基本信息
鄢德洪  男  硕导  中国科学院深圳先进技术研究院
电子邮件: dh.yan@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码: 510080

研究领域

从事髓系来源的抑制性细胞(MDSC)在癌症中的基础与转化研究

招生信息

招生方向
鉴定调控MDSC分化和功能的新靶点
阐明脂质代谢调控MDSC分化和功能的作用
生物材料在靶向MDSC细胞疗法或/与其他药物联合的抗肿瘤免疫治疗研究
招生专业

071010  生物化学与分子生物学

071009  细胞生物学

教育背景

2010-09--2013-06   中山大学中山医学院   博士
2007-09--2010-07   华南农业大学   硕士
2003-09--2007-07   湖北大学   本科

工作经历

   
工作简历
2020-01~现在, 中国科学院深圳先进技术研究院, 副研究员/硕士研究生导师
2017-01~2019-12,中国科学院深圳先进技术研究院, 助理研究员
2014-09~2016-12,中国科学院深圳先进技术研究院, 博士后
2013-07~2014-08,广州永诺生物科技有限公司, 技术副总监
社会兼职
2020-08-18-今,Frontiers in Genetics杂志, 审稿人,专刊客座编辑
2020-05-29-今,Basic & Clinical Pharmacology & Toxicology杂志, 审稿人
2020-04-11-今,OncoImmunology杂志, 审稿人
2016-12-31-2021-12-31,美国免疫学会, 会员

教授课程

生物技术前沿

专利与奖励

   
奖励信息
(1) AAI Early Career Faculty Grant 2021, , 国家级, 2020
(2) AAI Travel Grants for IUIS 2019, , 国家级, 2019
(3) AAI Travel Grants for the 5th European Congress of Immunology, , 国家级, 2018
专利成果
[1] 万晓春, 鄢德洪, 张梦琪. 青蒿素在靶向抑制髓系来源的抑制性细胞及其在制备肿瘤免疫治疗药物中的应用. CN114191430A, 2022-03-18.
[2] 万晓春, 崔璐璐, 毕嘉成, 鄢德洪. 鼠源抗人IgE单克隆抗体的制备方法及其应用. CN: CN107383200B, 2021-04-09.

出版信息

   
发表论文
[1] Adeleye O. Adeshakin, Funmilayo O. Adeshakin, Dehong Yan, Xiaochun Wan. Regulating Histone Deacetylase Signaling Pathways of Myeloid-Derived Suppressor Cells Enhanced T Cell-Based Immunotherapy. Frontiers in Immunology[J]. 2022, 13(781660): https://doi.org/10.3389/fimmu.2022.781660.
[2] Mengqi Zhang, Lulu Wang, Wan Liu, Tian Wang, Francesco De Sanctis, Lifang Zhu, Guizhong Zhang, Jian Cheng, Qin Cao, Jingying Zhou, Aldo Tagliabue, Vincenzo Bronte, Dehong Yan, Xianchun Wan, Guang Yu. Targeting inhibition of accumulation and function of myeloid-derived suppressor cells by artemisinin via PI3K/AKT, mTOR and MAPK pathways enhances anti-PD-L1 immunotherapy in melanoma and liver tumors. Journal of Immunology Research[J]. 2022, 2022(2253436): https://doi.org/10.1155/2022/2253436.
[3] Adeleye Oluwatosin Adeshakin, Wan Liu, Funmilayo O. Adeshakin, Lukman O. Afolabi, Mengqi Zhang, Guizhong Zhang, Lulu Wang, Zhihuan Li, Lilong Lin, Qin Cao, Dehong Yan, Xiaochun Wan. Regulation of ROS in myeloid-derived suppressor cells through targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy. Cellular Immunology[J]. 2021, 362(104286): http://dx.doi.org/10.1016/j.cellimm.2021.104286.
[4] Adeleye Oluwatosin Adeshakin, Funmilayo O. Adeshakin, Wan Liu, Hua Li, Dehong Yan, Xiaochun Wan. Lipidomics data on the effect of lipofermata on myeloid-derived suppressor cells in the spleens of tumor-bearing mice.. Data in Brief[J]. 2021, 35(106882): http://dx.doi.org/10.1016/j.dib.2021.106882.
[5] Lu-Lu Wang, Dehong Yan, Xue Tang, Mengqi Zhang, Shilin Liu, Ying Wang, Min Zhang, Guichi Zhou, Tonghui Li, Feifei Jiang, Xiaowen Chen, Feiqiu Wen, Sixi Liu, Huirong Mai. High Expression of BCL11A Predicts Poor Prognosis for Childhood MLL-r ALL. Frontiers in Oncology[J]. 2021, 11(755188): https://doi.org/10.3389/fonc.2021.755188.
[6] Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai H. Chen, Xiaochun Wan. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. Journal of Experimental Medicine[J]. 2020, 217(2): e20182005-, https://doi.org/10.1084/jem.20182005.
[7] Adeleye O. Adeshakin, Dehong Yan, Mengqi Zhang, Lulu Wang, Funmilayo O. Adeshakin, Wan Liu, Xiaochun Wan. Blockade of myeloid-derived suppressor cell function by valproic acid enhanced anti-PD-L1 tumor immunotherapy. Biochemical and Biophysical Research Communications[J]. 2020, 522(3): 604-611, http://dx.doi.org/10.1016/j.bbrc.2019.11.155.
[8] Dehong Yan, Adeleye O. Adeshakin, Meichen Xu, Lukman O. Afolabi, Guizhong Zhang, Youhai H. Chen, Xiaochun Wan. Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor. Frontiers in Immunology[J]. 2019, 10(1399): https://doi.org/10.3389/fimmu.2019.01399.
[9] 鄢德洪, 徐美晨, 王婧惠, 万晓春. 青蒿素类药物靶标及其免疫调节抗肿瘤机制研究进展. 免疫学杂志[J]. 2018, 34(8): 713-721, http://lib.cqvip.com/Qikan/Article/Detail?id=675761048.
[10] Dehong Yan, Quan Yang, Maohua Shi, Limei Zhong, Changyou Wu, Tao Meng, Huiyong Yin, Jie Zhou. Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating JAK2/STAT3 pathway.. European Journal of Immunology[J]. 2013, 43(11): 2943-2955, https://doi.org/10.1002/eji.201343472.

科研活动

   
科研项目
( 1 ) PUFA重编程MDSC脂质代谢的分子机制及其在肿瘤免疫逃逸中的作用研究, 负责人, 国家任务, 2016-01--2018-12
( 2 ) PUFA重编程MDSC脂质代谢引起肿瘤免疫逃逸的机制研究, 负责人, 国家任务, 2016-01--2017-12
( 3 ) 抑癌基因TIPE2打破肿瘤免疫耐受的分子机制, 负责人, 地方任务, 2016-06--2018-06
( 4 ) 乳腺癌治疗新靶点研究, 参与, 地方任务, 2017-06--2020-06
( 5 ) 双抗原识别型 CAR 回路的设计合成与优化, 参与, 国家任务, 2020-01--2024-12
( 6 ) 青蒿素靶向 MDSCs 逆转肿瘤微环境免疫抑制状态的机制研究, 负责人, 地方任务, 2020-06--2023-05
( 7 ) TIPE2介导脂质代谢重编程调控MDSC功能极化的分子机制及其在肿瘤免疫抑制中的作用研究, 负责人, 国家任务, 2021-01--2024-12
( 8 ) 24通量核酸提取、扩增微流控芯片系统研究, 负责人, 国家任务, 2021-12--2024-11
( 9 ) 靶向阻断DGAT1介导的MDSC免疫抑制功能增强PD-L1抗体疗效的分子机制研究, 负责人, 地方任务, 2022-01--2024-12
参与会议
(1)Artemisinin selectively induces ferroptosis and reverses the immunosuppressive state of MDSCs in T-cell lymphoma   Dehong Yan, Mengqi Zhang and Xiaochun Wan   2021-05-10
(2)TIPE2调控肿瘤发生过程中髓系抑制性细胞 (MDSC)功能极化的新机制   广东省免疫学会 2020 年学术年会   鄢德洪   2020-12-05
(3)STAT3 induces the expression of fatty acid transport proteins (FATP2 and FATP4) to promote myeloid-derived suppressor cells function in tumor   Adeleye Oluwatosin Adeshakin, Dehong Yan, Mengqi Zhang, Lukman Olalekan Afolabi, Funmilayo Oladunni Adeshakin and Xiaochun Wan   2020-05-08
(4) Artemisinin improves the efficiency of anti-PD-L1 therapy in T-cell lymphoma   Dehong Yan, Mengqi Zhang, Adeleye O. Adeshakin and Xiaochun Wan   2020-05-08
(5)Lipid metabolic pathways confer immunosuppressive function of myeloid-derived suppressor cells in tumor   Yan D. , Adeleye O.A. , Zhang M. , Xu M. , Chen Y.H. , Wan X   2019-10-19
(6)TIPE2 Protein Specifies the Functional Polarization of Myeloid-derived Suppressor Cells during Tumorigenesis    D. Yan, J. Wang, M. Xu, O. Adeleye, Y. Chen, X. Wan   2018-09-02
(7)TIPE2, an inflammation transfer switch, regulates the on-and-off immunosuppressive function of MDSCs in tumors   Dehong Yan, Jinghui Wang, Adeleye O. Adeshakin, Meichen Xu, Youhai H. Chen and Xiaochun Wan   2018-05-04
(8)抑癌基因TIPE2打破肿瘤免疫耐受的分子机制   中国免疫学会第十二届全国免疫学学术大会   鄢德洪,王婧惠,徐美晨,万晓春   2017-10-26
(9)TIPE2 is a novel direct target of STAT3 in MDSC and inhibition of its expression on MDSC enhanced T cell activation in tumor   De hong Yan, Jing hui Wang and Xiao chun Wan   2017-05-12