NK细胞的工程化改造与免疫治疗

研究主页: https://www.researchgate.net/profile/Bi_Jiacheng

2008-09--2014-06   中国科学技术大学   硕博连读
2004-09--2008-06   华南理工大学   学士

   

2026-03~现在, 中国科学院深圳先进技术研究院, 项目研究员(正高级)
2018-12~2026-03,中国科学院深圳先进技术研究院, 副研究员
2016-08~2018-12,中国科学院深圳先进技术研究院, 助理研究员
2014-09~2016-08,中国科学院深圳先进技术研究院, 博士后

   

（1） 合成免疫学, 科学出版社, 2025-09, 第 其他 作者

现指导学生

王萍  硕士研究生  086000-生物与医药  

目前实验室共有5名硕士联培研究生、2名博士联培研究生在读

1.Xu Y, Cai R, Liu M, Fan X, Wan X, Yang X*, Bi J*, Chen L*. TRIM11 potentiates antitumor immunity via inhibition of the IFN-γ/PD-L1 axis. Cell Death Differ, 2025. (*co-corresponding authors) (IF=15.4)

2.Lu Z, Bi J*, Zheng C, Cui L, Xia H, Wan X*, Chen YH*. Tumor Cell AMPK Activation Enhances NK Cell Anti-tumor Immunity and Synergizes with PD-L1 Blockade Therapy. Mol Ther, 2025. (*co-corresponding authors) (IF=12)

3.Bi J*, Jin X, Zheng C, Huang C, Zhong C, Zheng X, Tian Z*, Sun H*. Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8+ T Cells. Advanced Science. 2023, 2207499. (*co-corresponding authors) (IF=14.1)

4.Bi J*, Huang C, Jin X, Zheng C, Huang Y, Zheng X, Tian Z*, Sun H*. TIPE2 deletion improves the therapeutic potential of adoptively transferred NK cells. J Immunother Cancer, 2023, 11(2):e006002. (*co-corresponding authors) (IF=10.6)

5.Bi J*, Cheng C, Zheng C, Huang C, Zheng X, Wan X, Chen YH, Tian Z, Sun H*. TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity. Science Advances, 2021, 7(38):eabi6515 (*co-corresponding authors) (IF=12.5)

6.Bi J, Zheng C, Zheng X. Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells. Cell Mol Immunol 2021 Feb;18(2):496-497.(IF=19.8)

7.Bi J. NK cell dysfunction in COVID-19. Cell Mol Immunol 2021.(IF=19.8)

8.Bi J. CD226: a potent anti-tumor immunity driver that needs to be maintained. Cell Mol Immunol 2021.(IF=19.8)

9.Zheng C, Wu H, Lu Z, Bi J*, Wan X*. IL-33-induced reactive oxygen species are required for optimal metabolic programming in group 2 innate lymphoid cells. Cell Mol Immunol 2020. (*co-corresponding authors) (IF=19.8)

10.Bi J, Zheng X, Chen Y, Wei H, Sun R*, Tian Z*. TIGIT safeguards liver regeneration through regulating natural killer cell-hepatocyte crosstalk. Hepatology 2014, 60(4): 1389-1398.(IF=15.8)

11.Bi J, Zhang Q, Liang D, Xiong L, Wei H, Sun R*, Tian Z*. T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis. Hepatology 2014, 59(5): 1715-1725.(IF=15.8)