Aike Guo
Institute of Neuroscience,
Shanghai Institutes for Biologucal Sciences
Chinese Academy of Sciences
320 Yue Yang Road
Shanghai 200031,
Tel: 86- 21- 5492-1785
Fax:86-21-54921735 ;

Institute Of Biophysics,
State Key Laboratory of Brain and Cognitive Science,CAS
Beijing 100101
China ;

Research Areas

Neuroscience, Neurogenetics, Biophysics


1960-1965: Dept. of Biophysics, Moscow University, USSR.
1977-1979: Dr.rer.nat (Doktor rerum naturalium mit dem Gesamturteil "augezeichnet") ("Summa cum laude") awarded by Muenchen University ,Germany, Tutors: Prof. Dr. Dr.h.c. H.Autrum & Prof. Dr. U.Smola (Zoologische Institut der Universitaet). Luisenstrasse 14. D8000 Muenchen 2. Germany.


1979—1986 Research Assistant, IBP (Institute of Biophysics)
CAS (Chinese Academy of Sciences)
1986—1988 Research Associate, IBP, CAS
1988—present Research Professor, IBP, CAS
1999—present Senior Investigator, ION (Institute of Neuroscience)
SIBS (Shanghai Institutes for Biological Sciences), CAS
1982.1130—1984.0630 Visiting Researcher (MPI for biological Cybernetics, Tuebingen, Germany), Host: W.Reichardt
1987.04.01—1987.08.10 Visiting Researcher (MPI for biological Cybernetics, Tuebingen. Germany ), Host:W.Reichardt
1988.11—1989.04 Visiting Professor (MPI for biological Cybernetics, Germany)
1993.12—1994.06 Visiting Researcher (Host: M. Heisenberg, Lehrstuhl fuer Genetik (Biozentrum), Wuerzburg, Germany; and K. Goetz, MPI-for biological Cybernetics, Germany)
1984—1991 Head of Dept. of Visual Information Processing, IBP, CAS
1991—1995 Head of Dept of Neurobiology, IBP, CAS
1989—1997 Head of Academic Committee of Laboratory of Visual Information Processing, IBP, CAS
1999—present Senior Investigator of ION, SIBS, CAS

Honors & Distinctions

1) Awarded the 2nd Prize of Natural Science by the CAS,for the research project <Fotoperception and motion computation of compound visual system>.
2) <HLHL Prize> for Life Science in 2006.


1.Liu, H., Zhou, B., Yan, W., Lei, Z., Zhao, X., Zhang, K., and Guo, A. (2014) Astrocyte-like glial cells physiologically regulate olfactory processing through the modification of ORN-PN synaptic strength in Drosophila. Eur. J. Neurosci. 40: 2744-2754.
2.Lei, Z., Chen, K., Li, H., Liu, H., and Guo, A.(2013) The GABA system regulates the sparse coding of odors in the mushroom bodies of Drosophila. Biochem. Biophys. Res. Commun. 436: 35-40.
3.Li, H., Li, Y., Lei, Z., Wang, K., and Guo, A. (2013) Transformation of odor selectivity from projection neurons to single mushroom body neurons mapped with dual-color calcium imaging. Proc. Natl. Acad. Sci. USA. 110: 12084-12089.
4.Yang, X., and Guo, A. (2013) Distinct acute zones for visual stimuli in different visual tasks in Drosophila. PLoS One 8: e61313.
5.Wu, Y., Ren, Q., Li, H., and Guo, A. (2012) The GABAergic anterior paired lateral neurons facilitate olfactory reversal learning in Drosophila. Learn. Mem. 19: 478-486.
6.Ren, Q., Li, H., Wu, Y., Ren, J., and Guo, A.(2012)A gabaergic inhibitory neural circuit regulates visual reversal learning in drosophila. J. Neurosci. 32:11524 –11538
7.Chen, B., Liu, H., Ren, J., and Guo, A. (2012) Mutation of Drosophila dopamine receptor DopR leads to male-male courtship behavior. Biochem Biophys Res Commun. 423: 557-563.
8. Li, X., Yu, F., and Guo, A. (2009) Sleep Deprivation Specifically Impairs Short-term Olfactory Memory in Drosophila. Sleep 32: 1417-1424.
9. Liu, T., Dartevelle, L., Yuan, C., Wei, H., Wang, Y., Ferveur, J, and Guo, A. (2009) Reduction of dopamine level enhances the attractiveness of male Drosophila to other males. PLoS ONE 4: e4574.
10. Lu, S., Fang, J., Guo, A., and Peng, Y. (2009) Impact of network topology on decision-making. Neural Netw. 22: 30-40.
11. Liu, T., Dartevelle, L., Yuan, C., Wei, H., Wang, Y., Ferveur J., and Guo, A. (2008) Increased dopamine level enhances male-male courtship in Drosophila. J. Neurosci. 28: 5539-5546.
12. Xi, W., Peng, Y., Guo, J., Ye, Y., Zhang, K., Yu, F., and Guo, A. (2008) Mushroom bodies modulate salience-based selective fixation behavior in Drosophila. Eur. J. Neurosci., 27: 1441-1451.
13. Zhang, K., Guo, J., Peng, Y., Xi, W., and Guo, A. (2007) Dopamine-Mushroom Body Circuit Regulates Saliency-Based Decision-Making in Drosophila. Science 316: 1901-1904.
14. Peng, Y., Xi, W., Zhang, W., Zhang, K., and Guo, A. (2007) Experience Improves Feature Extraction in Drosophila. J. Neurosci. 27: 5139-5145.
15. Xu, S., Cang, C., Liu, X., Peng, Y., Ye, Y., Zhao, Z., and Guo, A. (2006) Thermal nociception in adult Drosophila: behavioral characterization and the role of the painless gene. Genes Brain Behav. 5(8): 602-613.
16. Guo, J., and Guo, A. (2005) Crossmodal Interactions Between Olfactory and Visual Learning in Drosophila. Science 309: 307-310.
17. Zhou, X., Yuan, C., and Guo, A. (2005) Drosophila Olfactory Response Rhythms Require Clock Genes but Not Pigment Dispersing Factor or Lateral Neurons. J. Biol. Rhythm. 20: 237-244.
18. Ye, Y., Xi, W., Peng, Y., Wang, Y., and Guo, A. (2004) Long-term but not short-term blockade of dopamine release in Drosophila impairs orientation during flight in a visual attention paradigm. Eur. J. Neurosci. 20: 1001-1007.
19. Tang, S., and Guo, A. (2001) Choice behavior of Drosophila facing contradictory visual cues. Science, 294: 1543-1547.

Research Interests

Due to its sophisticated genetics, relatively simple anatomy, rich array of behaviors, and its remarkable conservation of molecular mechanisms to mammals, Drosophila has become the “Jack of all trades” in the life sciences. The current research interest of our lab is to understand the molecular, cellular, and integrative mechanisms underlying learning, memory and higher cognitive functions, e.g., decision-making and cross-modal memory synergism, in Drosophila. In particular, we aim at understanding how neural circuit might use the reward information for controlling goal-directed behavior, such as selective attention, decision-choice-action and intentional behavior.

In addition to the main line of research described above, we have also pursued several side-projects, including thermal nociception, circadian clock, male-male courtship, drug addiction as well as the neurodegenerations in flies. The long-term goal in these projects is elucidate whether the circuits underlying addictive or courtship behaviors have anything in common with those required for decision making processes.



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