基本信息
![](/self/img/767a82a9-3bea-48d0-9a2d-29d8ae084337.jpg)
朱正江 男 博导 中国科学院上海有机化学研究所
电子邮件: jiangzhu@sioc.ac.cn
通信地址: 上海市海科路100号13号楼
邮政编码: 201210
研究领域
代谢组学技术;质谱技术; 生物信息学
招生信息
招生专业
071009-细胞生物学070302-分析化学
招生方向
代谢组学质谱分析生物信息学
教育背景
2011-10--2014-01 The Scripps Research Institute 博士后2006-08--2011-10 University of Massachusetts Amherst 博士2002-09--2006-06 南京大学 本科
工作经历
工作简历
2013-09~现在, 上海有机化学研究所生物与化学交叉研究中心, 研究员
出版信息
发表论文
[1] Cai, Yuping, Zhou, Zhiwei, Zhu, ZhengJiang. Advanced analytical and informatic strategies for metabolite annotation in untargeted metabolomics. TRAC-TRENDS IN ANALYTICAL CHEMISTRY. 2023, 第 3 作者 通讯作者 158: http://dx.doi.org/10.1016/j.trac.2022.116903.[2] Mingdu Luo, Yandong Yin, Zhiwei Zhou, Haosong Zhang, Xi Chen, Hongmiao Wang, Zheng-Jiang Zhu. A mass spectrum-oriented computational method for ion mobility-resolved untargeted metabolomics. NATURE COMMUNICATIONS[J]. 2023, 第 7 作者 通讯作者 14(1): 1-15, http://dx.doi.org/10.1038/s41467-023-37539-0.[3] Wang, Hongmiao, Jia, Huixun, Gao, Yang, Zhang, Haosong, Fan, Jin, Zhang, Lijie, Ren, Fandong, Yin, Yandong, Cai, Yuping, Zhu, Ji, Zhu, ZhengJiang. Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer. NATURE COMMUNICATIONS[J]. 2022, 第 11 作者 通讯作者 13(1): http://dx.doi.org/10.1038/s41467-022-35511-y.[4] Wang, Ruohong, Yin, Yandong, Li, Jingshu, Wang, Hongmiao, Lv, Wanting, Gao, Yang, Wang, Tangci, Zhong, Yedan, Zhou, Zhiwei, Cai, Yuping, Su, Xiaoyang, Liu, Nan, Zhu, ZhengJiang. Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila. NATURE COMMUNICATIONS[J]. 2022, 第 13 作者 通讯作者 13(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000813768100022.[5] Zhou, Zhiwei, Luo, Mingdu, Zhang, Haosong, Yin, Yandong, Cai, Yuping, Zhu, ZhengJiang. Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking. NATURE COMMUNICATIONS[J]. 2022, 第 6 作者 通讯作者 13(1): http://dx.doi.org/10.1038/s41467-022-34537-6.[6] Liu, Wenbin, Zhang, Weidong, Li, Tongzhou, Zhou, Zhiwei, Luo, Mingdu, Chen, Xi, Cai, Yuping, Zhu, ZhengJiang. Four-Dimensional Untargeted Profiling of N-Acylethanolamine Lipids in the Mouse Brain Using Ion Mobility-Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2022, 第 8 作者 通讯作者 94(36): 12472-12480, [7] Xi Chen, Yandong Yin, Mingdu Luo, Zhiwei Zhou, Yuping Cai, ZhengJiang Zhu. Trapped ion mobility spectrometry-mass spectrometry improves the coverage and accuracy of four-dimensional untargeted lipidomics. ANALYTICA CHIMICA ACTA[J]. 2022, 第 6 作者 通讯作者 1210: [8] Shen, Xia, Wang, Can, Liang, Ningning, Liu, Zhen, Li, Xinde, Zhu, ZhengJiang, Merriman, Tony R, Dalbeth, Nicola, Terkeltaub, Robert, Li, Changgui, Yin, Huiyong. Serum Metabolomics Identifies Dysregulated Pathways and Potential Metabolic Biomarkers for Hyperuricemia and Gout. ARTHRITIS & RHEUMATOLOGY[J]. 2021, 第 6 作者73(9): 1738-1748, http://dx.doi.org/10.1002/art.41733.[9] Deng, Kui, Zhao, Falin, Rong, Zhiwei, Cao, Lei, Zhang, Liuchao, Li, Kang, Hou, Yan, Zhu, ZhengJiang. WaveICA 2.0: a novel batch effect removal method for untargeted metabolomics data without using batch information. METABOLOMICS[J]. 2021, 第 8 作者 通讯作者 17(10): [10] Qiu, Jiaqian, Li, Tongzhou, Zhu, ZhengJiang. Multi-dimensional characterization and identification of sterols in untargeted LC-MS analysis using all ion fragmentation technology. ANALYTICA CHIMICA ACTA[J]. 2021, 第 3 作者 通讯作者 1142: 108-117, http://dx.doi.org/10.1016/j.aca.2020.10.058.[11] Tongzhou Li, Yandong Yin, Zhiwei Zhou, Jiaqian Qiu, Wenbin Liu, Xueting Zhang, Kaiwen He, Yuping Cai, ZhengJiang Zhu. Ion mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain. NATURE COMMUNICATIONS[J]. 2021, 第 9 作者 通讯作者 12(1): http://dx.doi.org/10.1038/s41467-021-24672-x.[12] Mei, Xinyu, Guo, Yuan, Xie, Zhangdan, Zhong, Yedan, Wu, Xiaofen, Xu, Daichao, Li, Ying, Liu, Nan, Zhu, ZhengJiang. RIPK1 regulates starvation resistance by modulating aspartate catabolism. NATURE COMMUNICATIONS[J]. 2021, 第 9 作者 通讯作者 12(1): http://dx.doi.org/10.1038/s41467-021-26423-4.[13] Lv, Jiali, Wang, Jialin, Shen, Xiaotao, Liu, Jia, Zhao, Deli, Wei, Mengke, Li, Xia, Fan, Bingbing, Sun, Yawen, Xue, Fuzhong, Zhu, ZhengJiang, Zhang, Tao. A serum metabolomics analysis reveals a panel of screening metabolic biomarkers for esophageal squamous cell carcinoma. CLINICAL AND TRANSLATIONAL MEDICINE[J]. 2021, 第 11 作者 通讯作者 11(5): https://doaj.org/article/39583dca4d4d457d926450c329d6b7fe.[14] Chuchu Wang, Jia Tu, Shengnan Zhang, Bin Cai, Zhenying Liu, Shouqiao Hou, Qinglu Zhong, Xiao Hu, Wenbin Liu, Guohui Li, Zhijun Liu, Lin He, Jiajie Diao, ZhengJiang Zhu, Dan Li, Cong Liu. Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly. NATURE COMMUNICATIONS[J]. 2020, 第 14 作者11(1): http://dx.doi.org/10.1038/s41467-020-15270-4.[15] Li Zhenwei, Hou Jinjun, Deng Yanping, Zhi Haijuan, Wu Wenyong, Yan Bingpeng, Chen Tingting, Tu Jia, Zhu Zhengjiang, Wu Wanying, Guo Dean. Exploring the protective effects of Danqi Tongmai tablet on acute myocardial ischemia rats by comprehensive metabolomics profiling. PHYTOMEDICINE[J]. 2020, 第 9 作者74: http://dx.doi.org/10.1016/j.phymed.2019.152918.[16] Rong, Zhiwei, Tan, Qilong, Cao, Lei, Zhang, Liuchao, Deng, Kui, Huang, Yue, Zhu, ZhengJiang, Li, Zhenzi, Li, Kang. NormAE: Deep Adversarial Learning Model to Remove Batch Effects in Liquid Chromatography Mass Spectrometry-Based Metabolomics Data. ANALYTICAL CHEMISTRY[J]. 2020, 第 7 作者92(7): 5082-5090, http://dx.doi.org/10.1021/acs.analchem.9b05460.[17] Tsugawa, Hiroshi, Ikeda, Kazutaka, Takahashi, Mikiko, Satoh, Aya, Mori, Yoshifumi, Uchino, Haruki, Okahashi, Nobuyuki, Yamada, Yutaka, Tada, Ipputa, Bonini, Paolo, Higashi, Yasuhiro, Okazaki, Yozo, Zhou, Zhiwei, Zhu, ZhengJiang, Koelmel, Jeremy, Cajka, Tomas, Fiehn, Oliver, Saito, Kazuki, Arita, Masanori, Arita, Makoto. A lipidome atlas in MS-DIAL 4. NATURE BIOTECHNOLOGY[J]. 2020, 第 14 作者38(10): 1159-+, http://dx.doi.org/10.1038/s41587-020-0531-2.[18] Bridi, Michelle C D, Zong, FangJiao, Min, Xia, Luo, Nancy, Tran, Trinh, Qiu, Jiaqian, Severin, Daniel, Zhang, XueTing, Wang, Guanglin, Zhu, ZhengJiang, He, KaiWen, Kirkwood, Alfredo. Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits. NEURON[J]. 2020, 第 10 作者105(4): 621-+, http://dx.doi.org/10.1016/j.neuron.2019.11.011.[19] Chen, Xi, Yin, Yandong, Zhou, Zhiwei, Li, Tongzhou, Zhu, ZhengJiang. Development of a combined strategy for accurate lipid structural identification and quantification in ion-mobility mass spectrometry based untargeted lipidomics. ANALYTICA CHIMICA ACTA[J]. 2020, 第 5 作者 通讯作者 1136: 115-124, http://dx.doi.org/10.1016/j.aca.2020.08.048.[20] Guo, Lin, Gao, Jing, Gao, Yang, Zhu, Zhengjiang, Zhang, Yaoyang. Aspirin Reshapes Acetylomes in Inflammatory and Cancer Cells via CoA-Dependent and CoA-Independent Pathways. JOURNAL OF PROTEOME RESEARCH[J]. 2020, 第 4 作者19(2): 962-972, https://www.webofscience.com/wos/woscc/full-record/WOS:000513085100035.[21] Luo, MingDu, Zhou, ZhiWei, Zhu, ZhengJiang. The Application of Ion Mobility-Mass Spectrometry in Untargeted Metabolomics: from Separation to Identification. 分析检测(英文)[J]. 2020, 第 3 作者 通讯作者 4(3): 163-174, http://lib.cqvip.com/Qikan/Article/Detail?id=7107072410.[22] You, Yingnan, Gao, Yang, Wang, Han, Li, Jingshu, Zhang, Xiang, Zhu, Zhengjiang, Liu, Nan. Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration. FRONTIERS IN PHARMACOLOGY[J]. 2020, 第 6 作者11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770224/.[23] Zhiwei Zhou, Mingdu Luo, Xi Chen, Yandong Yin, Xin Xiong, Ruohong Wang, ZhengJiang Zhu. Ion mobility collision cross-section atlas for known and unknown metabolite annotation in untargeted metabolomics. NATURE COMMUNICATIONS[J]. 2020, 第 7 作者 通讯作者 11(1): https://doaj.org/article/e6d6e634999a4c0f9fc4d90b78491cb2.[24] Shen, Xiaotao, Zhu, ZhengJiang. MetFlow: an interactive and integrated workflow for metabolomics data cleaning and differential metabolite discovery. BIOINFORMATICS[J]. 2019, 第 2 作者 通讯作者 35(16): 2870-2872, https://www.webofscience.com/wos/woscc/full-record/WOS:000487292100028.[25] Xiaotao Shen, Ruohong Wang, Xin Xiong, Yandong Yin, Yuping Cai, Zaijun Ma, Nan Liu, ZhengJiang Zhu. Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomics. NATURE COMMUNICATIONS[J]. 2019, 第 8 作者 通讯作者 10(1): 1-14, https://doaj.org/article/483ceccdfc294c00b995f17e16a13252.[26] Zhou, Zhiwei, Shen, Xiaotao, Chen, Xi, Tu, Jia, Xiong, Xin, Zhu, ZhengJiang. LipidIMMS Analyzer: integrating multi-dimensional information to support lipid identification in ion mobility-mass spectrometry based lipidomics. BIOINFORMATICS[J]. 2019, 第 6 作者 通讯作者 35(4): 698-700, [27] Tu, Jia, Zhou, Zhiwei, Li, Tongzhou, Zhu, ZhengJiang. The emerging role of ion mobility-mass spectrometry in lipidomics to facilitate lipid separation and identification. TRAC-TRENDS IN ANALYTICAL CHEMISTRY. 2019, 第 4 作者 通讯作者 116: 332-339, http://dx.doi.org/10.1016/j.trac.2019.03.017.[28] Deng, Kui, Zhang, Fan, Tan, Qilong, Huang, Yue, Song, Wei, Rong, Zhiwei, Zhu, ZhengJiang, Li, Zhenzi, Li, Kang. WaveICA: A novel algorithm to remove batch effects for large-scale untargeted metabolomics data based on wavelet analysis. ANALYTICA CHIMICA ACTA[J]. 2019, 第 7 作者1061: 60-69, http://dx.doi.org/10.1016/j.aca.2019.02.010.[29] Yin, Yandong, Wang, Ruohong, Cai, Yuping, Wang, Zhuozhong, Zhu, ZhengJiang. DecoMetDIA: Deconvolution of Multiplexed MS/MS Spectra for Metabolite Identification in SWATH-MS-Based Untargeted Metabolomics. ANALYTICAL CHEMISTRY[J]. 2019, 第 5 作者 通讯作者 91(18): 11897-11904, https://www.webofscience.com/wos/woscc/full-record/WOS:000487156900054.[30] Wang, Ruohong, Yin, Yandong, Zhu, ZhengJiang. Advancing untargeted metabolomics using data-independent acquisition mass spectrometry technology. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2019, 第 3 作者 通讯作者 411(19): 4349-4357, [31] Wang, Zhuozhong, Cui, Binbin, Zhang, Fan, Yang, Yue, Shen, Xiaotao, Li, Zhong, Zhao, Weiwei, Zhang, Yuanyuan, Deng, Kui, Rong, Zhiwei, Yang, Kai, Yu, Xiwen, Li, Kang, Han, Peng, Zhu, ZhengJiang. Development of a Correlative Strategy To Discover Colorectal Tumor Tissue Derived Metabolite Biomarkers in Plasma Using Untargeted Metabolomics. ANALYTICAL CHEMISTRY[J]. 2019, 第 15 作者 通讯作者 91(3): 2401-2408, http://dx.doi.org/10.1021/acs.analchem.8b05177.[32] Xue, JianHuang, Chen, GuoDong, Hao, Fuhua, Chen, Hui, Fang, Zhaoyuan, Chen, FangFang, Pang, Bo, Yang, QingLin, Wei, Xinben, Fan, QiangQiang, Xin, Changpeng, Zhao, Jiaohong, Deng, Xuan, Wang, BangAn, Zhang, XiaoJie, Chu, Yueying, Tang, Hui, Yin, Huiyong, Ma, Weimin, Chen, Luonan, Ding, Jianping, Weinhold, Elmar, Kohli, Rahul M, Liu, Wen, Zhu, ZhengJiang, Huang, Kaiyao, Tang, Huiru, Xu, GuoLiang. A vitamin-C-derived DNA modification catalysed by an algal TET homologue. NATURE[J]. 2019, 第 25 作者569(7757): 581-+, [33] Ma, Zaijun, Wang, Hui, Cai, Yuping, Wang, Han, Niu, Kongyan, Wu, Xiaofen, Ma, Huanhuan, Yang, Yun, Tong, Wenhua, Liu, Feng, Liu, Zhandong, Zhang, Yaoyang, Liu, Rui, Zhu, ZhengJiang, Liu, Nan. Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila. ELIFE[J]. 2018, 第 14 作者 通讯作者 7: https://doaj.org/article/9cf7759066d24f918441bcbfdd73a2ff.[34] Zhou, Zhiwei, Tu, Jia, Zhu, ZhengJiang. Advancing the large-scale CCS database for metabolomics and lipidomics at the machine-learning era. CURRENT OPINION IN CHEMICAL BIOLOGY. 2018, 第 3 作者 通讯作者 42: 34-41, http://dx.doi.org/10.1016/j.cbpa.2017.10.033.[35] Yang, Kai, Zhang, Fan, Han, Peng, Wang, Zhuozhong, Deng, Kui, Zhang, Yuanyuan, Zhao, Weiwei, Song, Wei, Cai, Yuqing, Li, Kang, Cui, Binbin, Zhu, ZhengJiang. Metabolomics approach for predicting response to neoadjuvant chemotherapy for colorectal cancer. METABOLOMICS[J]. 2018, 第 12 作者 通讯作者 14(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000442051000001.[36] Jia, Huixun, Shen, Xiaotao, Guan, Yun, Xu, Meimei, Tu, Jia, Mo, Miao, Xie, Li, Yuan, Jing, Zhang, Zhen, Cai, Sanjun, Zhu, Ji, Zhu, ZhengJiang. Predicting the pathological response to neoadjuvant chemoradiation using untargeted metabolomics in locally advanced rectal cancer. RADIOTHERAPY AND ONCOLOGY[J]. 2018, 第 12 作者 通讯作者 128(3): 548-556, http://dx.doi.org/10.1016/j.radonc.2018.06.022.[37] Zha, Haihong, Cai, Yuping, Yin, Yandong, Wang, Zhuozhong, Li, Kang, Zhu, ZhengJiang. SWATHtoMRM: Development of High-Coverage Targeted Metabolomics Method Using SWATH Technology for Biomarker Discovery. ANALYTICAL CHEMISTRY[J]. 2018, 第 6 作者 通讯作者 90(6): 4062-4070, http://dx.doi.org/10.1021/acs.analchem.7b05318.[38] Tu, Jia, Yin, Yandong, Xu, Meimei, Wang, Ruohong, Zhu, ZhengJiang. Absolute quantitative lipidomics reveals lipidome-wide alterations in aging brain. METABOLOMICS[J]. 2018, 第 5 作者 通讯作者 14(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000424713300010.[39] Yang, Xiangyun, Wang, Zhiyuan, Guo, Lin, Zhu, Zhengjiang, Zhang, Yaoyang. Proteome-Wide Analysis of N-Glycosylation Stoichiometry Using SWATH Technology. JOURNAL OF PROTEOME RESEARCH[J]. 2017, 第 4 作者16(10): 3830-3840, https://www.webofscience.com/wos/woscc/full-record/WOS:000412789400031.[40] Lin, Ran, Mo, Yan, Zha, Haihong, Qu, Zhipeng, Xie, Pancheng, Zhu, ZhengJiang, Xu, Ying, Xiong, Yue, Guan, KunLiang. CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. MOLECULAR CELL[J]. 2017, 第 6 作者68(1): 198-+, http://dx.doi.org/10.1016/j.molcel.2017.09.008.[41] Zhou, Zhiwei, Tu, Jia, Xiong, Xin, Shen, Xiaotao, Zhu, ZhengJiang. LipidCCS: Prediction of Collision Cross-Section Values for Lipids with High Precision To Support Ion Mobility-Mass Spectrometry-Based Lipidomics. ANALYTICAL CHEMISTRY[J]. 2017, 第 5 作者 通讯作者 89(17): 9559-9566, https://www.webofscience.com/wos/woscc/full-record/WOS:000410014900133.[42] Zhou, Zhiwei, Xiong, Xin, Zhu, ZhengJiang. MetCCS predictor: a web server for predicting collision cross-section values of metabolites in ion mobility-mass spectrometry based metabolomics. BIOINFORMATICS[J]. 2017, 第 11 作者33(14): 2235-2237, https://www.webofscience.com/wos/woscc/full-record/WOS:000405289100080.[43] Lu, Jianhong, Chen, Buxing, Chen, Tingting, Guo, Shuyuan, Xue, Xinli, Chen, Qun, Zhao, Mingming, Xia, Lin, Zhu, Zhengjiang, Zheng, Lemin, Yin, Huiyong. Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases. REDOX BIOLOGY[J]. 2017, 第 9 作者12(-): 899-907, http://dx.doi.org/10.1016/j.redox.2017.04.032.[44] Zhou, Zhiwei, Shen, Xiaotao, Tu, Jia, Zhu, ZhengJiang. Large-Scale Prediction of Collision Cross-Section Values for Metabolites in Ion Mobility-Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2016, 第 11 作者88(22): 11084-11091, https://www.webofscience.com/wos/woscc/full-record/WOS:000388154700045.[45] Li, Hao, Cai, Yuping, Guo, Yuan, Chen, Fangfang, Zhu, ZhengJiang. MetDIA: Targeted Metabolite Extraction of Multiplexed MS/MS Spectra Generated by Data-Independent Acquisition. ANALYTICAL CHEMISTRY[J]. 2016, 第 11 作者88(17): 8757-8764, https://www.webofscience.com/wos/woscc/full-record/WOS:000382805900058.[46] Shen, Xiaotao, Gong, Xiaoyun, Cai, Yuping, Guo, Yuan, Tu, Jia, Li, Hao, Zhang, Tao, Wang, Jialin, Xue, Fuzhong, Zhu, ZhengJiang. Normalization and integration of large-scale metabolomics data using support vector regression. METABOLOMICS[J]. 2016, 第 10 作者 通讯作者 12(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000378755000001.[47] Wang, Jialin, Zhang, Tao, Shen, Xiaotao, Liu, Jia, Zhao, Deli, Sun, Yawen, Wang, Lu, Liu, Yingjun, Gong, Xiaoyun, Liu, Yanxun, Zhu, ZhengJiang, Xue, Fuzhong. Serum metabolomics for early diagnosis of esophageal squamous cell carcinoma by UHPLC-QTOF/MS. METABOLOMICS[J]. 2016, 第 11 作者 通讯作者 12(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000379508500008.[48] Cai, Yuping, Weng, Kai, Guo, Yuan, Peng, Jie, Zhu, ZhengJiang. An integrated targeted metabolomic platform for high-throughput metabolite profiling and automated data processing. METABOLOMICS[J]. 2015, 第 5 作者 通讯作者 11(6): 1575-1586, https://www.webofscience.com/wos/woscc/full-record/WOS:000363040600009.[49] Kurczy, Michael E, Zhu, ZhengJiang, Ivanisevic, Julijana, Schuyler, Adam M, Lalwani, Kush, Santidrian, Antonio F, David, John M, Giddabasappa, Anand, Roberts, Amanda J, Olivos, Hernando J, OBrien, Peter J, Franco, Lauren, Fields, Matthew W, Paris, Liliana P, Friedlander, Martin, Johnson, Caroline H, Epstein, Adrian A, Gendelman, Howard E, Wood, Malcolm R, Felding, Brunhilde H, Patti, Gary J, Spilker, Mary E, Siuzdak, Gary. Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. NATURE COMMUNICATIONS[J]. 2015, 第 2 作者6: 5998-5998, https://www.webofscience.com/wos/woscc/full-record/WOS:000348829500005.[50] Xia, Hongguang, Najafov, Ayaz, Geng, Jiefei, GalanAcosta, Lorena, Han, Xuemei, Guo, Yuan, Shan, Bing, Zhang, Yaoyang, Norberg, Erik, Zhang, Tao, Pan, Lifeng, Liu, Junli, Coloff, Jonathan L, Ofengeim, Dimitry, Zhu, Hong, Wu, Kejia, Cai, Yu, Yates, John R, Zhu, Zhengjiang, Yuan, Junying, VakifahmetogluNorberg, Helin. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. JOURNAL OF CELL BIOLOGY[J]. 2015, 第 19 作者210(5): 705-716, http://dx.doi.org/10.1083/jcb.201503044.[51] Ivanisevic, Julijana, Zhu, ZhengJiang, Plate, Lars, Tautenhahn, Ralf, Chen, Stephen, OBrien, Peter J, Johnson, Caroline H, Marletta, Michael A, Patti, Gary J, Siuzdak, Gary. Toward 'Omic Scale Metabolite Profiling: A Dual Separation-Mass Spectrometry Approach for Coverage of Lipid and Central Carbon Metabolism. ANALYTICAL CHEMISTRY[J]. 2013, 第 2 作者85(14): 6876-6884, https://www.webofscience.com/wos/woscc/full-record/WOS:000322059600048.[52] Zhu, ZhengJiang, Schultz, Andrew W, Wang, Junhua, Johnson, Caroline H, Yannone, Steven M, Patti, Gary J, Siuzdak, Gary. Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. NATURE PROTOCOLS[J]. 2013, 第 1 作者8(3): 451-460, https://www.webofscience.com/wos/woscc/full-record/WOS:000317110600002.[53] Zhu, ZhengJiang, Posati, Tamara, Moyano, Daniel F, Tang, Rui, Yan, Bo, Vachet, Richard W, Rotello, Vincent M. The Interplay of Monolayer Structure and Serum Protein Interactions on the Cellular Uptake of Gold Nanoparticles. SMALL[J]. 2012, 第 1 作者8(17): 2659-2663, https://www.webofscience.com/wos/woscc/full-record/WOS:000308303600007.[54] Zhu, ZhengJiang, Tang, Rui, Yeh, YiCheun, Miranda, Oscar R, Rotello, Vincent M, Vachet, Richard W. Determination of the Intracellular Stability of Gold Nanoparticle Monolayers Using Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2012, 第 1 作者84(10): 4321-4326, https://www.webofscience.com/wos/woscc/full-record/WOS:000303965500014.[55] ZhengJiang Zhu. Effect of Surface Charge on the Uptake and Distribution of Gold Nanoparticles in Plants. Environ. Sci. Technol.. 2012, 第 1 作者[56] Tautenhahn, Ralf, Cho, Kevin, Uritboonthai, Winnie, Zhu, Zhengjiang, Patti, Gary J, Siuzdak, Gary. An accelerated workflow for untargeted metabolomics using the METLIN database. NATURE BIOTECHNOLOGY. 2012, 第 4 作者30(9): 826-828, https://www.webofscience.com/wos/woscc/full-record/WOS:000308705700012.[57] Zhu, ZhengJiang, Yeh, YiCheun, Tang, Rui, Yan, Bo, Tamayo, Joshua, Vachet, Richard W, Rotello, Vincent M. Stability of quantum dots in live cells. NATURE CHEMISTRY[J]. 2011, 第 1 作者 通讯作者 3(12): 963-968, https://www.webofscience.com/wos/woscc/full-record/WOS:000297685800015.[58] ZhengJiang Zhu. Host-Guest Chemistry inside Living Cells: Recognition-Mediated Activation of Therapeutic Gold Nanoparticles. Nature Chemistry. 2010, 第 1 作者[59] Zhu, ZhengJiang, Carboni, Rachel, Quercio, Michael J, Jr, Yan, Bo, Miranda, Oscar R, Anderton, Douglas L, Arcaro, Kathleen F, Rotello, Vincent M, Vachet, Richard W. Surface Properties Dictate Uptake, Distribution, Excretion, and Toxicity of Nanoparticles in Fish. SMALL[J]. 2010, 第 1 作者6(20): 2261-2265, https://www.webofscience.com/wos/woscc/full-record/WOS:000283890500010.[60] Yan, Bo, Zhu, ZhengJiang, Miranda, Oscar R, Chompoosor, Apiwat, Rotello, Vincent M, Vachet, Richard W. Laser desorption/ionization mass spectrometry analysis of monolayer-protected gold nanoparticles. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2010, 第 2 作者396(3): 1025-1035, https://www.webofscience.com/wos/woscc/full-record/WOS:000273845200008.[61] Zhu, ZhengJiang, Rotello, Vincent M, Vachet, Richard W. 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