基本信息
段自磊 男 中国科学院昆明动物研究所
电子邮件: duanzilei@mail.kiz.ac.cn
通信地址: 云南省昆明市五华区教场东路32号
邮政编码:
电子邮件: duanzilei@mail.kiz.ac.cn
通信地址: 云南省昆明市五华区教场东路32号
邮政编码:
研究领域
1、天然药物功能蛋白质组学
2、活性多肽与疾病(溃疡性结肠炎、阿尔兹海默症、细菌或病毒感染、卒中等)机理
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
天然药物功能蛋白质组学;活性多肽与疾病机理
教育背景
2012-09--2017-06 中国科学院昆明动物研究所 博士2008-09--2012-06 商丘师范学院 学士
工作经历
工作简历
2021-01~现在, 中国科学院昆明动物研究所, 副研究员2017-07~2020-12,中国科学院昆明动物研究所, 助理研究员
专利与奖励
奖励信息
(1) 全国科技系统抗击新冠肺炎先进集体, 部委级, 2021
出版信息
发表论文
[1] Yuan, Bingqian, Lu, Xiaoyu, Yang, Min, He, Qiyi, Cha, Zhuocen, Fang, Yaqun, Yang, Yan, Xu, Lei, Yan, Jingting, Lai, Ren, Wang, Aili, Yu, Xiaodong, Duan, Zilei. A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus. FRONTIERS IN MICROBIOLOGY[J]. 2022, 第 13 作者 通讯作者 13: http://dx.doi.org/10.3389/fmicb.2022.1029366.[2] Chen, Xue, Deng, Suixin, Wang, Wenchao, Castiglione, Stefania, Duan, Zilei, Luo, Lei, Cianci, Francesca, Zhang, Xiaoxue, Xu, Jianglei, Li, Hao, Zhao, Jizong, Kamau, Peter Muiruri, Zhang, Zhiye, Mwangi, James, Li, Jiali, Shu, Yousheng, Hu, Xintian, Mazzanti, Michele, Lai, Ren. Human antimicrobial peptide LL-37 contributes to Alzheimer's disease progression. MOLECULAR PSYCHIATRY[J]. 2022, 第 5 作者27(11): 4790-4799, http://dx.doi.org/10.1038/s41380-022-01790-6.[3] Liao, Zhiyi, Tang, Xiaopeng, Chen, Wenlin, Jiang, Xuelong, Chen, Zhongzheng, He, Kai, Li, Quan, Duan, Zilei, He, Xiaoqin, Kamau, Peter Muiruri, Lv, Longbao, Zhang, Zhiye, Rong, Mingqiang, Lv, Qiumin, Lai, Ren. Shrew's venom quickly causes circulation disorder, analgesia and hypokinesia. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2022, 第 8 作者79(1): http://dx.doi.org/10.1007/s00018-021-04116-x.[4] Duan, Zilei, Zhang, Juan, Chen, Xue, Liu, Ming, Zhao, Hongwen, Jin, Lin, Zhang, Zhiye, Luan, Ning, Meng, Ping, Wang, Jing, Tan, Zhaoxia, Li, Yaxiong, Deng, Guohong, Lai, Ren. Role of LL-37 in thrombotic complications in patients with COVID-19. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2022, 第 1 作者79(6): http://dx.doi.org/10.1007/s00018-022-04309-y.[5] Qiao, Jingxin, Li, YueShan, Zeng, Rui, Liu, FengLiang, Luo, RongHua, Huang, Chong, Wang, YiFei, Zhang, Jie, Quan, Baoxue, Shen, Chenjian, Mao, Xin, Liu, Xinlei, Sun, Weining, Yang, Wei, Ni, Xincheng, Wang, Kai, Xu, Ling, Duan, ZiLei, Zou, QingCui, Zhang, HaiLin, Qu, Wang, Long, YangHaoPeng, Li, MingHua, Yang, RuiCheng, Liu, Xiaolong, You, Jing, Zhou, Yangli, Yao, Rui, Li, WenPei, Liu, JingMing, Chen, Pei, Liu, Yang, Lin, GuiFeng, Yang, Xin, Zou, Jun, Li, Linli, Hu, Yiguo, Lu, GuangWen, Li, WeiMin, Wei, YuQuan, Zheng, YongTang, Lei, Jian, Yang, Shengyong. SARS-CoV-2 M-pro inhibitors with antiviral activity in a transgenic mouse model. SCIENCE[J]. 2021, 第 18 作者371(6536): 1374-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099175/.[6] Xia, Bingqing, Shen, Xurui, He, Yang, Pan, Xiaoyan, Liu, FengLiang, Wang, Yi, Yang, Feipu, Fang, Sui, Wu, Yan, Duan, Zilei, Zuo, Xiaoli, Xie, Zhuqing, Jiang, Xiangrui, Xu, Ling, Chi, Hao, Li, Shuangqu, Meng, Qian, Zhou, Hu, Zhou, Yubo, Cheng, Xi, Xin, Xiaoming, Jin, Lin, Zhang, HaiLin, Yu, DanDan, Li, MingHua, Feng, XiaoLi, Chen, Jiekai, Jiang, Hualiang, Xiao, Gengfu, Zheng, YongTang, Zhang, LeiKe, Shen, Jingshan, Li, Jia, Gao, Zhaobing. SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target. Cell Research[J]. 2021, 第 10 作者31(8): 847-860, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7058844&detailType=1.[7] Zhu, TengYu, Qiu, Huan, Cao, QiQi, Duan, ZiLei, Liu, FengLiang, Song, TianZhang, Liu, Yang, Fang, YaQun, Wu, GuangMing, Zheng, YongTang, Ding, WenJun, Lai, Ren, Jin, Lin. Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice. ZOOLOGICAL RESEARCH[J]. 2021, 第 4 作者42(3): 335-+, http://dx.doi.org/10.24272/j.issn.2095-8137.2021.088.[8] Tian, RenRong, Yang, CuiXian, Zhang, Mi, Feng, XiaoLi, Luo, RongHua, Duan, ZiLei, Li, JianJian, Liu, JiaFa, Yu, DanDan, Xu, Ling, Zheng, HongYi, Li, MingHua, Fan, HongLi, Wang, JiaLi, Dong, XingQi, Zheng, YongTang. Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study. ZOOLOGICAL RESEARCH[J]. 2021, 第 6 作者42(2): 161-169, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6980679&detailType=1.[9] Liu, FengLiang, Wu, Kaixin, Sun, Jiaoyang, Duan, Zilei, Quan, Xiongzhi, Kuang, Junqi, Chu, Shilong, Pang, Wei, Gao, Han, Xu, Ling, Li, YingChang, Zhang, HaiLin, Wang, XueHui, Luo, RongHua, Feng, XiaoLi, Schoeler, Hans R, Chen, Xinwen, Pei, Duanqing, Wu, Guangming, Zheng, YongTang, Chen, Jiekai. Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation. NATIONAL SCIENCE REVIEW[J]. 2021, 第 4 作者8(2): 9-11, http://lib.cqvip.com/Qikan/Article/Detail?id=7104077532.[10] Li, Yan, Zhang, Jinyong, Duan, Zilei, Wang, Ning, Sun, Xiangcheng, Zhang, Yanjing, Fu, Li, Liu, Kaiyun, Yang, Yongjun, Pan, Shulei, Shi, Yun, Zeng, Hao, Guo, Gang, Lai, Ren, Zou, Quanming. High-throughput screening and evaluation of repurposed drugs targeting the SARS-CoV-2 main protease. SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2021, 第 3 作者6(1): 2978-2980, http://dx.doi.org/10.1038/s41392-021-00763-5.[11] Wang, Gan, Yang, MengLi, Duan, ZiLei, Liu, FengLiang, Jin, Lin, Long, ChengBo, Zhang, Min, Tang, XiaoPeng, Xu, Ling, Li, YingChang, Kamau, Peter Muiruri, Yang, Lian, Liu, HongQi, Xu, JingWen, Chen, JieKai, Zheng, YongTang, Peng, XiaoZhong, Lai, Ren. Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models. CELL RESEARCH[J]. 2021, 第 3 作者31(1): 17-24, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6896529&detailType=1.[12] Chuanbin Shen, Ming Liu, Runjia Xu, Gan Wang, June Li, Pingguo Chen, Wenjing Ma, James Mwangi, Qiumin Lu, Zilei Duan, Zhiye Zhang, Fatima Zohra Dahmani, Daniel Thomas Mackeigan, Heyu Ni, Ren Lai. The 14-3-3ζ–c-Src–integrin-β3 complex is vital for platelet activation. BLOOD. 2020, 第 10 作者136(8): 974-988, http://dx.doi.org/10.1182/blood.2019002314.[13] Tang, Xiaopeng, Chen, Mengrou, Duan, Zilei, Mwangi, James, Li, Pengpeng, Lai, Ren. Isolation and Characterization of Poecistasin, an Anti-Thrombotic Antistasin-Type Serine Protease Inhibitor from Leech Poecilobdella manillensis. TOXINS[J]. 2018, 第 3 作者10(11): https://www.webofscience.com/wos/woscc/full-record/WOS:000451315900008.[14] Duan, Zilei, Fang, Yaqun, Sun, Yang, Luan, Ning, Chen, Xue, Chen, Mengrou, Han, Yajun, Yin, Yizhu, Mwangi, James, Niu, Junkun, Wang, Kunhua, Miao, Yinglei, Zhang, Zhiye, Lai, Ren. Antimicrobial peptide LL-37 forms complex with bacterial DNA to facilitate blood translocation of bacterial DNA and aggravate ulcerative colitis. SCIENCEBULLETIN[J]. 2018, 第 1 作者63(20): 1364-1375, http://dx.doi.org/10.1016/j.scib.2018.09.014.[15] Xu, Cheng, He, Xiaoqin, Liu, Weihui, Chen, Yan, Zhou, Chunling, Duan, Zilei, Lu, Qiumin, Yan, Xiuwen, Zhang, Zhiye, Zheng, Ruiqiang. An inhibitor peptide of toll-like receptor 2 shows therapeutic potential for allergic conjunctivitis. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2017, 第 6 作者46(X): 9-15, http://dx.doi.org/10.1016/j.intimp.2017.02.024.[16] Luan, Ning, Zhou, Chunling, Li, Pengpeng, Ombati, Rose, Yan, Xiuwen, Mo, Guoxiang, Rong, Mingqiang, Lai, Ren, Duan, Zilei, Zheng, Ruiqiang. Joannsin, a novel Kunitz-type FXa inhibitor from the venom of Prospirobolus joannsi. THROMBOSIS AND HAEMOSTASIS[J]. 2017, 第 9 作者 通讯作者 117(6): 1031-1039, https://www.webofscience.com/wos/woscc/full-record/WOS:000402591300003.[17] Liu, Han, Duan, Zilei, Tang, Jing, Lv, Qiumin, Rong, Mingqiang, Lai, Ren. A short peptide from frog skin accelerates diabetic wound healing. FEBS JOURNAL[J]. 2014, 第 2 作者281(20): 4633-4643, http://dx.doi.org/10.1111/febs.12968.[18] Zhu, Yuqin, Duan, Zilei, Mo, Guoxiang, Shen, Chuanbin, Lv, Longbao, Chen, Wenlin, Lai, Ren. A novel 26RFa peptide containing both analgesic and anti-inflammatory functions from Chinese tree shrew. BIOCHIMIE[J]. 2014, 第 2 作者102(X): 112-116, http://dx.doi.org/10.1016/j.biochi.2014.02.014.[19] Zhang, Zhiye, Mu, Lixian, Tang, Jing, Duan, Zilei, Wang, Fengyu, Wei, Lin, Rong, Mingqiang, Lai, Ren. A Small Peptide with Therapeutic Potential for Inflammatory Acne Vulgaris. PLOS ONE[J]. 2013, 第 4 作者8(8): https://doaj.org/article/fff831ac5bf947a1a67ac5e50a1e5ce9.
科研活动
科研项目
( 1 ) 抗菌蛋白/肽高效表达与生 产, 负责人, 国家任务, 2022-11--2026-10