General

Jun CAI, Professor, Beijing Institute of Genomics, CAS

Email: juncai@big.ac.cn

Research Areas

 

Major areas of research interests

l  New genomic technologies including single-cell genomics and bioinformatics methods for identification of genomic variations in various types of somatic cells

l  Identification of heterogeneity, cell lineages and cell evolution of somatic cell populations

l  Inference of the underlying key mutations or genes driving abnormal cell proliferation in disease occurrence



Education

 l  2005 - Ph.D.: in Computational Biology, Department of Automation, Tsinghua University, China.


 l  1999 - B.S.: Department of Automation, Tsinghua University, China.

 


Experience

   
Work Experience

l  2016 - Now: Adjunct professor, Savaid Medical School, University of Chinese Academy of Sciences, China.


l  2015 - Now: Principal Investigator, Beijing Institute of Genomics, CAS, China;


l  2009 - 2014: Research Investigator, Beijing Institute of Genomics, CAS, China.


l  2006 - 2008: Postdoctoral associate, Department of Bioengineering, University of Illinois at Urbana-Champaign (UIUC), USA.


Publications

 

(1)   Xuexia Miao#, Xi Li#, Lifei Wang, Caihong Zheng*, Jun Cai*, DSMNC: a database of somatic mutations in normal cells, Nucleic Acids Research, gky1045, 2018, https://doi.org/10.1093/nar/gky1045 (Corresponding author)

 

(2)   Shuai Gao#, Caihong Zheng#, Gang Chang#, Wenqiang Liu, Xiaochen Kou, Kun Tian, Li Tao, Kai Xu, Hong Wang, Jun Cai*, Jianhui Tian*, Shaorong Gao*, Unique Features of Mutations Revealed by Sequentially Reprogrammed Induced Pluripotent Stem Cells, Nature Communications, 2015.2.18, 6 (Citations: 15; Co-corresponding author)

 

(3)   Jun Cai, Xuexia Miao, Yueying Li, Cory Smith, Kitman Tsang, Linzhao Cheng*, Qian-fei Wang*, Whole-Genome Sequencing Identifies Genetic Variances in Culture-Expanded Human Mesenchymal Stem Cells, Stem Cell Reports, 2014.8.12, 3(2): 227~233 (Citations: 7; the first author))

 

(4)   Caihong Zheng, Xuexia Miao, Yanen Li, Ying Huang, Jue Ruan, Xi Ma, Li Wang, Chung-I Wu*, Jun Cai*, Determination of Genomic Copy Number Alteration Emphasizing a Restriction-site Based Strategy of Genome Re-sequencing, Bioinformatics, 2013.11.15, 29(22): 2813~2821 (Citations: 3; Corresponding author)

 

(5)    Lan Jiang#, Jing Zhang#, Jing-Jing Wang#, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci*, Jiang Liu*, Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos, Cell, 2013.5.9, 153(4): 773~784. (Citations: 139; Co-author)

 

(6)   Yong Tao#, Jue Ruan#, Shiou-Hwei Yeh#, Xuemei Lu#, Yu Wang#, Weiwei Zhai#, Jun Cai#, Shaoping Ling, Qiang Gong, Zecheng Chong, Zhengzhong Qu, Qianqian Li, Jiang Liu, Jin Yang, Caihong Zheng, Changqing Zeng, Hurng-Yi Wang, Jing Zhang, Sheng-Han Wang, Lingtong Hao, Lili Dong, Wenjie Li, Min Sun, Wei Zou, Caixia Yu, Chaohua Li, Guojing Liu, Lan Jiang, Jin Xu, Huanwei Huang, Chunyan Li, Shuangli Mi, Bing Zhang, Baoxian Chen, Wenming Zhao, Songnian Hu, Shi-Mei Zhuang, Yang Shen, Suhua Shi, Christopher Brown, Kevin P. White, Ding-Shinn Chen*, Pei-Jer Chen*, Chung-I Wu*, Rapid Growth of a Hepatocellular Carcinoma And the Driving Mutations Revealed by Cell-population Genetic Analysis of Whole-genome Data, Proceedings of the National Academy of Sciences of the United States of America, 2011.7.19, 108(29): 12042~12047 (Citations: 52; Co-first author)


Team members

(1)   PICai Jun

(2)   Team Staff: 

Dr. Zheng Caihong, 

Dr. Miao Xuexia, 

Dr. Ren Likun

(3)   Students:

Xu Wenqiu (2014 - present)

Wang Lifei (2015 - present)

Nie Rui (2015 - present)

Yu Zeyang (2016 - present)

Cui Boyu (2016 - present)

Wang Xiaodan (2017 - present)

Xiao Jingshu (2017 - present)

Li Xi (2018 - present)

Li Panpan (2019 - present)

Wang Cuixia (2019 - present)

(4) Graduated students: 

Miao Xuexia (PhD)

Zhuang wen (Master)

Li Xuan (Master)

Zhang Zhuofan (Master)

Zhao Ning (Master)