Using data and computational modelling driven technologies for biosystem design. Mainly include: Genome and pan-genome scale metabolic model reconstruction and analysis, metabolic pathway design, kinetic models of pathways and gene circuits, Development of computation tools and platforms for modelling analysis, in vitro metabolic pathway analysis, cell free synthetic biology, metabolic engineering for biochemicals production, Genome and metagenome data analysis.

1997 - 2001: School of Chemical Engineering & Technology, Tianjin University, P.R.China, Ph.D in Biochemical Engineering. 

1993 - 1996: Department of Chemical Engineering, Tianjin University, P.R.China. M.Eng. in Biochemical Engineering,

1989 - 1993: Department of Chemistry, Tianjin University, P.R.China. B.Sc. in Applied Chemistry,

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     2012 –  :    Professor, Tianjin Institute of Industrial Biotechnology, CAS

2005 –2012: Senior research fellow, School of Informatics, the University of Edinburgh.

2001 - 2005: Postdoc, Biochemical Engineering Division and then Department of Genome Analysis, GBF: German Research Centre for Biotechnology.

     1996 - 2001: Assistant Lecturer and Lecturer, Department of Bioengineering, School of Chemical Engineering, Tianjin University

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2014 Thomson Reuters Highly Cited Scientist

   

Chen Zhiqiang, Yuan Qianqian, Zheng Yangyang and Ma Hongwu (2017)Engineering Escherichia coli for poly-β-hydroxybutyrate production from methanol, Food Technology and Biotechnology, in revision

Yangyang Zheng, Qianqian Yuan, Xiaoyan Yang, Yan Zhang, Tao Chen, Hongwu Ma*, (2017) Engineering Escherichia coli For Poly-(3-hydroxybutyrate) Production Guided by Genome-scale Metabolic Network Analysis, Enzymes Microbial Tech., 106（11）60.

Qianqian Yuan , Teng Huang, Tong Hao, Feiran Li, Hongwu Ma*, Zhiwen Wang, Xueming Zhao* , Tao Chen*, Igor Goryanin，(2017) Pathway-Consensus Approach to Metabolic Network Reconstruction for Pseudomonas putida KT2440 by Systematic Comparison of Published Models,  PLOS ONE, 12(1):e0169437.

Xiaoyan Yang, Qianqian Yuan, Yangyang Zheng, Hongwu Ma* , Tao Chen, Xueming Zhao, (2016)  An engineered non-oxidative glycolysis pathway for acetone production in Escherichia coli, Biotechnology letters, 38(8), 1359-1365

Qinglong Meng, Yanfei Zhang, Xiaozhi Ju, Chunling Ma, Hongwu Ma*, Jiuzhou Chen, Ping Zheng, Jibin Sun, Jun Zhu, Yanhe Ma, Tao Chen*, Xueming Zhao，(2016) Production of 5-aminolevulinic acid by cell free multi-enzyme catalysis，J Biotechnology，226(1)8-13。

Wei Zhou, Chun You, Hongwu Ma, Yanhe Ma, and Y.-H. Percival Zhang (2016）One-Pot Biosynthesis of High-Concentration α-Glucose 1-Phosphate from Starch by Sequential Addition of Three Hyperthermophilic Enzymes, J Agric Food Chem.  64(8):1777-83

Zhenquan Lin, Yan Zhang, Yuan Qianqian,, Qiaojie Liu, Yifan Li, Zhiwen Wang, Hongwu Ma*,  Tao Chen*, Xueming Zhao, (2015) Metabolic engineering of Escherichia coli for poly(3-hydroxybutyrate) production via threonine bypass, Microb Cell Fact  14:185

Qinglong Meng, Yanfei Zhang, Chunling Ma, Hongwu Ma*, Tao Chen, Xueming Zhao，(2015) Purification and functional characterization of thermostable 5-aminolevulinic acid synthase，Biotechnology letters, 37（11）2247-2253。

Yanfei Zhang，Qinglong Meng，Hongwu Ma*，Yongfei Liu，Guoqiang Cao，Xiaoran Zhang，Ping Zheng， Jibin Sun，Dawei Zhang，Wenxia Jiang，Yanhe Ma，(2015) Determination of key enzymes for threonine synthesis through in vitro metabolic pathway analysis, Microbial Cell Factories 14（1）：86

Larisa Kiseleva1, Sofya K. Garushyants, Hongwu Ma, David J.W. Simpson , Viatcheslav Fedorovich , Michael F. Cohen , Igor Goryanin, (2015) Taxonomic and functional metagenomic analysis of anodic communities in two pilot-scale microbial fuel cells treating different industrial wastewaters, Journal of Integrative Bioinformatics, 12(1):273.

Zhang Y, Lin Z, Liu Q, Li Y, Wang Z, Ma H, Chen T, Zhao X. (2015) Engineering of Serine-Deamination pathway, Entner-Doudoroff pathway and pyruvate dehydrogenase complex to improve poly(3-hydroxybutyrate) production in Escherichia coli. Microb Cell Factories 13(1):172

GC Sharp, HW Ma, PYK Saunders, JE Norman （2013）A computational model of lipopolysaccharide-induced nuclear factor kappa B activation: a key signalling pathway in preterm labour. PLOS ONE (in review)

Tong Hao, Binbin Han, Hongwu Ma, Jing Fu, Hui Wang, Zhiwen Wang, Bincai Tang, Tao Chen, Xueming Zhao. (2013)  In silico Metabolic Engineering of Bacillus Subtilis for Improved Production of Riboflavin, Egl-237, (R,R)-2,3-butanediol and Isobutanol, Molecular Biosystems，DOI: 10.1039/C3MB25568A

Z Liu, HW Ma*, I Goryanin (2013) A semi-automated genome annotation comparison and integration scheme. BMC Bioinformatics, 14:172.

Hao, T., Ma, H﹡., Zhao, X., and Goryanin, I. (2012). The Reconstruction and Analysis of Tissue Specific Human Metabolic Networks. Mol. BioSyst., 8:663-670.

FC Boogerd, HW Ma, F Bruggeman, W van Heeswijk, R García-Contreras, D Molenaar, K Krab, H Westerhoff  (2011) AmtB-mediated NH3 transport in prokaryotes must be active and as a consequence regulation of transport by GlnK is mandatory to limit futile cycling of NH4+ / NH3. FEBS letters 585(1) 23-28

Hao, T., Ma, H﹡., Zhao, X., and Goryanin, I. (2010). Compartmentalization of the Edinburgh Human Metabolic Network. BMC bioinformatics 11, 393.

Ma, H., Boogerd, F. C., and Goryanin, I. (2009). Modelling nitrogen assimilation of Escherichia coli at low ammonium concentration. Journal of biotechnology 144, 175-83.

Ma, H., and Goryanin, I. (2008). Human metabolic network reconstruction and its impact on drug discovery and development. Drug discovery today 13, 402-8.

da Silva, M. R., Ma, H., and Zeng, A. (2008). Centrality, Network Capacity, and Modularity as Parameters to Analyze the Core-Periphery Structure in Metabolic Networks. Proceedings of the IEEE 96, 1411-1420.

Ma, H., Sorokin, A., Mazein, A., Selkov, A., Selkov, E., Demin, O., and Goryanin, I. (2007). The Edinburgh human metabolic network reconstruction and its functional analysis. Molecular systems biology 3, 135.

Wang, Q., Yang, Y., Ma, H., and Zhao, X. (2007). Metabolic network properties help assign weights to elementary modes to understand physiological flux distributions. Bioinformatics 23, 1049-52.

Van den Bulcke, T., Van Leemput, K., Naudts, B., van Remortel, P., Ma, H., Verschoren, A., De Moor, B., and Marchal, K. (2006). SynTReN: a generator of synthetic gene expression data for design and analysis of structure learning algorithms. BMC bioinformatics 7, 43.

Ma, H., Buer, J., and Zeng, A. (2004). Hierarchical structure and modules in the Escherichia coli transcriptional regulatory network revealed by a new top-down approach. BMC bioinformatics 5, 199.

Ma, H., Kumar, B., Ditges, U., Gunzer, F., Buer, J., and Zeng, A. (2004). An extended transcriptional regulatory network of Escherichia coli and analysis of its hierarchical structure and network motifs. Nucleic acids research 32, 6643-9.

Ma, H., Zhao, X., Yuan, Y., and Zeng, A. (2004). Decomposition of metabolic network into functional modules based on the global connectivity structure of reaction graph. Bioinformatics 20, 1870-6.

Ma, H., and Zeng, A. (2004). Phylogenetic comparison of metabolic capacities of organisms at genome level. Molecular phylogenetics and evolution 31, 204-13.

Ma, H., and Zeng, A. (2003). The connectivity structure, giant strong component and centrality of metabolic networks. Bioinformatics 19, 1423-30.

Ma, H., and Zeng, A. (2003). Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms. Bioinformatics 19, 270-7.