 2 作者
（30） ESPRIT-Tree: hierarchical clustering analysis of millions of 16S rRNA pyrosequences in quasilinear computational time, NUCLEIC ACIDS RESEARCH, 2011, 第 1 作者
（31） Fast Implementation of l1 Regularized Learning Algorithms Using Gradient Descent Methods, 10th SIAM International Conference on Data Mining, 2010, 第 1 作者
（32） Advanced computational algorithms for microbial community analysis using massive 16S rRNA sequence data, NUCLEIC ACIDS RESEARCH, 2010, 第 2 作者
（33） Effective structure learning for EDA via L1-regularizedbayesian networks, Proceedings of the 12th annual conference on Genetic and evolutionary computation conference, 2010, 第 1 作者
（34） ESPRIT: estimating species richness using large collections of 16S rRNA pyrosequences, NUCLEIC ACIDS RESEARCH, 2009, 第 2 作者
（35） Online Feature Selection Algorithm with Bayesian l(1) Regularization, ADVANCESINKNOWLEDGEDISCOVERYANDDATAMININGPROCEEDINGS, 2009, 第 1 作者  通讯作者
（36） Duple-EDA and sample density balancing, Duple-EDA and sample density balancing, 中国科学F辑英文版, 2009, 第 1 作者
（37） Semi-Supervised Feature Selection Under Logistic I-RELIEF Framework, 19TH INTERNATIONAL CONFERENCE ON PATTERN RECOGNITION, VOLS 1-6, 2008, 第 2 作者
（38） Combining Nomogram and Microarray Data for Predicting Prostate Cancer Recurrence, 8TH IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING, VOLS 1 AND 2, 2008, 第 2 作者
（39） Cross Entropy and Adaptive Variance Scaling in Continuous EDA, GECCO 2007: GENETIC AND EVOLUTIONARY COMPUTATION CONFERENCE, VOL 1 AND 2, 2007, 第 1 作者  通讯作者
（40） Probabilistic Modeling for continuous EDA with Boltzmann selection and Kullback-Leibeler divergence, GECCO 2006: GENETIC AND EVOLUTIONARY COMPUTATION CONFERENCE, VOL 1 AND 2, 2006, 第 1 作者  通讯作者
（41） Global planning from local eyeshot: An implementation of observation-based plan coordination in robocup simulation games, Lecture Notes in Computer Science 2377, 2002, 第 1 作者

   

（ 1 ） 时空与模态异构跨病种SDB 队列的融合建模 和挖掘分析, 负责人, 国家任务, 2025-02--2029-01
（ 2 ） 元件智能设计平台, 负责人, 中国科学院计划, 2025-01--2027-01
（ 3 ） 新型生物医学研究支撑系统的知识整合研究服务体系, 负责人, 中国科学院计划, 2020-01--2024-12
（ 4 ） 面向代谢疾病的肠道菌群分析关键技术研发, 负责人, 地方任务, 2017-07--2019-06
（ 5 ） 慢病运动康复服务系统在社区的示范应用, 负责人, 中国科学院计划, 2016-01--2017-12
（ 6 ） 穿戴式睡眠监测与夜间心脑血管事件预 警系统, 负责人, 地方任务, 2016-01--2018-12
（ 7 ） 健康大数据分析技术工程实验室, 负责人, 地方任务, 2016-01--2018-12
（ 8 ） 面向进化基因组学的高通量测序数据流形建模, 负责人, 国家任务, 2015-01--2018-12
（ 9 ） 脑肿瘤网络登记平台的建立和维护, 负责人, 国家任务, 2015-01--2017-12
（ 10 ） 基于伪度量空间分割树的超高深度测序比对处理与定量基因组学分析, 负责人, 国家任务, 2013-01--2015-12
（ 11 ） 心脑血管疾病的异构数据整合性预警建模技术, 参与, 地方任务, 2013-01--2015-12
（ 12 ） 先进院择优中心资助, 参与, 研究所自主部署, 2012-01--2012-12
（ 13 ） 先进院低成本健康2012年重点突破经费/子课题, 负责人, 研究所自主部署, 2012-01--2013-12