Antibody discovery and engineering

Protein drug design

Strucutural analysis

09/2016 - 02/2020 Ph.D. Pathogenic Organisms

                 Medical School, University of Chinese Academy of Sciences, China

   

01/2025 – now   Associate professor in Shenzhen Institutes of Advanced Technology,

               Chinese Academy of Sciences, Principal investigator

08/2021 – 09/2024 Postdoctoral research scientist in Columbia university, USA

08/2020 – 08/2021 Scientist in Jiangsu Hengrui Pharmaceutical Co., Ltd., China

Selected publications:

Qian Wang^#, Sho Iketani^#, Zhiteng Li^#, Liyuan Liu^#, Yicheng Guo^#, Yiming Huang, Anthony D Bowen, Michael Liu, Maple Wang, Jian Yu, Riccardo Valdez, Adam S Lauring, Zizhang Sheng, Harris H Wang, Aubree Gordon, Lihong Liu*, David D Ho*. (2023) Alarming antibody evasion properties of rising

SARS-CoV-2 BQ and XBB subvariants. Cell, 186(2), 279-286. https://doi.org/10.1016/j.cell.2022.12.018

 

Qian Wang^#, Zhiteng Li^#, Jerren Ho, Yicheng Guo, Andre Yanchen Yeh, Hiroshi Mohri, Michael Liu, Maple Wang, Jian Yu, Jayesh G Shah, Jennifer Y Chang, Favio Herbas, Michael T Yin, Magdalena E Sobieszczyk, Zizhang Sheng, Lihong Liu*, David D Ho*. (2022) Resistance of SARS-CoV-2 omicron subvariant BA. 4.6 to antibody neutralisation. The Lancet Infectious Diseases, 22(12), 1666-1668. https://doi.org/10.1016/S1473-3099(22)00694-6

 

Qian Wang^#, Zhiteng Li^#, Yicheng Guo^#, Ian A Mellis^#, Sho Iketani, Michael Liu, Jian Yu, Riccardo Valdez, Adam S Lauring, Zhizhang Sheng, Aubree Gordon, Lihong Liu*, David D Ho*. (2023) Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2. iScience. 26, 108254. https://doi.org/10.1016/j.isci.2023.108254

 

Ruchao Peng^#, Zhiteng Li^#, Ying Xu^#, Shaoshuai He, Qi Peng, Lian-ao Wu, Ying Wu, Jianxun Qi, Peiyi Wang, Yi Shi*, and George F. Gao*. (2019) Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4. Proceedings of the National Academy of Sciences of the United States of America, 116(38):18928-18936. https://doi.org/10.1073/pnas.1909400116

 

Qian Wang^#, Sho Iketani^#, Zhiteng Li, Yicheng Guo, Andre Yanchen Yeh, Michael Liu, Jian Yu, Zizhang Sheng, Yaoxing Huang, Lihong Liu*, David D Ho*. (2022) Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA. 2.75. Cell Host & Microbe, 30(11), 1512-1517. https://doi.org/10.1016/j.chom.2022.09.002

 

Qian Wang^#, Yicheng Guo^#, Liyuan Liu^#, Logan T. Schwanz, Zhiteng Li, Manoj S. Nair, Jerren Ho, Richard M. Zhang, Sho Iketani, Jian Yu, Yiming Huang, Yiming Qu, Riccardo Valdez, Adam S. Lauring, Yaoxing Huang, Aubree Gordon, Harris H. Wang, Lihong Liu*, David D. Ho*. (2024) Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike. Nature. 624(639–644). https://doi.org/10.1038/s41586023-06750-w

 

Qian Wang^#, Yicheng Guo^#, Sho Iketani, Manoj S Nair, Zhiteng Li, Hiroshi Mohri, Maple Wang, Jian Yu, Anthony D Bowen, Jennifer Y Chang, Jayesh G Shah, Nadia Nguyen, Zhiwei Chen, Kathrine Meyers, Michael T Yin, Magdalena E Sobieszczyk, Zizhang Sheng, Yaoxing Huang, Lihong Liu*, David D Ho*. Antibody evasion by SARS-CoV-2 Omicron subvariants BA. 2.12. 1, BA. 4 and BA. 5. Nature, 608(7923), 603-608. https://doi.org/10.1038/s41586-022-05053-w