基本信息
陈宇  男  博导  中国科学院深圳先进技术研究院
电子邮件: yu.chen@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码: 518055

研究领域

        人类的认知功能取决于大脑中神经元所形成的精细网络,而神经元间的交流则依赖于突触传递。突触功能障碍与阿尔兹海默病、帕金森病等在内的诸多神经退行性疾病密切相关。因而,突触蛋白的精准分布、突触信号传递在时间和空间上的精细调控是神经生物学研究的中心议题。
        陈宇博士长期专注于神经系统突触发育、可塑性的分子基础,以及神经退行性疾病(如阿尔兹海默病)的病理机制等方面的研究。他发现了一系列调控树突和突触功能的重要蛋白,提示了在神经系统发育和功能执行过程中神经信号从细胞表面受体通过支架蛋白、激酶等向细胞内传递的关键步骤。其研究方向主要包括以下几个方面:
(1)突触的基础研究:对细胞表面受体、支架蛋白、激酶等介导的突触信号进行研究,结合光遗传调控手段,解释突触发育和可塑性调控过程中的动态变化及其分子基础。
(2) 神经退行性疾病机制研究:通过运用不同的疾病模型,包括非人灵长类动物模型,研究突触功能在阿尔兹海默病病变条件下发生的变化,以及内在的分子生物学机制和关键信号通路,提示可能的干预靶点。
(3) 阿尔兹海默病生物标志物和干预措施研究:利用交叉学科手段,研究适用于中国人群的、易于采集和测量的生物标志物,并发展可能的干预手段;同时协助临床医务工作者实施国际规范的操作流程,提升在诊断、样品采集和分析方面的水平。


招生信息

   
招生专业
071006-神经生物学
071010-生物化学与分子生物学
071009-细胞生物学
招生方向
神经发育、可塑性和退行性病变的调控机制
神经发育和可塑性调控的分子细胞机制

教育背景

2003-09--2007-08   香港科技大学   哲学博士
1998-09--2002-08   中山大学   理学学士

工作经历

   
工作简历
2021-06~现在, 中国科学院深圳先进技术研究院, 脑所 副所长
2019-07~现在, 深港脑科学创新研究院, 院长助理(兼)
2017-04~现在, 中国科学院深圳先进技术研究院, 脑疾病中心主任
2016-12~现在, 中国科学院深圳先进技术研究院, 脑所 所长助理
2015-04~现在, 中国科学院深圳先进技术研究院, 研究员
2010-11~2015-04,香港科技大学, 研究助理教授
2009-09~2010-10,香港科技大学, 访问学者
2007-09~2009-08,香港科技大学, 副研究员
2003-03~2003-08,香港科技大学, 初级研究员
社会兼职
2019-12-18-今,中国青年科技工作者协会, 会员

教授课程

神经生物学基础

专利与奖励


奖励信息
(1) 2021年度中国神经科学重大进展, 其他, 2021
(2) 香港青年科学家奖(finalist), , 其他, 2007
专利成果
[1] 陈宇, 陈艺菁, 樊颖颖, 陈岳文, 许进英. 一种阿尔兹海默症生物标志物天冬酰胺及其应用. CN202111074848.5, 2022-09-14.
[2] 陈宇, 陈艺菁, 樊颖颖, 陈岳文, 许进英. 一种阿尔兹海默症生物标志物及其筛选方法和应用. CN202111042127.6, 2022-09-07.
[3] 陈宇, 屈雪琪, 林力, 陈岳文. 一种神经退行性疾病标志物Prnp及其应用. CN114645086A, 2022-06-21.
[4] 陈宇, 屈雪琪, 林力, 原琳. Cox6c检测引物及其应用. WO2022120917A1, 2022-06-16.
[5] 陈宇, 陈艺菁, 陈岳文, 许进英, 樊颖颖. 检测阿尔兹海默症肠道菌群标志物的表达丰度的方法和装置. CN114622022A, 2022-06-14.
[6] 陈宇, 屈雪琪, 林力, 陈岳文, 许进英. 一种提取神经突触体的方法. CN114621921A, 2022-06-14.
[7] 陈宇, 屈雪琪, 林力, 原琳. 一种Cox6c检测引物及其应用. CN114622007A, 2022-06-14.
[8] 陈宇, 陈艺菁, 李寅虎, 樊颖颖, 陈岳文, 陈静, 柴岳. 一种基于粪便的阿尔兹海默症生物标志物及其应用. CN202210448068.0, 2022-04-26.
[9] 陈宇, 陈艺菁, 李寅虎, 樊颖颖, 陈岳文, 柴岳, 陈静. 一种阿尔兹海默症生物标志物及其应用. CN202210448532.6, 2022-04-26.
[10] 陈宇, 许进英, 陈岳文, 柴岳, 陈静. 一种蛋白棒状体标志物及其应用. CN202210443960.X, 2022-04-25.
[11] 陈宇, 叶涛, 陈艺菁, 樊颖颖, 陈岳文, 许进英. 一种阿尔兹海默症生物标志物S-甲基-5'-硫代腺苷及其应用. CN202111091735.6, 2021-09-17.
[12] 陈宇, 陈艺菁, 樊颖颖, 陈岳文, 叶涛, 许进英. 一种阿尔兹海默症生物标志物肌苷及其应用. CN202111059965.4, 2021-09-10.
[13] 陈宇, 陈艺菁, 樊颖颖, 陈岳文, 叶涛, 许进英. 一种阿尔兹海默症生物标志物L-缬氨酸及其应用. CN202111059934.9, 2021-09-10.
[14] 陈宇, 屈雪琪, 毛梦, 林力, 叶涛. 一种阿尔茨海默症的标记物及其应用. CN202110739095.9, 2021-06-30.
[15] 陈宇, 陈岳文, 许进英, 陈艺菁. 一种神经退行性疾病标志物Chromogranin B及其应用. CN: CN112858684A, 2021-05-28.
[16] 陈宇, 陈岳文, 许进英, 陈艺菁. 一种神经退行性疾病标志物β-spectrin及其应用. CN: CN112858685A, 2021-05-28.
[17] 李伟丽, 陈宇, 陈岳文. 一种可调式双孔插芯针夹持器. CN: CN211560186U, 2020-09-25.

出版信息

   
发表论文
[1] Cao, Han, Zhou, Xiaopu, Chen, Yu, Ip, Fanny C F, Chen, Yuewen, Lai, Nicole C H, Lo, Ronnie M N, Tong, Estella P S, Mok, Vincent C T, Kwok, Timothy C Y, Fu, Amy K Y, Ip, Nancy Y, Alzheimers Dis Neuroimaging Initi. Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk. JOURNAL OF ALZHEIMERS DISEASE[J]. 2022, 86(4): 1861-1873, [2] Zhang, Zhen, Cui, Liang, Huang, Yanlu, Chen, Yu, Li, Yuehua, Guo, Qihao. Changes of Regional Neural Activity Homogeneity in Preclinical Alzheimer's Disease: Compensation and Dysfunction. FRONTIERS IN NEUROSCIENCE[J]. 2021, 15: http://dx.doi.org/10.3389/fnins.2021.646414.
[3] Jiang, Yuanbing, Zhou, Xiaopu, Ip, Fanny C, Chan, Philip, Chen, Yu, Lai, Nicole C H, Cheung, Kit, Lo, Ronnie M N, Tong, Estella P S, Wong, Bonnie W Y, Chan, Andrew L T, Mok, Vincent C T, Kwok, Timothy C Y, Mok, Kin Y, Hardy, John, Zetterberg, Henrik, Fu, Amy K Y, Ip, Nancy Y. Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging. ALZHEIMERS & DEMENTIA. 2021, http://dx.doi.org/10.1002/alz.12369.
[4] Chen, Yijing, Xu, Jinying, Chen, Yu. Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders. NUTRIENTSnull. 2021, 13(6): http://dx.doi.org/10.3390/nu13062099.
[5] Tao Ye, Yangyang Duan, Hayley W S Tsang, He Xu, Yuewen Chen, Han Cao, Yu Chen, Amy K Y Fu, Nancy Y Ip. Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases. Communications Biology[J]. 2021, 4(1): https://doaj.org/article/70fb7c21e42e47428a1ea40e2a8b140e.
[6] David Goertsen, Nicholas C Flytzanis, Nick Goeden, Miguel R Chuapoco, Alexander Cummins, Yijing Chen, Yingying Fan, Qiangge Zhang, Jitendra Sharma, Yangyang Duan, Liping Wang, Guoping Feng, Yu Chen, Nancy Y Ip, James Pickel, Viviana Gradinaru. AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset. Nature Neuroscience[J]. 2021, 25(1): 106-115, [7] Yangyang Duan, Ye Tao, Qu Zhe, Yuewen Chen, Miranda Abigail, Zhou, Xiaopu, Lok Ka-Chun, Yu Chen, Fu, Amy K Y, Gradinaru Viviana, Nancy Y lp. Brain-wide Cas9-mediated cleavage of a disease-causing gene eases amyloid-related pathologies in mouse models of familial Alzheimer’s disease. Nature Biomedical Engineering[J]. 2021, [8] Lin Yuan, Wanying Yi, Changyu Sun, Shuangshuang Ma, Jiali Wang, Saijuan Liu, Yijing Chen, Yuewen Chen, Yu Chen. EphB2 activates CREB-dependent expression of Annexin A1 to regulate dendritic spine morphogenesis. Biochemical and Biophysical Research Communications[J]. 2021, 584: 107-115, [9] Liao, Chunyan, Xu, Jinying, Chen, Yu, Ip, Nancy Y. Retinal Dysfunction in Alzheimer's Disease and Implications for Biomarkers. BIOMOLECULESnull. 2021, 11(8): http://dx.doi.org/10.3390/biom11081215.
[10] Li, Qiqi, Zheng, Yicong, Guo, Anjie, Chen, Yu, Zhang, Si, Li, Jie. Pseudokineococcus galaxeicola sp. nov., isolated from mucus of a stony coral. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2020, 70(11): 5671-5675, https://www.webofscience.com/wos/woscc/full-record/WOS:000608414600010.
[11] Chen, Yuewen, Xu, Jinying, Zhang, Yulin, Ma, Shuangshuang, Yi, Wanying, Liu, Saijuan, Yu, Xiaojun, Wang, Jiali, Chen, Yu. Coronin 2B regulates dendrite outgrowth by modulating actin dynamics. FEBS LETTERS[J]. 2020, 594(18): 2975-2987, http://dx.doi.org/10.1002/1873-3468.13886.
[12] Ouyang, Li, Chen, Yu, Wang, Ye, Chen, Yuewen, Fu, Amy K Y, Fu, WingYu, Ip, Nancy Y. p39-associated Cdk5 activity regulates dendritic morphogenesis. SCIENTIFIC REPORTS[J]. 2020, 10(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603351/.
[13] Chen, Yijing, Fang, Lihua, Chen, Shuo, Zhou, Haokui, Fan, Yingying, Lin, Li, Li, Jing, Xu, Jinying, Chen, Yuewen, Ma, Yingfei, Chen, Yu. Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer's Disease. BIOMED RESEARCH INTERNATIONAL[J]. 2020, 2020: https://doaj.org/article/fb16f83bda19424aae44eb69492030ed.
[14] Xiaopu Zhou, Yu Chen, Fanny C F Ip, Nicole C H Lai, Yolanda Y T Li, Yuanbing Jiang, Huan Zhong, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M N Lo, Kit Cheung, Estella P S Tong, Ho Ko, Maryam Shoai, Kin Y Mok, John Hardy, Vincent C T Mok, Timothy C Y Kwok, Amy K Y Fu, Nancy Y Ip. Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring. 2020, 12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403835/.
[15] Yuewen Chen, Jinying Xu, Xiaopu Zhou, Saijuan Liu, Yulin Zhang, Shuangshuang Ma, Amy KY Fu, Nancy Y Ip, Yu Chen. IDENTIFICATION OF PROTEIN PHOSPHORYLATION ASSOCIATED WITH ABERRANT SYNAPTIC FUNCTION IN ALZHEIMER'S DISEASE. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2019, 15(7): P1324-P1325, [16] Xu, Zhenyan, Chen, Yuewen, Chen, Yu. Spatiotemporal Regulation of Rho GTPases in Neuronal Migration. CELLSnull. 2019, 8(6): https://doaj.org/article/53c7970349284bc3a1f3690f09e4230b.
[17] Chen, Yuewen, Xu, Jinying, Zhou, Xiaopu, Liu, Saijuan, Zhang, Yulin, Ma, Shuangshuang, Fu, Amy K Y, Ip, Nancy Y, Chen, Yu. Changes of Protein Phosphorylation Are Associated with Synaptic Functions during the Early Stage of Alzheimer's Disease. ACS CHEMICAL NEUROSCIENCE[J]. 2019, 10(9): 3986-3996, https://www.webofscience.com/wos/woscc/full-record/WOS:000487179600009.
[18] Chen, Yu, Fu, Amy K Y, Ip, Nancy Y. Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies. PHARMACOLOGY & THERAPEUTICSnull. 2019, 195: 186-198, http://dx.doi.org/10.1016/j.pharmthera.2018.11.006.
[19] Xiaopu Zhou, Yu Chen, Kin Y Mok, Timothy C Y Kwok, Vincent C T Mok, Qihao Guo, Fanny C Ip, Yuewen Chen, Nandita Mullapudi, Alzheimers Disease Neuroimaging Initiative, Paola GiustiRodrguez, Patrick F Sullivan, John Hardy, Amy K Y Fu, Yun Li, Nancy Y Ip. Non-coding variability at the APOE locus contributes to the Alzheimer's risk. NATURE COMMUNICATIONS[J]. 2019, 10(1): http://dx.doi.org/10.1038/s41467-019-10945-z.
[20] 陈宇. Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis (co-first). Proc Natl Acad Sci U S A. 2018, [21] Zhou, Xiaopu, Chen, Yu, Mok, Kin Y, Zhao, Qianhua, Chen, Keliang, Chen, Yuewen, Hardy, John, Li, Yun, Fu, Amy K Y, Guo, Qihao, Ip, Nancy Y, Alzheimers Dis Neuroimagi. Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(8): 1697-1706, http://ir.siat.ac.cn:8080/handle/172644/13859.
[22] 陈宇, 叶玉如. 阿尔茨海默症发病机制和干预策略研究. 科技纵览. 2017, 78-79, http://lib.cqvip.com/Qikan/Article/Detail?id=672683485.
[23] Li, Jian, Xu, Qiang, Teng, Bin, Yu, Chen, Li, Jian, Song, Liang, Lai, Yuxiao, Zhang, Jian, Zheng, Wei, Ren, PeiGen. Investigation of angiogenesis in bioactive 3-dimensional poly (D,L-lactide-co-glycolide)/nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect. ACTA BIOMATERIALIA[J]. 2016, 42: 389-399, http://dx.doi.org/10.1016/j.actbio.2016.06.024.
[24] Chen, Yu, Liang, Zhuoyi, Fei, Erkang, Chen, Yuewen, Zhou, Xiaopu, Fang, Weiqun, Fu, WingYu, Fu, Amy K Y, Ip, Nancy Y. Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. PLOS ONE[J]. 2015, 10(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000358621000018.
[25] Chen, Yu, Fu, Amy K Y, Ip, Nancy Y. Axin: An emerging key scaffold at the synapse. IUBMB LIFEnull. 2013, 65(8): 685-691, https://www.webofscience.com/wos/woscc/full-record/WOS:000322255400005.
[26] 叶玉如. 2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP—2. Nat Neurosci. 2012, 15(1): 39-47, [27] 陈宇. ARMS/Kidins220 is required for neurotrophin and ephrin receptor-dependent dendrite development.. 2012, [28] Chen, Yu, Fu, Amy K Y, Ip, Nancy Y. Eph receptors at synapses: Implications in neurodegenerative diseases. CELLULAR SIGNALLINGnull. 2012, 24(3): 606-611, http://dx.doi.org/10.1016/j.cellsig.2011.11.016.
[29] Fu, Amy K Y, Hung, KwokWang, Fu, WingYu, Shen, Chong, Chen, Yu, Xia, Jun, Lai, KwokOn, Ip, Nancy Y. APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. NATURE NEUROSCIENCE[J]. 2011, 14(2): 181-U263, https://www.webofscience.com/wos/woscc/full-record/WOS:000286595400015.
[30] Fang, WeiQun, Ip, Jacque P K, Li, Rui, Ng, Yu Pong, Lin, ShengCai, Chen, Yu, Fu, Amy K Y, Ip, Nancy Y. Cdk5-Mediated Phosphorylation of Axin Directs Axon Formation during Cerebral Cortex Development. JOURNAL OF NEUROSCIENCE[J]. 2011, 31(38): 13613-13624, https://www.webofscience.com/wos/woscc/full-record/WOS:000295083300025.
[31] Zhang, Peng, Yu, PeiChun, Tsang, Anthony H K, Chen, Yu, Fu, Amy K Y, Fu, WingYu, Chung, Kenny K, Ip, Nancy Y. S-Nitrosylation of Cyclin-Dependent Kinase 5 (Cdk5) Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development. JOURNAL OF NEUROSCIENCE[J]. 2010, 30(43): 14366-14370, https://www.webofscience.com/wos/woscc/full-record/WOS:000283790800012.
[32] Chen, Yu, Fu, WingYu. EphB Maintains Dendritic Spine Morphology through Focal Adhesion Kinase. JOURNAL OF NEUROSCIENCEnull. 2009, 29(42): 13091-13093, https://www.webofscience.com/wos/woscc/full-record/WOS:000271002600001.
[33] 陈宇. Bidirectional signaling of ErbB and Eph receptors at synapses.. Neuron Glia Biology. 2009, [34] Wang, Jie, Xu, Ruisong, Ma, Yueliang, Miao, Li, Cai, Rui, Chen, Yu. The research of air pollution based on spectral features in leaf surface of Ficus microcarpa in Guangzhou, China. ENVIRONMENTAL MONITORING AND ASSESSMENT[J]. 2008, 142(1-3): 73-83, http://ir.scsio.ac.cn/handle/344004/899.
[35] Miao, Li, Xu, Ruisong, Ma, Yueliang, Zhu, Zhaoyu, Wang, Jie, Cai, Rui, Chen, Yu. Geochemistry and biogeochemistry of rare earth elements in a surface environment (soil and plant) in South China. ENVIRONMENTAL GEOLOGY[J]. 2008, 56(2): 225-235, http://www.irgrid.ac.cn/handle/1471x/341247.
[36] Zelda H Cheung, Wing Hong Chin, Yu Chen, Yu Pong Ng, Nancy Y Ip. Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.. PLoS Biology[J]. 2007, 5(4): 865-877, https://doaj.org/article/a8d5b1f9a1234c2fb24108873dcdf91b.
[37] Fu, WingYu, Chen, Yu, Sahin, Mustafa, Zhao, XiaoSu, Shi, Lei, Bikoff, Jay B, Lai, KwokOn, Yung, WingHo, Fu, Amy K Y, Greenberg, Michael E, Ip, Nancy Y. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. NATURE NEUROSCIENCE[J]. 2007, 10(1): 67-76, https://www.webofscience.com/wos/woscc/full-record/WOS:000243096100017.
[38] Shuo Luo, Yu Chen, KwokOn Lai, Juan Carlos Arvalo, Stanley C Froehner, Marvin E Adams, Moses V Chao, Nancy Y Ip. α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner. The Journal of Cell Biology. 2005, 169(5): 813-824, [39] Lai, KO, Chen, Y, Po, HM, Lok, KC, Gong, K, Ip, NY. Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle - Implications in the regulation of acetylcholinesterase expression. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2004, 279(14): 13383-13392, https://www.webofscience.com/wos/woscc/full-record/WOS:000220478500015.
[40] Farghaian Hovik, Chen Yu, Fu Ada W. Y., Fu Amy K. Y., Ip Jacque P. K., Ip Nancy Y., Turnley Ann M., Cole Adam R.. Scapinin-induced Inhibition of Axon Elongation Is Attenuated by Phosphorylation and Translocation to the Cytoplasm. The Journal of Biological Chemistry. 286(22): 19724-19734, http://dx.doi.org/10.1074/jbc.M110.205781.

科研活动

   
科研项目
( 1 ) 老年痴呆症的分子机制研究, 参与, 国家任务, 2013-01--2017-08
( 2 ) 广东省脑科学及疾病与药物研究重点实验室, 参与, 地方任务, 2013-01--2015-12
( 3 ) 神经退行性疾病发病机理和药物研发, 参与, 地方任务, 2012-01--2016-12
( 4 ) 香港科技大学深圳生物医药中心, 参与, 地方任务, 2012-12--2015-12
( 5 ) Cdk5依赖性的Axin磷酸化在神经元极化过程中的作用, 负责人, 其他任务, 2010-01--2013-12
( 6 ) 阿尔茨海默症的环路机制和干预措施研究, 负责人, 地方任务, 2016-01--2018-12
( 7 ) 非人灵长类视觉神经再生研究, 参与, 地方任务, 2017-01--2019-12
( 8 ) 新型非人灵长类脑疾病模型及机理研究, 负责人, 中国科学院计划, 2016-01--2018-12
( 9 ) 周期蛋白依赖性蛋白激酶5调控神经突触发育的机制研究, 负责人, 国家任务, 2017-01--2020-12
( 10 ) 非人灵长类脑缺血后认知行为损伤评价研究, 负责人, 地方任务, 2017-07--2020-06
( 11 ) 阿尔茨海默症的诊治方法研究, 参与, 地方任务, 2018-12--2022-12
( 12 ) SORL1遗传变异体在阿尔茨海默症病变过程中的作用机制研究, 负责人, 国家任务, 2020-12--2024-12
( 13 ) 神经退行性疾病的生物标志物研究, 负责人, 地方任务, 2020-01--2023-12
( 14 ) 阿尔茨海默症的诊治方法研究—广东省脑科学专项, 负责人, 地方任务, 2018-12--2022-12

合作情况

        陈宇博士与浙医二院、华山医院长期合作,利用交叉学科手段,研究适用于中国人群的、易于采集和测量的阿尔兹海默病生物标志物,并发展可能的干预手段。同时协助临床医务工作者实施国际规范的操作流程,通过与国际科学组织Alzheimer’s Association以及阿尔兹海默病神经成像计划ADNI的合作,成功地将国际上先进的管理经验和实验方法引入浙医二院、华山医院等内地合作医院,提升了在阿尔兹海默病诊断、数据管理、样品采集和样品库管理等方面的水平。
项目协作单位

(1)香港科技大学

(2)浙江大学第二附属医院

(3)浙江大学
(4)复旦大学附属华山医院

指导学生

已指导学生

许进英  博士研究生  071006-神经生物学  

原琳  硕士研究生  071009-细胞生物学  

柴岳  硕士研究生  071006-神经生物学  

现指导学生

王春莲  博士研究生  071006-神经生物学  

杨玉洁  硕士研究生  086000-生物与医药