核医学成像与脑成像的数据分析及应用

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070202-粒子物理与原子核物理

核医学成像
神经成像

2015-09--2020-06   中国科学院大学   博士
2011-09--2015-06   中国科学技术大学   学士

   

2023-01~现在, 中国科学院高能物理研究所, 副研究员
2022-07~2023-01,中国科学院高能物理研究所, 助理研究员
2020-07~2022-06,中国科学院高能物理研究所, 博士后

2021-08-01-2026-08-01,中国图学学会第八届理事会医学图学与设备专业委员会委员, 委员

（1） Prediction of alzheimer's disease time to dementia onset using cross-sectional data from spatiotemporal biomarker progression patterns, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2026

（2） ComBat-Centiloid: A Calibration-Free Method for Quantifying Centiloid Values in Amyloid PET Imaging, Brain Science Advances, 2025

（3） Unified spatial normalization method of brain PET images using adaptive probabilistic brain atlas, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022

（4） Modular architecture of metabolic brain network and its effects on the spread of perturbation impact, NEUROIMAGE, 2019

（5） Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020

（1） Cerebral glucose metabolism basis of prognostic differences between paraneoplastic and non-paraneoplastic anti-GABABR encephalitis, Neuroscience Letters, 2026, 第 3 作者
（2） Prediction of alzheimer’s disease time to dementia onset using cross-sectional data from spatiotemporal biomarker progression patterns, European Journal of Nuclear Medicine and Molecular Imaging, 2026, 第 1 作者
（3） Differential Neural Substrates of Freezing of Gait in Cerebral Small Vessel Disease and Parkinson Disease: A Dual-tracer PET Study, CLINICAL NUCLEAR MEDICINE, 2026, 第 3 作者
（4） 18F-FDG, 18F-FP-CIT, and 18F-Florzolotau PET Imaging in Progressive Supranuclear Palsy Region-Specific Correlations Between Glucose Metabolism, Dopaminergic Function, and Tau Pathology, CLINICAL NUCLEAR MEDICINE, 2026, 第 4 作者
（5） Gestational age-specific DTI templates of the neonatal brain: Application in preterm developmental study, NEUROIMAGE, 2026, 第 4 作者
（6） Higher cerebellum florbetapir uptake in cerebral amyloid angiopathy compared to Alzheimer's disease: A dual florbetapir and FDG PET study, JOURNAL OF ALZHEIMER'S DISEASE REPORTS, 2025, 第 5 作者
（7） Patterns of Tau pathology in patients with anti-IgLON5 disease visualized by Florzolotau (18F) PET, JOURNAL OF NEUROLOGY, 2025, 第 5 作者
（8） Comparative 18FFlorzolotau and 18FFDG PET Imaging Patterns in Anti-IgLON5 Disease and Progressive Supranuclear Palsy, Clinical Nuclear Medicine, 2025, 第 3 作者
（9） Brain development during the lifespan of cynomolgus monkeys, NEUROIMAGE, 2025, 第 6 作者
（10） ComBat-Centiloid: A Calibration-Free Method for Quantifying Centiloid Values in Amyloid PET Imaging, BRAIN SCIENCE ADVANCES, 2025, 第 1 作者
（11） Higher Blood-brain barrier permeability in patients with major depressive disorder identified by DCE-MRI imaging, PSYCHIATRY RESEARCH-NEUROIMAGING, 2024, 第 5 作者
（12） Harmonizing T1-Weighted Images to Improve Consistency of Brain Morphology Among Different Scanner Manufacturers in Alzheimer's disease, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2023, 第 2 作者
（13） Dopaminergic damage pattern predicts phenoconversion time in isolated rapid eye movement sleep behavior disorder, European Journal of Nuclear Medicine and Molecular Imaging, 2023, 
（14） Aging-Related Modular Architectural Reorganization of the Metabolic Brain Network, BRAIN CONNECTIVITY, 2022, 第 3 作者
（15） Increased Blood-Brain Barrier Permeability of the Thalamus Correlated With Symptom Severity and Brain Volume Alterations in Patients With Schizophrenia, BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 2022, 第 3 作者
（16） Unified spatial normalization method of brain PET images using adaptive probabilistic brain atlas, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022, 第 1 作者
（17） Automatic method for individual parcellation of manganese-enhanced magnetic resonance imaging of rat brain, FRONTIERS IN NEUROSCIENCE, 2022, 第 2 作者
（18） Crossed cerebellar diaschisis-related supratentorial hemodynamic and metabolic status measured by PET/MR in assessing postoperative prognosis in chronic ischemic cerebrovascular disease patients with bypass surgery, ANNALS OF NUCLEAR MEDICINE, 2022, 第 3 作者
（19） Retrosplenial Cortex Effects Contextual Fear Formation Relying on Dysgranular Constituent in Rats, FRONTIERS IN NEUROSCIENCE, 2022, 第 4 作者
（20） Nucleus accumbens-linked executive control networks mediating reversal learning in tree shrew brain, Nucleus accumbens-linked executive control networks mediating reversal learning in tree shrew brain, 动物学研究, 2022, 第 5 作者
（21） Deep Learning With 18F-Fluorodeoxyglucose-PET Gives Valid Diagnoses for the Uncertain Cases in Memory Impairment of Alzheimer's Disease, FRONTIERS IN AGING NEUROSCIENCE, 2021, 第 2 作者
（22） Subthreshold depression may exist on a spectrum with major depressive disorder: Evidence from gray matter volume and morphological brain network, JOURNAL OF AFFECTIVE DISORDERS, 2020, 第 1 作者
（23） Distinct relationships of amyloid-beta and tau deposition to cerebral glucose metabolic networks in Alzheimer’s disease, NEUROSCIENCE LETTERS, 2020, 第 6 作者
（24） Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 第 2 作者
（25） Age-associated reorganization of metabolic brain connectivity in Chinese children, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 第 3 作者
（26） Alterations of regional homogeneity in Parkinson's disease with mild cognitive impairment: a preliminary resting-state fMRI study, NEURORADIOLOGY, 2020, 第 3 作者
（27） A stereotaxic MRI template set of mouse brain with fine sub-anatomical delineations: Application to MEMRI studies of 5XFAD mice, MAGNETIC RESONANCE IMAGING, 2019, 第 8 作者
（28） The negative correlation between energy consumption and communication efficiency in motor network, NUCLEAR MEDICINE COMMUNICATIONS, 2019, 第 6 作者
（29） Tau PET Distributional Pattern in AD Patients with Visuospatial Dysfunction, CURRENT ALZHEIMER RESEARCH, 2019, 第 6 作者
（30） Gray matter reduction related to decreased serum creatinine and increased triglyceride, Hemoglobin A1C, and low-density lipoprotein in subjects with obesity, NEURORADIOLOGY, 2019, 第 6 作者
（31） A human brain tau PET template in MNI space for the voxel-wise analysis of Alzheimer’s disease, JOURNAL OF NEUROSCIENCE METHODS, 2019, 第 7 作者
（32） Modular architecture of metabolic brain network and its effects on the spread of perturbation impact, NEUROIMAGE, 2019, 第 1 作者
（33） Stereotaxic 18F-FDG PET and MRI templates with three-dimensional digital atlas for statistical parametric mapping analysis of tree shrew brain, JOURNAL OF NEUROSCIENCE METHODS, 2018, 第 5 作者
（34） Structural and functional brain network of human retrosplenial cortex, NEUROSCIENCE LETTERS, 2018, 第 7 作者
（35） Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke, Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke, NEUROSCIENCE BULLETIN, 2018, 第 5 作者
（36） Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study, OBESITYSURGERY, 2018, 第 8 作者
（37） An Automatic Method for Generating an Unbiased Intensity Normalizing Factor in Positron Emission Tomography Image Analysis After Stroke, An Automatic Method for Generating an Unbiased Intensity Normalizing Factor in Positron Emission Tomography Image Analysis After Stroke, 神经科学通报：英文版, 2018, 第 6 作者

   

（ 1 ） 基于多模态脑影像的个体化亚型识别及其在预测抑郁症针刺快速起效中的应用, 负责人, 研究所自主部署, 2026-01--2027-12
（ 2 ） 基于正电子发射断层成像分子生物标志物实现阿尔茨海默症发病年龄的预测, 负责人, 研究所自主部署, 2024-07--2027-06
（ 3 ） 多中心PET脑成像数据校正方法研究, 负责人, 国家任务, 2023-01--2025-12
（ 4 ） 多探针PET脑成像数据联合分析方法的研究及软件平台的建立, 参与, 国家任务, 2022-01--2025-12
（ 5 ） 基于动态FDGPET的个体脑代谢网络的建立方法及其应用, 负责人, 国家任务, 2021-06--2022-06
（ 6 ） 多模态PET/MRI脑成像联合处理方法研究, 参与, 国家任务, 2020-01--2023-12
（ 7 ） 多中心脑结构磁共振成像数据校正方法的研究, 参与, 国家任务, 2018-01--2021-12

（1）Inhibitory and Promotive Effects of Amyloid-β on Tau: A Stage-Dependent Analysis in Alzheimer’s Disease   欧洲核医学协会年会   张天昊   2025-10-04

   

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毛广娟  博士研究生  070202-粒子物理与原子核物理