液相色谱-质谱分析方法开发与应用

定量蛋白质组学

   

071010-生物化学与分子生物学
0710J3-生物信息学

系统生物学
生命分析化学

2010-09--2015-06   浙江大学   博士
2006-07--2010-06   浙江大学   学士

理学学士（药学）

医学博士（药物分析学）

   

2022-05~现在, 国科大杭高院, 副教授
2015-07~2022-04,浙江中医药大学, 讲师、副教授（硕导）

发表论文

Mengtian Shi, Chiyuan Huang, Renhui Chen, David Chen*, Binjun Yan*. A new evaluation metric for quantitative accuracy of LC-MS/MS based proteomics with data-independent acquisition, Journal of Proteome Research, 2024, 23(9): 3780-3790.

Siyu Cai, Yuan Su, Mengtian Shi, Dandan Wang, David Chen*, Binjun Yan*. Simultaneous quantification of six proteins related to liver injury using nano liquid chromatography–tandem mass spectrometry, Rapid Communications in Mass Spectrometry, 2024, 38: e9754.

Binjun Yan*, Mengtian Shi, Siyu Cai, Yuan Su, Renhui Chen, Chiyuan Huang, David Chen*. Data-driven tool for cross-run ion selection and peak-picking in quantitative proteomics with data-independent acquisition LC-MS/MS, Analytical Chemistry, 2023, 95(45): 16558-16566.

Noorfatimah Yahaya*, Zi-ao Huang, Binjun Yan, David Chen*. Capillary electrophoresis–mass spectrometry analysis of bisphenol A and its analogues in bottled tea beverages with dynamic pH focusing, Food Chemistry, 2022, 372: 131220.

Menglan Shen, Qiaoyan Zhang, Luping Qin*, Binjun Yan*. Single standard substance for the simultaneous determination of eleven components in the extract of Paeoniae Radix Alba (root of Paeonia lactiflora Pall.). Journal of Analytical Methods in Chemistry. 2021, 2021: 8860776.

Zhiwei Ge, Kuanyong Zhang, David Chen*, Binjun Yan*, Data-driven development of liquid chromatography-mass spectrometry methods for combined sample matrices, Talanta, 2021, 224: 121880.

Binjun Yan, Zi-Ao Huang, Noorfatimah Yahaya, David Chen*. Enantioselective analysis in complex matrices using capillary electrophoresis-mass spectrometry: A case study of the botanical drug Corydalis Rhizoma. Journal of Chromatography B, 2020, 1152: 122216.

Shunnan Zhang, Haoshu Xiong, Lihong Zhou, Wei Ju, Zhexuan Yang, Kaijing Yan, Binjun Yan*, Haibin Qu*. Development and validation of in-line near-infrared spectroscopy based analytical method for commercial production of a botanical drug product. Journal of Pharmaceutical and Biomedical Analysis. 2019, 174: 674-682.

Binjun Yan*, Menglan Shen, Jinyang Fang, Danni Wei, Luping Qin*. Advancement in the chemical analysis of Paeoniae Radix (Shaoyao). Journal of Pharmaceutical and Biomedical Analysis. 2018, 160: 276-288.

Danni Wei, Guilin Cheng, Kaiyi Huang, Jinyang Fang, Binjun Yan*. Hydrodistillation condition adjustment for different material particle sizes: a method to increase batch-to-batch quality consistency. International Journal of Food Science & Technology. 2018, 53(5): 1140-1148.

Hua Yin, Li Zou, Yunjie Sheng, Xue Bai, Qiang Liu, Binjun Yan*. Rapid HPLC analytical method development for herbal medicine formulae based on retention rules acquired from the constituting herbs. Analytical Sciences. 2018, 34(2): 207-214.

Jinyang Fang, Bo Yang, Zhiwei Ge, Xue Bai, Binjun Yan*. Single standard substance for the determination of nine volatile components in the distillate of Fructus Gardeniae and Radix Curcumae (an intermediate of Xingnaojing Injection). Journal of Separation Science. 2017, 40(20): 3946-3957.

Binjun Yan*, Xue Bai, Yunjie Sheng, Fanzhu Li. Statistical model based HPLC analytical method adjustment strategy to adapt to different sets of analytes in complicated samples. Phytochemical Analysis. 2017, 28(5): 424-432.

Binjun Yan, Zhonghua Fang, Lijuan Shen, Haibin Qu*. Root cause analysis of quality defects using HPLC-MS fingerprint knowledgebase for batch-to-batch quality control of herbal drugs. Phytochemical Analysis. 2015, 26(4): 261-268.

Binjun Yan, Haibin Qu*. Rapid screening of critical process parameters based on near infrared spectroscopy: a case study of the ethanol precipitation process. Analytical Methods. 2015, 7(11): 4616-4620.

Binjun Yan, Teng Chen, Zhilin Xu, Haibin Qu*. Rapid process development of chromatographic process using direct analysis in real time mass spectrometry as a process analytical technology tool. Journal of Pharmaceutical and Biomedical Analysis. 2014, 94: 106-110.

Binjun Yan, Yao Li, Zhengtai Guo, Haibin Qu*. Quality by Design for herbal drugs: A feedforward control strategy and an approach to define the acceptable ranges of critical quality attributes. Phytochemical Analysis. 2014, 25(1): 59-65.

Binjun Yan, Haibin Qu*. An approach to optimize the batch mixing process for improving the quality consistency of the products made from traditional Chinese medicines. Journal of Zhejiang University-Science B. 2013, 14(11): 1041-1048.

Binjun Yan, Haibin Qu*. Multivariate data analysis of UV spectra in monitoring elution and determining endpoint of chromatography using polyamide column. Journal of Separation Science. 2013, 36(7): 1231-1237.

科研项目

国家自然科学基金面上项目（82073956），2021.01至2024.12，67.2万元，主持

国家自然科学基金青年项目（81703462），2018.01至2020.12，24.12万元，主持

中国博士后科学基金项目（2018M642495），2018.11至2020.12，5万元，主持

浙江省科技厅公益技术项目（LGF19H280005），2019.01至2021.12，10万元，主持

基于液相色谱-质谱联用的蛋白质组定量软件

https://github.com/ybinjun/CRISP-DIA/releases