课题组研究领域主要聚焦多细胞互作微环境中细胞的身份决定与维持、细胞间协作和组织、器官衰老与再生等科学问题，运用计算生物学与大规模高通量实验技术相结合的方法，从功能基因组学、表观遗传学、染色质高级结构以及单细胞生物学等多个生物学层面，系统性地阐释多细胞微环境的性质、功能与分子调控机制。

   

0710Z1-基因组学
0710J3-生物信息学
071010-生物化学与分子生物学

基因组学，生物信息学，计算生物学
发育生物学，干细胞，细胞微环境

2006-09--2012-06   中国科学院遗传与发育生物学研究所   生物信息学博士
2000-09--2004-06   湖南大学   管理学学士

   

2018-06~现在, 中国科学院动物研究所, 研究员
2014-05~2018-06,美国加州大学圣地亚哥分校, 博士后
2012-07~2014-04,中国科学院遗传与发育生物学研究所, 博士后
2004-07~2006-02,中国工商银行软件开发中心, 软件工程师

2019-09-01-2024-08-31,中国科学技术大学博士生导师, 博士生导师

实用生物信息学（2）：多组学数据整合与深度挖掘

   

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[14] Zhang, Kai, Zhang, Xiaorong, Cai, Zhiqiang, Zhou, Jie, Cao, Ran, Zhao, Ya, Chen, Zonggui, Wang, Dehe, Ruan, Wen, Zhao, Qian, Liu, Guangqiao, Xue, Yuanchao, Qin, Yan, Zhou, Bing, Wu, Ligang, Nilsen, Timothy, Zhou, Yu, Fu, XiangDong. A novel class of microRNA-recognition elements that function only within open reading frames. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2018, 第 14 作者25(11): 1019-+, http://202.127.25.143/handle/331003/3372.
[15] Gao, Yijun, Chang, Matthew T, McKay, Daniel, Na, Na, Zhou, Bing, Yaeger, Rona, Torres, Neilawattie M, Muniz, Keven, Drosten, Matthias, Barbacid, Mariano, Caponigro, Giordano, Stuart, Darrin, Moebitz, Henrik, Solit, David B, AbdelWahab, Omar, Taylor, Barry S, Yao, Zhan, Rosen, Neal. Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties. CANCER DISCOVERY[J]. 2018, 第 5 作者8(5): 648-661, https://www.webofscience.com/wos/woscc/full-record/WOS:000431293900027.
[16] Li, Xiao, Zhou, Bing, Chen, Liang, Gou, LanTao, Li, Hairi, Fu, XiangDong. GRID-seq reveals the global RNA-chromatin interactome. NATURE BIOTECHNOLOGY[J]. 2017, 第 2 作者35(10): 940-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000412764600018.
[17] Cui, Xia, Lu, Falong, Qiu, Qi, Zhou, Bing, Gu, Lianfeng, Zhang, Shuaibin, Kang, Yanyuan, Cui, Xiekui, Ma, Xuan, Yao, Qingqing, Ma, Jinbiao, Zhang, Xiaoyu, Cao, Xiaofeng. REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis. NATURE GENETICS[J]. 2016, 第 4 作者48(6): 694-699, http://dx.doi.org/10.1038/ng.3556.
[18] Qiu, Jinsong, Zhou, Bing, Thol, Felicitas, Zhou, Yu, Chen, Liang, Shag, Changwei, Deboever, Christopher, Hou, Jiayi, Li, Hairi, Chaturvedi, Anuhar, Ganser, Arnold, Bejar, Rafael, Zhang, DongEr, Fu, XiangDong, Heuser, Michael. Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators. RNA[J]. 2016, 第 2 作者22(10): 1535-1549, http://dx.doi.org/10.1261/rna.056101.116.
[19] Xue, Yuanchao, Qian, Hao, Hu, Jing, Zhou, Bing, Zhou, Yu, Hu, Xihao, Karakhanyan, Aziz, Pang, Zhiping, Fu, XiangDong. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. NATURE NEUROSCIENCE[J]. 2016, 第 4 作者19(6): 807-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000376744600011.
[20] Wei, Chaoliang, Xiao, Rui, Chen, Liang, Cui, Hanwei, Zhou, Yu, Xue, Yuanchao, Hu, Jing, Zhou, Bing, Tsutsui, Taiki, Qiu, Jinsong, Li, Hairi, Tang, Liling, Fu, XiangDong. RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. MOLECULAR CELL[J]. 2016, 第 8 作者62(6): 875-889, http://dx.doi.org/10.1016/j.molcel.2016.06.003.
[21] Yu Zhou, Andrew D Chisholm, Michael G Rosenfeld, Zhijie Liu, Yishi Jin, Lizhen Chen, XiangDong Fu, Bing Zhou, Chaoliang Wei. CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins. ELIFE,5,(2016-06-01). 2016, 第 8 作者
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