Free Radical Chemistry/Toxicology; Mechanism of Synergistic Toxicity

PhD. (1999) Biochemistry, Hebrew University-Hadassah Medical School (Jerusalem, Israel)

                 MSc. (1989) Organic Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS) (Lanzhou, China)

   

2013-present, Director, the Joint Institute of Environmental Sciences, Research Center for Eco-Environmental Sciences, CAS and Hong Kong Baptist University

2006-present, Professor, Research Center for Eco-Environmental Sciences, CAS

2006-present, Affiliated Faculty Member, Linus Pauling Institute, Oregon State University

2002-2006, Assistant Professor (Sr. Res.) and Principal Investigator, Linus Pauling Institute, Oregon State  University

1999-2002, Faculty Research Associate, Linus Pauling Institute, Oregon State  University

1992-1993, Visiting Scholar, Hebrew University-Hadassah Medical School, Israel

1989-1995, Lecturer, Qingdao University Medical  School

Free radical chemistry and biology

   

1. Zhu B.Z., Chao X.J., Huang C.H., Li Y. (2016) Delivering the cell-impermeable DNA ‘light-switch’ Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method. Chem. Sci 7:4016-4023 (Cover story)
2. Mao, L., Huang, C.H., Gao, H.Y., Kalyanaraman, B., Zhu, B.Z. (2015) Intrinsic chemiluminescence generation during advanced oxidation of persistent halogenated aromatic carcinogens. Environ. Sci. Technol. 49: 7940-7947.
3. Huang, C.H.; Ren, F.R.; Shan, G.Q.; Qin, H.; Mao, L.; Zhu, B.Z. (2015) Molecular mechanism of metal-independent decomposition of organic      hydroperoxides by the halogenated quinoid carcinogens and the potential biological implications. Chem. Res. Toxicol., 28, 831-837.  (Cover story)
4. Zhu B.Z., Hollenberg PF (2015) Chemical toxicology in China: A special issue. Chem. Res. Toxicol. 28: 279-280. (Guest Editor’s      Editorial)
5. Shan GQ, Yu A, Zhao QF, Huang CH, Zhu LY, Zhu B.Z. (2015) A combined experimental and computational investigation on the unusual      molecular mechanism of Lossen rearrangement reaction activated by the carcinogenic halogenated quinones. J. Org. Chem. 80: 180-189.
6. Li Y, Huang CH, Liu YX, Mao L, Zhu B.Z. (2014) Detoxifying polyhalogenated catechols through a copper-chelating agent by forming stable and redox-inactive hydrogen-bonded complexes with an unusual perpendicular structure Chemistry-A European Journal,      20(40):13028-33
7. Huang, C. H.; Shan, G. Q.; Mao, L.; Kalyanaraman, B.; Qin, H.; Ren, F. R.; Zhu, B. Z. (2013) The first purification and unequivocal      characterization of the radical form of the carbon-centered quinone ketoxy radical adduct. Chem. Commun. 49: 6436-6438
8. Qin H, Huang CH, Mao L, Xia HY, Kalyanaraman B, Shao J, Shan GQ, Zhu BZ. (2013) Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens. Free Radic. Biol. Med. 63，459-466
9. Shao      J, Huang CH, Kalyanaraman B, Zhu B.Z. (2013) Potent methyl      oxidation of 5-methyl-2’-deoxycytidine      by halogenated      quinoid carcinogens and hydrogen      peroxide via a metal-independent mechanism. Free Radic. Biol. Med. 60, 177-182
10. Zhu B.Z., Mao L., Huang C.H., Qin H., Fan R.M.,      Kalyanaraman B., Zhu J.G. (2012) Unprecedented hydroxyl radical-dependent two-step      chemiluminescence production by polyhalogenated quinoid carcinogens and H₂O₂. Proc. Natl.      Acad. Sci. USA 109:      16046-16051.
11. Sheng Z.G., Zhu B.Z. (2011) Low Concentrations of      Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by      G-Protein-Coupled Receptor 30 and Estrogen Receptor-α. Environ. Health Perspect. 119: 1775-1780.
12. Zhu B.Z., Zhu      J.G.,      Kalyanaraman B., Mao L.      and Shan      G.Q. (2010) Detoxifying polyhalogenated      quinones by hydroxamic acids via an unusual double Lossen rearrangement. Proc. Natl. Acad. Sci. USA 107:      20286-20290.
13. Zhu B.Z., Shan      G.Q., Huang C.H. and Kalyanaraman B. (2009) Metal-independent decomposition of hydroperoxides by      halogenated quinones: Detection and identification of a quinone ketoxy      radical. Proc. Natl. Acad. Sci. USA      106: 11466-11471.
14.  Zhu B.Z., Kalyanaraman B. and Jiang G.B. (2007) Molecular Mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones. Proc. Natl. Acad. Sci. USA 104: 17575-17578.
15. Zhu B.Z., Zhao H.T., Kalyanaraman B. Liu J., Shan G.Q., Du Y.G. and Frei B. (2007) Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones. Proc. Natl. Acad. Sci. USA 104: 3698-3702.

已指导学生

单国强  01  19367  

范瑞梅  01  19367  

朱俊歌  01  19367  

毛莉  01  19367  

覃浩  01  19367  

夏海英  01  19367  

刘玉祥  01  19367  

李岩  01  19367  

任福荣  01  19367  

黄春华  01  19367  

邵波  01  19367  

高慧颖  01  19367  

巢细娟  01  19367  

现指导学生

沈忱  01  19367  

李锋  01  19367  

谢琳娜  01  19132  

严诸颖  01  19132  

黄蓉  01  19367  

徐丹  01  19132  

肖璇  02  67011  

秦丽  01  19367  

唐苗  01  19132  

唐天舒  02  63224  

李培林   02  67011  

2013 “Outstanding Science & Technology Achievement Prize of the CAS” (as one of the three outstanding contributors)