Small molecule targeted drugs are an important part of clinical anticancer drugs. The discovery of natural lead compounds provides novel molecular structures for candidate compounds of new drugs, which is an efficient way to develop new anti-tumor drugs. Therefore, the use of natural products as lead compounds for the development of anti-tumor drugs has great development potential and application prospects. Our group uses high-throughput screening technology to find natural peptide molecules with anti-cancer activity, design and synthesize artificial peptide molecules with biological functions, study the anti-cancer mechanism of natural peptides and biomimetic peptides, and apply them to targeted therapy of tumor.

2009-9 to 2014-6 PhD in cell biology, State Key Laboratory of Biotherapy, Sichuan University, China

2005-9 to 2009-7 Bachelor of Science, School of Life Science / Wu Yuzhang College, Sichuan University, China

   

2016-11 to 2018-11  Assistant Researcher, Nano Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

2014-07 to 2016-10  Postdoc，Nano Center, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Master Course: Chemical Biology, chapter_protein-protein interaction in drug development

Ke Liu, Lijing Fang1#, Haiyan Sun, Zhengyin Pan,...Targeting Polo-like Kinase 1 by a Novel Pyrrole-imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth in vivo.  Molecular Cancer Therapeutics, 2018.  (SCI, IF = 5.764)

Liu, K., Lei, R., Li, Q., Wang, X. X., Wu, Q., An, P., ... & Wang, F. Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Scientific Reports,2016,6:21019. doi:10.1038/srep21019. （SCI, IF = 5.578）

Ke Liu, Quan Lin, Yanxia Wei, Renbing He, Ximing Shao, Zhihao Ding, Jianchao Zhang, Minyan Zhu. Gαs regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression [J]. Neuroscience letters, 2015, 597: 97-103.（SCI IF = 2.06）

Ximing Shao*, Ke Liu*, Yi Fan, Zhihao Ding, Min Chen, Minyan Zhu, Lee S. Weinstein，Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity, Journal of Genetics and Genomics (2015), doi: 10.1016/j.jgg.2015.08.006.（SCI, IF = 3.58）

Ao, L., Wu, C., Liu, K., Wang, W., Fang, L., Huang, L., & Su, W. (2018). Polydopamine-Derivated Hierarchical Nanoplatforms for Efficient Dual-Modal Imaging-Guided Combination in Vivo Cancer Therapy. ACS applied materials & interfaces, 10(15), 12544-12552. （SCI, IF = 8.097）

Shao, X., Ding, Z., Zhao, M., Liu, K., Sun, H., Chen, J., ... & Li, H. (2017). Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4. Journal of Biological Chemistry, jbc-M117. (SCI, IF = 4.010)

Pan, Z., Wu, C., Wang, W., Cheng, Z., Yao, G., Liu, K., ... & Su, W. (2017). Total synthesis and stereochemical assignment of gymnopeptides A and B. Organic letters, 19(17), 4420-4423. (SCI, IF = 6.492 )

Haiyan Sun, Yi Li,Lei Zhang, Ximing Shao, Ke Liu et al. Numb positively regulates autophagic flux via regulating lysosomal function[J]. Biochemical and biophysical research communications, 2017, 491(3): 780-786. (SCI， IF = 2.47)

Zhang, J., Shao, X., Sun, H., Liu, K., Ding, Z., Chen, J., ... & Li, H. (2016). NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling. Oncotarget. (SCI, IF= 5.08)

Lei R, Zhang K, Liu K, et al. Transferrin receptor facilitates TGF-β and BMP signaling activation to control craniofacial morphogenesis[J]. Cell Death & Disease, 2016, 7(6): e2282 （SCI, IF = 5.378）

1. PCT invention patent, PLK1 inhibitor, its preparation method and application, 

inventors (Su Wu, Li Hongchang, Fang Lijing, Liu Ke, Zhang Jianchao, Pan Zhengyin), CN106866635.

2. Invention patent, an Aurora A protein inhibitor, its preparation method and pharmaceutical use, 

the inventors (Li Hongchang, Su Wu, Fang Lijing, Lu Danyi, Zhang Jianchao, Liu Ke), CN 109970720

natural peptide molecular mechanism

biomimetic peptide drugs

Tumor targeted therapy

Mitochondrial biology

2016 - Reserve Talent of High-level Professional in Shenzhen